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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 3 CEP/COS, 2 EU WC, 4 Listed Suppliers, $ API Reference Price

8 API Suppliers
3 CEP/COS
2 EU WC
4 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 Listed Dossiers

2 FDF Dossiers
2 Listed Dossiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

media
1 DATA COMPILATION #PharmaFlow

MARKET PLACE

4 APIs, 2 FDF Dossiers

marketPlace
4 APIs
2 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM

otherSolutions
2 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 198

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

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0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 52214-84-3, 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid, Lipanor, Ciprofibratum, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid, Ciprofibrato

Molecular Formula

C₁₃H₁₄Cl₂O₃

Molecular Weight

289.15 g/mol

InChI Key

KPSRODZRAIWAKH-UHFFFAOYSA-N

FDA UNII

F8252JGO9S

Ciprofibrate is a fibrate derivative with antilipidemic activity.

1 2D Structure

Ciprofibrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

2.1.2 InChI

InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

2.1.3 InChI Key

KPSRODZRAIWAKH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(C(=O)O)OC1=CC=C(C=C1)C2CC2(Cl)Cl

2.2 Other Identifiers

2.2.1 UNII

F8252JGO9S

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hyperlipen

2. Lipanor

3. Modalim

4. Oroxadin

5. Win 35,833

2.3.2 Depositor-Supplied Synonyms

1. 52214-84-3

2. 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic Acid

3. Lipanor

4. Ciprofibratum

5. 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic Acid

6. Ciprofibrato

7. Modalim

8. Win 35833

9. Win-35833

10. Propanoic Acid, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-

11. Mfcd00467135

12. 2-(p-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropionic Acid

13. Nsc-759617

14. F8252jgo9s

15. Chebi:50867

16. Propanoic Acid, 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-

17. Ncgc00164447-01

18. 2-{[4-(2,2-dichlorocyclopropyl)phenyl]oxy}-2-methylpropanoic Acid

19. Dsstox_cid_331

20. Dsstox_rid_75519

21. Dsstox_gsid_20331

22. Ciprofibratum [inn-latin]

23. Ciprofibrato [inn-spanish]

24. Hiperlipen

25. Ciprol

26. Smr000857190

27. Ccris 173

28. Sr-01000075734

29. Einecs 257-744-6

30. Ciprofibrate (usan/inn)

31. Brn 1984981

32. Unii-f8252jgo9s

33. 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionic Acid

34. Ciprofibrate?

35. Ciprofibrate [usan:inn:ban]

36. 2-(4-(2,2-dichlorocyclopropyl)phenoxy)2-methylpropanoic Acid

37. 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic Acid

38. Cas-52214-84-3

39. Ciprofibrate- Bio-x

40. Prestwick0_001076

41. Prestwick1_001076

42. Prestwick2_001076

43. Prestwick3_001076

44. Ciprofibrate [mi]

45. Ciprofibrate [inn]

46. C 0330

47. Ciprofibrate [usan]

48. Lopac0_000168

49. Schembl26870

50. Bspbio_001092

51. Ciprofibrate [mart.]

52. Mls002154143

53. Mls006011758

54. Ciprofibrate [who-dd]

55. Win35833

56. Spbio_002996

57. Bpbio1_001202

58. Chembl557555

59. Gtpl3438

60. Dtxsid8020331

61. Bcpp000277

62. Ciprofibrate [ep Impurity]

63. Ciprofibrate For System Suitability

64. Hms1571g14

65. Hms2098g14

66. Hms2235j14

67. Hms3260b17

68. Hms3369b22

69. Hms3656p09

70. Hms3715g14

71. Pharmakon1600-01502008

72. Ciprofibrate [ep Monograph]

73. Bcp03728

74. Hy-b0664

75. Tox21_112121

76. Tox21_201359

77. Tox21_302840

78. Tox21_500168

79. Bbl010821

80. Bdbm50371235

81. Nsc759617

82. S2665

83. Stk624758

84. Akos005557843

85. Tox21_112121_1

86. Ac-1018

87. Bcp9000533

88. Ccg-204263

89. Db09064

90. Ks-1201

91. Lp00168

92. Nsc 759617

93. Sdccgsbi-0050156.p002

94. Ncgc00015202-02

95. Ncgc00015202-03

96. Ncgc00015202-04

97. Ncgc00015202-05

98. Ncgc00015202-06

99. Ncgc00015202-08

100. Ncgc00015202-20

101. Ncgc00015202-21

102. Ncgc00093652-01

103. Ncgc00093652-02

104. Ncgc00256361-01

105. Ncgc00258911-01

106. Ncgc00260853-01

107. Bd164311

108. Bcp0726000148

109. Ab00514032

110. Eu-0100168

111. Ft-0602946

112. Sw197242-4

113. D03521

114. O10468

115. Ab00514032_06

116. 214c843

117. A828985

118. J-520054

119. Q3496452

120. Sr-01000075734-1

121. Sr-01000075734-4

122. Sr-01000075734-7

123. Brd-a49358627-001-03-9

124. Brd-a49358627-001-10-4

125. 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionic Acid

126. Ciprofibrate, European Pharmacopoeia (ep) Reference Standard

127. 2-[4-[2,2-bis(chloranyl)cyclopropyl]phenoxy]-2-methyl-propanoic Acid

128. Ciprofibrate For System Suitability, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₄Cl₂O₃
Molecular Weight	289.15 g/mol
XLogP3	3.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	288.0319997 g/mol
Monoisotopic Mass	288.0319997 g/mol
Topological Polar Surface Area	46.5 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	333
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Peroxisome Proliferators

A class of nongenotoxic CARCINOGENS that induce the production of hepatic PEROXISOMES and induce hepatic neoplasms after long-term administration. (See all compounds classified as Peroxisome Proliferators.)

