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Ciprofloxacin Hydrochloride

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ACTIVE PHARMA INGREDIENTS

55 API Suppliers, 23 USDMF, 18 CEP/COS, 3 JDMF, 12 EU WC, 19 KDMF, 21 NDC API, 22 Listed Suppliers, $ API Reference Price

55 API Suppliers
23 USDMF
18 CEP/COS
3 JDMF
12 EU WC
19 KDMF
21 NDC API
22 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

213 FDF Dossiers, 87 FDA Orange Book, 39 Europe, 37 Canada, 2 South Africa, 48 Listed Dossiers

213 FDF Dossiers
87 FDA Orange Book
39 Europe
37 Canada
2 South Africa
48 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% BASE, OINTMENT;OPHTHALMIC - EQ 0.3% BASE, SUSPENSION/DROPS;OTIC - EQ 0.2% BASE;1%

drugProductComposition
SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% BASE
OINTMENT;OPHTHALMIC - EQ 0.3% BASE
SUSPENSION/DROPS;OTIC - EQ 0.2% BASE;1%

RELATED EXCIPIENT COMPANIES

3 Rochem International Inc, 17 SPI Pharma, 2 Seqens, 7 DKSH, 8 Faran Shimi Pharmaceutical, 8 Boai NKY Pharmaceuticals Ltd, 14 Gangwal Healthcare, 8 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 1 ACG Worldwide, 15 Actylis, 1 Aeon Procare, 1 Alcedo Pharmachem, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 34 BASF, 2 Clariant, 11 Corel Pharma Chem, 1 Curia, 6 DFE Pharma, 4 Finar, 13 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 5 Ingredion Pharma Solutions, 33 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 16 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 4 Novo Excipients, 4 Pharmatrans-Sanaq, 9 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 27 Roquette, 15 Seppic, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 3 The Dow Chemical Company, 2 Ulanqab Kema New Material, 1 Valens Pharmachem, 4 Vasa Pharmachem

relatedExcipients
3 Rochem International Inc
17 SPI Pharma
2 Seqens
7 DKSH
8 Faran Shimi Pharmaceutical
8 Boai NKY Pharmaceuticals Ltd
14 Gangwal Healthcare
8 Nanjing Well Pharmaceutical
2 Pfanstiehl
1 ACG Worldwide
15 Actylis
1 Aeon Procare
1 Alcedo Pharmachem
9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
34 BASF
2 Clariant
11 Corel Pharma Chem
1 Curia
6 DFE Pharma
4 Finar
13 Gangwal Chemicals
7 Ideal Cures Pvt Ltd
5 Ingredion Pharma Solutions
33 Kerry
4 Kima Chemical
6 Lonza Capsugel
16 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
4 Novo Excipients
4 Pharmatrans-Sanaq
9 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
27 Roquette
15 Seppic
7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
2 Ulanqab Kema New Material
1 Valens Pharmachem
4 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

94 Fillers, Diluents & Binders, 57 Coating Systems & Additives, 48 Direct Compression, 41 Disintegrants & Superdisintegrants, 38 Solubilizers, 34 Controlled & Modified Release, 33 Granulation, 33 Thickeners and Stabilizers, 29 Parenteral, 26 Topical, 24 Taste Masking, 22 Lubricants & Glidants, 21 Co-Processed Excipients, 20 Film Formers & Plasticizers, 18 Chewable & Orodispersible Aids, 10 Emulsifying Agents, 8 API Stability Enhancers, 6 Surfactant & Foaming Agents, 5 Coloring Agents, 5 Rheology Modifiers, 5 Empty Capsules, 4 Vegetarian Capsules

DIGITAL CONTENT

8 DATA COMPILATION #PharmaFlow, 15 NEWS #PharmaBuzz

media
8 DATA COMPILATION #PharmaFlow
15 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 US Medicaid Prescriptions, 6 Finished Drug Prices

globalSalesInformation
3 US Medicaid Prescriptions
6 Finished Drug Prices

MARKET PLACE

43 APIs, 3 FDF Dossiers

marketPlace
43 APIs
3 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 US Patents, 10 Health Canada Patents

patents
1 US Patents
10 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 1 USP , 1 Others

otherSolutions
3 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 26

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

213

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

3,226,129

Annual Reports (USD Million)

Finished Drug Prices

337 RELATED EXCIPIENT COMPANIES

581EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Ciprofloxacin hcl, 93107-08-5, 86483-48-9, 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, Cipro, Chebi:310388

Molecular Formula

C₁₇H₁₉ClFN₃O₃

Molecular Weight

367.8 g/mol

InChI Key

DIOIOSKKIYDRIQ-UHFFFAOYSA-N

FDA UNII

0MP32MFP6C

A broad-spectrum antimicrobial carboxyfluoroquinoline.

