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Ciclesonide

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12 API Suppliers
6 USDMF
5 CEP/COS
1 JDMF
3 EU WC
4 KDMF
3 NDC API
2 VMF
9 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

4 Intermediates Suppliers

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

40 FDF Dossiers, 5 FDA Orange Book, 16 Europe, 4 Canada, 2 Australia, 8 South Africa, 5 Listed Dossiers

40 FDF Dossiers
5 FDA Orange Book
16 Europe
4 Canada
2 Australia
8 South Africa
5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

AEROSOL, METERED;NASAL - 0.037MG/INH, AEROSOL, METERED;INHALATION - 0.08MG/INH, AEROSOL, METERED;INHALATION - 0.16MG/INH, SPRAY, METERED;NASAL - 0.05MG/SPRAY

drugProductComposition
AEROSOL, METERED;NASAL - 0.037MG/INH
AEROSOL, METERED;INHALATION - 0.08MG/INH
AEROSOL, METERED;INHALATION - 0.16MG/INH
SPRAY, METERED;NASAL - 0.05MG/SPRAY

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3 US Medicaid Prescriptions, 13 Finished Drug Prices, 3 Annual Reports

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13 Finished Drug Prices
3 Annual Reports

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2 APIs

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PATENTS & EXCLUSIVITIES

4 US Patents, 15 Health Canada Patents

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4 US Patents
15 Health Canada Patents

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1 EDQM

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Coral Ciclesonide

Synopsis

ACTIVE PHARMA INGREDIENTS

12

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6

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5

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CEP/COS Certifications

1

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3

EU WC

4

KDMF

3

NDC API

2

VMF

9

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 25,764

MARKET PLACE

2

API

0

FDF

4INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

40

FDF Dossiers

5

FDA Orange Book

FDA (Orange Book)

16

Europe

4

Canada

2

Australia

8

South Africa

5

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

1

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

4

US Patents

0

US Exclusivities

15

Health Canada Patents

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GLOBAL SALES INFORMATION

US Medicaid (USD)

34,845,315

Annual Reports (USD Million)

96

Finished Drug Prices

98 RELATED EXCIPIENT COMPANIES

171EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Alvesco, Omnaris, 126544-47-6, Zetonna, Rpr251526, Rpr-251526

Molecular Formula

C₃₂H₄₄O₇

Molecular Weight

540.7 g/mol

InChI Key

LUKZNWIVRBCLON-GXOBDPJESA-N

FDA UNII

S59502J185

Ciclesonide

Ciclesonide is a nonhalogenated, synthetic, inhaled corticosteroid (ICS) with anti-inflammatory and potential antiviral activities. Upon administration by oral inhalation into the lungs, ciclesonide (CIC) is converted by local esterases to its active metabolite desisobutyryl-ciclesonide (des-CIC), which binds to intracellular glucocorticoid receptors (GRs). The ligand-bound GRs regulate gene expressions, which lead to inhibitory activities against multiple cell types, such as mast cells, eosinophils, basophils, lymphocytes, macrophages and neutrophils, and various mediators associated with inflammation, such as histamine, eicosanoids, leukotrienes and cytokines. In addition, ciclesonide may suppress the replication of human coronavirus by targeting viral nonstructural protein 15 (NSP15).

1 2D Structure

Ciclesonide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate

2.1.2 InChI

InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1

2.1.3 InChI Key

LUKZNWIVRBCLON-GXOBDPJESA-N

2.1.4 Canonical SMILES

CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6

2.1.5 Isomeric SMILES

CC(C)C(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)O[C@H](O2)C6CCCCC6

2.2 Other Identifiers

2.2.1 UNII

S59502J185

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (r)-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Cyclohexanecarboxaldehyde, 21-isobutyrate

2. Alvesco

3. Omnaris

2.3.2 Depositor-Supplied Synonyms

1. Alvesco

2. Omnaris

3. 126544-47-6

4. Zetonna

5. Rpr251526

6. Rpr-251526

7. Ciclesonide [inn]

8. 141845-82-1

9. Bi54903

10. S59502j185

11. [2-[(1s,2s,4r,6r,8s,9s,11s,12s,13r)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate

12. [2-[(1s,2s,4r,8s,9s,11s,12s,13r)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate

13. Osonase

14. Osonide

15. Omnair

16. Rpr 251526

17. Alvesco Hfa

18. Omnaris Hfa

19. Alvesco (tn)

20. Omnaris (tn)

21. Ciclesonide [usan:inn]

22. Btr-15k

23. Ciclesonide (jan/usan/inn)

24. Btr-15

25. Tbn-15

26. (r)-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Cyclohexanecarboxaldehyde, 21-isobutyrate

