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Chemistry

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Also known as: Cycletanide, 89943-82-8, Bn-1270, Win 90,000, Win-90000, Chg7qc509w
Molecular Formula
C14H12ClNO2
Molecular Weight
261.70  g/mol
InChI Key
CVKNDPRBJVBDSS-UHFFFAOYSA-N
FDA UNII
CHG7QC509W

Cicletanine
Cicletanine is a dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.
1 2D Structure

Cicletanine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
2.1.2 InChI
InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3
2.1.3 InChI Key
CVKNDPRBJVBDSS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NC=C2C(OCC2=C1O)C3=CC=C(C=C3)Cl
2.2 Other Identifiers
2.2.1 UNII
CHG7QC509W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,3-dihydro-6-methyl-7-hydroxy-3-(4-chlorophenyl)furo(3,4-d)pyridine

2. Bn 1270

3. Bn-1270

4. Cicletanide

5. Cicletanine Hydrochloride

6. Cycletanide

7. Justar

8. Tenstaten

2.3.2 Depositor-Supplied Synonyms

1. Cycletanide

2. 89943-82-8

3. Bn-1270

4. Win 90,000

5. Win-90000

6. Chg7qc509w

7. 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol

8. Tenstaten

9. Justar

10. (+/-)bn-1270

11. Cicletanina

12. Cicletaninum

13. Cicletaninum [latin]

14. (+/-)-cicletanine

15. Cicletanina [spanish]

16. Unii-chg7qc509w

17. Cicletanine [usan:inn:ban]

18. Cicletanine [mi]

19. Cicletanine [inn]

20. Cicletanine (usan/inn)

21. Cicletanine [usan]

22. (+-)-bn-1270

23. Cicletanine [mart.]

24. Schembl49794

25. Cicletanine [who-dd]

26. Chembl191886

27. (r)-(-)-cicletanine

28. Dtxsid70868972

29. Chebi:135078

30. (+-)-3-(p-chlorophenyl)-1,3-dihydro-6-methylfuro(3,4-c)pyridin-7-ol

31. Akos022665941

32. Db12766

33. Bn-50417

34. Bn-50418

35. Ds-017342

36. D03487

37. (+/-)-bn-1270

38. Q5119443

39. 3-(4-chlorophenyl)-6-methyl-1h,3h-furo[3,4-c]pyridin-7-ol

40. Furo(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, (+-)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 261.70 g/mol
Molecular Formula C14H12ClNO2
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass261.0556563 g/mol
Monoisotopic Mass261.0556563 g/mol
Topological Polar Surface Area42.4 Ų
Heavy Atom Count18
Formal Charge0
Complexity294
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)


4.2 ATC Code

C - Cardiovascular system

C03 - Diuretics

C03B - Low-ceiling diuretics, excl. thiazides

C03BX - Other low-ceiling diuretics

C03BX03 - Cicletanine


ABOUT THIS PAGE

Cicletanine Manufacturers

A Cicletanine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cicletanine, including repackagers and relabelers. The FDA regulates Cicletanine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cicletanine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cicletanine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cicletanine Suppliers

A Cicletanine supplier is an individual or a company that provides Cicletanine active pharmaceutical ingredient (API) or Cicletanine finished formulations upon request. The Cicletanine suppliers may include Cicletanine API manufacturers, exporters, distributors and traders.

click here to find a list of Cicletanine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cicletanine USDMF

A Cicletanine DMF (Drug Master File) is a document detailing the whole manufacturing process of Cicletanine active pharmaceutical ingredient (API) in detail. Different forms of Cicletanine DMFs exist exist since differing nations have different regulations, such as Cicletanine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cicletanine DMF submitted to regulatory agencies in the US is known as a USDMF. Cicletanine USDMF includes data on Cicletanine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cicletanine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cicletanine suppliers with USDMF on PharmaCompass.

Cicletanine GMP

Cicletanine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cicletanine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cicletanine GMP manufacturer or Cicletanine GMP API supplier for your needs.

Cicletanine CoA

A Cicletanine CoA (Certificate of Analysis) is a formal document that attests to Cicletanine's compliance with Cicletanine specifications and serves as a tool for batch-level quality control.

Cicletanine CoA mostly includes findings from lab analyses of a specific batch. For each Cicletanine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cicletanine may be tested according to a variety of international standards, such as European Pharmacopoeia (Cicletanine EP), Cicletanine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cicletanine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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