1 2D Structure

Ciprofloxacin Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride

2.1.2 InChI

InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H

2.1.3 InChI Key

DIOIOSKKIYDRIQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl

2.2 Other Identifiers

2.2.1 UNII

0MP32MFP6C

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Anhydrous, Ciprofloxacin Hydrochloride

2. Bay 09867

3. Bay-09867

4. Bay09867

5. Ciprinol

6. Cipro

7. Ciprofloxacin

8. Ciprofloxacin Hydrochloride Anhydrous

9. Ciprofloxacin Monohydrochloride Monohydrate

10. Hydrochloride Anhydrous, Ciprofloxacin

11. Hydrochloride, Ciprofloxacin

12. Monohydrate, Ciprofloxacin Monohydrochloride

13. Monohydrochloride Monohydrate, Ciprofloxacin

2.3.2 Depositor-Supplied Synonyms

1. Ciprofloxacin Hcl

2. 93107-08-5

3. 86483-48-9

4. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

5. Cipro

6. Chebi:310388

7. Ciprofloxacin Hydrochloride Anhydrous

8. 0mp32mfp6c

9. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hydrochloride

10. Ciprofloxacin (monohydrochloride)

11. Bay-o-9867

12. Ciprofloxacin Hydrochloride (anh.)

13. Bay O 9867

14. Cetraxal

15. Ciprobay

16. Ciproxan

17. Ciproxin

18. Flociprin

19. Ciflox

20. Mfcd00079044

21. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hcl

22. 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic Acid;hydrochloride

23. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Xhydrochloride

24. Bay-o 9867

25. 93107-08-5 (hcl)

26. 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic Acid Hydrochloride

27. Dsstox_cid_27768

28. Dsstox_rid_82545

29. Dsstox_gsid_47788

30. Ciprofloxacin (as Hydrochloride)

31. Prestwick_67

32. 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic Acid; Hydrochloride

33. 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinolin-7-yl)-piperazin-1-ium; Chloride

34. Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride

35. Nsc620634

36. Ciprofloxacin Hydrochloride (anhydrous)

37. Ciprofloxacin 100 Microg/ml In Methanol

38. Ncgc00016959-01

39. Cas-93107-08-5

40. Unii-0mp32mfp6c

41. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Hydrochloride

42. 3-quiolinecarboxylic Acid

43. Ciprofloxacine Hydrochloride

44. Epitope Id:174846

45. Cambridge Id 5807784

46. Ciprofloxacini Hydrochloridum

47. Chembl1202

48. Schembl42310

49. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Monohydrochloride

50. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Monohydrochloride

51. Ciprofloxacin Hcl/lactate

52. Dtxsid1047788

53. Hy-b0356a

54. Ciprofloxacin Hydrochloride (1:x)

55. Hms1568g08

56. Bcp13634

57. Bcp14336

58. Tox21_110712

59. S5008

60. Akos005111008

61. Tox21_110712_1

62. Cs-8134

63. Ks-5012

64. Nsc-620634

65. Sb73037

66. Ncgc00016959-06

67. 3-quinolinecarboxylic Acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-, Hydrochloride

68. Ac-23972

69. Bim-0048462.p001

70. Ciprofloxacin 1000 Microg/ml In Methanol

71. Ciprofloxacin Hydrochloride [who-dd]

72. Ft-0623850

73. Ft-0623851

74. A16969

75. H10663

76. A859872

77. Q-200860

78. Q27105154

79. F0001-2378

80. Cpx; Cetraxal; Ciloxan; Cipro; Bay-09867 Hydrochloride

81. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hcl

82. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacidxhydrochloride

83. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Hydrochloride (1:1)