27. Unii-s59502j185

28. Ncgc00167484-01

29. (11?,16?)-16,17-[[(r)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione

30. Alvesco 80

31. Zetonna (tn)

32. Alvesco, Ciclesonide

33. Byk-20426

34. Alvesco 160

35. By-9010

36. Ks-1165

37. Ac1miwnr

38. Ciclesonide [mi]

39. Ciclesonide [jan]

40. Ciclesonide [usan]

41. Ciclesonide [vandf]

42. Schembl3688

43. Ciclesonide [mart.]

44. Dsstox_cid_26659

45. Dsstox_rid_81802

46. Dsstox_gsid_46659

47. Ciclesonide [who-dd]

48. B-9207-015

49. Gtpl7469

50. El-87-6

51. Chembl2040682

52. Dtxsid9046659

53. Chebi:31397

54. Ciclesonide, >=98% (hplc)

55. Ciclesonide [orange Book]

56. Ciclesonide [ep Monograph]

57. Hms3714n07

58. Ex-a4195

59. Hy-b0625

60. Zinc3915154

61. Tox21_112486

62. Bdbm50247997

63. S4646

64. Akos015994702

65. Ac-1330

66. Ccg-269962

67. Db01410

68. Ncgc00167972-01

69. Pregna-1,4-diene-3,20-dione, 16,17-(((r)-cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha)-

70. Pregna-1,4-diene-3,20-dione, 16,17-((cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha(r))-

71. Ciclesonide 100 Microg/ml In Acetonitrile

72. C3701

73. Cas-141845-82-1

74. C72110

75. D01703

76. 544c476

77. A899067

78. Sr-01000942227

79. Q5119448

80. Sr-01000942227-1

81. Ciclesonide, European Pharmacopoeia (ep) Reference Standard

82. (11?,16?)-16,17-[[(r)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione

83. 2-((6ar,6bs,7s,8as,8bs,10r,11ar,12as,12bs)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bh-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl Isobutyrate

84. 2h-naphth (2',1':4,5) Indeno (1,2-d) (1,3) Dioxole, Pregna-1,4-diene-3,20-dione Deriv.

85. Pregna-1,4-diene-3,20-dione, 16,17-(((r)-cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11.beta.,16.alpha.)

2.3.3 Other Synonyms

1. Desisobutyrylciclesonide

2. Desisobuytyryl Ciclesonide

3. Desisobutyryl Ciclesonide

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₃₂H₄₄O₇
Molecular Weight	540.7 g/mol
XLogP3	5.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	540.30870374 g/mol
Monoisotopic Mass	540.30870374 g/mol
Topological Polar Surface Area	99.1 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	1100
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Alvesco
PubMed Health	Ciclesonide
Drug Classes	Anti-Inflammatory, Endocrine-Metabolic Agent
Drug Label	The active component of ALVESCO 80 mcg Inhalation Aerosol, and ALVESCO 160 mcg Inhalation Aerosol is ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydr...
Active Ingredient	Ciclesonide
Dosage Form	Aerosol, metered
Route	Inhalation
Strength	0.08mg/inh; 0.16mg/inh
Market Status	Prescription
Company	Takeda Gmbh

2 of 6
Drug Name	Omnaris
PubMed Health	Ciclesonide
Drug Classes	Anti-Inflammatory, Endocrine-Metabolic Agent
Drug Label	The active component of OMNARIS Nasal Spray is ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna -1,4-diene-3,20-dione, 16,17-[[R-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-,(11,16)-. Ciclesoni...
Active Ingredient	Ciclesonide
Dosage Form	Spray, metered; Spray
Route	nasal; Nasal
Strength	50mcg; 0.05mg/inh
Market Status	Prescription
Company	Nycomed Us; Takeda Gmbh

3 of 6
Drug Name	Zetonna
PubMed Health	Ciclesonide
Drug Classes	Anti-Inflammatory, Endocrine-Metabolic Agent
Drug Label	The active component of ZETONNA Nasal Aerosol is ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna -1,4-diene-3,20-dione, 16,17-[[R-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-,(11,16)-. Cicleso...
Active Ingredient	Ciclesonide
Dosage Form	Aerosol, metered
Route	Nasal
Strength	0.037mg/inh
Market Status	Prescription
Company	Takeda Gmbh

