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Chlorhexidine Gluconate

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ACTIVE PHARMA INGREDIENTS

47 API Suppliers, 28 USDMF, 9 CEP/COS, 9 JDMF, 7 EU WC, 1 VMF, 15 Listed Suppliers, $ API Reference Price

47 API Suppliers
28 USDMF
9 CEP/COS
9 JDMF
7 EU WC
1 VMF
15 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

166 FDF Dossiers, 49 FDA Orange Book, 17 Europe, 67 Canada, 9 South Africa, 24 Listed Dossiers

166 FDF Dossiers
49 FDA Orange Book
17 Europe
67 Canada
9 South Africa
24 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

AEROSOL, METERED;TOPICAL - 4%, SOLUTION;TOPICAL - 2%, TABLET;DENTAL - 2.5MG, SOLUTION;TOPICAL - 2%;70%, SPONGE;TOPICAL - 2%;70% (1.5ML), SPONGE;TOPICAL - 2%;70% (10.5ML), SPONGE;TOPICAL - 2%;70% (1ML), SPONGE;TOPICAL - 2%;70% (26ML), SPONGE;TOPICAL - 2%;70% (3ML), SOLUTION;TOPICAL - 61%;1%, SWAB;TOPICAL - 3.15%;70% (1.6ML), SWAB;TOPICAL - 3.15%;70% (1ML), SWAB;TOPICAL - 3.15%;70% (5.1ML), SWAB;TOPICAL - 2%;70% (0.67ML), SWAB;TOPICAL - 2%;70% (1.75ML), SWAB;TOPICAL - 2%;70% (5.25ML)

drugProductComposition
AEROSOL, METERED;TOPICAL - 4%
SOLUTION;TOPICAL - 2%
TABLET;DENTAL - 2.5MG
SOLUTION;TOPICAL - 2%;70%
SPONGE;TOPICAL - 2%;70% (1.5ML)
SPONGE;TOPICAL - 2%;70% (10.5ML)
SPONGE;TOPICAL - 2%;70% (1ML)
SPONGE;TOPICAL - 2%;70% (26ML)
SPONGE;TOPICAL - 2%;70% (3ML)
SOLUTION;TOPICAL - 61%;1%
SWAB;TOPICAL - 3.15%;70% (1.6ML)
SWAB;TOPICAL - 3.15%;70% (1ML)
SWAB;TOPICAL - 3.15%;70% (5.1ML)
SWAB;TOPICAL - 2%;70% (0.67ML)
SWAB;TOPICAL - 2%;70% (1.75ML)
SWAB;TOPICAL - 2%;70% (5.25ML)

RELATED EXCIPIENT COMPANIES

5 Rochem International Inc, 4 SPI Pharma, 2 Seqens, 12 DKSH, 1 Pharm-RX Chemical, 1 Faran Shimi Pharmaceutical, 3 Boai NKY Pharmaceuticals Ltd, 1 Gangwal Healthcare, 10 Nanjing Well Pharmaceutical, 3 Pfanstiehl, 4 ACG Worldwide, 18 Actylis, 1 Alcedo Pharmachem, 23 BASF, 2 BioSpectra, 1 Clariant, 6 Corel Pharma Chem, 4 Finar, 5 Gangwal Chemicals, 2 Ideal Cures Pvt Ltd, 9 Kerry, 1 Kima Chemical, 3 Lonza Capsugel, 1 Lubrizol Life Science Health, 3 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nippon Fine Chemical, 2 Nomisma Healthcare, 1 Novo Excipients, 2 Pluviaendo, 1 Qualicaps, 19 Roquette, 16 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries, 1 The Dow Chemical Company, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 1 Zhejiang Huakang Pharmaceutical

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2 US Medicaid Prescriptions, 4 Finished Drug Prices

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2 US Medicaid Prescriptions
4 Finished Drug Prices

MARKET PLACE

32 APIs, 1 FDF Dossiers

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32 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

9 US Patents, 1 US Exclusivities

patents
9 US Patents
1 US Exclusivities

Synopsis

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API Suppliers

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CEP/COS

JDMF

EU WC

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NDC API

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API REF. PRICE (USD/KG)

