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1. Acetonchloroform
2. Anhydrous Chlorobutanol
3. Chlorbutol
4. Chloretone
5. Chlorobutanol, Anhydrous
6. Trichlorbutanol
1. 57-15-8
2. Chlorbutol
3. Chloretone
4. 1,1,1-trichloro-2-methyl-2-propanol
5. 1,1,1-trichloro-2-methylpropan-2-ol
6. Chloreton
7. Chlorbutanol
8. Acetonchloroform
9. Acetone Chloroform
10. Acetochlorone
11. Chlortran
12. Anhydrous Chlorobutanol
13. Coliquifilm
14. Clortran
15. Dentalone
16. Khloreton
17. Methaform
18. Sedaform
19. Chlorobutanol, Anhydrous
20. 2-propanol, 1,1,1-trichloro-2-methyl-
21. Trichlorisobutylalcohol
22. Trichloro-tert-butanol
23. Chlorobutanolum
24. Trichlorobutanol
25. Trichloro-t-butyl Alcohol
26. 2-(trichloromethyl)-2-propanol
27. 1,1,1-trichloro-tert-butyl Alcohol
28. Tert-trichlorobutyl Alcohol
29. Beta,beta,beta-trichloro-tert-butyl Alcohol
30. Trichloro-tert-butyl Alcohol
31. Nsc 44794
32. Chlorobutanol Hemihydrate
33. 2-(trichloromethyl)propan-2-ol
34. 2-propanol, 2-methyl-1,1,1-trichloro-
35. Hm4yqm8wrc
36. Nsc-44794
37. 1,1,1-trichloro-2-methyl-propan-2-ol
38. Mfcd00004461
39. 6001-64-5
40. Ncgc00159392-02
41. Ncgc00159392-05
42. Chlorbutanolum
43. Chlorbutolum
44. Chlorobutanol Hydrate
45. Dsstox_cid_21217
46. Dsstox_rid_79651
47. Wln: Qx1&1&xggg
48. Dsstox_gsid_41217
49. .beta.,.beta.,.beta.-trichloro-tert-butyl Alcohol
50. Caswell No. 185
51. Clorobutanolo [dcit]
52. 1,1-trichloro-tert-butyl Alcohol
53. Clorobutanol
54. Clorobutanolo
55. 1,1-trichloro-2-methyl-2-propanol
56. 2-propanol,1,1-trichloro-2-methyl-
57. Cas-57-15-8
58. Clorobutanol [inn-spanish]
59. Chlorobutanolum [inn-latin]
60. .beta.,.beta.-trichloro-tert-butyl Alcohol
61. Trichloro-2-methylpropan-2-ol
62. 28471-22-9
63. Hsdb 2761
64. Nsc-760101
65. Unii-hm4yqm8wrc
66. Einecs 200-317-6
67. Epa Pesticide Chemical Code 017501
68. Brn 0878167
69. 1, 1, 1-trichloro-2-methyl-2-propanol Hydrate
70. Acetonechloroform
71. Ai3-00048
72. 2-propanol, Trichloro-2-methyl-
73. Chloretone (tn)
74. Chlorobutanol [inn:ban:jan:nf]
75. Chloretone Hemihydrate
76. 2,2,2-trichloro-1,1-dimethylethanol
77. Chlorobutanol, Hydrous
78. T-trichlorobutyl Alcohol
79. Chlorobutanol [ii]
80. Chlorobutanol [mi]
81. Chlorobutanol [inn]
82. Chlorobutanol [jan]
83. Schembl1040
84. Chlorobutanol [hsdb]
85. Chlorobutanol [inci]
86. Acetone Chloroform Hemihydrate
87. Chlorobutanol [vandf]
88. 4-01-00-01629 (beilstein Handbook Reference)
89. 2-trichhloromethyl-2-propanol
90. Chlorobutanol [usp-rs]
91. Chlorobutanol [who-dd]
92. Chlorobutanol [who-ip]
93. Chembl1439973
94. Chlorobutanol (jp17/nf/inn)
95. Dtxsid1041217
96. 2-(trichloromethyl)-propan-2-ol
97. Nsc4596
98. Nsc5208
99. Chebi:134813
100. Molport-003-925-931
101. Chlorobutanol [green Book]
102. Hms3264c17
103. Pharmakon1600-01506102
104. Cs-b1703
105. Hy-b1263
106. Nsc-4596
107. Nsc-5208
108. Nsc44794
109. Zinc1482005
110. Chlorobutanol [ep Monograph]
111. Tox21_111629
112. Bdbm50417941
113. Nsc760101
114. S3705
115. Chlorobutanol, Anhydrous [ii]
116. Akos003619059
117. Chlorobutanolum [who-ip Latin]
118. Tox21_111629_1
119. 2-methyl-1,1,1-trichloro-2-propanol
120. Ccg-213842
121. Db11386
122. Ncgc00159392-03
123. Ncgc00159392-04
124. Chlorobutanol, Anhydrous [who-ip]
125. Cs-15316
126. Sy277495
127. Ft-0605936
128. Ft-0612881
129. T0386
130. Chlorobutanol, Anhydrous [ep Impurity]
131. En300-19331
132. C13278
133. D01942
134. Ab01563200_01
135. 1,1,1-trichloro-2-methylpropan-2-ol Hemihydrate
136. Sr-01000944257
137. Q1047468
138. Sr-01000944257-1
139. W-105484
140. Z1259084902
| Molecular Weight | 177.45 g/mol |
|---|---|
| Molecular Formula | C4H7Cl3O |
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 175.956248 g/mol |
| Monoisotopic Mass | 175.956248 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 83.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Adrenergic alpha-Agonists; Adrenergic Agents; Sympathomimetics; Vasoconstrictor Agents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
TOPICALLY AS SOLN IN CLOVE OIL AS DENTAL ANALGESIC. IT HAS LOCAL ANESTHETIC POTENCY TO MILD DEGREE & HAS BEEN EMPLOYED AS ANESTHETIC DUSTING POWDER (1 TO 5%) OR OINTMENT (10%).
