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Chemistry

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Also known as: 57-62-5, 7-chlorotetracycline, Chlorotetracycline, Aureomycin, Acronize, Chlormax
Molecular Formula
C22H23ClN2O8
Molecular Weight
478.9  g/mol
InChI Key
DHPRQBPJLMKORJ-XRNKAMNCSA-N
FDA UNII
WCK1KIQ23Q

Chlortetracycline
A TETRACYCLINE with a 7-chloro substitution.
1 2D Structure

Chlortetracycline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
2.1.2 InChI
InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26-27,30,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1
2.1.3 InChI Key
DHPRQBPJLMKORJ-XRNKAMNCSA-N
2.1.4 Canonical SMILES
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O
2.1.5 Isomeric SMILES
C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O
2.2 Other Identifiers
2.2.1 UNII
WCK1KIQ23Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-epimer Chlortetracycline

2. Aureocyclin

3. Aureomycin

4. Aureomycine

5. Biomycin

6. Bisulfate, Chlortetracycline

7. Calcium Salt Chlortetracycline

8. Chlorotetracycline

9. Chlortetracycline Bisulfate

10. Chlortetracycline Hydrochloride

11. Chlortetracycline Monohydrochloride

12. Chlortetracycline Sulfate (1:1)

13. Chlortetracycline Sulfate (2:1)

14. Chlortetracycline, 4 Epimer

15. Chlortetracycline, 4-epimer

16. Chlortetracycline, Calcium Salt

17. Hydrochloride, Chlortetracycline

18. Monohydrochloride, Chlortetracycline

19. Salt Chlortetracycline, Calcium

2.3.2 Depositor-Supplied Synonyms

1. 57-62-5

2. 7-chlorotetracycline

3. Chlorotetracycline

4. Aureomycin

5. Acronize

6. Chlormax

7. Clortetraciclina

8. Chlortetracyclinum

9. Aureomycin A-377

10. Biomycin

11. (4s,4as,5as,6s,12as)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

12. Duomycin

13. Wck1kiq23q

14. Aureomykoin

15. Chrysomykine

16. Aureocina

17. Biomitsin

18. Flamycin

19. Uromycin

20. Biomycin A

21. Chebi:27644

22. Ctc (abtibiotic)

23. Tri-chlortetracycline

24. Aureomycin (tn)

25. Chlortetracycline (inn)

26. Chlortetracycline [inn]

27. Caswell No. 219b

28. Unii-wck1kiq23q

29. Aueromycin

30. Chlortetracycline [inn:ban]

31. Chlortetracyclinum [inn-latin]

32. Clortetraciclina [inn-spanish]

33. 2-naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s,4as,5as,6s,12as)-

34. Einecs 200-341-7

35. Mfcd00864876

36. Epa Pesticide Chemical Code 006301

37. Spectrum_000727

38. Spectrum_001315

39. Prestwick0_000145

40. Prestwick1_000145

41. Prestwick2_000145

42. Spectrum2_000802

43. Spectrum3_000348

44. Spectrum4_001001

45. Spectrum4_001791

46. Spectrum5_000461

47. Spectrum5_001870

48. Pig Liver-chlortetracycline

49. Schembl3110

50. Pig Kidney (ctc Free)

51. Pig Muscle (ctc Free)

52. Schembl62861

53. Bspbio_002015

54. Kbiogr_001461

55. Kbiogr_002364

56. Kbioss_001207

57. Kbioss_001795

58. Chlortetracycline [mi]

59. Divk1c_000253

60. Spbio_000663

61. Spbio_002189

62. Chembl404520

63. Schembl4099094

64. Chembl1622557

65. Dtxsid9022811

66. Schembl19981439

67. Chlortetracycline [vandf]

68. Hms500m15

69. Hy-b1327a

70. Kbio1_000253

71. Kbio2_001207

72. Kbio2_001795

73. Kbio2_003775

74. Kbio2_004363

75. Kbio2_006343

76. Kbio2_006931

77. Kbio3_001235

78. Chlortetracycline [mart.]

79. Ninds_000253

80. Chlortetracycline [who-dd]

81. (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

82. Rkl10090

83. Lmpk07000004

84. Zinc19701769

85. Chlortetracycline [green Book]

86. Zinc100154659

87. Zinc100302624

88. Ccg-269531

89. Chlortetracycline [ep Impurity]

90. Db09093

91. Idi1_000253

92. Ncgc00178862-01

93. Ncgc00178862-04

94. E702

95. Sbi-0051312.p003

96. Cs-0013541

97. Lymecycline Impurity G [ep Impurity]

98. C06571

99. D07689

100. H10649

101. Ab00643434_03

102. 864c876

103. Q417948

104. Q-200843

105. (4s,5as,6s,12as)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

2.4 Create Date
2011-12-26
3 Chemical and Physical Properties
Molecular Weight 478.9 g/mol
Molecular Formula C22H23ClN2O8
XLogP3-1.3
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count2
Exact Mass478.1142934 g/mol
Monoisotopic Mass478.1142934 g/mol
Topological Polar Surface Area182 Ų
