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Chemistry

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Also known as: 81129-83-1, Cilastatin sodium salt, Cilastatin na, Mls001401364, Sodium;(z)-7-[(2r)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate, Mk-791
Molecular Formula
C16H25N2NaO5S
Molecular Weight
380.4  g/mol
InChI Key
QXPBTTUOVWMPJN-QBNHLFMHSA-M

Cilastatin Sodium
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
1 2D Structure

Cilastatin Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate
2.1.2 InChI
InChI=1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1
2.1.3 InChI Key
QXPBTTUOVWMPJN-QBNHLFMHSA-M
2.1.4 Canonical SMILES
CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)[O-])C.[Na+]
2.1.5 Isomeric SMILES
CC1(C[C@@H]1C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)/C(=O)[O-])C.[Na+]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Cilastatin

2. Cilastatin Monosodium Salt

3. Mk 0791

4. Mk 791

5. Mk-791

6. Mk0791

7. Mk791

8. Monosodium Salt, Cilastatin

9. Salt, Cilastatin Monosodium

10. Sodium, Cilastatin

2.2.2 Depositor-Supplied Synonyms

1. 81129-83-1

2. Cilastatin Sodium Salt

3. Cilastatin Na

4. Mls001401364

5. Sodium;(z)-7-[(2r)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate

6. Mk-791

7. Dsstox_cid_26915

8. Dsstox_rid_82013

9. Dsstox_gsid_46915

10. Sodium;(z)-7-[(2s)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate

11. Chebi:59511

12. Cas-81129-83-1

13. Ncgc00181346-01

14. Cilastatino

15. Cilastatin Sodium, Bio-x

16. Ncgc00167838-01

17. Chembl1201057

18. Cilastatin Sodium (jp17/usp)

19. Dtxsid2046915

20. Hms2051l07

21. Hms2233j15

22. Ex-a4989

23. Tox21_112591

24. Tox21_112804

25. Mfcd08459332

26. Akos015962007

27. Ac-3375

28. Ccg-100932

29. Nc00182

30. Bc164306

31. Smr000469147

32. Sodium (z)-7-(((r)-2-amino-2-carboxyethyl)thio)-2-((s)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoate

33. Cilastatin Sodium 100 Microg/ml In Water

34. B7156

35. D02194

36. L-642957

37. [r-[r*,s*-(z)]]-7-[(2-amino-2-carboxyethyl)thio]-2- [[(2,2-dimethylcyclopropyl)carbonyl]amino]-2- Heptenoic Acid Monosodium Salt

38. Sodium(z)-7-(((r)-2-amino-2-carboxyethyl)thio)-2-((s)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoate

2.3 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 380.4 g/mol
Molecular Formula C16H25N2NaO5S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass380.13818736 g/mol
Monoisotopic Mass380.13818736 g/mol
Topological Polar Surface Area158 Ų
Heavy Atom Count25
Formal Charge0
Complexity525
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Protease Inhibitors

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES). (See all compounds classified as Protease Inhibitors.)


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23-Dec-2022
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