$ 2

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API

FDF

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FINISHED DOSAGE FORMULATIONS

166

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

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177 RELATED EXCIPIENT COMPANIES

303EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Chlorhexidine digluconate, Hibiclens, 18472-51-0, Peridex, Dyna-hex, Bioscrub

Molecular Formula

C₃₄H₅₄Cl₂N₁₀O₁₄

Molecular Weight

897.8 g/mol

InChI Key

YZIYKJHYYHPJIB-UUPCJSQJSA-N

FDA UNII

MOR84MUD8E

Chlorhexidine Gluconate is the gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

1 2D Structure

Chlorhexidine Gluconate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

2.1.2 InChI

InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1

2.1.3 InChI Key

YZIYKJHYYHPJIB-UUPCJSQJSA-N

2.1.4 Canonical SMILES

C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.C(C(C(C(C(C(=O)O)O)O)O)O)O.C(C(C(C(C(C(=O)O)O)O)O)O)O

2.1.5 Isomeric SMILES

C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

MOR84MUD8E

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1,1'-hbcb

2. Avagard

3. Chlorhexamed

4. Chlorhexidine Bigluconate

5. Chlorhexidine Digluconate

6. Corsodyl Ici

7. Curasept Ads 220

8. Dyna-hex

9. Eludril

10. Gibitan

11. Hexidine

12. Hibiclens

13. Hibident

14. Hibiscrub

15. Hibisol

16. Hibitane

17. Peridex

18. Perio Chip

2.3.2 Depositor-Supplied Synonyms

1. Chlorhexidine Digluconate

2. Hibiclens

3. 18472-51-0

4. Peridex

5. Dyna-hex

6. Bioscrub

7. Chlorhexidine D-digluconate

8. Exidine

9. Microderm

10. Periochip

11. Periogard

12. Unisept

13. Brian Care

14. Steri-stat

15. Cida-stat

16. Hibistat

17. Pharmaseal Scrub Care

18. Chg Scrub

19. Prevacare

20. Chlorhexidine Digluconate Solution

21. Chlorhexidine Di-d-gluconate

22. Mor84mud8e

23. Nsc-753971

24. Hibiscrub

25. Hibitane

26. 1,1'-hexamethylene Bis(5-(p-chlorophenyl)biguanide), Digluconate

27. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) Di-d-gluconate

28. Bacticlens

29. Chlorhexamed

30. Kleersight

31. Corsodyl

32. Disteryl

33. Hibident

34. Hibidil

35. Orahexal

36. Plurexid

37. Septeal

38. Abacil

39. Fight Bac

40. Plac Out

41. Prevacare R

42. Arlacide G

43. Hibitane 5

44. 2,4,11,13-tetraazatetradecanediimidamide, N,n''-bis(4-chlorophenyl)-3,12-diimino-, Di-d-gluconate

45. Chlorhexidin Glukonatu

46. Peridex (antiseptic)

47. Bactoshield Chg 2%

48. Caswell No. 481g

49. Unii-mor84mud8e

50. Pwriochip

51. Chlorhexidin Glukonatu [czech]

52. 1,6-bis(n5-[p-chlorophenyl]-n1-biguanido)hexane

53. Phiso-med

54. Hibitane Gluconate

55. Hibiclens (tn)

56. Periogard (tn)

57. Drg-0091

58. Einecs 242-354-0

59. Peridex (tn)

60. Mfcd00083599

61. Chlohexidine Gluconate

62. Epa Pesticide Chemical Code 045504

63. Readyprep Chg

64. Chlorhexidine Gluconate [usan:usp:jan]

65. Ec 242-354-0

66. Schembl34468

67. 1,6-bis(5-(p-chlorophenyl)biguandino)hexane Digluconate

68. Chembl4297088

69. Dtxsid5034519

70. Chebi:28312

71. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) Gluconate

72. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate

73. Chx Plus Concentrate Premium Chlorhexidine Teat Dip Concentrate

74. Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, Digluconate

75. Chlorhexidine Gluconate (jp17/usp)

76. Chlorhexidine Gluconate [jan]

77. Chlorhexidine Gluconate [usan]

78. Akos015896303

79. Akos025310696

80. Chlorhexidine Gluconate [mart.]

81. Chlorhexidine Gluconate [vandf]

82. Nsc 753971

83. Chlorhexidine D-digluconate [mi]

84. Chlorhexidine Digluconate [inci]

85. Chlorhexidine Gluconate [who-dd]

86. Gluconic Acid, Compd. With 1,1'-hexamethylene Bis(5-(p-chlorophenyl)biguanide) (2:1), D-

87. D-gluconic Acid, Compd. With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

88. D-gluconic Acid, Compound With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

89. Chlorhexidine Gluconate [orange Book]

90. Chlorhexidine Gluconate [usp Impurity]

91. Avagard Component Chlorhexidine Gluconate

92. C08038

93. D00858

94. Chlorhexidine Digluconate Solution, 20% In H2o

95. Soluprep Component Chlorhexidine Gluconate

96. Chloraprep Component Chlorhexidine Gluconate

97. Chlorhexidine Gluconate Component Of Avagard

98. Chlorhexidine Digluconate, 20% W/v Aqueous Solution

99. Chlorhexidine Gluconate Component Of Soluprep

100. J-011837

101. Chlorhexidine Gluconate Component Of Chloraprep

102. Chlorhexidine Digluconate Solution [ep Monograph]

103. 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate

104. Chlorhexidine Digluconate, Pharmaceutical Secondary Standard; Certified Reference Material

105. 1,1'-hexamethylenebis[5-(p-chlorophenyl)biguanide] (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic Acid(1:2)

106. 1-(4-chlorophenyl)-3-[n-[6-[[n-[n-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]guanidine; (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic Acid

107. 2,4,11,13-tetraazatetradecanediimidamide, N,n''-bis(4-chlorophenyl)-3,12-diimino-, Digluconate

108. 2,4,11,13-tetraazatetradecanediimidamide, N,n'-bis(4-chlorophenyl)-3,12-diimino-, Di-d-gluconate

109. D-gluconic Acid, Compd With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

110. D-gluconic Acid, Compd. With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecane Diimidamide (2:1)

111. D-gluconic Acid, Compd. With N1,n14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

112. N',n'''''-hexane-1,6-diylbis[n-(4-chlorophenyl)(imidodicarbonimidic Diamide)]--d-gluconic Acid (1/2)

2.4 Create Date

2006-10-23

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₅₄Cl₂N₁₀O₁₄
Molecular Weight	897.8 g/mol
Hydrogen Bond Donor Count	18
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	23
Exact Mass	896.3198018 g/mol
Monoisotopic Mass	896.3198018 g/mol
Topological Polar Surface Area	455 Å²
Heavy Atom Count	60
Formal Charge	0
Complexity	819
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Chlorhexidine gluconate
Drug Label	Chlorhexidine Gluconate is an oral rinse containing 0.12% chlorhexidine gluconate (1,11-hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium...
Active Ingredient	Chlorhexidine gluconate
Dosage Form	Cloth; Solution; Sponge
Route	Dental; Topical
Strength	0.12%; 2%; 4%
Market Status	Over the Counter; Prescription
Company	Lyne; Wockhardt; Sage Prods; Hi Tech Pharma; Teva; Xttrium; Becton Dickinson

2 of 2
Drug Name	Chlorhexidine gluconate
Drug Label	Chlorhexidine Gluconate is an oral rinse containing 0.12% chlorhexidine gluconate (1,11-hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium...
Active Ingredient	Chlorhexidine gluconate
Dosage Form	Cloth; Solution; Sponge
Route	Dental; Topical
Strength	0.12%; 2%; 4%
Market Status	Over the Counter; Prescription
Company	Lyne; Wockhardt; Sage Prods; Hi Tech Pharma; Teva; Xttrium; Becton Dickinson

4.2 Therapeutic Uses

Antiseptic; disinfectant. (Vet): antiseptic; disinfectant.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 371

Cleanser: As a surgical hand scrub, skin wound and general skin cleanser, health care personnel hand wash, and for preoperative skin preparation. Chlorhedine gluconate significantly reduces the number of microorganisms on the hands and forearms prior to surgery or patient care. /Chlorhexidine gluconate-topical/

Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

EXPL THER To determine if chlorhexidine can be used as an intervention to prolong the time to relapse of oral candidiasis. SUBJECTS AND METHODS: A double-blinded randomized clinical trial was performed in 75 HIV/AIDS subjects with oral candidiasis. Clotrimazole troche was prescribed, and the subjects were re-examined every 2 weeks until the lesions were completely eradicated. The subjects were then randomly divided into two groups; 0.12% chlorhexidine (n = 37, aged 22-52 years, mean 34 years) and 0.9% normal saline (n = 38, aged 22-55 years, mean 38 years). They were re-examined every 2 weeks until the next episode was observed. RESULTS: The time to recurrence of oral candidiasis between the chlorhexidine and the saline group was not statistically significant (P > 0.05). The following variables were significantly associated with the time of recurrence; frequency of antifungal therapy (P = 0.011), total lymphocyte (P = 0.017), alcohol consumption (P = 0.043), and candidiasis on gingiva (P = 0.048). The subjects with lower lymphocyte showed shorter oral candidiasis-free periods (P = 0.034). CONCLUSIONS: Chlorhexidine showed a small but not statistically significant effect in maintenance of oral candidiasis-free period. This lack of significance may be due to the small sample size. Further study should be performed to better assess the size of the effect, or to confirm our findings.

PMID:18627504 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253386 Nittayananta W et al; Oral Dis. (7): 665-70 (2008)

/EXPTL Therapy:/ Rats were injected with 10 mg/kg azoxymethane sc weekly for 12 weeks to induce colorectal cancers. At 20 weeks, subtotal colectomies were performed on rats with colorectal tumors and without peritoneal implants or liver metastases. At the time of surgery, a cut portion of the tumor was placed in the abdomen for 30 minutes; the rats then randomly received peritoneal irrigation with chlorhexidine, or sterile water (control). Eight weeks postoperatively a necropsy was performed. At that time, obvious and suspected recurrences and the anastomotic area were sampled for histologic evaluation. Significant differences were seen with chlorhexidine vs. water for gross tumor (P=0.05) and microscopic tumor (P<0.05).

Stuntz M et al; Dis Colon Rectum 40 (9): 1058-8 (1997)

4.3 Drug Warning

For external use only: For external use only. Keep out of eyes, ears, and mouth. Chlorhexidine gluconate should not be used as a preoperative skin preparation of the face or head. Misuse of products containing chlorhexidine gluconate has been reported to cause serious and permanent eye injury when it has been permitted to enter and remain in the eye during surgical procedures. If chlohexidine gluconate should contact these areas, rinse out promptly and thoroughly with cold water. Avoid contact with neninges. Do not use in genital area. /Chlorhexidine gluconate-topical/

Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

Sensitivity: Chlorhexidine gluconate should not be used by persons who have a sensitivity to it or its components.

Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

Hypersensitivity reactions: Irritation, sensitization, and generalized allergic reactions have been reported with chlorhexidine-containing products, especially in the genital areas. If adverse reactions occur and last more than 72 hr, discontinue use immediately and, if severe, contact a health care provider.

Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

Deafness: Chlorhexidine gluconate has been reported to cause deafness when instilled in the middle ear through perforate ear drums. /Chlorhexidine gluconate-topical/

Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

For more Drug Warnings (Complete) data for CHLORHEXIDINE (8 total), please visit the HSDB record page.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

Dermatologic Agents

Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Decreased Cell Wall Integrity [PE]

5.3 Absorption, Distribution and Excretion

34 newborn infants who had been bathed in a standard manner with Hibiscrub were studied to find out whether it was absorbed percutaneously. Low levels of chlorhexidine were found in the blood of all 10 babies sampled by heel prick, and 5 of 24 from whom venous blood was taken. /Chlorhexidine gluconate/

PMID:475414 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545570 Cowen J et al; Arch Dis Child 54 (5): 379-83 (1979)

Percutaneous absorption of the antimicrobial agent chlorhexidine (labelled with carbon-14) was studied in rats. Less than 5% of the topically applied chlorhexidine was absorbed during a 5-day period. Excretion of absorbed radioactivity occurred mainly in the feces.

