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Chemistry

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Also known as: 1418274-28-8, Gs-9674, Cilofexor [inn], Px104, Yun2306954, 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid
Molecular Formula
C28H22Cl3N3O5
Molecular Weight
586.8  g/mol
InChI Key
KZSKGLFYQAYZCO-UHFFFAOYSA-N
FDA UNII
YUN2306954

Cilofexor
Cilofexor is under investigation in clinical trial NCT02943447 (Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis).
1 2D Structure

Cilofexor

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid
2.1.2 InChI
InChI=1S/C28H22Cl3N3O5/c29-20-2-1-3-21(30)24(20)25-18(26(39-33-25)15-4-5-15)12-38-17-6-7-19(22(31)11-17)28(37)13-34(14-28)23-10-16(27(35)36)8-9-32-23/h1-3,6-11,15,37H,4-5,12-14H2,(H,35,36)
2.1.3 InChI Key
KZSKGLFYQAYZCO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=CC(=C(C=C4)C5(CN(C5)C6=NC=CC(=C6)C(=O)O)O)Cl
2.2 Other Identifiers
2.2.1 UNII
YUN2306954
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl)methoxy)phenyl)-3-hydroxy-1-azetidinyl)isonicotinic Acid

2. 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic Acid

2.3.2 Depositor-Supplied Synonyms

1. 1418274-28-8

2. Gs-9674

3. Cilofexor [inn]

4. Px104

5. Yun2306954

6. 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic Acid

7. Gs 9674

8. 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic Acid

9. 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)-3-hydroxy-1-azetidinyl)-4-pyridinecarboxylic Acid

10. 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic Acid

11. 4-pyridinecarboxylic Acid, 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)-3-hydroxy-1-azetidinyl)-

12. 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-4-pyridinecarboxylic Acid

13. Cilofexor (gs(c)\9674)

14. Chembl4297613

15. Schembl14641986

16. Unii-yun2306954

17. Gtpl10644

18. Gs 9674 [who-dd]

19. Bcp29283

20. Bdbm50511109

21. Gs9674

22. S6547

23. Db15168

24. Ac-35893

25. Example 13/9 [us10485795b2]

26. Hy-109083

27. Cs-0039260

28. F78361

29. A927993

30. 2163097-55-8

2.4 Create Date
2013-03-21
3 Chemical and Physical Properties
Molecular Weight 586.8 g/mol
Molecular Formula C28H22Cl3N3O5
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass585.062504 g/mol
Monoisotopic Mass585.062504 g/mol
Topological Polar Surface Area109 Ų
Heavy Atom Count39
Formal Charge0
Complexity867
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of primary sclerosing cholangitis


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ABOUT THIS PAGE

Cilofexor Manufacturers

A Cilofexor manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cilofexor, including repackagers and relabelers. The FDA regulates Cilofexor manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cilofexor API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cilofexor Suppliers

A Cilofexor supplier is an individual or a company that provides Cilofexor active pharmaceutical ingredient (API) or Cilofexor finished formulations upon request. The Cilofexor suppliers may include Cilofexor API manufacturers, exporters, distributors and traders.

Cilofexor GMP

Cilofexor Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cilofexor GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cilofexor GMP manufacturer or Cilofexor GMP API supplier for your needs.

Cilofexor CoA

A Cilofexor CoA (Certificate of Analysis) is a formal document that attests to Cilofexor's compliance with Cilofexor specifications and serves as a tool for batch-level quality control.

Cilofexor CoA mostly includes findings from lab analyses of a specific batch. For each Cilofexor CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cilofexor may be tested according to a variety of international standards, such as European Pharmacopoeia (Cilofexor EP), Cilofexor JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cilofexor USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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