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    Chemistry

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    Also known as: Chloroquine diphosphate, 50-63-5, Resochin, Arechin, Aralen phosphate, Chingamin phosphate
    Molecular Formula
    C18H32ClN3O8P2
    Molecular Weight
    515.9  g/mol
    InChI Key
    QKICWELGRMTQCR-UHFFFAOYSA-N
    FDA UNII
    6E17K3343P
    Chloroquine Phosphate
    Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.
    1 2D Structure

    Chloroquine Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
    2.1.2 InChI
    InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
    2.1.3 InChI Key
    QKICWELGRMTQCR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    6E17K3343P
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Arechin

    2. Chingamin Phosphate

    3. Chloroquine Bis(dihydrogenphosphate) Dihydrate

    4. Chloroquine Diphosphate

    5. Chloroquine Diphosphate, (+)-isomer

    6. Chloroquine Diphosphate, (+-)-isomer

    7. Chloroquine Diphosphate, (-)-isomer

    8. Delagil

    9. Khingamin Phosphate

    10. N(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, Phosphate (1:2)

    11. Resochin

    12. Unspecified Phosphate Of Chloroquine Diphosphate

    2.3.2 Depositor-Supplied Synonyms

    1. Chloroquine Diphosphate

    2. 50-63-5

    3. Resochin

    4. Arechin

    5. Aralen Phosphate

    6. Chingamin Phosphate

    7. Chloroquine Bis(phosphate)

    8. Chloroquine Diphosphate Salt

    9. Avloclor

    10. Delagil

    11. Chloroquine (phosphate)

    12. Khingamin

    13. Miniquine

    14. Tanakan

    15. Tanakene

    16. Aralen Diphosphate

    17. Gontochin Phosphate

    18. N4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-1,4-diamine Bis(phosphate)

    19. Chloroquin Diphosphate

    20. Nsc 14050

    21. Ipsen 225

    22. Chloroquinediphosphate

    23. Mfcd00069852

    24. 3377 Rp

    25. 50-63-5 (diphosphate)

    26. Sn 7,618

    27. Nsc-14050

    28. 6e17k3343p

    29. Sn-7618

    30. Wr-1522

    31. Chingaminum

    32. Alermine

    33. H-stadur

    34. Dsstox_cid_24681

    35. Dsstox_rid_80393

    36. Dsstox_gsid_44681

    37. 1,4-pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-n(sup 1),n(sup 1)-diethyl-, Phosphate (1:2)

    38. Chlorochin Diphosphate

    39. Tanakan (antimalarial)

    40. 4-n-(7-chloroquinolin-4-yl)-1-n,1-n-diethylpentane-1,4-diamine;phosphoric Acid

    41. Dl-chloroquine Diphosphate

    42. Ccris 1554

    43. Sr-01000075548

    44. Einecs 200-055-2

    45. Wr 1522

    46. Chloroquine Dihydrogen Phosphate (1:2)

    47. Unikinon

    48. Ai3-14952

    49. Unii-6e17k3343p

    50. Chloroquine Phosphate [usp:ban]

    51. Chloroquindiphosphat

    52. Chloroquini Phosphas

    53. Prestwick_867

    54. Aralen (tn)

    55. Cas-50-63-5

    56. Ncgc00015256-01

    57. 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat [german]

    58. 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2)

    59. N4-(7-chloro-4-quinolinyl)-n1,n1-dimethyl-1,4-pentanediamine Diphosphate Salt

    60. Chloroquine Diphosphate,(s)

    61. 1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-n1,n1-diethyl-, Phosphate (1:2)

    62. N(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-1,4-pentanediamine, Phosphate (1:2)

    63. 1,4-diamine Bis(phosphate)

    64. Chloroquine Phosphate (usp)

    65. Schembl40827

    66. Chembl58510

    67. Spectrum1500179

    68. Chloroquine Diphosphate, Sulfate

    69. Dtxsid7044681

    70. Hms501e06

    71. Hms1569n17

    72. Hms1920o05

    73. Hms2091c16

    74. Hms2096n17

    75. Hms3260l14

    76. Hms3713n17

    77. Bcp31956

    78. Chloroquine Diphosphate [mi]

    79. Tox21_110115

    80. Tox21_202838

    81. Tox21_500296

    82. 7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat

    83. Ccg-39643

    84. Chloroquine Phosphate [vandf]

    85. S4157

    86. Chloroquine Phosphate [mart.]

    87. Akos004910410

    88. Chloroquine Phosphate [usp-rs]

    89. Chloroquine Phosphate [who-dd]

    90. Chloroquine Phosphate [who-ip]

    91. N4-(7-chloro-4-quinolyl)-n1,n1-diethyl-pentane-1,4-diamine; Phosphoric Acid

    92. Quinoline, 7-chloro-4-(4-diethylamino-1-methyl-butylamino)-, Diphosphate

    93. Tox21_110115_1

    94. Cs-3811

    95. Dt-0015

    96. Lp00296

    97. 1,4-pentanediamine, N4-(7-chloro-4-quinolinyl)-n',n'-diethyl-, (+-)-, Phosphate (1:2)