Heavy Atom Count33
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used in the manufacuring of medicated animal feeds.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Antiprotozoal Agents

Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.3 ATC Code

S01AA02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AB - Antiinfectives and antiseptics for local oral treatment

A01AB21 - Chlortetracycline


D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06A - Antibiotics for topical use

D06AA - Tetracycline and derivatives

D06AA02 - Chlortetracycline


J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01A - Tetracyclines

J01AA - Tetracyclines

J01AA03 - Chlortetracycline


S - Sensory organs

S01 - Ophthalmologicals

S01A - Antiinfectives

S01AA - Antibiotics

S01AA02 - Chlortetracycline


5.4 Absorption, Distribution and Excretion

Absorption

Chortetracycline reaches peak plasma concentation in about 3 hours. Its oral bioavailability is 25-30%.


Route of Elimination

Chlortetracycline is mainly eliminated in feces. Renal function does not appear to affect the rate of elimination.


Volume of Distribution

Chlortetracycline has a volume of distribution of 100 liters.


5.5 Metabolism/Metabolites

Chlortetracycline is not known to undergo significant metabolism.


5.6 Biological Half-Life

The half-life of Chlortetracycline is 5.6 hours.


5.7 Mechanism of Action

Chlortetracycline, like other tetracyclines, competes for the A site of the bacterial ribosome. This binding competes with tRNA carrying amino acids preventing the addition of more amino acids to the peptide chain. This inhibition of protein synthesis ultimately inhibits growth and reproduction of the bacterial cell as necessary proteins cannot be synthesized.


API Reference Price

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18-Jan-2021
04-Oct-2024
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ABOUT THIS PAGE

Chlortetracycline Manufacturers

A Chlortetracycline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlortetracycline, including repackagers and relabelers. The FDA regulates Chlortetracycline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlortetracycline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Chlortetracycline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Chlortetracycline Suppliers

A Chlortetracycline supplier is an individual or a company that provides Chlortetracycline active pharmaceutical ingredient (API) or Chlortetracycline finished formulations upon request. The Chlortetracycline suppliers may include Chlortetracycline API manufacturers, exporters, distributors and traders.

click here to find a list of Chlortetracycline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chlortetracycline NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chlortetracycline as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Chlortetracycline API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Chlortetracycline as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Chlortetracycline and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chlortetracycline NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Chlortetracycline suppliers with NDC on PharmaCompass.

Chlortetracycline GMP

Chlortetracycline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chlortetracycline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chlortetracycline GMP manufacturer or Chlortetracycline GMP API supplier for your needs.

Chlortetracycline CoA

A Chlortetracycline CoA (Certificate of Analysis) is a formal document that attests to Chlortetracycline's compliance with Chlortetracycline specifications and serves as a tool for batch-level quality control.

Chlortetracycline CoA mostly includes findings from lab analyses of a specific batch. For each Chlortetracycline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chlortetracycline may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlortetracycline EP), Chlortetracycline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlortetracycline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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