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    Chemistry

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    Also known as: 7758-19-2, Chlorous acid, sodium salt, Textone, Sodium;chlorite, Chlorite sodium, Naclo2
    Molecular Formula
    ClNaO2
    Molecular Weight
    90.44  g/mol
    InChI Key
    UKLNMMHNWFDKNT-UHFFFAOYSA-M
    FDA UNII
    G538EBV4VF
    Chlorite
    Used as an agent for cleaning drinking water. It is also used as an additive in products like toothpaste and mouthwash. Acidified sodium chlorite was approved by the U.S. Food and Drug Administration as of 2004, as an anti-microbial agent which is non-toxic, but not as a drug.
    1 2D Structure

    Chlorite

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;chlorite
    2.1.2 InChI
    InChI=1S/ClHO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1
    2.1.3 InChI Key
    UKLNMMHNWFDKNT-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    [O-]Cl=O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    G538EBV4VF
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Chlorite

    2.3.2 Depositor-Supplied Synonyms

    1. 7758-19-2

    2. Chlorous Acid, Sodium Salt

    3. Textone

    4. Sodium;chlorite

    5. Chlorite Sodium

    6. Naclo2

    7. G538ebv4vf

    8. Chebi:78667

    9. Sodium Chlorite (water Disinfection Byproducts)

    10. Textile

    11. Alcide Ld

    12. Neo Silox D

    13. Caswell No. 755

    14. Sodiumchlorite

    15. Ccris 1426

    16. Hsdb 733

    17. Chlorite (sodium Salt)

    18. Einecs 231-836-6

    19. Un1496

    20. Unii-g538ebv4vf

    21. Epa Pesticide Chemical Code 020502

    22. Chlorous Acid, Sodium Salt (1:1)

    23. Nao2cl

    24. Dsstox_cid_1272

    25. Ec 231-836-6

    26. Dsstox_rid_76050

    27. Dsstox_gsid_21272

    28. Sodium Chlorite [mi]

    29. Sodium Chlorite [hsdb]

    30. Sodium Chlorite [iarc]

    31. Sodium Chlorite [inci]

    32. Chembl1887585

    33. Dtxsid8021272

    34. Sodium Chlorite [who-dd]

    35. Tox21_302800

    36. Mfcd00003478

    37. Akos015843819

    38. Db13210

    39. Ncgc00091419-01

    40. Ncgc00256359-01

    41. Sodium Chlorite [un1496] [oxidizer]

    42. Cas-7758-19-2

    43. Ft-0695293

    44. C19523

    45. Q411294

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 90.44 g/mol
    Molecular Formula ClNaO2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass89.9484512 g/mol
    Monoisotopic Mass89.9484512 g/mol
    Topological Polar Surface Area40.1 Ų
    Heavy Atom Count4
    Formal Charge0
    Complexity13.5
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    /VET/ Sodium chlorite is used in veterinary medicine as a medical disinfectant in post-milking teat dip products used topically for the control of mastitis in dairy cattle.

    European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Sodium Chlorite, Summary Report. Available from, as of July 29, 2008: https://www.emea.europa.eu/pdfs/vet/mrls/sodiumchlorite.pdf

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    D - Dermatologicals

    D03 - Preparations for treatment of wounds and ulcers

    D03A - Cicatrizants

    D03AX - Other cicatrizants

    D03AX11 - Sodium chlorite

    5.2 Absorption, Distribution and Excretion

    ... The dermal absorption /was reported on/ Alcide, an antimicrobial compound consisting of solutions of sodium chlorite and lactic acid, which when mixed immediately before use result in the formation of chlorine dioxide. 0.6 g (36)Cl-labeled sodium chlorite as part of the Alcide was used to monitor absorption following application to the shaved backs of 10 female Sprague-Dawley rats. Maximum absorption of (36)Cl into plasma was observed after 72 hours, where a plasma concentration of 69.4 ug% (36)Cl was reached. The absorption half-life was calculated to be 22.1 hours, which corresponds to a rate constant of 0.0314 hr-1. /Alcide/

    USEPA; TOXICOLOGICAL REVIEW OF CHLORINE DIOXIDE AND CHLORITE (CAS Nos. 10049-04-4 and 7758-19-2) In Support of Summary Information on the Integrated Risk Information System (IRIS) p.4 (September 2000) EPA/635/R-00/007. Available from, as of July 31, 2008: https://cfpub.epa.gov/ncea/iris/index.cfm?fuseaction=iris.showSubstanceList

    ... Sodium chlorite /was/ shown to be well absorbed by the oral route in rats, by using radiolabelled compound (Cmax 1-2 hours). ... The main route of excretion ... appeared to be via the kidneys, predominantly as chloride (32% of the dose at 72 hours), with some chloride (32% of the dose at 72 hours) and a little chlorate (0.73% of the dose at 72 hours). ... 83% of the recovered dose was found in urine, and 13% in feces. ...

    European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Sodium Chlorite, Summary Report. Available from, as of July 29, 2008: https://www.emea.europa.eu/pdfs/vet/mrls/sodiumchlorite.pdf

    API Reference Price

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    13-Feb-2021
    07-Mar-2022
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