    98. Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, Phosphate (1:2)

    99. Ncgc00015256-12

    100. Ncgc00093746-01

    101. Ncgc00093746-02

    102. Ncgc00093746-03

    103. Ncgc00260384-01

    104. Ncgc00260981-01

    105. Ac-12463

    106. Chloroquine Phosphate [green Book]

    107. Hy-17589

    108. Sy021941

    109. Chloroquine Phosphate [orange Book]

    110. Chloroquine Phosphate [ep Monograph]

    111. Chloroquini Phosphas [who-ip Latin]

    112. Db-051808

    113. Chloroquine Diphosphate Salt, Solid, >=98%

    114. Chloroquine Phosphate [usp Monograph]

    115. Eu-0100296

    116. Ft-0602804

    117. C 6628

    118. D02125

    119. D70732

    120. 069c852

    121. A828213

    122. N4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-

    123. Sr-01000075548-1

    124. Sr-01000075548-3

    125. Sr-01000075548-5

    126. Q27264629

    127. F2173-1139

    128. 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline Phosphate

    129. 7-chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Bis(phosphate)

    130. 7-chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate

    131. Chloroquine Phosphate, United States Pharmacopeia (usp) Reference Standard

    132. N4-(7-chloro-4-quinolyl)-n1,n1-diethyl-1,4-pentanediamine Diphosphate

    133. 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2).

    134. Chloroquine Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

    135. Chloroquine Phosphate;aralen Phosphate;7-chloro-4-((4 Inverted Exclamation Mark -diethylamino-1-methylbutyl)amino)quinolinediphosphate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 515.9 g/mol
    Molecular Formula C18H32ClN3O8P2
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count8
    Exact Mass515.1353167 g/mol
    Monoisotopic Mass515.1353167 g/mol
    Topological Polar Surface Area184 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity359
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameChloroquine phosphate
    Drug LabelChloroquine phosphate, USP is a 4-aminoquinoline compound for oral administration. It is a white crystalline powder; odorless; has a bitter taste, and is discolored slowly on exposure to light. It is freely soluble in water, practically insoluble in...
    Active IngredientChloroquine phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 300mg base; eq 150mg base
    Market StatusPrescription
    CompanyIpca Labs; Natco Pharma; Hikma Pharms; Impax Labs

    2 of 2  
    Drug NameChloroquine phosphate
    Drug LabelChloroquine phosphate, USP is a 4-aminoquinoline compound for oral administration. It is a white crystalline powder; odorless; has a bitter taste, and is discolored slowly on exposure to light. It is freely soluble in water, practically insoluble in...
    Active IngredientChloroquine phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 300mg base; eq 150mg base
    Market StatusPrescription
    CompanyIpca Labs; Natco Pharma; Hikma Pharms; Impax Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Antimalarials

    Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

    Filaricides

    Pharmacological agents destructive to nematodes in the superfamily Filarioidea. (See all compounds classified as Filaricides.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Antimalarial [EPC]

