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Chemistry

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Also known as: 298-57-7, Stugeron, Stutgin, Cinarizine, Dimitronal, Stutgeron
Molecular Formula
C26H28N2
Molecular Weight
368.5  g/mol
InChI Key
DERZBLKQOCDDDZ-JLHYYAGUSA-N
FDA UNII
3DI2E1X18L

Cinnarizine
A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.
1 2D Structure

Cinnarizine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
2.1.2 InChI
InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
2.1.3 InChI Key
DERZBLKQOCDDDZ-JLHYYAGUSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
2.1.5 Isomeric SMILES
C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
2.2 Other Identifiers
2.2.1 UNII
3DI2E1X18L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine

2. Cinarizina Inkey

3. Cinarizina Ratiopharm

4. Cinarizine

5. Cinazire

6. Cinna

7. Cinnarizin Al

8. Cinnarizin Ratiopharm

9. Cinnarizin Siegfried

10. Cinnarizin Von Ct

11. Cinnarizin-ratiopharm

12. Cinnarizine L Tartrate

13. Cinnarizine L-tartrate

14. Cinnarizine L-tartrate (1:1)

15. Cinnarizine, (e)-isomer

16. Cinnarizine, Dihydrochloride

17. Cinnipirine

18. Cisaken

19. Dihydrochloride Cinnarizine

20. Dimitronal

21. L-tartrate, Cinnarizine

22. R 516

23. R-516

24. R516

25. Stugeron

26. Stugeron Forte

27. Von Ct, Cinnarizin

2.3.2 Depositor-Supplied Synonyms

1. 298-57-7

2. Stugeron

3. Stutgin

4. Cinarizine

5. Dimitronal

6. Stutgeron

7. Dimitron

8. Folcodal

9. Labyrin

10. Midronal

11. Mitronal

12. Glanil

13. Sepan

14. Cinazyn

15. Aplactan

16. Cinnageron

17. Lazeta

18. Marisan

19. Toliman

20. Cinaperazine

21. Cinnipirine

22. Cerepar

23. Cinnarizinum

24. Cerebolan

25. Cinarizina

26. Cinnacet

27. Corathiem

28. Giganten

29. Hilactan

30. Katoseran

31. Processine

32. Sedatromin

33. Siptazin

34. Spaderizine

35. Aplexal

36. Artate

37. Carecin

38. Denapol

39. Ixertol

40. Olamin

41. Eglen

42. 1-benzhydryl-4-cinnamylpiperazine

43. 16699-20-0

44. R 516

45. 1-cinnamyl-4-(diphenylmethyl)piperazine

46. R 1575

47. 516 Md

48. Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-

49. 1-benzhydryl-4-cinnamylpiperazin

50. 1-benzhydryl-4-[(e)-3-phenylprop-2-enyl]piperazine

51. Stunarone

52. 1-(diphenylmethyl)-4-[(2e)-3-phenylprop-2-en-1-yl]piperazine

53. (e)-1-benzhydryl-4-cinnamylpiperazine

54. 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine

55. R-516

56. 1-trans-cinnamyl-4-diphenylmethylpiperazine

57. 1-benzhydryl-4-[(e)-cinnamyl]piperazine

58. Chembl43064

59. Mls000028498

60. 3di2e1x18l

61. Piperazine, 1-cinnamyl-4-(diphenylmethyl)-

62. Chebi:31403

63. R-1575

64. 516-md

65. Nsc-758400

66. 1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)piperazine

67. Libotasin

68. Senoger

69. Smr000058307

70. Votegol

71. Zepamol

72. Cero-aterin

73. Dsstox_cid_2821

74. Dsstox_rid_76744

75. Dsstox_gsid_22821

76. Cinarizina [inn-spanish]

77. Cinnarizinum [inn-latin]

78. Apotomin

79. Stonoron

80. Cinnarizine [usan:inn:ban:jan]

81. Sr-01000003093

82. Einecs 206-064-8

83. Md 516

84. Brn 0626121

85. Unii-3di2e1x18l

86. Cinnarizine (jan/usan/inn)

87. 1-cinnamyl-4-diphenylmethylpiperazine

88. N-benzhydryl-n'-cinnamylpiperazine

89. Ncgc00015246-02

90. 1185242-27-6

91. Cas-298-57-7

