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Chemistry

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Also known as: 69-09-0, Chlorpromazine hcl, Sonazine, Chloractil, Klorproman, Klorpromex
Molecular Formula
C17H20Cl2N2S
Molecular Weight
355.3  g/mol
InChI Key
FBSMERQALIEGJT-UHFFFAOYSA-N
FDA UNII
9WP59609J6

Chlorpromazine Hydrochloride
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
1 2D Structure

Chlorpromazine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
2.1.3 InChI Key
FBSMERQALIEGJT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
9WP59609J6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aminazine

2. Chlorazine

3. Chlordelazine

4. Chlorpromazine

5. Contomin

6. Fenactil

7. Hydrochloride, Chlorpromazine

8. Largactil

9. Propaphenin

10. Thorazine

2.3.2 Depositor-Supplied Synonyms

1. 69-09-0

2. Chlorpromazine Hcl

3. Sonazine

4. Chloractil

5. Klorproman

6. Klorpromex

7. Marazine

8. Norcozine

9. Promacid

10. Hebanil

11. Promapar

12. Hybernal

13. Lomazine

14. Neurazine

15. Plegomazin

16. Promachel

17. Promexin

18. Taroctyl

19. Tranzine

20. Hibernal

21. Unitensen

22. Nci-c05210

23. Chlorpromazine (hydrochloride)

24. Aminazin Monohydrochloride

25. Fenactil Monohydrochloride

26. Chloropromazine Monohydrochloride

27. Ampliactil Monohydrochloride

28. Hibanil

29. Chlorpromazinium Chloride

30. Chlorpromazine Monohydrochloride

31. [3-(2-chloro-10h-phenothiazin-10-yl)propyl]-dimethylamine Hydrochloride

32. Chloropromazine Hydrochloride

33. Propaphen

34. 10-(3-dimethylaminopropyl)-2-chlorophenothiazine Monohydrochloride

35. Thorazine Hydrochloride

36. 3-(2-chlorophenothiazin-10-yl)-n,n-dimethylpropan-1-amine;hydrochloride

37. 3-(2-chloro-10h-phenothiazin-10-yl)-n,n-dimethylpropan-1-amine Hydrochloride

38. Mls000069401

39. Chebi:3649

40. 2-chloro-10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride

41. 10h-phenothiazine-10-propanamine, 2-chloro-n,n-dimethyl-, Monohydrochloride

42. Nsc-17479

43. 9wp59609j6

44. 69-09-0 (hcl)

45. Aminazinum

46. Megatil

47. Smr000058254

48. 2-chloro-10-(3-dimethylaminopropyl)phenothiazine Hydrochloride

49. 4560 Rp Hydrochloride

50. Chlorpromazine, Hydrochloride

51. Contomin Hydrochloride

52. Megaphen Hydrochloride

53. Phenothiazine Hydrochloride

54. Largactil Monohydrochloride

55. Cpz (van)

56. Nsc17479

57. Ccris 6221

58. [3-(2-chloro-10h-phenothiazin-10-yl)propyl]dimethylamine Hydrochloride

59. Cas-69-09-0

60. Sr-01000000012

61. Einecs 200-701-3

62. Nsc 17479

63. Chloropromazin Hydrochloride

64. Largaktyl

65. Ai3-28023

66. Unii-9wp59609j6

67. Prestwick_58

68. Sonazine (tn)

69. Chlorpromazine Hydrochloride Intensol

70. Mfcd00012654

71. Chlorpromazine Chloride

72. Ac1lcwf1

73. Chlorpromazine Hydrochloride [usp:ban:jan]

74. Opera_id_1294

75. Dsstox_cid_4827

76. Chlorpromazini Hydrochloridum

77. Chembl1713

78. Dsstox_rid_77545

79. Dsstox_gsid_24827

80. Schembl41771

81. Mls001148603

82. Mls002222157

83. Chlorpromazin-d6 Hydrochloride

84. Dtxsid7024827

85. Hy-b0407a

86. Chlorpromazine Hydrochloride, 98%

87. Hms1568m09

88. Bcp30284

89. Tox21_300517

90. Tox21_500249

91. Nsc226514

92. S2456

93. Akos005111082

94. Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, Monohydrochloride

95. Ccg-220064

96. Ccg-221553

97. Chlorpromazine-[13c,d3] Hydrochloride

98. Lp00249

99. Nc00552

100. 7-[diethylamino]coumarin-3-carbonylazide

101. Chlorpromazine Hydrochloride (jp17/usp)

102. Chlorpromazine Hydrochloride [mi]

103. Ncgc00024409-09

104. Ncgc00093711-01

105. Ncgc00093711-02

106. Ncgc00180973-01

107. Ncgc00254272-01

108. Ncgc00260934-01

109. Ac-10573

110. Chlorpromazine Hydrochloride [jan]

111. Ls-14587

112. Chlorpromazine Hydrochloride [mart.]

113. Chlorpromazine Hydrochloride [vandf]

114. C-165

115. Chlorpromazine Hydrochloride [usp-rs]

116. Chlorpromazine Hydrochloride [who-dd]

117. Chlorpromazine Hydrochloride [who-ip]

118. Chlorpromazine Hydrochloride, >=98% (tlc)

119. Eu-0100249

120. Ft-0623715

121. Ft-0665009

122. Sw196373-5

123. C 8138

124. C07952

125. Chlorpromazine, Hydrochloride - Cas 69-09-0

126. D00789

127. D89519

128. Mls-0090820.0001

129. Chlorpromazine Hydrochloride [green Book]

130. Wln: T C666 Bn Isj B3n1&1 Eg &gh

131. 012c654

132. Chlorpromazine Hydrochloride [ep Impurity]

133. Chlorpromazine Hydrochloride [ep Monograph]

134. Chlorpromazine Hydrochloride [orange Book]

135. Chlorpromazine Hydrochloride [usp Monograph]

136. Chlorpromazini Hydrochloridum [who-ip Latin]

137. Q-200842

138. Sr-01000000012-2

139. Sr-01000000012-9

140. Chlorpromazine Hydrochloride 100 Microg/ml In Methanol

141. Q27106159

142. Z1259155914

143. 2-chloro-10-(3-dimethylaminopropyl) Phenothiazine Hydrochloride

144. Chlorpromazine Hydrochloride, Meets Usp Testing Specifications

145. Chlorpromazine Hydrochloride, Vetranal(tm), Analytical Standard

146. 2-chloro-10-(3-dimethylaminopropyl)phenothiazine Monohydrochloride

147. 2-chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride

148. Chlorpromazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

149. 10h-phenothiazine-10-propanamine Hydrochloride, 2-chloro-n,n-dimethyl-

150. 3-(2-chlorophenothiazin-10-yl)-n,n-dimethylpropan-1-amine;hydrochloride.

151. Chlorpromazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

152. 10h-phenothiazine-10-propanamine, 2-chloro-n,n-dimethyl-, Hydrochloride (1:1)

153. Chlorpromazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

154. Chlorpromazine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.3.3 Other Synonyms

1. 2-chlorophenothiazine

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 355.3 g/mol
Molecular Formula C17H20Cl2N2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass354.0724252 g/mol
Monoisotopic Mass354.0724252 g/mol
Topological Polar Surface Area31.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity339
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameChlorpromazine hydrochloride
Drug LabelDESCRIPTION Chlorpromazine hydrochloride, a dimethylamine derivative of phenothiazine, has a chemical formula of 2-chloro-10-[3(-dimethylamino) propyl] phenothiazine monohydochloride. It is available in tablets for oral administration. It has the fol...
Active IngredientChlorpromazine hydrochloride
Dosage FormInjectable; Tablet
RouteInjection; Oral
Strength25mg/ml; 200mg; 100mg; 25mg; 50mg; 10mg
Market StatusPrescription
CompanyHikma Maple; Usl Pharma; Sandoz

2 of 2  
Drug NameChlorpromazine hydrochloride
Drug LabelDESCRIPTION Chlorpromazine hydrochloride, a dimethylamine derivative of phenothiazine, has a chemical formula of 2-chloro-10-[3(-dimethylamino) propyl] phenothiazine monohydochloride. It is available in tablets for oral administration. It has the fol...
Active IngredientChlorpromazine hydrochloride
Dosage FormInjectable; Tablet
RouteInjection; Oral
Strength25mg/ml; 200mg; 100mg; 25mg; 50mg; 10mg
Market StatusPrescription
CompanyHikma Maple; Usl Pharma; Sandoz

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Phenothiazines [CS]; Phenothiazine [EPC]

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Chlorpromazine Hcl USP/EP/IH

Date of Issue : 2021-10-22

Valid Till : 2024-10-21

Written Confirmation Number : WC-0511

Address of the Firm : Plot No 80 A Road No. 5, Jawaharlal Nehru pharma city, Parawada(M), Vishakhapatn...

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Chlorpromazine Hydrochloride

Date of Issue : 2013-12-19

Valid Till : 2016-11-21

Written Confirmation Number : WC-258

Address of the Firm : Industrial Extension Area, Phase III Gangyal, Jammu 180010

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Chlorpromazine HCl USP/EP

Date of Issue : 2022-02-02

Valid Till : 2024-06-07

Written Confirmation Number : WC-0317

Address of the Firm : Plot.No 43 & 44, IDA Phase-II, Pashamylaram, Patancheru Mandal, Medak Disctrict,...

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Chlorpromazine HCL/EP

Date of Issue : 2020-11-27

Valid Till : 2021-06-07

Written Confirmation Number : WC-0317A2

Address of the Firm : Plot.No 43 & 44, IDA Phase-II, Pashamylaram, Patancheru Mandal, Medak Disctrict,...

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Chlorpromazine Hydrochloride EP

Date of Issue : 2024-02-19

Valid Till : 2027-02-19

Written Confirmation Number : WC-0578

Address of the Firm : Sy.No.405 & 408, Veliminedu (Village), Chityal (Mandal), Nalgonda District — 5...

