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Chemistry

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Also known as: 7085-44-1, Chlorothiazide sodium [usan:usp], Chlorothiazide (sodium), Chlorothiazide sodium salt, Sn86fg7n2k, 6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide, monosodium salt
Molecular Formula
C7H5ClN3NaO4S2
Molecular Weight
317.7  g/mol
InChI Key
CPIWHAFLBZQYLQ-UHFFFAOYSA-N
FDA UNII
SN86FG7N2K

Chlorothiazide Sodium
Chlorothiazide Sodium is the sodium salt form of chlorothiazide, a short-acting, benzothiadiazinesulfonamide derivative belonging to the class of thiazide diuretics. Chlorothiazide is excreted unchanged by the kidneys.
1 2D Structure

Chlorothiazide Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;6-chloro-1,1-dioxo-16,2,4-benzothiadiazin-2-ide-7-sulfonamide
2.1.2 InChI
InChI=1S/C7H5ClN3O4S2.Na/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-3H,(H2-,9,10,11,12,13);/q-1;+1
2.1.3 InChI Key
CPIWHAFLBZQYLQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)[N-]C=N2.[Na+]
2.2 Other Identifiers
2.2.1 UNII
SN86FG7N2K
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 7085-44-1

2. Chlorothiazide Sodium [usan:usp]

3. Chlorothiazide (sodium)

4. Chlorothiazide Sodium Salt

5. Sn86fg7n2k

6. 6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide, Monosodium Salt

7. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide, Monosodium Salt

8. Diuril Sodium

9. Sodium Diuril

10. Diuril (tn)

11. Chlorothiazide Sodium [usan]

12. Einecs 230-387-3

13. Unii-sn86fg7n2k

14. Lyovac Diuril

15. Chlorothiazide Sodium (usp)

16. Chembl1200616

17. Hy-b0224a

18. Dtxsid00221091

19. Chlorothiazide Sodium [vandf]

20. Chlorothiazide Sodium [mart.]

21. Chlorothiazide Sodium [who-dd]

22. Chlorothiazide Sodium Salt [mi]

23. Chlorothiazide Sodium [orange Book]

24. Chlorothiazide Sodium [usp Impurity]

25. Cs-0030911

26. D03471

27. Q27289300

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 317.7 g/mol
Molecular Formula C7H5ClN3NaO4S2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass316.9307700 g/mol
Monoisotopic Mass316.9307700 g/mol
Topological Polar Surface Area124 Ų
Heavy Atom Count18
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameChlorothiazide sodium
Active IngredientChlorothiazide sodium
Dosage FormInjectable
RouteInjection
Strengtheq 500mg base/vial
Market StatusPrescription
CompanyFresenius Kabi Usa; Mylan Institutional; Luitpold; Sun Pharma Global

2 of 2  
Drug NameChlorothiazide sodium
Active IngredientChlorothiazide sodium
Dosage FormInjectable
RouteInjection
Strengtheq 500mg base/vial
Market StatusPrescription
CompanyFresenius Kabi Usa; Mylan Institutional; Luitpold; Sun Pharma Global

5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Pharmacological Classes
Thiazide Diuretic [EPC]; Thiazides [CS]; Increased Diuresis [PE]

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ABOUT THIS PAGE

Chlorothiazide Sodium Manufacturers

A Chlorothiazide Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlorothiazide Sodium, including repackagers and relabelers. The FDA regulates Chlorothiazide Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlorothiazide Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Chlorothiazide Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Chlorothiazide Sodium Suppliers

A Chlorothiazide Sodium supplier is an individual or a company that provides Chlorothiazide Sodium active pharmaceutical ingredient (API) or Chlorothiazide Sodium finished formulations upon request. The Chlorothiazide Sodium suppliers may include Chlorothiazide Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Chlorothiazide Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chlorothiazide Sodium USDMF

A Chlorothiazide Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Chlorothiazide Sodium active pharmaceutical ingredient (API) in detail. Different forms of Chlorothiazide Sodium DMFs exist exist since differing nations have different regulations, such as Chlorothiazide Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Chlorothiazide Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Chlorothiazide Sodium USDMF includes data on Chlorothiazide Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chlorothiazide Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Chlorothiazide Sodium suppliers with USDMF on PharmaCompass.

Chlorothiazide Sodium GMP

Chlorothiazide Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chlorothiazide Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chlorothiazide Sodium GMP manufacturer or Chlorothiazide Sodium GMP API supplier for your needs.

Chlorothiazide Sodium CoA

A Chlorothiazide Sodium CoA (Certificate of Analysis) is a formal document that attests to Chlorothiazide Sodium's compliance with Chlorothiazide Sodium specifications and serves as a tool for batch-level quality control.

Chlorothiazide Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Chlorothiazide Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chlorothiazide Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlorothiazide Sodium EP), Chlorothiazide Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlorothiazide Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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