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Chemistry

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Also known as: 773-76-2, 5,7-dichloroquinolin-8-ol, 5,7-dichloro-8-hydroxyquinoline, 5,7-dichloro-8-quinolinol, Capitrol, Chlorquinol
Molecular Formula
C9H5Cl2NO
Molecular Weight
214.04  g/mol
InChI Key
WDFKMLRRRCGAKS-UHFFFAOYSA-N
FDA UNII
2I8BD50I8B

Chloroxine
Chloroxine is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.
1 2D Structure

Chloroxine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5,7-dichloroquinolin-8-ol
2.1.2 InChI
InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
2.1.3 InChI Key
WDFKMLRRRCGAKS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
2.2 Other Identifiers
2.2.1 UNII
2I8BD50I8B
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Chloroxine Hydrofluoride

2. Chlorquinol

3. Dichlorohydroxyquinoline

4. Dichloroquine

5. Quixalin

2.3.2 Depositor-Supplied Synonyms

1. 773-76-2

2. 5,7-dichloroquinolin-8-ol

3. 5,7-dichloro-8-hydroxyquinoline

4. 5,7-dichloro-8-quinolinol

5. Capitrol

6. Chlorquinol

7. Dichloroxin

8. Quixalin

9. Chloroxyquinoline

10. Dichloroquinolinol

11. Dikhloroskin

12. Clofuzid

13. Endiaron

14. Quinolor

15. Dichlorohydroxyquinoline

16. Chlofucid

17. Quesyl

18. 5,7-dichlorooxine

19. 5,7-dichloroxine

20. 8-quinolinol, 5,7-dichloro-

21. 5,7-dichloro-8-oxyquinoline

22. Chlorohydroxyquinoline

23. Chloroxine [usan]

24. 5,7-dichlor-8-hydroxychinolin

25. Nsc 3904

26. Nsc-3904

27. Mfcd00006786

28. 2i8bd50i8b

29. 5,7-dichloro-8-hydroquinoline

30. Chebi:59477

31. Nsc3904

32. Chloroxine (usan)

33. As-229

34. Ncgc00095264-01

35. Dsstox_cid_2801

36. Dsstox_rid_76734

37. Dsstox_gsid_22801

38. Cas-773-76-2

39. Ccris 5751

40. Capitrol Cream Shampoo

41. Sr-01000747474

42. Einecs 212-258-3

43. Brn 0153606

44. Unii-2i8bd50i8b

45. 5,7-dichlor-8-hydroxychinolin [german]

46. Sq 16401

47. Capitrol (tn)

48. Spectrum_001434

49. Chloroxine [mi]

50. 5,7-dichloro-8-oxine

51. Spectrum2_000687

52. Spectrum3_001156

53. Spectrum4_000744

54. Spectrum5_001444

55. Chloroxine [vandf]

56. 8-quinolinol,7-dichloro-

57. Chloroxine [mart.]

58. Cid_2722

59. Schembl3350

60. Chloroxine [who-dd]

61. Oprea1_486275

62. Regid_for_cid_2722

63. Bspbio_002711

64. Kbiogr_001068

65. Kbioss_001914

66. 5-21-03-00286 (beilstein Handbook Reference)

