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Chemistry

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Also known as: Chymotrypsin substrate i, colorimetric, 9004-07-3, 4-[[2-[[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid, A-chymotrypsin, Dtxsid30988741, Akos024350585
Molecular Formula
C23H25N5O8
Molecular Weight
499.5  g/mol
InChI Key
CFYIUBWVKZQDOG-UHFFFAOYSA-N

Chymotrypsin
A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.
1 2D Structure

Chymotrypsin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[[2-[[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid
2.1.2 InChI
InChI=1S/C23H25N5O8/c29-19(10-11-22(32)33)24-13-20(30)25-14-21(31)27-18(12-15-4-2-1-3-5-15)23(34)26-16-6-8-17(9-7-16)28(35)36/h1-9,18H,10-14H2,(H,24,29)(H,25,30)(H,26,34)(H,27,31)(H,32,33)
2.1.3 InChI Key
CFYIUBWVKZQDOG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CNC(=O)CNC(=O)CCC(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Alpha-chymotrypsin Choay

2. Alphacutane

3. Avazyme

2.2.2 Depositor-Supplied Synonyms

1. Chymotrypsin Substrate I, Colorimetric

2. 9004-07-3

3. 4-[[2-[[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic Acid

4. A-chymotrypsin

5. Dtxsid30988741

6. Akos024350585

7. Db-055212

8. Ft-0641215

9. N-succinyl-gly-gly-phe-p-nitroanilide, Protease Substrate

10. N-(3-carboxy-1-oxopropyl)glycylglycyl-n-(4-nitrophenyl)-l-phenylalaninamide

11. 4-hydroxy-4-({2-hydroxy-2-[(2-hydroxy-2-{[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]imino}ethyl)imino]ethyl}imino)butanoic Acid

2.2.3 Other Synonyms

1. Alpha Chymotrypsin

2.3 Create Date
2005-09-13
3 Chemical and Physical Properties
Molecular Weight 499.5 g/mol
Molecular Formula C23H25N5O8
XLogP30.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count12
Exact Mass499.17031277 g/mol
Monoisotopic Mass499.17031277 g/mol
Topological Polar Surface Area200 Ų
Heavy Atom Count36
Formal Charge0
Complexity801
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

EXPTL USE (MEDICATION (VET):): CHYMOTRYPSIN CAN BE SHOWN TO HAVE AN ANTI-INFLAMMATORY ACTION IN EXPTL ANIMALS, BUT ONLY WHEN THE ENZYME IS ADMIN PARENTERALLY IN DOSES 10 TO 20 TIMES THOSE EMPLOYED CLINICALLY & PRIOR TO THE PRODN OF THE INFLAMMATION.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 957


...USED FOR RELIEF OF SYMPTOMS RELATED TO EPISIOTOMY. ITS USEFULNESS IN INFLAMMATORY STATES SECONDARY TO SURGICAL OR PHYSICAL TRAUMA REMAINS UNPROVEN.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 957


ALPHA-CHYMOTRYPSIN...IS...USED IN CATARACT OPERATIONS TO LOOSEN THE LENS AFTER INCISION OF CORNEA. AFTER THE CORNEOSCLERAL OR CORNEOSCLERALCONJUNCTIVAL INCISION, THE POSTERIOR CHAMBER IS IRRIGATED WITH ABOUT 2 ML OF ENZYME SOLN (150 UNITS PER ML) TO FRAGMENT FIBERS OF THE ZONULE (ENZYMATIC ZONULOLYSIS).

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 957


...FOR DEBRIDEMENT OF NECROTIC WOUNDS, ULCERS, ABSCESSES, EMPYEMAS, & FISTULAS. IT HAS BEEN USED ALSO FOR LIQUIFACTION OF BLOOD & EXUDATES THAT HAVE NOT BECOME ORGANIZED BY FIBROUS TISSUE.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 972


For more Therapeutic Uses (Complete) data for CHYMOTRYPSIN (10 total), please visit the HSDB record page.


