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    Chemistry

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    Also known as: Lhrh, Lh-rh, Gonadoliberin, luliberin, Gnrh, 9034-40-6, 71447-49-9
    Molecular Formula
    C55H75N17O13
    Molecular Weight
    1182.3  g/mol
    InChI Key
    XLXSAKCOAKORKW-UHFFFAOYSA-N
    Gonadorelin
    A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
    1 2D Structure

    Gonadorelin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
    2.1.2 InChI
    InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
    2.1.3 InChI Key
    XLXSAKCOAKORKW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Cystorelin

    2. Dirigestran

    3. Factrel

    4. Fsh Releasing Hormone

    5. Fsh-releasing Hormone

    6. Gn-rh

    7. Gnrh

    8. Gonadoliberin

    9. Gonadorelin

    10. Gonadorelin Acetate

    11. Gonadorelin Hydrochloride

    12. Gonadotropin Releasing Hormone

    13. Gonadotropin-releasing Hormone

    14. Kryptocur

    15. Lfrh

    16. Lh Fsh Releasing Hormone

    17. Lh Releasing Hormone

    18. Lh-fsh Releasing Hormone

    19. Lh-releasing Hormone

    20. Lh-rh

    21. Lhfsh Releasing Hormone

    22. Lhfshrh

    23. Lhrh

    24. Luliberin

    25. Luteinizing Hormone Releasing Hormone

    26. Luteinizing Hormone-releasing Hormone

    27. Releasing Hormone, Lhfsh

    2.2.2 Depositor-Supplied Synonyms

    1. Lhrh

    2. Lh-rh

    3. Gonadoliberin, Luliberin

    4. Gnrh

    5. 9034-40-6

    6. 71447-49-9

    7. Lhrh, Human

    8. Ncgc00182043-01

    9. 6918-09-8

    10. Chembl1981292

    11. Luteinizing Hormone Releasingfactor

    12. Bcp12609

    13. Bcp12654

    14. Luteinizing Hormone Releasing Factor

    15. Syntheticgonadotropin-releasinghormone

    16. Db00644

    17. Ncgc00389662-01

    18. Luteinizing Hormone Releasing Hormone Human

    19. Db-057197

    20. Ft-0628048

    21. C07607

    22. A821811

    23. L000690

    24. Luteinizing Hormone Releasing Hormone Human Acetate Salt;lhrh

    25. Lhrh;lh-releasing Factor;gonadorelina;glp-his-trp-ser-tyr-gly-leu-ser-pro-gly-nh2

    26. N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-azanyl-2-oxidanylidene-ethyl)carbamoyl]pyrrolidin-1-yl]-5-[bis(azanyl)methylideneamino]-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]amino]-3-(4-hydroxyphenyl)-1-o

    27. N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropa

    2.3 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 1182.3 g/mol
    Molecular Formula C55H75N17O13
    XLogP3-2.4
    Hydrogen Bond Donor Count16
    Hydrogen Bond Acceptor Count15
    Rotatable Bond Count31
    Exact Mass1181.57302551 g/mol
    Monoisotopic Mass1181.57302551 g/mol
    Topological Polar Surface Area475 Ų
    Heavy Atom Count85
    Formal Charge0
    Complexity2390
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count8
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use

    5.2 Absorption, Distribution and Excretion

    Absorption

    Rapidly absorbed when injected

    5.3 Metabolism/Metabolites

    Rapidly hydrolyzed to inactive peptide components

    5.4 Biological Half-Life

    Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes

    5.5 Mechanism of Action

    Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.

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    29-Nov-2024
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    CHORIONIC GONADOTROPIN Manufacturers

    A CHORIONIC GONADOTROPIN manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CHORIONIC GONADOTROPIN, including repackagers and relabelers. The FDA regulates CHORIONIC GONADOTROPIN manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CHORIONIC GONADOTROPIN API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of CHORIONIC GONADOTROPIN manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    CHORIONIC GONADOTROPIN Suppliers

    A CHORIONIC GONADOTROPIN supplier is an individual or a company that provides CHORIONIC GONADOTROPIN active pharmaceutical ingredient (API) or CHORIONIC GONADOTROPIN finished formulations upon request. The CHORIONIC GONADOTROPIN suppliers may include CHORIONIC GONADOTROPIN API manufacturers, exporters, distributors and traders.

    click here to find a list of CHORIONIC GONADOTROPIN suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    CHORIONIC GONADOTROPIN USDMF

    A CHORIONIC GONADOTROPIN DMF (Drug Master File) is a document detailing the whole manufacturing process of CHORIONIC GONADOTROPIN active pharmaceutical ingredient (API) in detail. Different forms of CHORIONIC GONADOTROPIN DMFs exist exist since differing nations have different regulations, such as CHORIONIC GONADOTROPIN USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A CHORIONIC GONADOTROPIN DMF submitted to regulatory agencies in the US is known as a USDMF. CHORIONIC GONADOTROPIN USDMF includes data on CHORIONIC GONADOTROPIN's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The CHORIONIC GONADOTROPIN USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of CHORIONIC GONADOTROPIN suppliers with USDMF on PharmaCompass.

    CHORIONIC GONADOTROPIN NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing CHORIONIC GONADOTROPIN as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for CHORIONIC GONADOTROPIN API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture CHORIONIC GONADOTROPIN as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain CHORIONIC GONADOTROPIN and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a CHORIONIC GONADOTROPIN NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of CHORIONIC GONADOTROPIN suppliers with NDC on PharmaCompass.

    CHORIONIC GONADOTROPIN GMP

    CHORIONIC GONADOTROPIN Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of CHORIONIC GONADOTROPIN GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CHORIONIC GONADOTROPIN GMP manufacturer or CHORIONIC GONADOTROPIN GMP API supplier for your needs.

    CHORIONIC GONADOTROPIN CoA

    A CHORIONIC GONADOTROPIN CoA (Certificate of Analysis) is a formal document that attests to CHORIONIC GONADOTROPIN's compliance with CHORIONIC GONADOTROPIN specifications and serves as a tool for batch-level quality control.

    CHORIONIC GONADOTROPIN CoA mostly includes findings from lab analyses of a specific batch. For each CHORIONIC GONADOTROPIN CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    CHORIONIC GONADOTROPIN may be tested according to a variety of international standards, such as European Pharmacopoeia (CHORIONIC GONADOTROPIN EP), CHORIONIC GONADOTROPIN JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CHORIONIC GONADOTROPIN USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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