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1222
WHEN ADMIN ORALLY, IT HAS MUCH THE SAME THERAPEUTIC USE AS CHLORAL HYDRATE. HENCE, CHLOROBUTANOL HAS BEEN EMPLOYED AS SEDATIVE & HYPNOTIC. IT HAS BEEN TAKEN ORALLY TO ALLAY VOMITING DUE TO GASTRITIS. DOSE--TOPICAL. ... IN TABLETS OR CAPSULES.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1222
MEDICATION (VET): ANTISEPTIC & LOCAL ANESTHETIC; INTERNALLY, IT IS USED AS SEDATIVE & HYPNOTIC. IT APPEARS TO BE OF VALUE IN GASTRITIS WITH PERSISTENT VOMITING IN DOGS.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1222
For more Therapeutic Uses (Complete) data for CHLORETONE (7 total), please visit the HSDB record page.
VET WARNING: ... NOT FOR USE AS MOTION SICKNESS DRUG IN CATS AS REPEATED USE IN THIS SPECIES CAUSES RESP CENTER DEPRESSION & MAY BE FATAL. AVOID USE IN ANIMALS WITH LIVER OR KIDNEY PATHOLOGY.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 104
RESEMBLES CHLORAL HYDRATE BUT NO GASTRIC IRRITATION.
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-177
ALLERGIC REACTIONS ... INCLUDE ERYTHEMA, SCARLATINIFORM EXANTHEMS, URTICARIA, AND ECZEMATOID DERMATITIS. THE ERUPTION USUALLY BEGINS ON THE FACE OR BACK AND SPREADS TO THE NECK, CHEST, AND ARMS; IT MAY BE FOLLOWED BY DESQUAMATION ... /CHLORAL HYDRATE/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 128
UNDESIRABLE CNS EFFECTS INCLUDE LIGHTHEADEDNESS, MALAISE, ATAXIA, & NIGHTMARES. "HANGOVER" ALSO MAY OCCUR ... /CHLORAL HYDRATE/
Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 381
4. 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB).
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-177
No approved therapeutic indications on its own.
Chlorobutanol is a detergent preservative with a broad spectrum of antimicrobial activity. _In vitro_, chlorobutanol demonstrated to inhibit platelet aggregation and release via unknown mechanisms. A study proposes that the antiplatelet effect of chlorobutanol may occur from inhibition of the arachidonic acid pathway. It attenuated thromboxane B2 formation, elevation of cytosolic free calcium, and ATP release, and additionally exhibited a significant inhibitory activity toward several aggregation inducers in a time- and concentration-dependent manner. Chlorobutanol may exert a direct negative inotropic effect on myocardial cells to isometric tension produced by the heart. Chlorobutanol was shown to induce conjunctival and corneal cell toxicity _in vitro_: at a concentration of 0.1%, Cbl caused near depletion of the squamous layer while degeneration of corneal epithelial cells, generation of conspicuous membranous blebs, cytoplasmic swelling, and occasional breaks in the external cell membrane were observed at a concentration of 0.5%.
Preservatives, Pharmaceutical
Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants. (See all compounds classified as Preservatives, Pharmaceutical.)
A - Alimentary tract and metabolism
A04 - Antiemetics and antinauseants
A04A - Antiemetics and antinauseants
A04AD - Other antiemetics
A04AD04 - Chlorobutanol
Absorption
Following oral administration in healthy subjects, the plasma concentration fell by 50% in 24 hours post-administration.