67. Mls000681736

68. Bidd:gt0763

69. Divk1c_000578

70. Spectrum1503202

71. Spbio_000813

72. Zinc1131

73. Chembl1200596

74. Chloroxine [orange Book]

75. Dtxsid5022801

76. Bdbm32147

77. Hms501m20

78. Kbio1_000578

79. Kbio2_001914

80. Kbio2_004482

81. Kbio2_007050

82. Kbio3_002211

83. Ninds_000578

84. Hms1923k05

85. Hms2092n04

86. Hms2609a16

87. Hms3259e17

88. Hms3655g16

89. Hms3712o06

90. Pharmakon1600-01503202

91. Capitrol Cream Shampoo (salt/mix)

92. Amy23282

93. Component Of Capitrol Cream Shampoo

94. Hy-b0295

95. 5,7-dichloro-8-quinolinol, 99%

96. Tox21_111494

97. Ac9195

98. Ccg-40039

99. Nsc758398

100. S1839

101. Stk075368

102. 5,7-dichloroquinolin-8-ol;chloroxine

103. Akos000271338

104. Tox21_111494_1

105. Ac-4820

106. Db01243

107. Nc00505

108. Nsc-758398

109. Idi1_000578

110. Upcmld0enat5752182:001

111. Ncgc00095264-02

112. Ncgc00095264-03

113. Ncgc00095264-04

114. Ncgc00095264-05

115. Smr000312779

116. Sy016017

117. Tg2-36-1

118. Sbi-0051782.p002

119. A9795

120. D0412

121. Ft-0623709

122. Sw198618-2

123. D03472

124. Ab00052323-08

125. Ab00052323_09

126. Ab00052323_10

127. Sr-01000747474-2

128. Sr-01000747474-3

129. W-104320

130. Brd-k17075857-001-06-9

131. Q12029435

132. F0918-0943

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 214.04 g/mol
Molecular Formula C9H5Cl2NO
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass212.9748192 g/mol
Monoisotopic Mass212.9748192 g/mol
Topological Polar Surface Area33.1 Ų
Heavy Atom Count13
Formal Charge0
Complexity191
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.


5.2 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.3 Mechanism of Action

Although the mechanism of action is not understood, chloroxine may slow down mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp. Chloroxine induces SOS-DNA repair in E. coli, so chloroxine may be genotoxic to bacteria.


API SUPPLIERS

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AXYNTIS Group

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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AXYNTIS Group

France
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AXYNTIS Group

France
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Chloroxine

About the Company : Axyntis Group, founded in 2007, is France’s leading independent multi-site player in fine chemicals with a €90 million annual turnover. Axyntis has become a key producer of API...

Axyntis Group, founded in 2007, is France’s leading independent multi-site player in fine chemicals with a €90 million annual turnover. Axyntis has become a key producer of APIs in France through acquisitions & partnerships. It has two divisions (dyes and fine chemicals) and places a strong focus on diversification and innovation. It operates 3 cGMP sites in France, of which 2 are FDA-inspected. It provides CDMO services to its partners for their API or advanced intermediate projects, from early-stage development to the commercial phase, including preparative chromatography (Kyrapharm subsidiary). It also commercializes proprietary APIs.
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FDA Orange Book

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CHLOROXINE

Brand Name : CAPITROL

Dosage Form : SHAMPOO;TOPICAL

Dosage Strength : 2%

Approval Date : 1982-01-01

Application Number : 17594

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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Europe

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Betamethasone; Chloroxine

Brand Name : Beben Clorossina 

Dosage Form :

Dosage Strength : Cream Derm 30 G 0.1% + 0.5%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Betamethasone; Chloroxine

Brand Name : Beben Clorossina

Dosage Form :

Dosage Strength : Skin Emuls 30 Ml 0.1% + 0.5%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Betamethasone; Chloroxine

Brand Name : Beben Clorossina

Dosage Form :

Dosage Strength : Cream Derm 30 G 0.025% + 0.5%  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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ABOUT THIS PAGE

Chloroxine Manufacturers

A Chloroxine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chloroxine, including repackagers and relabelers. The FDA regulates Chloroxine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chloroxine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Chloroxine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Chloroxine Suppliers

A Chloroxine supplier is an individual or a company that provides Chloroxine active pharmaceutical ingredient (API) or Chloroxine finished formulations upon request. The Chloroxine suppliers may include Chloroxine API manufacturers, exporters, distributors and traders.

click here to find a list of Chloroxine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chloroxine GMP

Chloroxine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chloroxine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chloroxine GMP manufacturer or Chloroxine GMP API supplier for your needs.

Chloroxine CoA

A Chloroxine CoA (Certificate of Analysis) is a formal document that attests to Chloroxine's compliance with Chloroxine specifications and serves as a tool for batch-level quality control.

Chloroxine CoA mostly includes findings from lab analyses of a specific batch. For each Chloroxine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chloroxine may be tested according to a variety of international standards, such as European Pharmacopoeia (Chloroxine EP), Chloroxine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chloroxine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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