4 of 6
Drug Name	Alvesco
PubMed Health	Ciclesonide
Drug Classes	Anti-Inflammatory, Endocrine-Metabolic Agent
Drug Label	The active component of ALVESCO 80 mcg Inhalation Aerosol, and ALVESCO 160 mcg Inhalation Aerosol is ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydr...
Active Ingredient	Ciclesonide
Dosage Form	Aerosol, metered
Route	Inhalation
Strength	0.08mg/inh; 0.16mg/inh
Market Status	Prescription
Company	Takeda Gmbh

5 of 6
Drug Name	Omnaris
PubMed Health	Ciclesonide
Drug Classes	Anti-Inflammatory, Endocrine-Metabolic Agent
Drug Label	The active component of OMNARIS Nasal Spray is ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna -1,4-diene-3,20-dione, 16,17-[[R-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-,(11,16)-. Ciclesoni...
Active Ingredient	Ciclesonide
Dosage Form	Spray, metered; Spray
Route	nasal; Nasal
Strength	50mcg; 0.05mg/inh
Market Status	Prescription
Company	Nycomed Us; Takeda Gmbh

6 of 6
Drug Name	Zetonna
PubMed Health	Ciclesonide
Drug Classes	Anti-Inflammatory, Endocrine-Metabolic Agent
Drug Label	The active component of ZETONNA Nasal Aerosol is ciclesonide, a non-halogenated glucocorticoid having the chemical name pregna -1,4-diene-3,20-dione, 16,17-[[R-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-,(11,16)-. Cicleso...
Active Ingredient	Ciclesonide
Dosage Form	Aerosol, metered
Route	Nasal
Strength	0.037mg/inh
Market Status	Prescription
Company	Takeda Gmbh

4.2 Drug Indication

For the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.

For the alleviation of clinical signs of severe equine asthma (formerly known as Recurrent Airway Obstruction (RAO), Summer Pasture Associated Recurrent Airway Obstruction (SPA-RAO)).

5 Pharmacology and Biochemistry

5.1 Pharmacology

Ciclesonide is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite, C21-desisobutyryl-ciclesonide (des-ciclesonide or RM1) following intranasal application. Des-ciclesonide has anti-inflammatory activity with affinity for the glucocorticoid receptor that is 120 times higher than the parent compound. The precise mechanism through which ciclesonide affects allergic rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic inflammation.

5.2 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

5.3 ATC Code

QR03BA08

R - Respiratory system

R01 - Nasal preparations

R01A - Decongestants and other nasal preparations for topical use

R01AD - Corticosteroids

R01AD13 - Ciclesonide

R - Respiratory system

R03 - Drugs for obstructive airway diseases

R03B - Other drugs for obstructive airway diseases, inhalants

R03BA - Glucocorticoids

R03BA08 - Ciclesonide

5.4 Absorption, Distribution and Excretion

Absorption

Ciclesonide and des-ciclesonide have negligible oral bioavailability (both less than 1%) due to low gastrointestinal absorption and high first-pass metabolism. The intranasal administration of ciclesonide at recommended doses results in negligible serum concentrations of ciclesonide.

Clearance

152 L/hr [Following IV administration of 800 mcg of ciclesonide]

5.5 Metabolism/Metabolites

Des-ciclesonide undergoes metabolism in the liver to additional metabolites mainly by the cytochrome P450 (CYP) 3A4 isozyme and to a lesser extent by CYP 2D6.

5.6 Mechanism of Action

Glucocorticoids such as ciclesonide can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Ciclesonide reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Ciclesonide is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

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USDMF

01

Coral Drugs Pvt Ltd

India

Medlab Asia & Asia Health

Not Confirmed

Coral's API range includes Corticosteroids, Antihistamines. Hormones and Antineoplastics.

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Contact Supplier

India

Digital Content

Ciclesonide

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 38283

Submission : 2023-04-08

Status : Active

Type : II

Corel Drugs cGMP partner for APIs

Product Web Link

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02

Aarti Pharmalabs Ltd

India

Medlab Asia & Asia Health

Not Confirmed

Aarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

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India

Digital Content

Ciclesonide

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 23650

Submission : 2010-03-23

Status : Active

Type : II

Aarti Industries Company Banner

Product Web Link

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03

Alp Pharm Beijing Co Ltd

China

Medlab Asia & Asia Health

Not Confirmed

04

Dynamit Nobel Gmbh Explosivstoff Und...

