Find Ciforadenant manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Cpi-444, 1202402-40-1, V81444, Ciforadenant [inn], Cpi444, V-81444
Molecular Formula
C20H21N7O3
Molecular Weight
407.4  g/mol
InChI Key
KURQKNMKCGYWRJ-HNNXBMFYSA-N
FDA UNII
8KFO2187CP

Ciforadenant
Ciforadenant is a small molecule immune checkpoint inhibitor of the adenosine A2A receptor (ADORA2A) with potential antineoplastic activity. Upon oral administration, ciforadenant binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment. This may stimulate anti-tumor immune responses, resulting in tumor regression.
1 2D Structure

Ciforadenant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-(5-methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridin-2-yl]methyl]triazolo[4,5-d]pyrimidin-5-amine
2.1.2 InChI
InChI=1S/C20H21N7O3/c1-12-5-6-16(30-12)17-18-19(24-20(21)23-17)27(26-25-18)9-13-3-2-4-14(22-13)10-29-15-7-8-28-11-15/h2-6,15H,7-11H2,1H3,(H2,21,23,24)/t15-/m0/s1
2.1.3 InChI Key
KURQKNMKCGYWRJ-HNNXBMFYSA-N
2.1.4 Canonical SMILES
CC1=CC=C(O1)C2=C3C(=NC(=N2)N)N(N=N3)CC4=NC(=CC=C4)COC5CCOC5
2.1.5 Isomeric SMILES
CC1=CC=C(O1)C2=C3C(=NC(=N2)N)N(N=N3)CC4=NC(=CC=C4)CO[C@H]5CCOC5
2.2 Other Identifiers
2.2.1 UNII
8KFO2187CP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (s)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3h-(1,2,3)triazolo(4,5-d)pyrimidin-5-amine

2. Cpi-444

2.3.2 Depositor-Supplied Synonyms

1. Cpi-444

2. 1202402-40-1

3. V81444

4. Ciforadenant [inn]

5. Cpi444

6. V-81444

7. Ciforadenant [usan]

8. 8kfo2187cp

9. (s)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

10. 7-(5-methyl-2-furanyl)-3-[[6-[[[(3s)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3h-1,2,3-triazolo[4,5-d]pyrimidin-5-amine

11. Ciforadenant (usan)

12. 3h-1,2,3-triazolo(4,5-d)pyrimidin-5-amine, 7-(5-methyl-2-furanyl)-3-((6-((((3s)-tetrahydro-3-furanyl)oxy)methyl)-2-pyridinyl)methyl)-

13. 7-(5-methylfuran-2-yl)-3-[[6-[[(3s)-oxolan-3-yl]oxymethyl]pyridin-2-yl]methyl]triazolo[4,5-d]pyrimidin-5-amine

14. Cpi 444

15. (s)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3h-(1,2,3)triazolo(4,5-d)pyrimidin-5-amine

16. Ciforadenant [usan:inn]

17. Unii-8kfo2187cp

18. V 81444

19. Ciforadenant [who-dd]

20. Schembl536782

21. Chembl4297184

22. Gtpl10190

23. Amy16758

24. Bcp20881

25. Ex-a1716

26. Bdbm50553404

27. Nsc801812

28. S6646

29. Who 10767

30. Akos037647889

31. Cs-7627

32. Nsc-801812

33. V81444;triazolo-pyramidine Derivative

34. As-75173

35. Hy-101978

36. D11547

37. A901713

38. (s)-7-(5-methylfuran-2-yl)-3-((6-((tetrahydrofuran-3-yloxy)methyl)pyridin-2-yl)methyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

39. 3-((6-(((s)-tetrahydrofuran-3-yloxy)methyl)pyridin-2-yl)methyl)-7-(5-methylfuran-2-yl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

40. 7-(5-methylfuran-2-yl)-3-[(6-{[(3s)-oxolan-3-yloxy]methyl}pyridin-2-yl)methyl]-3h-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

2.4 Create Date
2010-01-11
3 Chemical and Physical Properties
Molecular Weight 407.4 g/mol
Molecular Formula C20H21N7O3
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass407.17058756 g/mol
Monoisotopic Mass407.17058756 g/mol
Topological Polar Surface Area127 Ų
Heavy Atom Count30
Formal Charge0
Complexity573
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Ciforadenant Manufacturers

A Ciforadenant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ciforadenant, including repackagers and relabelers. The FDA regulates Ciforadenant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ciforadenant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ciforadenant Suppliers

A Ciforadenant supplier is an individual or a company that provides Ciforadenant active pharmaceutical ingredient (API) or Ciforadenant finished formulations upon request. The Ciforadenant suppliers may include Ciforadenant API manufacturers, exporters, distributors and traders.

Ciforadenant GMP

Ciforadenant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ciforadenant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ciforadenant GMP manufacturer or Ciforadenant GMP API supplier for your needs.

Ciforadenant CoA

A Ciforadenant CoA (Certificate of Analysis) is a formal document that attests to Ciforadenant's compliance with Ciforadenant specifications and serves as a tool for batch-level quality control.

Ciforadenant CoA mostly includes findings from lab analyses of a specific batch. For each Ciforadenant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ciforadenant may be tested according to a variety of international standards, such as European Pharmacopoeia (Ciforadenant EP), Ciforadenant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ciforadenant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty