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Chemistry

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Also known as: 79-04-9, 2-chloroacetyl chloride, Acetyl chloride, chloro-, Chloracetyl chloride, Chloroacetic chloride, Monochloroacetyl chloride
Molecular Formula
C2H2Cl2O
Molecular Weight
112.94  g/mol
InChI Key
VGCXGMAHQTYDJK-UHFFFAOYSA-N
FDA UNII
K5UML06YUO

Chloroacetyl Chloride
1 2D Structure

Chloroacetyl Chloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-chloroacetyl chloride
2.1.2 InChI
InChI=1S/C2H2Cl2O/c3-1-2(4)5/h1H2
2.1.3 InChI Key
VGCXGMAHQTYDJK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(C(=O)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
K5UML06YUO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Monochloroacetyl Chloride

2.3.2 Depositor-Supplied Synonyms

1. 79-04-9

2. 2-chloroacetyl Chloride

3. Acetyl Chloride, Chloro-

4. Chloracetyl Chloride

5. Chloroacetic Chloride

6. Monochloroacetyl Chloride

7. Chloroacetylchloride

8. Chloroacetic Acid Chloride

9. Chlorure De Chloracetyle

10. Chloracetylchloride

11. Chlorid Kyseliny Chloroctove

12. Chloro Acetyl Chloride

13. Chloro-acetyl Chloride

14. Chloroethanoyl Chloride

15. K5uml06yuo

16. Acetyl Chloride, 2-chloro-

17. Monochloroacetic Acid Chloride

18. .alpha.-chloroacetyl Chloride

19. Chebi:34624

20. Mfcd00000725

21. Ccris 9145

22. Hsdb 973

23. Chlorure De Chloracetyle [french]

24. Chlorid Kyseliny Chloroctove [czech]

25. Einecs 201-171-6

26. Unii-k5uml06yuo

27. Un1752

28. Brn 0605439

29. Chloroacetylchlonde

30. Chloroacetylchoride

31. Chloroactylchloride

32. Chloroacetylchlorid

33. Chloro Acetylchlorid

34. Chloroacetyl Choride

35. Chloroactyl Chloride

36. Choroacetyl Chloride

37. Chioroacetyl Chloride

38. Chloro-acetylchloride

39. Chloroacetyl-chloride

40. Chloro Acetylchloride

41. Ch2clcocl

42. Clch2cocl

43. Chloro-actyl Chloride

44. Chloroacethyl Chloride

45. 2-chloroacetylchloride

46. Chloroacetyl Chloride-

47. A-chloroacetyl Chloride

48. 2-chloro Acetylchloride

49. 2-chloro-acetylchloride

50. 2-chloroacetic Chloride

51. Alpha-chloroacetylchloride

52. 2-chloro-acetyl Chloride

53. Alpha-chloro-acetylchloride

54. Dsstox_cid_6472

55. Alpha-chloroacetyl Chloride

56. Ec 201-171-6

57. 2-chloranylethanoyl Chloride

58. Schembl9584

59. 2-chloroacetic Acid Chloride

60. Chloroacetyl Chloride, 98%

61. Dsstox_rid_78120

62. Dsstox_gsid_26472

63. Chembl3187685

64. Dtxsid4026472

65. Chloracetyl Chloride [mi]

66. Amy40193

67. Bcp25293

68. Zinc3860850

69. Chloroacetyl Chloride [hsdb]

70. Tox21_200644

71. Bbl013127

72. Stk399762

73. Akos000121312

74. Un 1752

75. Cas-79-04-9

76. Ncgc00248777-01

77. Ncgc00258198-01

78. Vs-03683

79. Chloroacetyl Chloride [un1752] [poison]

80. Chloroacetyl Chloride, Purum, >=99.0% (gc)

81. A839561

82. Q411258

83. J-520024

84. F2190-0033

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 112.94 g/mol
Molecular Formula C2H2Cl2O
XLogP31.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass111.9482701 g/mol
Monoisotopic Mass111.9482701 g/mol
Topological Polar Surface Area17.1 Ų
Heavy Atom Count5
Formal Charge0
Complexity42.9
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

Oxidation of the vinyl halide carcinogen and hepatotoxin vinylidene chloride (VDC) by microsomal cytochrome p450 yields 2,2-dichloroacetaldehyde, 2-chloroacetyl chloride, 2-chloroacetic acid, and l,l-dichloroethylene oxide. The roles of these metabolites in covalent modification of proteins and reduced glutathione (GSH) were examined. 2-Chloroacetyl chloride reacted with model thiols at least 10(3)-fold faster than did l,l-dichloroethylene oxide and at least 10(5)-fold faster than did 2,2-dichloroacetaldehyde or 2-chloroacetic acid.

PMID:3965130 Liebler DC et al; Cancer Res 45 (1): 186-93 (1985)


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PharmaCompass offers a list of Chloroacetyl Chloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chloroacetyl Chloride manufacturer or Chloroacetyl Chloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chloroacetyl Chloride manufacturer or Chloroacetyl Chloride supplier.

PharmaCompass also assists you with knowing the Chloroacetyl Chloride API Price utilized in the formulation of products. Chloroacetyl Chloride API Price is not always fixed or binding as the Chloroacetyl Chloride Price is obtained through a variety of data sources. The Chloroacetyl Chloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Chloroacetyl Chloride

Synonyms

79-04-9, 2-chloroacetyl chloride, Acetyl chloride, chloro-, Chloracetyl chloride, Chloroacetic chloride, Monochloroacetyl chloride

Cas Number

79-04-9

Unique Ingredient Identifier (UNII)

K5UML06YUO

Chloroacetyl Chloride Manufacturers

A Chloroacetyl Chloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chloroacetyl Chloride, including repackagers and relabelers. The FDA regulates Chloroacetyl Chloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chloroacetyl Chloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Chloroacetyl Chloride Suppliers

A Chloroacetyl Chloride supplier is an individual or a company that provides Chloroacetyl Chloride active pharmaceutical ingredient (API) or Chloroacetyl Chloride finished formulations upon request. The Chloroacetyl Chloride suppliers may include Chloroacetyl Chloride API manufacturers, exporters, distributors and traders.

Chloroacetyl Chloride GMP

Chloroacetyl Chloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chloroacetyl Chloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chloroacetyl Chloride GMP manufacturer or Chloroacetyl Chloride GMP API supplier for your needs.

Chloroacetyl Chloride CoA

A Chloroacetyl Chloride CoA (Certificate of Analysis) is a formal document that attests to Chloroacetyl Chloride's compliance with Chloroacetyl Chloride specifications and serves as a tool for batch-level quality control.

Chloroacetyl Chloride CoA mostly includes findings from lab analyses of a specific batch. For each Chloroacetyl Chloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chloroacetyl Chloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Chloroacetyl Chloride EP), Chloroacetyl Chloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chloroacetyl Chloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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