Germany

Medlab Asia & Asia Health

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05

Micronisierungs Kontor Oberrot Gmbh

Germany

Medlab Asia & Asia Health

Not Confirmed

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Sterling Spa

Italy

Medlab Asia & Asia Health

Not Confirmed

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"CICLESONIDE","year":"2021","qtr":"Q2","strtotime":1619461800,"product":"CICLESONIDE PH. EUR (PHARMACEUTICAL RAW MATERIAL) (INV NO. EX\/0525\/21-22 DT. 22. 04.2021)","address":"UDYOG KSHETRA,2ND FLOOR,MULUNDGOREGAON LINK ROAD,MULUND (W),","city":"MUMBAI \/ MAHARASHTRA","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"MADRID","customer":"ARANTA NAVARRO ALVAREZ","customerCountry":"SPAIN","quantity":"0.12","actualQuantity":"0.12","unit":"KGS","unitRateFc":"45726.6","totalValueFC":"5310.4","currency":"USD","unitRateINR":3294600,"date":"27-Apr-2021","totalValueINR":"395352","totalValueInUsd":"5310.4","indian_port":"BOMBAY AIR","hs_no":"29329990","bill_no":"1393282","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"UDYOG KSHETRA,2ND FLOOR,MULUNDGOREGAON LINK ROAD,MULUND (W),, MUMBAI \/ MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623781800,"product":"CICLESONIDE EP BATCH NO. 7202021002,MFG","address":"805, AKASH DEEP BUILDING26-A, BARAKHAMBA ROAD","city":"NEW DELHI.","supplier":"CORAL DRUGS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"TO ORDER","customerCountry":"TURKEY","quantity":"1.75","actualQuantity":"1750","unit":"GMS","unitRateFc":"18.4","totalValueFC":"31599.4","currency":"USD","unitRateINR":1328,"date":"16-Jun-2021","totalValueINR":"2324000","totalValueInUsd":"31599.4","indian_port":"DELHI AIR","hs_no":"29372900","bill_no":"2448650","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"805, AKASH DEEP BUILDING26-A, BARAKHAMBA ROAD, NEW DELHI.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1637001000,"product":"CICLESONIDE PH.EUR (PHARMACEUTICAL RAW M","address":"UDYOG KSHETRA,2ND FLOOR,MULUNDGOREGAON LINK ROAD,MULUND (W),","city":"MUMBAI \/ MAHARASHTRA","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"LONDON - HEATHROW","customer":"HEMISPHERE FREIGHT SERVICES","customerCountry":"UNITED KINGDOM","quantity":"2.55","actualQuantity":"2.55","unit":"KGS","unitRateFc":"35000","totalValueFC":"88410","currency":"USD","unitRateINR":2581960.7843137258,"date":"16-Nov-2021","totalValueINR":"6584000","totalValueInUsd":"88410","indian_port":"BOMBAY AIR","hs_no":"29329990","bill_no":"6042896","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"UDYOG KSHETRA,2ND FLOOR,MULUNDGOREGAON LINK ROAD,MULUND (W),, MUMBAI \/ MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1640025000,"product":"CICLESONIDE EP 10.0 (NON-MICRONISED)","address":"A-14 - 15, MIDC AREA, CHINCHOLI,","city":"SOLAPUR,MAHARASHTRA","supplier":"VAMSI LABS","supplierCountry":"INDIA","foreign_port":"HO CHI MINH C","customer":"SPM JOINT STOCK COMPANY","customerCountry":"VIETNAM","quantity":"0.03","actualQuantity":"28","unit":"GMS","unitRateFc":"48","totalValueFC":"1325.8","currency":"USD","unitRateINR":3571.4285714285716,"date":"21-Dec-2021","totalValueINR":"100000","totalValueInUsd":"1325.8","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"6897523","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM, DEMOCRATIC REP. OF","selfForZScoreResived":"Micronized","supplierPort":"BOMBAY AIR","supplierAddress":"A-14 - 15, MIDC AREA, CHINCHOLI,, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693333800,"product":"CICLESONIDE BP MICRONISED.MDI GRADE","address":"A-14 & 15 MIDC AREA CHINCHOLI SOLAPUR","city":"SOLAPUR","supplier":"VAMSI LABS","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"OPSONIN PHARMA LIMITED","customerCountry":"BANGLADESH","quantity":"0.02","actualQuantity":"20","unit":"GMS","unitRateFc":"50","totalValueFC":"946.5","currency":"USD","unitRateINR":3920.0358000000001,"date":"30-Aug-2023","totalValueINR":"78400.716","totalValueInUsd":"946.5","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Micronized","supplierPort":"BOMBAY AIR","supplierAddress":"A-14 & 15 MIDC AREA CHINCHOLI SOLAPUR, SOLAPUR","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719167400,"product":"CICLESONIDE PH. EUR.