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    Chemistry

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    Also known as: Chlorhexidine digluconate, Hibiclens, 18472-51-0, Peridex, Dyna-hex, Bioscrub
    Molecular Formula
    C34H54Cl2N10O14
    Molecular Weight
    897.8  g/mol
    InChI Key
    YZIYKJHYYHPJIB-UUPCJSQJSA-N
    FDA UNII
    MOR84MUD8E
    Chlorhexidine Gluconate
    Chlorhexidine Gluconate is the gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
    1 2D Structure

    Chlorhexidine Gluconate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
    2.1.2 InChI
    InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
    2.1.3 InChI Key
    YZIYKJHYYHPJIB-UUPCJSQJSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.C(C(C(C(C(C(=O)O)O)O)O)O)O.C(C(C(C(C(C(=O)O)O)O)O)O)O
    2.1.5 Isomeric SMILES
    C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    MOR84MUD8E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,1'-hbcb

    2. Avagard

    3. Chlorhexamed

    4. Chlorhexidine Bigluconate

    5. Chlorhexidine Digluconate

    6. Corsodyl Ici

    7. Curasept Ads 220

    8. Dyna-hex

    9. Eludril

    10. Gibitan

    11. Hexidine

    12. Hibiclens

    13. Hibident

    14. Hibiscrub

    15. Hibisol

    16. Hibitane

    17. Peridex

    18. Perio Chip

    2.3.2 Depositor-Supplied Synonyms

    1. Chlorhexidine Digluconate

    2. Hibiclens

    3. 18472-51-0

    4. Peridex

    5. Dyna-hex

    6. Bioscrub

    7. Chlorhexidine D-digluconate

    8. Exidine

    9. Microderm

    10. Periochip

    11. Periogard

    12. Unisept

    13. Brian Care

    14. Steri-stat

    15. Cida-stat

    16. Hibistat

    17. Pharmaseal Scrub Care

    18. Chg Scrub

    19. Prevacare

    20. Chlorhexidine Digluconate Solution

    21. Chlorhexidine Di-d-gluconate

    22. Mor84mud8e

    23. Nsc-753971

    24. Hibiscrub

    25. Hibitane

    26. 1,1'-hexamethylene Bis(5-(p-chlorophenyl)biguanide), Digluconate

    27. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) Di-d-gluconate

    28. Bacticlens

    29. Chlorhexamed

    30. Kleersight

    31. Corsodyl

    32. Disteryl

    33. Hibident

    34. Hibidil

    35. Orahexal

    36. Plurexid

    37. Septeal

    38. Abacil

    39. Fight Bac

    40. Plac Out

    41. Prevacare R

    42. Arlacide G

    43. Hibitane 5

    44. 2,4,11,13-tetraazatetradecanediimidamide, N,n''-bis(4-chlorophenyl)-3,12-diimino-, Di-d-gluconate