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Chlorpromazine Hcl USP

Date of Issue : 2018-12-03

Valid Till : 2021-07-09

Written Confirmation Number : WC-0424

Address of the Firm : Plot no. 61 Additional Ambernath Ambernath East Dist. Thane 421506 Maharashtra

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Chlorpromazine Hydrochloride IH/USP/EP

Date of Issue : 2022-11-18

Valid Till : 2025-09-30

Written Confirmation Number : WC-0455

Address of the Firm : Sy No 14, IDA Gaddapotharm, Jinnaram, Sangareddy (DT), TS-502319

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Chlorpromazine Hydrochloride USP/BP/EP

Date of Issue : 2020-03-31

Valid Till : 2022-07-28

Written Confirmation Number : WC-0445A2

Address of the Firm : Plot No. IP No. 27-29, Parts of Sy. Nos 18, 273, 274 & 313, KIADB Industrial Are...

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Chlorpromazine Hcl USP/BP/EP

Date of Issue : 2020-03-31

Valid Till : 2022-07-28

Written Confirmation Number : WC-0445A3

Address of the Firm : Plot No. IP No. 27-29, Parts of Sy. Nos 18, 273, 274 & 313, KIADB Industrial Are...

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Chlorpromazine Hydrochloride USP/BP/EP

Date of Issue : 2019-07-22

Valid Till : 2022-07-22

Written Confirmation Number : WC-0139

Address of the Firm : # 15, KHB Industrial Area, Yelahanka, Bangalore-560 064

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18-Feb-2021
20-Dec-2024
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - 25MG/ML

USFDA APPLICATION NUMBER - 83329

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DOSAGE - TABLET;ORAL - 10MG

USFDA APPLICATION NUMBER - 83386

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DOSAGE - TABLET;ORAL - 25MG

USFDA APPLICATION NUMBER - 84112

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DOSAGE - TABLET;ORAL - 50MG

USFDA APPLICATION NUMBER - 84113

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DOSAGE - TABLET;ORAL - 100MG

USFDA APPLICATION NUMBER - 84114

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DOSAGE - TABLET;ORAL - 200MG

USFDA APPLICATION NUMBER - 84115

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ABOUT THIS PAGE

Chlorpromazine Hydrochloride Manufacturers

A Chlorpromazine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlorpromazine Hydrochloride, including repackagers and relabelers. The FDA regulates Chlorpromazine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlorpromazine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Chlorpromazine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Chlorpromazine Hydrochloride Suppliers

A Chlorpromazine Hydrochloride supplier is an individual or a company that provides Chlorpromazine Hydrochloride active pharmaceutical ingredient (API) or Chlorpromazine Hydrochloride finished formulations upon request. The Chlorpromazine Hydrochloride suppliers may include Chlorpromazine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Chlorpromazine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chlorpromazine Hydrochloride USDMF

A Chlorpromazine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Chlorpromazine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Chlorpromazine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Chlorpromazine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Chlorpromazine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Chlorpromazine Hydrochloride USDMF includes data on Chlorpromazine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chlorpromazine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Chlorpromazine Hydrochloride suppliers with USDMF on PharmaCompass.

Chlorpromazine Hydrochloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Chlorpromazine Hydrochloride Drug Master File in Japan (Chlorpromazine Hydrochloride JDMF) empowers Chlorpromazine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Chlorpromazine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Chlorpromazine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Chlorpromazine Hydrochloride suppliers with JDMF on PharmaCompass.

Chlorpromazine Hydrochloride CEP

A Chlorpromazine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Chlorpromazine Hydrochloride Certificate of Suitability (COS). The purpose of a Chlorpromazine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Chlorpromazine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Chlorpromazine Hydrochloride to their clients by showing that a Chlorpromazine Hydrochloride CEP has been issued for it. The manufacturer submits a Chlorpromazine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Chlorpromazine Hydrochloride CEP holder for the record. Additionally, the data presented in the Chlorpromazine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Chlorpromazine Hydrochloride DMF.

A Chlorpromazine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Chlorpromazine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Chlorpromazine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

Chlorpromazine Hydrochloride WC

A Chlorpromazine Hydrochloride written confirmation (Chlorpromazine Hydrochloride WC) is an official document issued by a regulatory agency to a Chlorpromazine Hydrochloride manufacturer, verifying that the manufacturing facility of a Chlorpromazine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Chlorpromazine Hydrochloride APIs or Chlorpromazine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Chlorpromazine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Chlorpromazine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Chlorpromazine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chlorpromazine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Chlorpromazine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Chlorpromazine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Chlorpromazine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chlorpromazine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Chlorpromazine Hydrochloride suppliers with NDC on PharmaCompass.

Chlorpromazine Hydrochloride GMP

Chlorpromazine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chlorpromazine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chlorpromazine Hydrochloride GMP manufacturer or Chlorpromazine Hydrochloride GMP API supplier for your needs.

Chlorpromazine Hydrochloride CoA

A Chlorpromazine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Chlorpromazine Hydrochloride's compliance with Chlorpromazine Hydrochloride specifications and serves as a tool for batch-level quality control.

Chlorpromazine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Chlorpromazine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chlorpromazine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlorpromazine Hydrochloride EP), Chlorpromazine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlorpromazine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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