Chow CP, et al; Toxicol Lett 1(4): 213-16 (1978)

The percutaneous absorption of chlorhexidine gluconate (chlorhexidine digluconate; Hibitane) through hairless rat skin with or without stratum corneum was studied. For tests carried out on whole skin, storage in cutaneous structures after 48 hr was more important than diffusion; the reverse was observed for stripped skin. When the skin was stripped, the amount absorbed was multiplied by approximately 100, and the amount stored in skin by approximately 10. The difference in chlorhexidine diffusion observed between whole and stripped skin was related to the physicochemical characteristics of chlorhexidine. /Chlorhexidine gluconate/

Lafforque C et al; Int J Pharm 147: 243-6 (1997)

To evaluate the elimination kinetics of chlorhexidine in milk when used as an intramammary infusion to stop lactation in cows. ... The study was performed in 2 phases. Three cows were studied in each phase. All cows were treated with chlorhexidine suspension by infusion into a mastitic mammary gland quarter after 2 milkings 24 hours apart. Foremilk samples (100 mL) were collected from treated and untreated (controls) mammary gland quarters of each cow. Chlorhexidine was extracted from raw milk, and residue concentrations were quantified by use of high-performance liquid chromatography. Foremilk samples from days 2, 5, and 8 were analyzed in phase I, and samples from time 0 and days 3, 7, 14, 21, 28, 35, and 42 were analyzed in phase II. In phases I and II, there was no quantifiable transference of chlorhexidine to milk in untreated mammary gland quarters. Measurable chlorhexidine residues were found in milk from treated mammary gland quarters of 2 cows throughout the 42-day sample period in phase II. Estimated mean elimination half-life for chlorhexidine in milk was 11.5 days.

PMID:12830870 Middleton JR et al; J Am Vet Med Assoc 222 (12): 1746-9 (2003)

5.4 Biological Half-Life

PMID:12830870 Middleton JR et al; J Am Vet Med Assoc 222 (12): 1746-9 (2003)

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Smaart Pharmaceutticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

09

ROHIT PLASTICS AND CHEMICALS

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

10

Reckitt Benckiser

United Kingdom

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Only 10 entries up to this point, click to access all

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USDMF

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CEP/COS

01

EVONIK OPERATIONS GMBH Essen DE

Germany

IPPE

Attending

Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!

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Germany

Virtual Booth

Digital Content

Chlorhexidine digluconate solution

Certificate Number : R1-CEP 2001-343 - Rev 05

Status : Valid

Issue Date : 2020-08-31

Type : Chemical

Substance Number : 658

02

Medichem, S.A. Sant Joan Despí ES

Spain

Antibody Engineering

Not Confirmed

Medichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

Contact Supplier

Spain

Virtual Booth

Digital Content

Chlorhexidine digluconate solution, CDG

Certificate Number : R1-CEP 2017-128 - Rev 00

Status : Valid

Issue Date : 2022-07-18

Type : Chemical

Substance Number : 658

03

Medichem, S.A. Sant Joan Despí ES

Spain

Antibody Engineering

Not Confirmed

Medichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

Contact Supplier

Spain

Virtual Booth

Digital Content

Chlorhexidine digluconate solution

Certificate Number : R1-CEP 1993-009 - Rev 04

Status : Valid

Issue Date : 2009-02-16

Type : Chemical

Substance Number : 658

04

AVA, INC. Willowbrook US

U.S.A

Antibody Engineering

Not Confirmed

05

BAJAJ HEALTHCARE LIMITED Thane (Wes...

India

Antibody Engineering

Not Confirmed

06

Bajaj Healthcare Limited Mumbai IN

India

Antibody Engineering

Not Confirmed

07

DISHMAN CARBOGEN AMCIS LIMITED Ahme...

Switzerland

Antibody Engineering

Not Confirmed

08

R.N. LABORATORIES Mumbai IN

India

Antibody Engineering

Not Confirmed

09

XTTRIUM LABORATORIES, INC. Mount Pr...