    45. Chlorhexidin Glukonatu

    46. Peridex (antiseptic)

    47. Bactoshield Chg 2%

    48. Caswell No. 481g

    49. Unii-mor84mud8e

    50. Pwriochip

    51. Chlorhexidin Glukonatu [czech]

    52. 1,6-bis(n5-[p-chlorophenyl]-n1-biguanido)hexane

    53. Phiso-med

    54. Hibitane Gluconate

    55. Hibiclens (tn)

    56. Periogard (tn)

    57. Drg-0091

    58. Einecs 242-354-0

    59. Peridex (tn)

    60. Mfcd00083599

    61. Chlohexidine Gluconate

    62. Epa Pesticide Chemical Code 045504

    63. Readyprep Chg

    64. Chlorhexidine Gluconate [usan:usp:jan]

    65. Ec 242-354-0

    66. Schembl34468

    67. 1,6-bis(5-(p-chlorophenyl)biguandino)hexane Digluconate

    68. Chembl4297088

    69. Dtxsid5034519

    70. Chebi:28312

    71. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) Gluconate

    72. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate

    73. Chx Plus Concentrate Premium Chlorhexidine Teat Dip Concentrate

    74. Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, Digluconate

    75. Chlorhexidine Gluconate (jp17/usp)

    76. Chlorhexidine Gluconate [jan]

    77. Chlorhexidine Gluconate [usan]

    78. Akos015896303

    79. Akos025310696

    80. Chlorhexidine Gluconate [mart.]

    81. Chlorhexidine Gluconate [vandf]

    82. Nsc 753971

    83. Chlorhexidine D-digluconate [mi]

    84. Chlorhexidine Digluconate [inci]

    85. Chlorhexidine Gluconate [who-dd]

    86. Gluconic Acid, Compd. With 1,1'-hexamethylene Bis(5-(p-chlorophenyl)biguanide) (2:1), D-

    87. D-gluconic Acid, Compd. With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

    88. D-gluconic Acid, Compound With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

    89. Chlorhexidine Gluconate [orange Book]

    90. Chlorhexidine Gluconate [usp Impurity]

    91. Avagard Component Chlorhexidine Gluconate

    92. C08038

    93. D00858

    94. Chlorhexidine Digluconate Solution, 20% In H2o

    95. Soluprep Component Chlorhexidine Gluconate

    96. Chloraprep Component Chlorhexidine Gluconate

    97. Chlorhexidine Gluconate Component Of Avagard

    98. Chlorhexidine Digluconate, 20% W/v Aqueous Solution

    99. Chlorhexidine Gluconate Component Of Soluprep

    100. J-011837

    101. Chlorhexidine Gluconate Component Of Chloraprep

    102. Chlorhexidine Digluconate Solution [ep Monograph]

    103. 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate

    104. Chlorhexidine Digluconate, Pharmaceutical Secondary Standard; Certified Reference Material

    105. 1,1'-hexamethylenebis[5-(p-chlorophenyl)biguanide] (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic Acid(1:2)

    106. 1-(4-chlorophenyl)-3-[n-[6-[[n-[n-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]guanidine; (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic Acid

    107. 2,4,11,13-tetraazatetradecanediimidamide, N,n''-bis(4-chlorophenyl)-3,12-diimino-, Digluconate

    108. 2,4,11,13-tetraazatetradecanediimidamide, N,n'-bis(4-chlorophenyl)-3,12-diimino-, Di-d-gluconate

    109. D-gluconic Acid, Compd With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

    110. D-gluconic Acid, Compd. With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecane Diimidamide (2:1)

    111. D-gluconic Acid, Compd. With N1,n14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

    112. N',n'''''-hexane-1,6-diylbis[n-(4-chlorophenyl)(imidodicarbonimidic Diamide)]--d-gluconic Acid (1/2)

    2.4 Create Date
    2006-10-23
    3 Chemical and Physical Properties
    Molecular Weight 897.8 g/mol
    Molecular Formula C34H54Cl2N10O14
    Hydrogen Bond Donor Count18
    Hydrogen Bond Acceptor Count16
    Rotatable Bond Count23
    Exact Mass896.3198018 g/mol
    Monoisotopic Mass896.3198018 g/mol
    Topological Polar Surface Area455 Ų
    Heavy Atom Count60
    Formal Charge0
    Complexity819
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameChlorhexidine gluconate
    Drug LabelChlorhexidine Gluconate is an oral rinse containing 0.12% chlorhexidine gluconate (1,11-hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium...
    Active IngredientChlorhexidine gluconate
    Dosage FormCloth; Solution; Sponge
    RouteDental; Topical
    Strength0.12%; 2%; 4%
    Market StatusOver the Counter; Prescription
    CompanyLyne; Wockhardt; Sage Prods; Hi Tech Pharma; Teva; Xttrium; Becton Dickinson

    2 of 2  
    Drug NameChlorhexidine gluconate
    Drug LabelChlorhexidine Gluconate is an oral rinse containing 0.12% chlorhexidine gluconate (1,11-hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium...
    Active IngredientChlorhexidine gluconate
    Dosage FormCloth; Solution; Sponge
    RouteDental; Topical
    Strength0.12%; 2%; 4%
    Market StatusOver the Counter; Prescription
    CompanyLyne; Wockhardt; Sage Prods; Hi Tech Pharma; Teva; Xttrium; Becton Dickinson

    4.2 Therapeutic Uses

    Antiseptic; disinfectant. (Vet): antiseptic; disinfectant.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 371

    Cleanser: As a surgical hand scrub, skin wound and general skin cleanser, health care personnel hand wash, and for preoperative skin preparation. Chlorhedine gluconate significantly reduces the number of microorganisms on the hands and forearms prior to surgery or patient care. /Chlorhexidine gluconate-topical/

    Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

    EXPL THER To determine if chlorhexidine can be used as an intervention to prolong the time to relapse of oral candidiasis. SUBJECTS AND METHODS: A double-blinded randomized clinical trial was performed in 75 HIV/AIDS subjects with oral candidiasis. Clotrimazole troche was prescribed, and the subjects were re-examined every 2 weeks until the lesions were completely eradicated. The subjects were then randomly divided into two groups; 0.12% chlorhexidine (n = 37, aged 22-52 years, mean 34 years) and 0.9% normal saline (n = 38, aged 22-55 years, mean 38 years). They were re-examined every 2 weeks until the next episode was observed. RESULTS: The time to recurrence of oral candidiasis between the chlorhexidine and the saline group was not statistically significant (P > 0.05). The following variables were significantly associated with the time of recurrence; frequency of antifungal therapy (P = 0.011), total lymphocyte (P = 0.017), alcohol consumption (P = 0.043), and candidiasis on gingiva (P = 0.048). The subjects with lower lymphocyte showed shorter oral candidiasis-free periods (P = 0.034). CONCLUSIONS: Chlorhexidine showed a small but not statistically significant effect in maintenance of oral candidiasis-free period. This lack of significance may be due to the small sample size. Further study should be performed to better assess the size of the effect, or to confirm our findings.

    PMID:18627504 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253386 Nittayananta W et al; Oral Dis. (7): 665-70 (2008)

    /EXPTL Therapy:/ Rats were injected with 10 mg/kg azoxymethane sc weekly for 12 weeks to induce colorectal cancers. At 20 weeks, subtotal colectomies were performed on rats with colorectal tumors and without peritoneal implants or liver metastases. At the time of surgery, a cut portion of the tumor was placed in the abdomen for 30 minutes; the rats then randomly received peritoneal irrigation with chlorhexidine, or sterile water (control). Eight weeks postoperatively a necropsy was performed. At that time, obvious and suspected recurrences and the anastomotic area were sampled for histologic evaluation. Significant differences were seen with chlorhexidine vs. water for gross tumor (P=0.05) and microscopic tumor (P<0.05).

    Stuntz M et al; Dis Colon Rectum 40 (9): 1058-8 (1997)

    4.3 Drug Warning

    For external use only: For external use only. Keep out of eyes, ears, and mouth. Chlorhexidine gluconate should not be used as a preoperative skin preparation of the face or head. Misuse of products containing chlorhexidine gluconate has been reported to cause serious and permanent eye injury when it has been permitted to enter and remain in the eye during surgical procedures. If chlohexidine gluconate should contact these areas, rinse out promptly and thoroughly with cold water. Avoid contact with neninges. Do not use in genital area. /Chlorhexidine gluconate-topical/

    Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

    Sensitivity: Chlorhexidine gluconate should not be used by persons who have a sensitivity to it or its components.

    Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

    Hypersensitivity reactions: Irritation, sensitization, and generalized allergic reactions have been reported with chlorhexidine-containing products, especially in the genital areas. If adverse reactions occur and last more than 72 hr, discontinue use immediately and, if severe, contact a health care provider.

    Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

    Deafness: Chlorhexidine gluconate has been reported to cause deafness when instilled in the middle ear through perforate ear drums. /Chlorhexidine gluconate-topical/

    Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180

    For more Drug Warnings (Complete) data for CHLORHEXIDINE (8 total), please visit the HSDB record page.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Infective Agents, Local

    Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

    Dermatologic Agents

    Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Decreased Cell Wall Integrity [PE]
    5.3 Absorption, Distribution and Excretion

    34 newborn infants who had been bathed in a standard manner with Hibiscrub were studied to find out whether it was absorbed percutaneously. Low levels of chlorhexidine were found in the blood of all 10 babies sampled by heel prick, and 5 of 24 from whom venous blood was taken. /Chlorhexidine gluconate/

    PMID:475414 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545570 Cowen J et al; Arch Dis Child 54 (5): 379-83 (1979)

    Percutaneous absorption of the antimicrobial agent chlorhexidine (labelled with carbon-14) was studied in rats. Less than 5% of the topically applied chlorhexidine was absorbed during a 5-day period. Excretion of absorbed radioactivity occurred mainly in the feces.

    Chow CP, et al; Toxicol Lett 1(4): 213-16 (1978)

    The percutaneous absorption of chlorhexidine gluconate (chlorhexidine digluconate; Hibitane) through hairless rat skin with or without stratum corneum was studied. For tests carried out on whole skin, storage in cutaneous structures after 48 hr was more important than diffusion; the reverse was observed for stripped skin. When the skin was stripped, the amount absorbed was multiplied by approximately 100, and the amount stored in skin by approximately 10. The difference in chlorhexidine diffusion observed between whole and stripped skin was related to the physicochemical characteristics of chlorhexidine. /Chlorhexidine gluconate/

    Lafforque C et al; Int J Pharm 147: 243-6 (1997)

    To evaluate the elimination kinetics of chlorhexidine in milk when used as an intramammary infusion to stop lactation in cows. ... The study was performed in 2 phases. Three cows were studied in each phase. All cows were treated with chlorhexidine suspension by infusion into a mastitic mammary gland quarter after 2 milkings 24 hours apart. Foremilk samples (100 mL) were collected from treated and untreated (controls) mammary gland quarters of each cow. Chlorhexidine was extracted from raw milk, and residue concentrations were quantified by use of high-performance liquid chromatography. Foremilk samples from days 2, 5, and 8 were analyzed in phase I, and samples from time 0 and days 3, 7, 14, 21, 28, 35, and 42 were analyzed in phase II. In phases I and II, there was no quantifiable transference of chlorhexidine to milk in untreated mammary gland quarters. Measurable chlorhexidine residues were found in milk from treated mammary gland quarters of 2 cows throughout the 42-day sample period in phase II. Estimated mean elimination half-life for chlorhexidine in milk was 11.5 days.

    PMID:12830870 Middleton JR et al; J Am Vet Med Assoc 222 (12): 1746-9 (2003)

    5.4 Biological Half-Life

    To evaluate the elimination kinetics of chlorhexidine in milk when used as an intramammary infusion to stop lactation in cows. ... The study was performed in 2 phases. Three cows were studied in each phase. All cows were treated with chlorhexidine suspension by infusion into a mastitic mammary gland quarter after 2 milkings 24 hours apart. Foremilk samples (100 mL) were collected from treated and untreated (controls) mammary gland quarters of each cow. Chlorhexidine was extracted from raw milk, and residue concentrations were quantified by use of high-performance liquid chromatography. Foremilk samples from days 2, 5, and 8 were analyzed in phase I, and samples from time 0 and days 3, 7, 14, 21, 28, 35, and 42 were analyzed in phase II. In phases I and II, there was no quantifiable transference of chlorhexidine to milk in untreated mammary gland quarters. Measurable chlorhexidine residues were found in milk from treated mammary gland quarters of 2 cows throughout the 42-day sample period in phase II. Estimated mean elimination half-life for chlorhexidine in milk was 11.5 days.

    PMID:12830870 Middleton JR et al; J Am Vet Med Assoc 222 (12): 1746-9 (2003)

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C.,, THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"RAW MATERIALS FOR PHARMACEUTICAL INDUSTRY- CHLORHEXIDINE GLUCONATE SOLUTION BP","address":"18\/338,NARSI NATHA STREET,MASJID","city":"MUMBAI ,MAHARASHTRA","supplier":"SMIT EXPORT PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"MOMBASA","customer":"TO THE ORDER","customerCountry":"KENYA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"5.9","totalValueFC":"579.2","currency":"USD","unitRateINR":486.72019999999998,"date":"30-Oct-2024","totalValueINR":"48672.02","totalValueInUsd":"579.2","indian_port":"JNPT","hs_no":"29420090","bill_no":"5282757","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"KENYA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"18\/338,NARSI NATHA STREET,MASJID, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"CHLORHEXIDINE DIGLUCONATE","year":"2021","qtr":"Q1","strtotime":1612809000,"product":"041385-AP CHLORHEXIDINE DIGLUCONATE, 20% W\/V AQ. SOLN.,NON-STERILE","address":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN EXPRESS","city":"HIGH WAY, SION(E) MUMBA,MAHARASHTRA","supplier":"THERMO FISHER SCIENTIFIC ","supplierCountry":"UNITED STATES","foreign_port":"","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"1.50","actualQuantity":"1.5","unit":"LTR","unitRateFc":"82.4","totalValueFC":"125.3","currency":"USD","unitRateINR":"6081.1","date":"09-Feb-2021","totalValueINR":"9121.68","totalValueInUsd":"125.3","indian_port":"HYDERABAD AIR","hs_no":"29252990","bill_no":"2688247","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Non-sterile","supplierPort":"","supplierAddress":"","customerAddress":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN EXPRESS"},{"dataSource":"API Import","activeIngredients":"CHLORHEXIDINE GLUCONATE","year":"2021","qtr":"Q2","strtotime":1619980200,"product":"CHLORHEXIDINE GLUCONATE SOLUTION 20%, USP","address":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"CYALUME SPECIALTY PRODUCTS","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"6","totalValueFC":"1511.1","currency":"USD","unitRateINR":"553.4","date":"03-May-2021","totalValueINR":"110684.03","totalValueInUsd":"1511.1","indian_port":"HYDERABAD AIR","hs_no":"29181990","bill_no":"3795483","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. K","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,"}]
    04-Jan-2021
    30-Oct-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - AEROSOL, METERED;TOPICAL - 4%

    USFDA APPLICATION NUMBER - 19127

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    DOSAGE - SOLUTION;TOPICAL - 2%

    USFDA APPLICATION NUMBER - 19422

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    DOSAGE - TABLET;DENTAL - 2.5MG

    USFDA APPLICATION NUMBER - 20774

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    DOSAGE - SOLUTION;TOPICAL - 2%;70%

    USFDA APPLICATION NUMBER - 208288

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    DOSAGE - SPONGE;TOPICAL - 2%;70% (1.5ML)

    USFDA APPLICATION NUMBER - 20832

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    DOSAGE - SPONGE;TOPICAL - 2%;70% (10.5ML)

    USFDA APPLICATION NUMBER - 20832

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    DOSAGE - SPONGE;TOPICAL - 2%;70% (1ML)

    USFDA APPLICATION NUMBER - 20832

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    DOSAGE - SPONGE;TOPICAL - 2%;70% (26ML)

    USFDA APPLICATION NUMBER - 20832

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    DOSAGE - SPONGE;TOPICAL - 2%;70% (3ML)

    USFDA APPLICATION NUMBER - 20832

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    DOSAGE - SOLUTION;TOPICAL - 61%;1%

    USFDA APPLICATION NUMBER - 21074

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    DOSAGE - SWAB;TOPICAL - 3.15%;70% (1.6ML)

    USFDA APPLICATION NUMBER - 21524

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    DOSAGE - SWAB;TOPICAL - 3.15%;70% (1ML)

    USFDA APPLICATION NUMBER - 21524

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    DOSAGE - SWAB;TOPICAL - 3.15%;70% (5.1ML)

    USFDA APPLICATION NUMBER - 21524

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    DOSAGE - SWAB;TOPICAL - 2%;70% (0.67ML)

    USFDA APPLICATION NUMBER - 21555

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    DOSAGE - SWAB;TOPICAL - 2%;70% (1.75ML)

    USFDA APPLICATION NUMBER - 21555

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    DOSAGE - SWAB;TOPICAL - 2%;70% (5.25ML)

    USFDA APPLICATION NUMBER - 21555

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