4.2 Drug Warning

...IT IS NOT RECOMMENDED FOR USE IN OPHTHALMIC SURGERY IN PT UNDER 20 YEARS OF AGE BECAUSE OF POSSIBLE LOSS OF VITREOUS HUMOR.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 957


GLAUCOMA, AS A COMPLICATION OF USE OF CHYMOTRYPSIN IN CATARACT EXTRACTIONS IN PT, HAS OCCURED USUALLY WITHIN 2 TO 5 DAYS AFTER OPERATION... THERE HAVE BEEN PRACTICALLY NO INDICATIONS OF LONGER-PERSISTING GLAUCOMA, FROM USE OF THE ENZYME.

Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974., p. 292


4.3 Drug Indication

No therapeutic indications.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Chymotrypsin is a digestive enzyme synthesized in the pancreas that plays an essential role in proteolysis, or the breakdown of proteins and polypeptides. As a component in the pancreatic juice, chymotrypsin aids in the digestion of proteins in the duodenum by preferentially cleaving peptide amide bonds.


5.2 ATC Code

B - Blood and blood forming organs

B06 - Other hematological agents

B06A - Other hematological agents

B06AA - Enzymes

B06AA04 - Chymotrypsin


S - Sensory organs

S01 - Ophthalmologicals

S01K - Surgical aids

S01KX - Other surgical aids

S01KX01 - Chymotrypsin


5.3 Absorption, Distribution and Excretion

Absorption

No pharmacokinetic data available.


Route of Elimination

No pharmacokinetic data available.


Volume of Distribution

No pharmacokinetic data available.


Clearance

No pharmacokinetic data available.


5.4 Metabolism/Metabolites

No pharmacokinetic data available.


5.5 Biological Half-Life

No pharmacokinetic data available.


5.6 Mechanism of Action

Chymotrypsin is synthesized by pancreatic acinar cells as an inactive precursor, chymotrypsinogen, that is secreted to the duodenum and activated via trypsin-induced cleavage. It also induces its own activation by cleaving essential amino acid residues in the oxyanion hole to produce -Chymotrypsin, which is a more stable form than -Chymotrypsin. Residues His-57, Asp-102, and Ser-195 form the catalytic triad while residues 189195, 214220, and 225228 form the primary substrate-binding pocket called S1 binding pocket. Residue 189 in the polar serine residue that lies at the bottom of the S1 binding pocket. Chymotrypsin favors aromatic residues like phenylalanine, tyrosine, and tryptophan but may hydrolyze other bonds in peptides at slower rates.


THEY SPLIT SECONDARY AMIDE OR PEPTIDE BONDS, CARBOXYLIC OR PHENOLIC ESTER BONDS & EVEN CARBON-CARBON BONDS. THEIR MAIN FUNCTION IS TO HYDROLYZE PEPTIDE BONDS DURING THE INTESTINAL DIGESTION OF PROTEINS. /CHYMOTRYPSINS/

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 293


API SUPPLIERS

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01

Enzymeking Biotechnology Co., Ltd

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
Not Confirmed
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Enzymeking Biotechnology Co., Ltd

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Pharma, Lab & Chemical Expo
Not Confirmed
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CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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02

Beijing Geyuantianrun Bio-tech Co,...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
Not Confirmed
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Beijing Geyuantianrun Bio-tech Co,...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Pharma, Lab & Chemical Expo
Not Confirmed
USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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03

Zhejiang Fengan Biopharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
Not Confirmed
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Zhejiang Fengan Biopharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Pharma, Lab & Chemical Expo
Not Confirmed
USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Eli Lilly

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
Not Confirmed
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Eli Lilly

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Pharma, Lab & Chemical Expo
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05

Waitaki Biosciences

New Zealand

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
Not Confirmed
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Waitaki Biosciences

New Zealand

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Worthington Biochemical Corporatio...

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
Not Confirmed
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Worthington Biochemical Corporatio...