U.S.A

Antibody Engineering

Not Confirmed

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JDMF

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EU WC

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VMF

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Listed Suppliers

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API Reference Price

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K","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1655058600,"product":"CHLORHEXIDINE GLUCONATE 20PCT SOLUTION (RE-IMPORT ON EXPORTED GOODS.SB NO-4008979 DT-25.11.2020)","address":"404,VIP PLAZA,","city":"MUMBAI, MAHARASHTRA","supplier":"KLEY HERTZ FARMACEUTICA ","supplierCountry":"SINGAPORE","foreign_port":"SANTOS","customer":"R N LABORATORIES","customerCountry":"INDIA","quantity":"1400.00","actualQuantity":"1400","unit":"KGS","unitRateFc":"8.2","totalValueFC":"11537.2","currency":"USD","unitRateINR":"642.9","date":"13-Jun-2022","totalValueINR":"900081","totalValueInUsd":"11537.2","indian_port":"Surat-EPZ\/SEZ","hs_no":"29251900","bill_no":"1003489","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"SANTOS","supplierAddress":"N\/A","customerAddress":"404,VIP PLAZA,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - AEROSOL, METERED;TOPICAL - 4%

USFDA APPLICATION NUMBER - 19127

DOSAGE - SOLUTION;TOPICAL - 2%

USFDA APPLICATION NUMBER - 19422

DOSAGE - TABLET;DENTAL - 2.5MG

USFDA APPLICATION NUMBER - 20774

DOSAGE - SOLUTION;TOPICAL - 2%;70%

USFDA APPLICATION NUMBER - 208288

DOSAGE - SPONGE;TOPICAL - 2%;70% (1.5ML)

USFDA APPLICATION NUMBER - 20832

DOSAGE - SPONGE;TOPICAL - 2%;70% (10.5ML)

USFDA APPLICATION NUMBER - 20832

DOSAGE - SPONGE;TOPICAL - 2%;70% (1ML)

USFDA APPLICATION NUMBER - 20832

DOSAGE - SPONGE;TOPICAL - 2%;70% (26ML)

USFDA APPLICATION NUMBER - 20832

DOSAGE - SPONGE;TOPICAL - 2%;70% (3ML)

USFDA APPLICATION NUMBER - 20832

DOSAGE - SOLUTION;TOPICAL - 61%;1%

USFDA APPLICATION NUMBER - 21074

DOSAGE - SWAB;TOPICAL - 3.15%;70% (1.6ML)

USFDA APPLICATION NUMBER - 21524

DOSAGE - SWAB;TOPICAL - 3.15%;70% (1ML)

USFDA APPLICATION NUMBER - 21524

DOSAGE - SWAB;TOPICAL - 3.15%;70% (5.1ML)

USFDA APPLICATION NUMBER - 21524

DOSAGE - SWAB;TOPICAL - 2%;70% (0.67ML)

USFDA APPLICATION NUMBER - 21555

DOSAGE - SWAB;TOPICAL - 2%;70% (1.75ML)

USFDA APPLICATION NUMBER - 21555

DOSAGE - SWAB;TOPICAL - 2%;70% (5.25ML)

USFDA APPLICATION NUMBER - 21555

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ACTIVE PHARMA INGREDIENTS

47 API Suppliers

28 USDMF

9 CEP/COS

9 JDMF

7 EU WC

1 VMF

15 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

166 FDF Dossiers

49 FDA Orange Book

17 Europe

67 Canada

9 South Africa

24 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

AEROSOL, METERED;TOPICAL - 4%

SOLUTION;TOPICAL - 2%

TABLET;DENTAL - 2.5MG

SOLUTION;TOPICAL - 2%;70%

SPONGE;TOPICAL - 2%;70% (1.5ML)

SPONGE;TOPICAL - 2%;70% (10.5ML)

SPONGE;TOPICAL - 2%;70% (1ML)

SPONGE;TOPICAL - 2%;70% (26ML)

SPONGE;TOPICAL - 2%;70% (3ML)

SOLUTION;TOPICAL - 61%;1%

SWAB;TOPICAL - 3.15%;70% (1.6ML)

SWAB;TOPICAL - 3.15%;70% (1ML)

SWAB;TOPICAL - 3.15%;70% (5.1ML)

SWAB;TOPICAL - 2%;70% (0.67ML)

SWAB;TOPICAL - 2%;70% (1.75ML)

SWAB;TOPICAL - 2%;70% (5.25ML)

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