Hypolipidemic Agents

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

4.2 ATC Code

C10AB08

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

C - Cardiovascular system

C10 - Lipid modifying agents

C10A - Lipid modifying agents, plain

C10AB - Fibrates

C10AB08 - Ciprofibrate

API SUPPLIERS

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CEP/COS

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EU WC

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Listed Suppliers

01

Zhejiang Hengkang Pharmaceutical

China

CPhI China

Attending

Zhejiang Hengkang Pharm Group is a dynamic pharmaceutical entity, spanning drug research, large-scale production, and global marketing.

Contact Supplier

China

Virtual Booth

Digital Content

Ciprofibrate

About the Company : Established in 2004 and headquartered in Hangzhou, Hengkang established multiple factories, research and sales centers in Zhejiang, Shandong, and Henan. With facilities conforming ...

Established in 2004 and headquartered in Hangzhou, Hengkang established multiple factories, research and sales centers in Zhejiang, Shandong, and Henan. With facilities conforming to global API standards, along with professional R&D and marketing teams, Hengkang’s operations span major pharmaceutical markets such as China, Europe, the CIS region, Japan, and South Korea. Hengkang has established long-term and stable relationships with nearly 70 countries overseas and hundreds of domestic enterprises.

02

Jiangsu Nhwa Pharmaceutical

China

Antibody Engineering

Not Confirmed

03

Nanjing Dorra Pharmaceutical Techno...

China

Antibody Engineering

Not Confirmed

04

Olon S.p.A

Italy

Antibody Engineering

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

01

Acromax

Ecuador

Antibody Engineering

Not Confirmed

02

Intas Pharmaceuticals

India

Antibody Engineering

Not Confirmed

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Listed Dossiers

01

Acromax

Ecuador

Antibody Engineering

Not Confirmed

02

Intas Pharmaceuticals

India

Antibody Engineering

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content

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DATA COMPILATION #PharmaFlow

Niche European Molecules: is there a business opportunity worth pursuing?

New drug development is a series of complex activities invariably involving tremendous financial investment. The undertaking, to bring a new drug to market, makes it almost impossible for smaller, privately held pharmaceutical companies, to even dream of such endeavors. Is it possible for companies, lacking the resources of the pharmaceutical majors, to expand the use of existing drugs, established in some countries but not marketed in others? Our PharmaCompass analysis this week looks at products, which have monographs in the European Pharmacopoeia but have never been approved in the United States. Would it surprise you that amylmetacresol, one of the two active ingredients in Strepsils, one of the world’s largest-selling sore throat product has never been approved for use in the United States? -Reckitt Benckiser, the company that owns the Strepsils brand, markets Cepacol for sore-throat relief in the United States. While Strepsils contains, amylmetacresol and dichlorobenzyl alcohol, Cepacol has a completely different set of active ingredients i.e. benzocaine and menthol. -Interestingly, while on the topic of throat relief, pholcodine, an opioid cough suppressant, is not prescribed in the United States where it is a Schedule I drug. However, as a class B substance in the United Kingdom, it can be purchased over-the-counter (OTC) in most pharmacies. -Ergometrine, used to facilitate childbirth, while on the WHO’s essential drug list for important medications in a basic health system has also never been sold in the United States. -Hypertension and congestive heart failure drug cilazapril is sold across Canada and other European countries. Although cilazapril is supposed to have limited advantages over other drugs in the same class, exports out of India to Turkey, New Zealand and Canada indicate a robust demand in these countries. -Some molecules, discovered in France like, anti-diarrhoeal drugs nifuroxazide and racecadotril, lipid lowering ciprofibrate or anti-cancer agent buserelin are used extensively in select countries. However, for reasons unknown, they have never been approved in other parts of the world. -Lymecycline, a broad-spectrum antibiotic belonging to the tetracycline class, is used in the treatment of acne and marketed by Galderma SA, a completely owned subsidiary of Nestle. Lymecycline is 5,000 times more soluble than tetracycline base and has unique pharmacological activity amongst the tetracycline class of molecules. As the product has been on the market for over a decade, generic versions are now also available across Europe. -As antibiotics continue to get increased attention in view of the growing concern of ‘superbugs’, there are antibiotics like roxithromycin and flucloxacillin, which are sold in the UK and Australia but have never obtained approval in the United States. Are these products safe? Countries like France, United Kingdom, and Canada, where many of the above mentioned drugs are marketed, have active pharmacovigilance programs, which monitor drugs, should there be any serious adverse events. Continued use for years in well regulated pharmaceutical markets is usually proof that the products are safe. However, for the antibiotic flucloxacillin, concerns have been identified regarding a genetic link associated with liver injury. While flucloxacillin has not been approved in the United States, the FDA website does provide details on this risk. Liver toxicity concerns have limited the sales of some commonly used OTC products like nimesulide and propyphenazone (brand name: Saridon) in some countries. Yet, there are parts of the developing world, where the sales continue to increase. There are graver concerns for products like cisapride, which was launched by Janssen for increased motility of the gastrointestinal tract but was withdrawn, from the US market, due to concerns of fatalities linked to cardiac arrhythmias. The product continues to be exported from India to countries like Switzerland, Thailand, Mexico, China and Canada. Our View: Reviewing the export data out of India, on the PharmaCompass database, it is clear that in the markets, where the above mentioned products are sold, there is substantial demand. Major pharmaceutical companies have little incentive in taking old molecules global since there is little intellectual property protection to assure the profits that they are used to. However, for others there may be an opportunity worth considering. Launching a new product is always a Herculean challenge, but hopefully the successful use in existing patient populations, is a good starting point. API manufactures can also review these products since there may be better margins in these niche molecules when compared with others, which have become commodities.