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Chemistry

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Also known as: 2-chlorobuta-1,3-diene, 2-chloro-1,3-butadiene, 126-99-8, 1,3-butadiene, 2-chloro-, Chlorobutadiene, 2-chlorobutadiene
Molecular Formula
C4H5Cl
Molecular Weight
88.53  g/mol
InChI Key
YACLQRRMGMJLJV-UHFFFAOYSA-N
FDA UNII
42L93DWV3A

Chloroprene
Toxic, possibly carcinogenic, monomer of neoprene, a synthetic rubber; causes damage to skin, lungs, CNS, kidneys, liver, blood cells and fetuses. Synonym: 2-chlorobutadiene.
1 2D Structure

Chloroprene

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-chlorobuta-1,3-diene
2.1.2 InChI
InChI=1S/C4H5Cl/c1-3-4(2)5/h3H,1-2H2
2.1.3 InChI Key
YACLQRRMGMJLJV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C=CC(=C)Cl
2.2 Other Identifiers
2.2.1 UNII
42L93DWV3A
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2-chlorobuta-1,3-diene

2. 2-chloro-1,3-butadiene

3. 126-99-8

4. 1,3-butadiene, 2-chloro-

5. Chlorobutadiene

6. 2-chlorobutadiene

7. Neoprene

8. Chloropreen

9. Cloroprene

10. 2-chlor-1,3-butadien

11. Polychloroprene

12. .beta.-chloroprene

13. Chloropren

14. 2-cloro-1,3-butadiene

15. 2-chloor-1,3-butadieen

16. 9010-98-4

17. Nsc 18589

18. 42l93dwv3a

19. Chebi:39481

20. Chloroprene (>96% Chloroprene)

21. Chloroprene (99.6% Chloroprene)

22. Nsc-18589

23. Beta-chloroprene

24. Chloropreen [dutch]

25. Cloroprene [italian]

26. 2-chloroprene

27. Chloroprene Polymer

28. Chloropren [german, Polish]

29. Ccris 873

30. Hsdb 1618

31. 2-chlor-1,3-butadien [german]

32. 2-chloor-1,3-butadieen [dutch]

33. 2-cloro-1,3-butadiene [italian]

34. Einecs 204-818-0

35. Un1991

36. Unii-42l93dwv3a

37. Chloroprene, Uninhibited [forbidden]

38. Chloroprene, Inhibited

39. .beta.-chlorobutadiene

40. Beta-chloroprene 2-chloro-1,3-butadiene

41. Chloroprene, Uninhibited

42. 2-chlorobutadiene 1,3

43. Chloroprene [hsdb]

44. Chloroprene [iarc]

45. Ec 204-818-0

46. Wln: 1uyg1u1

47. Chloropren(german, Polish)

48. Chembl555660

49. Dtxsid5020316

50. Bcp31738

51. Nsc18589

52. Zinc1561508

53. Chloro-1,3-butadiene, 2-

54. Akos028108417

55. Un 1991

56. Chloroprene 5000 Microg/ml In Methanol

57. C19208

58. C19502

59. Q410871

60. Chloroprene, Inhibited [un1991] [flammable Liquid, Poison]

61. 2-chlorobuta-1,3-diene;2-chloro-1,3-butadiene;1,3-butadiene, 2-chloro-

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 88.53 g/mol
Molecular Formula C4H5Cl
XLogP32.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count1
Exact Mass88.0079779 g/mol
Monoisotopic Mass88.0079779 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count5
Formal Charge0
Complexity54.7
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

... RAPIDLY ABSORBED BY SKIN ... .

Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 70


4.2 Metabolism/Metabolites

WHEN MIXT OF CHLOROPRENE IN AIR WAS PASSED THROUGH A MOUSE LIVER MICROSOMAL PREPN, A VOLATILE ALKYLATING METABOLITE WAS FORMED, AS DEMONSTRATED BY TRAPPING WITH 4-(4-NITROBENZYL)PYRIDINE.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V19 137 (1979)


4.3 Biological Half-Life

No reports found; [TDR, p. 334]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 334


ABOUT THIS PAGE

Chloroprene Manufacturers

A Chloroprene manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chloroprene, including repackagers and relabelers. The FDA regulates Chloroprene manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chloroprene API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Chloroprene Suppliers

A Chloroprene supplier is an individual or a company that provides Chloroprene active pharmaceutical ingredient (API) or Chloroprene finished formulations upon request. The Chloroprene suppliers may include Chloroprene API manufacturers, exporters, distributors and traders.

Chloroprene GMP

Chloroprene Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chloroprene GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chloroprene GMP manufacturer or Chloroprene GMP API supplier for your needs.

Chloroprene CoA

A Chloroprene CoA (Certificate of Analysis) is a formal document that attests to Chloroprene's compliance with Chloroprene specifications and serves as a tool for batch-level quality control.

Chloroprene CoA mostly includes findings from lab analyses of a specific batch. For each Chloroprene CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chloroprene may be tested according to a variety of international standards, such as European Pharmacopoeia (Chloroprene EP), Chloroprene JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chloroprene USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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