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Chemistry

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Also known as: 66564-14-5, Paxapride, Cidine, Cinitapride [inn], Cinitapride hydrogen tartrate, 4-amino-n-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide
Molecular Formula
C21H30N4O4
Molecular Weight
402.5  g/mol
InChI Key
ZDLBNXXKDMLZMF-UHFFFAOYSA-N
FDA UNII
R8I97I2L24

Cinitapride
Cinitapride is a gastroprokinetic agent and antiulcer benzamide with agonist activity at 5-HT1 and 5-HT4 receptors and antagonist activity at 5-HT2 receptors. It is marketed in Spain and Mexico.
1 2D Structure

Cinitapride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide
2.1.2 InChI
InChI=1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26)
2.1.3 InChI Key
ZDLBNXXKDMLZMF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOC1=CC(=C(C=C1C(=O)NC2CCN(CC2)CC3CCC=CC3)[N+](=O)[O-])N
2.2 Other Identifiers
2.2.1 UNII
R8I97I2L24
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-amino-n-(1-(3-cyclohexen-1-ylmethyl)-4-piperidyl)-2-ethoxy-5-nitrobenzamide

2. Blaston

3. Cidine

4. Cinitapride Tartrate

2.3.2 Depositor-Supplied Synonyms

1. 66564-14-5

2. Paxapride

3. Cidine

4. Cinitapride [inn]

5. Cinitapride Hydrogen Tartrate

6. 4-amino-n-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide

7. R8i97i2l24

8. 66564-14-5 (free Base)

9. Cinitapride (inn)

10. 4-amino-n-(1-(3-cyclohexen-1-ylmethyl)-4-piperidyl)-2-ethoxy-5-nitrobenzamide

11. Cinitaprida

12. Cinitapridum

13. Cinitapridum [inn-latin]

14. Cinitaprida [inn-spanish]

15. Cidin

16. Unii-r8i97i2l24

17. Paxapride (tn)

18. Cinitapride [mi]

19. 96623-56-2

20. Cinitapride [mart.]

21. (non-labelled)cinitapride-d5

22. Cinitapride [who-dd]

23. Schembl476454

24. Chembl2104523

25. Schembl19235643

26. Dtxsid60867232

27. Chebi:135642

28. Bcp04096

29. Hy-b2089

30. Akos015909742

31. Bcp9000531

32. Db08810

33. Bcp0726000107

34. Cs-0017505

35. Ft-0665049

36. D07700

37. Q5121012

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 402.5 g/mol
Molecular Formula C21H30N4O4
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass402.22670545 g/mol
Monoisotopic Mass402.22670545 g/mol
Topological Polar Surface Area113 Ų
Heavy Atom Count29
Formal Charge0
Complexity586
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

It is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


5.2 ATC Code

A - Alimentary tract and metabolism

A03 - Drugs for functional gastrointestinal disorders

A03F - Propulsives

A03FA - Propulsives

A03FA08 - Cinitapride


5.3 Absorption, Distribution and Excretion

Absorption

The absorption of cinitapride (12mg) following oral administration was rapid, with peak levels being achieved 2 h after dosing; absorption following intramuscular administration (4mg) was even more rapid, with peak levels (50% more that oral levels) being achieved 1 h after dosing.


5.4 Biological Half-Life

3-5 h during the first 8 h and a residual half-life greater than 15 h thereafter.


5.5 Mechanism of Action

Cinitapride is a substituted benzamide with 5-HT receptor antagonist and agonist activity.


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21-Jan-2021
12-Dec-2024
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Looking for 66564-14-5 / Cinitapride API manufacturers, exporters & distributors?

Cinitapride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cinitapride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cinitapride manufacturer or Cinitapride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cinitapride manufacturer or Cinitapride supplier.

PharmaCompass also assists you with knowing the Cinitapride API Price utilized in the formulation of products. Cinitapride API Price is not always fixed or binding as the Cinitapride Price is obtained through a variety of data sources. The Cinitapride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cinitapride

Synonyms

66564-14-5, Paxapride, Cidine, Cinitapride [inn], Cinitapride hydrogen tartrate, 4-amino-n-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide

Cas Number

66564-14-5

Unique Ingredient Identifier (UNII)

R8I97I2L24

About Cinitapride

Cinitapride is a gastroprokinetic agent and antiulcer benzamide with agonist activity at 5-HT1 and 5-HT4 receptors and antagonist activity at 5-HT2 receptors. It is marketed in Spain and Mexico.

Cinitapride Manufacturers

A Cinitapride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cinitapride, including repackagers and relabelers. The FDA regulates Cinitapride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cinitapride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cinitapride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cinitapride Suppliers

A Cinitapride supplier is an individual or a company that provides Cinitapride active pharmaceutical ingredient (API) or Cinitapride finished formulations upon request. The Cinitapride suppliers may include Cinitapride API manufacturers, exporters, distributors and traders.

click here to find a list of Cinitapride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cinitapride GMP

Cinitapride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cinitapride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cinitapride GMP manufacturer or Cinitapride GMP API supplier for your needs.

Cinitapride CoA

A Cinitapride CoA (Certificate of Analysis) is a formal document that attests to Cinitapride's compliance with Cinitapride specifications and serves as a tool for batch-level quality control.

Cinitapride CoA mostly includes findings from lab analyses of a specific batch. For each Cinitapride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cinitapride may be tested according to a variety of international standards, such as European Pharmacopoeia (Cinitapride EP), Cinitapride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cinitapride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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