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    Chemistry

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    Also known as:
    Molecular Formula
    C18H19ClN4
    Molecular Weight
    326.8  g/mol
    InChI Key
    ZUXABONWMNSFBN-UHFFFAOYSA-N
    Clozapine
    1 2D Structure

    Clozapine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
    2.1.2 InChI
    InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
    2.1.3 InChI Key
    ZUXABONWMNSFBN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
    2.1.5 Isomeric SMILES
    CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
    2.2 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 326.8 g/mol
    Molecular Formula C18H19ClN4
    XLogP33.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count1
    Exact Mass326.1298243 g/mol
    Monoisotopic Mass326.1298243 g/mol
    Topological Polar Surface Area30.9 A^2
    Heavy Atom Count23
    Formal Charge0
    Complexity584
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameClozapine
    PubMed HealthClozapine (By mouth)
    Drug ClassesAntipsychotic
    Drug LabelVERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
    Active IngredientClozapine
    Dosage FormTablet
    RouteOral
    Strength200mg; 100mg; 25mg; 50mg; 12.5mg
    Market StatusPrescription
    CompanyIvax Sub Teva Pharms; Sun Pharm Inds; Mylan

    2 of 6  
    Drug NameClozaril
    PubMed HealthClozapine (By mouth)
    Drug ClassesAntipsychotic
    Drug LabelCLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
    Active IngredientClozapine
    Dosage FormTablet
    RouteOral
    Strength100mg; 25mg
    Market StatusPrescription
    CompanyNovartis

    3 of 6  
    Drug NameFazaclo odt
    Active IngredientClozapine
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strength200mg; 100mg; 25mg; 150mg; 12.5mg
    Market StatusPrescription
    CompanyJazz Pharms Iii

    4 of 6  
    Drug NameClozapine
    PubMed HealthClozapine (By mouth)
    Drug ClassesAntipsychotic
    Drug LabelVERSACLOZ, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine.The structural formula is: VERSACLOZ is available as a free-flowing yellow suspension. Each mL c...
    Active IngredientClozapine
    Dosage FormTablet
    RouteOral
    Strength200mg; 100mg; 25mg; 50mg; 12.5mg
    Market StatusPrescription
    CompanyIvax Sub Teva Pharms; Sun Pharm Inds; Mylan

    5 of 6  
    Drug NameClozaril
    PubMed HealthClozapine (By mouth)
    Drug ClassesAntipsychotic
    Drug LabelCLOZARIL (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine.The structural formula isCLOZARIL is available in pale yellow tablets of 25mg...
    Active IngredientClozapine
    Dosage FormTablet
    RouteOral
    Strength100mg; 25mg
    Market StatusPrescription
    CompanyNovartis

    6 of 6  
    Drug NameFazaclo odt
    Active IngredientClozapine
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strength200mg; 100mg; 25mg; 150mg; 12.5mg
    Market StatusPrescription
    CompanyJazz Pharms Iii

    API Reference Price

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    02-Jan-2021
    11-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    DOSAGE - TABLET;ORAL - 100MG

    USFDA APPLICATION NUMBER - 19758

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    DOSAGE - TABLET;ORAL - 200MG

    USFDA APPLICATION NUMBER - 19758

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    DOSAGE - TABLET;ORAL - 25MG

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    DOSAGE - TABLET;ORAL - 50MG

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    USFDA APPLICATION NUMBER - 203479

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21590

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 12.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21590

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 150MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21590

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21590

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    DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL -...DOSAGE - TABLET, ORALLY DISINTEGRATING;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21590

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