92. Cinnarizine, Powder

93. Prestwick_115

94. Mfcd00056037

95. Piperazine, (e)-

96. Cinnarizine [mi]

97. Opera_id_1776

98. Prestwick2_000278

99. Prestwick3_000278

100. Cinnarizine [inn]

101. Cinnarizine [jan]

102. 1-(diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine

103. Cinnarizine [usan]

104. C 5270

105. Cinnarizine [mart.]

106. Lopac0_000314

107. Schembl44957

108. Schembl44958

109. Bspbio_000156

110. Cinnarizine [who-dd]

111. Mls001148649

112. Mls002207295

113. Mls002222167

114. Bpbio1_000172

115. Gtpl9072

116. 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine

117. Cid_1547484

118. Cinnarizine [ep Impurity]

119. Dtxsid80859311

120. Chebi:131176

121. 4-((2e)-3-phenylprop-2-enyl)-1-(diphenylmethyl)piperazine

122. Cinnarizine [ep Monograph]

123. Hms1568h18

124. Hms2095h18

125. Hms2234b20

126. Hms3260p10

127. Hms3712h18

128. Hms3885f20

129. Component Of Emesazine (salt/mix)

130. Hy-b1090

131. Tox21_110109

132. Tox21_500314

133. Bdbm50017657

134. Nsc290687

135. Nsc771642

136. Stk216257

137. Zinc19632891

138. Akos002134299

139. Stugeron

140. Dimitronal

141. Stutgin

142. Cinarizine

143. Tox21_110109_1

144. Ccg-204409

145. Cs-4656

146. Ks-5155

147. Lp00314

148. Nsc 758400

149. Nsc-290687

150. Nsc-771642

151. Sdccgsbi-0050302.p002

152. Qtl1_000023

153. Ncgc00018187-03

154. Ncgc00018187-04

155. Ncgc00018187-05

156. Ncgc00018187-06

157. Ncgc00018187-07

158. Ncgc00018187-09

159. Ncgc00018187-14

160. Ncgc00021488-03

161. Ncgc00021488-04

162. Ncgc00021488-05

163. Ncgc00260999-01

164. Bc167081

165. Ls-15144

166. Eu-0100314

167. S4727

168. A16455

169. D01295

170. D89561

171. 298c577

172. A820077

173. L001227

174. Q775073

175. 1-benzhydryl-4-[3-phenyl-2-propenyl]piperazine #

176. Sr-01000003093-2

177. Sr-01000003093-6

178. W-106970

179. W-110442

180. 1-benzhydryl-4-[(2e)-3-phenylprop-2-enyl]piperazine

181. Brd-k07220430-001-03-6

182. Brd-k74927006-001-01-2

183. 1-[di(phenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine

184. 1-(diphenylmethyl)-4-(3-phenylprop-2-en-1-yl)piperazine

185. Cinnarizine, European Pharmacopoeia (ep) Reference Standard

186. Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-

187. N90

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 368.5 g/mol
Molecular Formula C26H28N2
XLogP35.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass368.225248902 g/mol
Monoisotopic Mass368.225248902 g/mol
Topological Polar Surface Area6.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity429
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


4.2 ATC Code

N - Nervous system

N07 - Other nervous system drugs

N07C - Antivertigo preparations

N07CA - Antivertigo preparations

N07CA02 - Cinnarizine


4.3 Metabolism/Metabolites

Cinnarizine has known human metabolites that include 1-Benzhydrylpiperazine, 1-Cinnamylpiperazine, 4-{3-[4-(diphenylmethyl)piperazin-1-yl]prop-1-en-1-yl}phenol, 4-{phenyl[4-(3-phenylprop-2-en-1-yl)piperazin-1-yl]methyl}phenol, Benzophenone, and Cinnamaldehyde.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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01-Jan-2021
29-Mar-2025
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Looking for 298-57-7 / Cinnarizine API manufacturers, exporters & distributors?