    API Reference Price

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OF.","customerCountry":"SINGAPORE","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"29","totalValueFC":"1237.7","currency":"USD","unitRateINR":2080,"date":"24-Oct-2024","totalValueINR":"104000","totalValueInUsd":"1237.7","indian_port":"Bombay Air","hs_no":"29392040","bill_no":"5082351","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"292 PRINCESS STREET, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"PHARMACEUTICALS RAW MATERIAL: CHLOROQUINE PHOSPHATE IP","address":"207,LAXMI PLAZA,BLDG.,NO.9,","city":"MUMBAI MAHARASHTRA","supplier":"PHARMACHEM TECHNOLOGIES","supplierCountry":"INDIA","foreign_port":"APAPA","customer":"TO THE ORDER","customerCountry":"NIGERIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"25.2","totalValueFC":"24109.2","currency":"USD","unitRateINR":2025.8118200000001,"date":"30-Oct-2024","totalValueINR":"2025811.82","totalValueInUsd":"24109.2","indian_port":"JNPT","hs_no":"29392040","bill_no":"5292895","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NIGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"207,LAXMI PLAZA,BLDG.,NO.9,, MUMBAI MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731695400,"product":"PHARMACEUTICALS RAW MATERIAL: CHLOROQUINE PHOSPHATE BP","address":"207,LAXMI PLAZA,BLDG.,NO.9,","city":"MUMBAI MAHARASHTRA","supplier":"PHARMACHEM TECHNOLOGIES","supplierCountry":"INDIA","foreign_port":"APAPA","customer":"TO THE ORDER","customerCountry":"NIGERIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"25.1","totalValueFC":"48633","currency":"USD","unitRateINR":2052.0257700000002,"date":"16-Nov-2024","totalValueINR":"4104051.54","totalValueInUsd":"48633","indian_port":"JNPT","hs_no":"29392040","bill_no":"5668371","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NIGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"207,LAXMI PLAZA,BLDG.,NO.9,, MUMBAI MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732645800,"product":"DRUGS - CHLOROQUINE PHOSPHATE PH.EUR. (CHLOROQUINE PHOSPHATE)","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"IPCA LABORATORIES","supplierCountry":"INDIA","foreign_port":"LIMASSOL","customer":"OF","customerCountry":"CYPRUS","quantity":"1250.00","actualQuantity":"1250","unit":"KGS","unitRateFc":"30","totalValueFC":"35911.4","currency":"USD","unitRateINR":2424.4000000000001,"date":"27-Nov-2024","totalValueINR":"3030500","totalValueInUsd":"35911.4","indian_port":"JNPT","hs_no":"29392040","bill_no":"5948015","productDescription":"API","marketType":"REGULATED MARKET","country":"CYPRUS","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"48, KANDIVLI INDUSTRIAL ESTATE,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1674066600,"product":"CHLOROQUINE PHOSPHATE USP-20090469, LOT NO:CQP\/A\/0140620, FOR PHARMA USE ONLY","address":"901-911 9TH FLR ISCON ELEGANCE NR SHAPATH 5 S G HIGHWAY Contact No: 9","city":"AHMEDABAD","supplier":"AMNEAL PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NA","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"81.83","actualQuantity":"81.827","unit":"KGS","unitRateFc":"1850","totalValueFC":"204566.9","currency":"USD","unitRateINR":"204398","date":"19-Jan-2023","totalValueINR":"16725276.56","totalValueInUsd":"204566.9","indian_port":"AHMEDABAD AIR","hs_no":"29392040","bill_no":"4254225","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"901-911 9TH FLR ISCON ELEGANCE NR SHAPATH 5 S G HIGHWAY Contact No: 9"}]
    19-Jan-2021
    27-Nov-2024
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    ABOUT THIS PAGE

    Chloroquine Manufacturers

    A Chloroquine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chloroquine, including repackagers and relabelers. The FDA regulates Chloroquine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chloroquine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Chloroquine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Chloroquine Suppliers

    A Chloroquine supplier is an individual or a company that provides Chloroquine active pharmaceutical ingredient (API) or Chloroquine finished formulations upon request. The Chloroquine suppliers may include Chloroquine API manufacturers, exporters, distributors and traders.

    click here to find a list of Chloroquine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Chloroquine USDMF

    A Chloroquine DMF (Drug Master File) is a document detailing the whole manufacturing process of Chloroquine active pharmaceutical ingredient (API) in detail. Different forms of Chloroquine DMFs exist exist since differing nations have different regulations, such as Chloroquine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Chloroquine DMF submitted to regulatory agencies in the US is known as a USDMF. Chloroquine USDMF includes data on Chloroquine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chloroquine USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Chloroquine suppliers with USDMF on PharmaCompass.

    Chloroquine CEP

    A Chloroquine CEP of the European Pharmacopoeia monograph is often referred to as a Chloroquine Certificate of Suitability (COS). The purpose of a Chloroquine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Chloroquine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Chloroquine to their clients by showing that a Chloroquine CEP has been issued for it. The manufacturer submits a Chloroquine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Chloroquine CEP holder for the record. Additionally, the data presented in the Chloroquine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Chloroquine DMF.

    A Chloroquine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Chloroquine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Chloroquine suppliers with CEP (COS) on PharmaCompass.

    Chloroquine WC

    A Chloroquine written confirmation (Chloroquine WC) is an official document issued by a regulatory agency to a Chloroquine manufacturer, verifying that the manufacturing facility of a Chloroquine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Chloroquine APIs or Chloroquine finished pharmaceutical products to another nation, regulatory agencies frequently require a Chloroquine WC (written confirmation) as part of the regulatory process.

    click here to find a list of Chloroquine suppliers with Written Confirmation (WC) on PharmaCompass.

    Chloroquine NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chloroquine as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Chloroquine API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Chloroquine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Chloroquine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chloroquine NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Chloroquine suppliers with NDC on PharmaCompass.

    Chloroquine GMP

    Chloroquine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Chloroquine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chloroquine GMP manufacturer or Chloroquine GMP API supplier for your needs.

    Chloroquine CoA

    A Chloroquine CoA (Certificate of Analysis) is a formal document that attests to Chloroquine's compliance with Chloroquine specifications and serves as a tool for batch-level quality control.

    Chloroquine CoA mostly includes findings from lab analyses of a specific batch. For each Chloroquine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Chloroquine may be tested according to a variety of international standards, such as European Pharmacopoeia (Chloroquine EP), Chloroquine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chloroquine USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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