Route of Elimination
Under physiological conditions, chlorobutanol is unstable. The mean urinary recovery accounts for 9.6% of the dose orally administered.
Volume of Distribution
The volume of distribution was approximately 233 141 L in healthy individuals receiving oral chlorobutanol.
Clearance
In healthy subjects, the clearance was approximately 11.6 1.0 mL/min following oral administration.
Chlorobutanol is reported to undergo glucuronidation and sulphation.
Following oral administration, the terminal elimination half life in healthy subjects was 10.3 1.3 days.
As a detergent, chlorobutanol disrupts the lipid structure of the cell membrane and increases the cell permeability, leading to cell lysis. It induces conjunctival and corneal cell toxicity via causing cell retraction and cessation of normal cytokines, cell movement, and mitotic activity. It disrupts the barrier and transport properties of the corneal epithelium as well as inhibits the utilization of oxygen by the cornea. Chlorobutanol also inhibits oxygen use by the cornea, which increases susceptibility to infection.
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A Chlorobutanol Hemihydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlorobutanol Hemihydrate, including repackagers and relabelers. The FDA regulates Chlorobutanol Hemihydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlorobutanol Hemihydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Chlorobutanol Hemihydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Chlorobutanol Hemihydrate supplier is an individual or a company that provides Chlorobutanol Hemihydrate active pharmaceutical ingredient (API) or Chlorobutanol Hemihydrate finished formulations upon request. The Chlorobutanol Hemihydrate suppliers may include Chlorobutanol Hemihydrate API manufacturers, exporters, distributors and traders.
click here to find a list of Chlorobutanol Hemihydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Chlorobutanol Hemihydrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Chlorobutanol Hemihydrate active pharmaceutical ingredient (API) in detail. Different forms of Chlorobutanol Hemihydrate DMFs exist exist since differing nations have different regulations, such as Chlorobutanol Hemihydrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Chlorobutanol Hemihydrate DMF submitted to regulatory agencies in the US is known as a USDMF. Chlorobutanol Hemihydrate USDMF includes data on Chlorobutanol Hemihydrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chlorobutanol Hemihydrate USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Chlorobutanol Hemihydrate suppliers with USDMF on PharmaCompass.
A Chlorobutanol Hemihydrate CEP of the European Pharmacopoeia monograph is often referred to as a Chlorobutanol Hemihydrate Certificate of Suitability (COS). The purpose of a Chlorobutanol Hemihydrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Chlorobutanol Hemihydrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Chlorobutanol Hemihydrate to their clients by showing that a Chlorobutanol Hemihydrate CEP has been issued for it. The manufacturer submits a Chlorobutanol Hemihydrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Chlorobutanol Hemihydrate CEP holder for the record. Additionally, the data presented in the Chlorobutanol Hemihydrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Chlorobutanol Hemihydrate DMF.
A Chlorobutanol Hemihydrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Chlorobutanol Hemihydrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.
click here to find a list of Chlorobutanol Hemihydrate suppliers with CEP (COS) on PharmaCompass.
A Chlorobutanol Hemihydrate written confirmation (Chlorobutanol Hemihydrate WC) is an official document issued by a regulatory agency to a Chlorobutanol Hemihydrate manufacturer, verifying that the manufacturing facility of a Chlorobutanol Hemihydrate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Chlorobutanol Hemihydrate APIs or Chlorobutanol Hemihydrate finished pharmaceutical products to another nation, regulatory agencies frequently require a Chlorobutanol Hemihydrate WC (written confirmation) as part of the regulatory process.
click here to find a list of Chlorobutanol Hemihydrate suppliers with Written Confirmation (WC) on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chlorobutanol Hemihydrate as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Chlorobutanol Hemihydrate API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Chlorobutanol Hemihydrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Chlorobutanol Hemihydrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chlorobutanol Hemihydrate NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Chlorobutanol Hemihydrate suppliers with NDC on PharmaCompass.
Chlorobutanol Hemihydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Chlorobutanol Hemihydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chlorobutanol Hemihydrate GMP manufacturer or Chlorobutanol Hemihydrate GMP API supplier for your needs.
A Chlorobutanol Hemihydrate CoA (Certificate of Analysis) is a formal document that attests to Chlorobutanol Hemihydrate's compliance with Chlorobutanol Hemihydrate specifications and serves as a tool for batch-level quality control.
Chlorobutanol Hemihydrate CoA mostly includes findings from lab analyses of a specific batch. For each Chlorobutanol Hemihydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Chlorobutanol Hemihydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlorobutanol Hemihydrate EP), Chlorobutanol Hemihydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlorobutanol Hemihydrate USP).
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