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₉ClFN₃O₃
Molecular Weight	367.8 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	367.1098973 g/mol
Monoisotopic Mass	367.1098973 g/mol
Topological Polar Surface Area	72.9 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	571
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ciprofloxacin hydrochloride
PubMed Health	Ciprofloxacin Betaine/Ciprofloxacin Hydrochloride (By mouth)
Drug Classes	Antibacterial
Drug Label	Ciprofloxacin Tablets, USPis a synthetic broad spectrum antimicrobial agent for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pip...
Active Ingredient	Ciprofloxacin hydrochloride
Dosage Form	Solution/drops; Tablet
Route	Ophthalmic; Oral
Strength	eq 100mg base; eq 750mg base; eq 500mg base; eq 0.3% base; eq 250mg base
Market Status	Prescription
Company	Watson Labs; Nexus Pharms; Ranbaxy; Ivax Sub Teva Pharms; Apotex; Bausch And Lomb; Aurobindo Pharma; Taro; Dr Reddys Labs; Unique Pharm Labs; Carlsbad; Pharmaforce; Fdc; Mylan; Hikma; Akorn

2 of 2
Drug Name	Ciprofloxacin hydrochloride
PubMed Health	Ciprofloxacin Betaine/Ciprofloxacin Hydrochloride (By mouth)
Drug Classes	Antibacterial
Drug Label	Ciprofloxacin Tablets, USPis a synthetic broad spectrum antimicrobial agent for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pip...
Active Ingredient	Ciprofloxacin hydrochloride
Dosage Form	Solution/drops; Tablet
Route	Ophthalmic; Oral
Strength	eq 100mg base; eq 750mg base; eq 500mg base; eq 0.3% base; eq 250mg base
Market Status	Prescription
Company	Watson Labs; Nexus Pharms; Ranbaxy; Ivax Sub Teva Pharms; Apotex; Bausch And Lomb; Aurobindo Pharma; Taro; Dr Reddys Labs; Unique Pharm Labs; Carlsbad; Pharmaforce; Fdc; Mylan; Hikma; Akorn

4.2 Drug Indication

Treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

Cytochrome P-450 CYP1A2 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Quinolones [CS]; Quinolone Antimicrobial [EPC]

API SUPPLIERS

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USDMF

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

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FDA Orange Book

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Europe

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% ...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% BASE

USFDA APPLICATION NUMBER - 19992

DOSAGE - OINTMENT;OPHTHALMIC - EQ 0.3% BASE

USFDA APPLICATION NUMBER - 20369

DOSAGE - SUSPENSION/DROPS;OTIC - EQ 0.2% BASE...DOSAGE - SUSPENSION/DROPS;OTIC - EQ 0.2% BASE;1%

USFDA APPLICATION NUMBER - 20805

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Ciprofloxacin Hydrochloride

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

55 API Suppliers

23 USDMF

18 CEP/COS

3 JDMF

12 EU WC

19 KDMF

21 NDC API

22 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

213 FDF Dossiers

87 FDA Orange Book

39 Europe

37 Canada

2 South Africa

48 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% BASE

OINTMENT;OPHTHALMIC - EQ 0.3% BASE

SUSPENSION/DROPS;OTIC - EQ 0.2% BASE;1%

RELATED EXCIPIENT COMPANIES

3 Rochem International Inc

17 SPI Pharma

2 Seqens

7 DKSH

8 Faran Shimi Pharmaceutical

8 Boai NKY Pharmaceuticals Ltd

14 Gangwal Healthcare

8 Nanjing Well Pharmaceutical

2 Pfanstiehl

1 ACG Worldwide

15 Actylis

1 Aeon Procare

1 Alcedo Pharmachem

9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

34 BASF

2 Clariant

11 Corel Pharma Chem

1 Curia

6 DFE Pharma

4 Finar

13 Gangwal Chemicals

7 Ideal Cures Pvt Ltd

5 Ingredion Pharma Solutions

33 Kerry

4 Kima Chemical

6 Lonza Capsugel

16 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

4 Novo Excipients

4 Pharmatrans-Sanaq

9 Pluviaendo

4 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

27 Roquette

15 Seppic

7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shanghai Welltone Material Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

12 Sigachi Industries

3 The Dow Chemical Company

2 Ulanqab Kema New Material

1 Valens Pharmachem

4 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

94 Fillers, Diluents & Binders

57 Coating Systems & Additives

48 Direct Compression

41 Disintegrants & Superdisintegrants

38 Solubilizers

34 Controlled & Modified Release