Cinnarizine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cinnarizine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cinnarizine manufacturer or Cinnarizine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cinnarizine manufacturer or Cinnarizine supplier.

PharmaCompass also assists you with knowing the Cinnarizine API Price utilized in the formulation of products. Cinnarizine API Price is not always fixed or binding as the Cinnarizine Price is obtained through a variety of data sources. The Cinnarizine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cinnarizine

Synonyms

298-57-7, Stugeron, Stutgin, Cinarizine, Dimitronal, Stutgeron

Cas Number

298-57-7

Unique Ingredient Identifier (UNII)

3DI2E1X18L

About Cinnarizine

A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.

Cinnarizine Manufacturers

A Cinnarizine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cinnarizine, including repackagers and relabelers. The FDA regulates Cinnarizine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cinnarizine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Cinnarizine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Cinnarizine Suppliers

A Cinnarizine supplier is an individual or a company that provides Cinnarizine active pharmaceutical ingredient (API) or Cinnarizine finished formulations upon request. The Cinnarizine suppliers may include Cinnarizine API manufacturers, exporters, distributors and traders.

click here to find a list of Cinnarizine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cinnarizine USDMF

A Cinnarizine DMF (Drug Master File) is a document detailing the whole manufacturing process of Cinnarizine active pharmaceutical ingredient (API) in detail. Different forms of Cinnarizine DMFs exist exist since differing nations have different regulations, such as Cinnarizine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cinnarizine DMF submitted to regulatory agencies in the US is known as a USDMF. Cinnarizine USDMF includes data on Cinnarizine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cinnarizine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cinnarizine suppliers with USDMF on PharmaCompass.

Cinnarizine CEP

A Cinnarizine CEP of the European Pharmacopoeia monograph is often referred to as a Cinnarizine Certificate of Suitability (COS). The purpose of a Cinnarizine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Cinnarizine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Cinnarizine to their clients by showing that a Cinnarizine CEP has been issued for it. The manufacturer submits a Cinnarizine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Cinnarizine CEP holder for the record. Additionally, the data presented in the Cinnarizine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Cinnarizine DMF.

A Cinnarizine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Cinnarizine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Cinnarizine suppliers with CEP (COS) on PharmaCompass.

Cinnarizine WC

A Cinnarizine written confirmation (Cinnarizine WC) is an official document issued by a regulatory agency to a Cinnarizine manufacturer, verifying that the manufacturing facility of a Cinnarizine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Cinnarizine APIs or Cinnarizine finished pharmaceutical products to another nation, regulatory agencies frequently require a Cinnarizine WC (written confirmation) as part of the regulatory process.

click here to find a list of Cinnarizine suppliers with Written Confirmation (WC) on PharmaCompass.

Cinnarizine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cinnarizine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Cinnarizine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Cinnarizine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Cinnarizine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cinnarizine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Cinnarizine suppliers with NDC on PharmaCompass.

Cinnarizine GMP

Cinnarizine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cinnarizine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cinnarizine GMP manufacturer or Cinnarizine GMP API supplier for your needs.

Cinnarizine CoA

A Cinnarizine CoA (Certificate of Analysis) is a formal document that attests to Cinnarizine's compliance with Cinnarizine specifications and serves as a tool for batch-level quality control.

Cinnarizine CoA mostly includes findings from lab analyses of a specific batch. For each Cinnarizine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cinnarizine may be tested according to a variety of international standards, such as European Pharmacopoeia (Cinnarizine EP), Cinnarizine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cinnarizine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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