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Pharma, Lab & Chemical Expo
Not Confirmed
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07

Sichuan Deebio Pharmaceutical Co.,...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo
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08

SAFC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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SAFC

U.S.A

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BBI Solutions

United Kingdom

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BBI Solutions

United Kingdom

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Guangzhou Tosun Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1653330600,"product":"TRYPSIN\/CHYMOTRYPSIN 6:1 BATCH NO. TYPCT","address":"204,205,206 SHIROMANI COMPLEX,NEHR UNAGAR","city":"AHMEDABAD,GUJARAT","supplier":"METEORIC BIOPHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"NUTRITION FORMULATORS INC.","customerCountry":"UNITED STATES","quantity":"18.00","actualQuantity":"18","unit":"KGS","unitRateFc":"175","totalValueFC":"3131.2","currency":"USD","unitRateINR":13444.444444444445,"date":"24-May-2022","totalValueINR":"242000","totalValueInUsd":"3131.2","indian_port":"AHMEDABAD AIR","hs_no":"29349990","bill_no":"1602991","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"AHMEDABAD AIR","supplierAddress":"204,205,206 SHIROMANI COMPLEX,NEHR UNAGAR, AHMEDABAD,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1684348200,"product":"TRYPSIN CHYMOTRYPSIN 6 1 BATCH NO TCT2305001 AS PER INVOICE","address":"204,205,206 SHIROMANI COMPLEX,NEHR UNAGAR","city":"AHMEDABAD,GUJARAT","supplier":"METEORIC BIOPHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"TO THE ORDER","customerCountry":"UNITED STATES","quantity":"12.00","actualQuantity":"12","unit":"KGS","unitRateFc":"175","totalValueFC":"2066","currency":"USD","unitRateINR":14166.666666666666,"date":"18-May-2023","totalValueINR":"170000","totalValueInUsd":"2066","indian_port":"AHMEDABAD AIR","hs_no":"29349990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"AHMEDABAD AIR","supplierAddress":"204,205,206 SHIROMANI COMPLEX,NEHR UNAGAR, AHMEDABAD,GUJARAT","customerAddress":""}]
24-May-2022
18-May-2023
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ABOUT THIS PAGE

Chymotrypsin Manufacturers

A Chymotrypsin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chymotrypsin, including repackagers and relabelers. The FDA regulates Chymotrypsin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chymotrypsin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Chymotrypsin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Chymotrypsin Suppliers

A Chymotrypsin supplier is an individual or a company that provides Chymotrypsin active pharmaceutical ingredient (API) or Chymotrypsin finished formulations upon request. The Chymotrypsin suppliers may include Chymotrypsin API manufacturers, exporters, distributors and traders.

click here to find a list of Chymotrypsin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chymotrypsin USDMF

A Chymotrypsin DMF (Drug Master File) is a document detailing the whole manufacturing process of Chymotrypsin active pharmaceutical ingredient (API) in detail. Different forms of Chymotrypsin DMFs exist exist since differing nations have different regulations, such as Chymotrypsin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Chymotrypsin DMF submitted to regulatory agencies in the US is known as a USDMF. Chymotrypsin USDMF includes data on Chymotrypsin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chymotrypsin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Chymotrypsin suppliers with USDMF on PharmaCompass.

Chymotrypsin CEP

A Chymotrypsin CEP of the European Pharmacopoeia monograph is often referred to as a Chymotrypsin Certificate of Suitability (COS). The purpose of a Chymotrypsin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Chymotrypsin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Chymotrypsin to their clients by showing that a Chymotrypsin CEP has been issued for it. The manufacturer submits a Chymotrypsin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Chymotrypsin CEP holder for the record. Additionally, the data presented in the Chymotrypsin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Chymotrypsin DMF.

A Chymotrypsin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Chymotrypsin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Chymotrypsin suppliers with CEP (COS) on PharmaCompass.

Chymotrypsin GMP

Chymotrypsin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chymotrypsin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chymotrypsin GMP manufacturer or Chymotrypsin GMP API supplier for your needs.

Chymotrypsin CoA

A Chymotrypsin CoA (Certificate of Analysis) is a formal document that attests to Chymotrypsin's compliance with Chymotrypsin specifications and serves as a tool for batch-level quality control.

Chymotrypsin CoA mostly includes findings from lab analyses of a specific batch. For each Chymotrypsin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chymotrypsin may be tested according to a variety of international standards, such as European Pharmacopoeia (Chymotrypsin EP), Chymotrypsin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chymotrypsin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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