(PHARMACEUTICAL RAWMATERIALS)(INV NO. PEX\/0227\/24-25 DT. 05.06.2024)","address":"2ND FLOOR, GODOWN No. 204","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"TO ORDER","customerCountry":"CANADA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"35000","totalValueFC":"17170.1","currency":"USD","unitRateINR":2866696,"date":"24-Jun-2024","totalValueINR":"1433348","totalValueInUsd":"17170.1","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"1895398","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"2ND FLOOR, GODOWN No. 204, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724265000,"product":"CICLESONIDE EP (MICRONISED)","address":"A-14 15, MIDC AREA, CHINCHOLI","city":"N\/A","supplier":"VAMSI LABS","supplierCountry":"INDIA","foreign_port":"MOSCOW DOMODEDOVO","customer":"TO THE ORDER OF ...","customerCountry":"RUSSIA","quantity":"0.40","actualQuantity":"400","unit":"GMS","unitRateFc":"1500","totalValueFC":"7021.1","currency":"INR","unitRateINR":1472.2950000000001,"date":"22-Aug-2024","totalValueINR":"588918","totalValueInUsd":"7021.1","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"3383860","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Micronized","supplierPort":"Bombay Air","supplierAddress":"A-14 15, MIDC AREA, CHINCHOLI, N\/A","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623695400,"product":"CICLESONIDE UNMICRONIZED (API) (CICLESONIDE) (BATCH NO. CLS-001\/20) (FOR R&D PURPOSED ONLY)","address":"B\/2 MAHALAXMI CHAMBERS22 BHULABHAI DESAI ROAD","city":"MUMBAI. MAHARASHTRA","supplier":"STERLING SPA","supplierCountry":"ITALY","foreign_port":"ROME","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"0.2","unit":"KGS","unitRateFc":"30000","totalValueFC":"6033","currency":"USD","unitRateINR":"2218500","date":"15-Jun-2021","totalValueINR":"443700","totalValueInUsd":"6033","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"4321086","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"ROME","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS22 BHULABHAI DESAI ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1624559400,"product":"CICLESONIDE UNMICRONIZED (CICLESONIDE) (BATCH NO. CLS-001\/20)","address":"B\/2 MAHALAXMI CHAMBERS22 BHULABHAI DESAI ROAD","city":"MUMBAI. MAHARASHTRA","supplier":"STERLING SPA","supplierCountry":"ITALY","foreign_port":"ROME","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"3.45","actualQuantity":"3.45","unit":"KGS","unitRateFc":"30000","totalValueFC":"104913.4","currency":"USD","unitRateINR":"2236500","date":"25-Jun-2021","totalValueINR":"7715925","totalValueInUsd":"104913.4","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"4447947","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"ROME","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS22 BHULABHAI DESAI ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703183400,"product":"CICLESONIDE (CICLESONIDE UNMICRONIZED (API)), BATCH NO- CLS-002\/20","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"STERLING SPA","supplierCountry":"ITALY","foreign_port":"ROME","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.06","actualQuantity":"0.06","unit":"KGS","unitRateFc":"30000","totalValueFC":"1812","currency":"USD","unitRateINR":"2514000","date":"22-Dec-2023","totalValueINR":"150840","totalValueInUsd":"1812","indian_port":"Delhi Air","hs_no":"29372900","bill_no":"9354212","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"ROME","supplierAddress":"VIA DELLA CARBONERIA, 30 SOLOMEO 06073 CORCIANO PERUGIA -SDNF ITALY","customerAddress":"B\/2 MAHALAXMI CHAMBERS"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - AEROSOL, METERED;NASAL - 0.037MG/INH

USFDA APPLICATION NUMBER - 202129

DOSAGE - AEROSOL, METERED;INHALATION - 0.08MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.08MG/INH

USFDA APPLICATION NUMBER - 21658

DOSAGE - AEROSOL, METERED;INHALATION - 0.16MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.16MG/INH

USFDA APPLICATION NUMBER - 21658

DOSAGE - SPRAY, METERED;NASAL - 0.05MG/SPRAY

USFDA APPLICATION NUMBER - 22004

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Finished Drug Prices

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Brand Name : Alvesco

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Brand Name : Alvesco

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08

Brand Name : Ciclesonide Sandoz

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09

Brand Name : Ciclesonide Sandoz

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10

Brand Name : Alvesco

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COVIS

Antibody Engineering

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Antibody Engineering

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COVIS

Antibody Engineering

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