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Cifenline

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 1 USDMF, 3 JDMF, 1 NDC API, 1 Listed Suppliers

4 API Suppliers
1 USDMF
3 JDMF
1 NDC API
1 Listed Suppliers

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Chemistry

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Also known as: 100678-32-8, Cifenline succinate, Cipralan, Cibenol, Cifenline succinate [usan], 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole succinate

Molecular Formula

C₂₂H₂₄N₂O₄

Molecular Weight

380.4 g/mol

InChI Key

XFUIOIWYMHEPIE-UHFFFAOYSA-N

FDA UNII

38G16RWJ37

1 2D Structure

Cifenline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

butanedioic acid;2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole

2.1.2 InChI

InChI=1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)

2.1.3 InChI Key

XFUIOIWYMHEPIE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN=C(N1)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4.C(CC(=O)O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

38G16RWJ37

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(2,2-diphenylcyclopropyl)-2-imidazoline

2. Cibenzoline

3. Cifenline

4. Cifenline Succinate

5. Cifenline, (s)-isomer

6. Cipralan

7. Exacor

2.3.2 Depositor-Supplied Synonyms

1. 100678-32-8

2. Cifenline Succinate

3. Cipralan

4. Cibenol

5. Cifenline Succinate [usan]

6. 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole Succinate

7. 85589-37-3

8. Cibenzoline Succinate [jan]

9. Ro 22-7796/001

10. 38g16rwj37

11. Butanedioic Acid, Compd. With 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole (1:1)

12. Cipralan; Exacor; Ro 22-7796/001

13. Ritmalan

14. Exacor

15. Butanedioic Acid;2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole

16. Cifenline Succinate (usan)

17. Cibenzoline Succinate (1:1)

18. Ncgc00162222-01

19. Ro-227796001

20. Unii-38g16rwj37

21. Cipralan (tn)

22. Cibenol (tn)

23. (+-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline Succinate (1:1)

24. 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazole Succinate

25. 1h-imidazole, 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-, Succinate

26. 1h-imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+-)-, Butanedioate (1:1)

27. Butanedioic Acid, Compd. With 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole

28. Dsstox_cid_27797

29. Dsstox_rid_82569

30. Dsstox_gsid_47820

31. Schembl121044

32. Cibenzoline Succinate (jp17)

33. Chembl3189111

34. Cifenline Succinate [mi]

35. Dtxsid0047820

36. Chebi:31396

37. Hms3262i07

38. Tox21_112004

39. Tox21_500683

40. Akos016339647

41. Cibenzoline Succinate [who-dd]

42. Ccg-221987

43. Ks-1343

44. Lp00683

45. Ro-227796

46. Ncgc00261368-01

47. Up-33901

48. Cas-100678-32-8

49. Ft-0623817

50. Cibenzoline Succinate, >=97% (nmr), Solid

51. D01455

52. 678c328

53. Ro-22-7796/001

54. J-000196

55. Q27256782

56. 1-[2-(z)-methoxyimino-2-(2-aminothiazol-4-yl)acetoxy]benzotrizole

57. (+/-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline Succinate (1:1)

58. 1h-imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (+/-)-, Butanedioate (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₄N₂O₄
Molecular Weight	380.4 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	380.17360725 g/mol
Monoisotopic Mass	380.17360725 g/mol
Topological Polar Surface Area	99 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	450
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

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