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Cimicoxib

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Synopsis

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Chemistry

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Also known as: 265114-23-6, Cimalgex, Cimicoxib [inn], Ur-8880, 4-(4-chloro-5-(3-fluoro-4-methoxyphenyl)-1h-imidazol-1-yl)benzenesulfonamide, W7fhj107mc

Molecular Formula

C₁₆H₁₃ClFN₃O₃S

Molecular Weight

381.8 g/mol

InChI Key

KYXDNECMRLFQMZ-UHFFFAOYSA-N

FDA UNII

W7FHJ107MC

Cimicoxib is a selective COX-2 inhibitor being developed by Affectis as a treatment for depression and schizophrenia. If approved, Cimicoxib would be the first drug in decades to treat depression by a new mechanism of action.

1 2D Structure

Cimicoxib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide

2.1.2 InChI

InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,19,22,23)

2.1.3 InChI Key

KYXDNECMRLFQMZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=C(C=C(C=C1)C2=C(N=CN2C3=CC=C(C=C3)S(=O)(=O)N)Cl)F

2.2 Other Identifiers

2.2.1 UNII

W7FHJ107MC

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 265114-23-6

2. Cimalgex

3. Cimicoxib [inn]

4. Ur-8880

5. 4-(4-chloro-5-(3-fluoro-4-methoxyphenyl)-1h-imidazol-1-yl)benzenesulfonamide

6. W7fhj107mc

7. 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide

8. Chembl435381

9. Chebi:76127

10. Cimicoxib (ema Epar: Veterinary)

11. 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1h-imidazol-1-yl]benzenesulfonamide

12. Ur 8880;ur-8880;ur8880

13. Benzenesulfonamide, 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1h-imidazol-1-yl]-

14. Unii-w7fhj107mc

15. Cimicoxib [mi]

16. Schembl3123310

17. Dtxsid30181093

18. Bcp24933

19. Zinc1494105

20. Bdbm50131593

21. Db05095

22. Ncgc00531794-01

23. Hy-100516

24. Cs-0019655

25. Q5120133

26. 4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonamide

27. 4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)-imidazol-1-yl]-benzenesulfonamide

28. Cimicoxib;4-(4-chloro-5-(3-fluoro-4-methoxyphenyl)-1h-imidazol-1-yl)benzene Sulfonamide

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₃ClFN₃O₃S
Molecular Weight	381.8 g/mol
XLogP3	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	381.0350183 g/mol
Monoisotopic Mass	381.0350183 g/mol
Topological Polar Surface Area	95.6 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	553
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in depression.

Relief of pain and inflammation associated with osteoarthritis .

Management of peri-operative pain due to orthopaedic or soft-tissue surgeries.

5 Pharmacology and Biochemistry

5.1 ATC Code

QM01AH93

5.2 Mechanism of Action

Depression and schizophrenia are inflammatory diseases. Increased levels of pro-inflammatory cytokines and prostaglandin E (PGE) have repeatedly been described in major depression. COX-2 inhibitors inhibit production of both. Cimicoxib is a selective COX-2 inhibitor. The mechanism by which some COX-2 inhibitors work in depression could be linked to their anti-inflammatory mechanisms.

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ABOUT THIS PAGE

Cimicoxib Manufacturers

A Cimicoxib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cimicoxib, including repackagers and relabelers. The FDA regulates Cimicoxib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cimicoxib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cimicoxib Suppliers

A Cimicoxib supplier is an individual or a company that provides Cimicoxib active pharmaceutical ingredient (API) or Cimicoxib finished formulations upon request. The Cimicoxib suppliers may include Cimicoxib API manufacturers, exporters, distributors and traders.

Cimicoxib GMP

Cimicoxib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cimicoxib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cimicoxib GMP manufacturer or Cimicoxib GMP API supplier for your needs.

Cimicoxib CoA

A Cimicoxib CoA (Certificate of Analysis) is a formal document that attests to Cimicoxib's compliance with Cimicoxib specifications and serves as a tool for batch-level quality control.

Cimicoxib CoA mostly includes findings from lab analyses of a specific batch. For each Cimicoxib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cimicoxib may be tested according to a variety of international standards, such as European Pharmacopoeia (Cimicoxib EP), Cimicoxib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cimicoxib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.