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1. (n-chloro-p-toluenesulfonamide)sodium
2. Chloramine T
3. Chloramine-t Anhydrous
4. Chloramine-t Trihydrate
5. Chloramine-t, 36cl-labeled
6. Clorina
7. Euclorina
8. Hydroclonazone
9. Sodium P-toluenesulfonchloramide
1. Chloramine T
2. 127-65-1
3. Chloralone
4. Chlorasan
5. Chlorozone
6. Tosylchloramide Sodium
7. Acti-chlore
8. Chloraseptine
9. Chlorazone
10. Chlorseptol
11. Multichlor
12. Tochlorine
13. Aktivin
14. Chlorazan
15. Chlorosol
16. Heliogen
17. Mannolite
18. Tampules
19. Tolamine
20. Sodium Chloramine T
21. Chlorina Aktivin
22. Monochloramine T
23. Sodium Chloro(tosyl)amide
24. Sodium Tosylchloramide
25. Sodium P-toluenesulfonchloramide
26. Chlorazene
27. Tosilcloramida Sodica
28. Tosylchloramide Sodique
29. Tosylchloramidum Natricum
30. Berkendyl
31. Clorina
32. Euclorina
33. Anexol
34. (n-chloro-p-toluenesulfonamido)sodium
35. Sodium P-toluenesulfonylchloramide
36. Cloramine T
37. N-chloro-p-toluenesulfonamide Sodium
38. Sodium N-chloro-p-toluenesulfonamide
39. Gyneclorina
40. Clorosan
41. Halamid
42. Mianine
43. Gansil
44. Chloramin Heyden
45. Kloramine-t
46. Tosylchloramide Sodium [inn]
47. Chloramin Dr. Fahlberg
48. Chebi:53767
49. N-chlorotoluenesulfonamide Sodium Salt
50. N-chloro-4-methylbenzylsulfonamide Sodium Salt
51. 328as34ym6
52. [chloro(p-tolylsulfonyl)amino]sodium
53. Aseptoclean
54. Desinfect
55. Tosylchloramid-natrium
56. 149358-73-6
57. Tosylchloramide Sodium (inn)
58. Chloramine-t Anhydrous
59. Caswell No. 170
60. Benzenesulfonamide, N-chloro-4-methyl-, Sodium Salt (1:1)
61. Chloramine-t [nf]
62. Nsc-36959
63. P-toluenesulfonchloramide Sodium Salt
64. Hsdb 4303
65. Sr-01000872612
66. N-chloro-p-toluenesulfonamide Sodium Salt
67. Einecs 204-854-7
68. Tosilcloramida Sodica [inn-spanish]
69. N-chloro-4-methylbenzenesulfonamide Sodium Salt
70. Nsc 36959
71. Tosylchloramide Sodique [inn-french]
72. Tosylchloramidum Natricum [inn-latin]
73. Ai3-18426c
74. Epa Pesticide Chemical Code 076502
75. Unii-328as34ym6
76. Chloramin T
77. P-toluenesulfonamide, N-chloro-, Sodium Salt
78. Sodiumchloro(tosyl)amide
79. Sodium Chloro(4-methylbenzenesulfonyl)azanide
80. Chloramine-t [mi]
81. Epitope Id:116223
82. Chloramine T [inci]
83. Chloramine-t [hsdb]
84. Schembl19335
85. Chembl1697734
86. Dtxsid6040321
87. Hms3264n19
88. Amy37206
89. Bcp12015
90. Hy-b0959
91. S6403
92. Akos015890257
93. Ccg-213937
94. Cs-4435
95. Tosylchloramide Sodium [who-dd]
96. Tosylchloramide Sodium [ep Impurity]
97. Ft-0654742
98. Sodium;chloro-(4-methylphenyl)sulfonylazanide
99. Tosylchloramide Sodium [ep Monograph]
100. En300-75322
101. Sodium Chloro[(4-methylphenyl)sulfonyl]azanide
102. D02445
103. D88065
104. Q420695
105. J-008582
106. Sr-01000872612-2
107. Sr-01000872612-3
108. W-108379
109. Chloramine (t) N-chloro-4-toluenesulfonamide,sodium Salt
| Molecular Weight | 227.64 g/mol |
|---|---|
| Molecular Formula | C7H7ClNNaO2S |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 226.9783716 g/mol |
| Monoisotopic Mass | 226.9783716 g/mol |
| Topological Polar Surface Area | 43.5 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 231 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).
Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-76
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
Disinfectants
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)
Indicators and Reagents
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)
Oxidants
Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). (See all compounds classified as Oxidants.)
D08AX04
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
D - Dermatologicals
D08 - Antiseptics and disinfectants
D08A - Antiseptics and disinfectants
D08AX - Other antiseptics and disinfectants
D08AX04 - Tosylchloramide sodium
Fingerlings and juvenile trout were exposed to 20 mg/L (twice the therapeutic concentration) of ring UL-14C-tosylchloramide sodium (purity 93.7%, specific activity 1.2 uCi/uM) for up to 1 hr and then transferred to fresh water for recovery to assess tissue accumulation and distribution of resulting residues. The temperature of the well water was 11.6 to 12.2 C. The estimated half-life of para-toluenesulfonamide equivalents in fingerlings was 27.3 hours whereas determined by HPLC the half-life of para-toluenesulfonamide residues in whole-body homogenates was 36.3 hours. The estimated half-life of residues in juvenile fish was 32.6 hours, based on radiometric data, while determined by HPLC the half-life for para-toluenesulfonamide residues in whole body samples was 40.3 hours. Elimination of total tosylchloramide sodium residues from fingerlings and juvenile whole-body homogenates, based on radiometric counts, was rapid but significantly faster from fingerlings (t1/2 of 27.3 hours) than from juveniles (t1/2 of 32.5 hours). ...Tosylchloramide sodium was poorly absorbed form the bath by both fingerling and juvenile trout. No residues of tosylchloramide sodium, only of the primary metabolite para-toluenesulfonamide, were found in any of the fish tissues in this study therefore, all tissue residues determined either by radiometric or by HPLC methods were reported on the basis of equivalent concentrations of para-toluenesulfonamide. The para-toluenesulfonamide equivalents concentration in whole body homogenates after 1 hr, based on radiometric analysis, was 980 ug/kg, a value about 5% of that in the exposure water, in fingerlings. In juveniles, this value was 570 ug/kg or about 3% of the concentration ing the exposure bath. The exposure of para-toluenesulfonamide in whole body homogenates, after 1 hr, based on HPLC analyses was 360 ug/kg in fingerlings and 170 ug/kg in juveniles.
European Agency for the Evaluation of Medicinal Products; Tosylchloramide Sodium Summary Report (February 1999) EMEA/MRL/570/99-FINAL. Available from, as of November 12, 2003: https://www.emea.eu.int/pdfs/vet/mrls/057099en.pdf
The percutaneous absorption of tosylchloramide sodium was investigated. Five lactating cows were treated twice daily during milking for 8 days. The teats were cleaned before milking with udder tissues dipped in a solution containing 0.5% tosylchloramide and thereafter dipped after milking into the same solution. The solutions containing 0.5% tosylchloramide were freshly prepared every day. Blood samples were taken from the Vena jugularis during the treatment, immediately before the last treatment and 30 minutes, 1, 2, 4, 8, 16, and 24 hours after the last treatment. The samples were tested with a HPLC method where tosylchloramide is hydrolysed into para-toluenesulfonamide before analyzing of the samples. The detection limit of the method was 5 ug/kg of para-toluenesulfonamide and 8 ug/kg for tosylchloramide. No residues of para-toluenesulfonamide could be detected in any blood samples. It is concluded that the absorption of tosylchloramide in blood in negligible after percutaneous application to the teat.
European Agency for the Evaluation of Medicinal Products; Tosylchloramide Sodium Summary Report (2-Extension to bovine) (March 2001) EMEA/MRL/782/01-FINAL. Available from, as of November 12, 2003: https://www.emea.eu.int/pdfs/vet/mrls/078201en.pdf
/Immunoglobulin E/ mediation is a possible mechanism of action for induction of environmental or occupational asthma by Chloramine T. /from table/
Rom, W.N. (ed.). Environmental and Occupational Medicine. 2nd ed. Boston, MA: Little, Brown and Company, 1992., p. 78
The major elastase inhibitor of human serum, alpha-1 proteinase inhibitor (A1PI), is susceptible to oxidative inactivation by a variety of agents, including chloramine T. We have examined the effects of chloramine T on the catalytic activity of porcine pancreatic (PPE) and human leukocyte elastase (HLE) and on the elastase inhibitory capacity of hamster, rat, and human serum as well as pure human A1PI. Both PPE and HLE, but not trypsin, were inhibited in a concentration-dependent manner by concentrations of chloramine T >0.1 mM. The abilities of rat and human serum and pure human A1PI to inhibit both PPE and HLE were inhibited in a concentration-dependent manner by chloramine T. In contrast only the ability of hamster serum to inhibit HLE was altered by exposure to chloramine T: inhibition of PPE was not effected. Gel exclusion chromatography disclosed the existence of two major peaks of elastase inhibitory activity in hamster plasma: one, with an approximate molecular weight of 55 K, eluting in the region of A1PI that was sensitive to chloramine T inactivation and one with a molecular weight of approximately 180 K which was chloramine T insensitive. The parenteral administration of chloramine T to hamsters resulted in a modest and transient diminution of the serum HLE inhibitory activity and an equally modest and transient elevation of PPE inhibitory activity.
PMID:3487448 Williams JC et al; Exp Lung Res 10 (4): 357-68 (1986)
Treatment of human erythrocyte membranes with active forms of chlorine (... chloramine T) resulted in a concentration-dependent inhibition of the membrane Na(+), K(+)- and Mg(2+)-ATPases. Membrane protein thiol group oxidation was consistent with inactivation of enzymes and preceded oxidation of tryptophan residues and chloramine formation.
PMID:11182291 Zavodnik IB et al; Free Radic Biol Med 30(4): 363-9 (2001)
The hypothesis that chloramine-T stimulates the basal Na+ efflux in barnacle fibers as the result of the entry of trigger Ca2+ into the myoplasm from the bathing medium was examined in this study. Two reasons for doing so can be given. One is that the oxidant is known to abolish inactivation in sodium and potassium channels. The other is that L-type Ca2+ channels are present in barnacle fibers, and an increase in internal free Ca2+ in these fibers is known to ... (i) Chloramine-T exerts a biphasic effect on the Na+ efflux: inhibition is followed by stimulation, the threshold concentration being 10-5 M. This is also found to be the threshold concentration for shortening of these fibers. ... (vii) The dose-response curve for chloramine-T shows a shift to the left in poisoned fibers. (viii) The magnitude of the rise in light emission depends on the external Ca2+ concentration. A rise fails to take place in the nominal absence of external Ca2+. Taken together, these results support the above hypothesis that chloramine-T causes the entry of trigger Ca2+ into the myoplasm from the outside and provide evidence that stimulation of the Na+ efflux is associated not only with this event but also with a reduced Na+ gradient resulting from inhibition of the membrane Na+/K(+)-ATPase system by the oxidant.
PMID:1329968 Wu JR et al; Biochim Biophys Acta 1112 (1): 99-104 (1992)
... The effect of chloramine-T on the inactivation of IK1 was examined in guinea-pig ventricular myocytes using the patch-clamp technique. Chloramine-T (2 mM) irreversibly inhibited the time-dependent decay of whole-cell IK1 inactivation. As a result, the negative slope region of the current-voltage (I-V) relationship was abolished. In cell-attached single channel recordings, the number of active channels in the patch decreased with time during the voltage-clamp step to the K+ equilibrium potential (EK) of -100 mV. Chloramine-T prevented this time-dependent decrease in channel number, and ensemble averaged currents exhibited abolishment of time-dependent decay of channel activity at EK -100 mV.
PMID:8088362 Koumi S et al; Eur J Pharmacol 258(3): 281-4 (1994)
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