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Cisatracurium Besylate

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ACTIVE PHARMA INGREDIENTS

26 API Suppliers, 11 USDMF, 5 CEP/COS, 1 EU WC, 5 NDC API, 19 Listed Suppliers, $ API Reference Price

26 API Suppliers
11 USDMF
5 CEP/COS
1 EU WC
5 NDC API
19 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

9 Intermediates Suppliers

9 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

89 FDF Dossiers, 46 FDA Orange Book, 2 Europe, 1 Canada, 11 South Africa, 29 Listed Dossiers

89 FDF Dossiers
46 FDA Orange Book
2 Europe
1 Canada
11 South Africa
29 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - EQ 10MG BASE/ML, INJECTABLE;INJECTION - EQ 2MG BASE/ML

drugProductComposition
INJECTABLE;INJECTION - EQ 10MG BASE/ML
INJECTABLE;INJECTION - EQ 2MG BASE/ML

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 Actylis, 2 Finar

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1 Nanjing Well Pharmaceutical
1 Actylis
2 Finar

EXCIPIENTS BY APPLICATIONS

2 Parenteral, 2 Topical, 1 Solubilizers

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2 Parenteral
2 Topical
1 Solubilizers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 25 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
25 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices

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2 Finished Drug Prices

MARKET PLACE

13 APIs, 10 FDF Dossiers

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13 APIs
10 FDF Dossiers

PATENTS & EXCLUSIVITIES

2 Health Canada Patents

patents
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 2 USP , 1 Others

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1 EDQM
2 USP
1 Others

Synnat Cisatracurium Besylate

Synopsis

ACTIVE PHARMA INGREDIENTS

26

API Suppliers

11

USDMF

5

CEP/COS

CEP/COS Certifications

0

JDMF

1

EU WC

0

KDMF

5

NDC API

0

VMF

19

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 36,663

MARKET PLACE

13

API

10

FDF

9INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

89

FDF Dossiers

46

FDA Orange Book

FDA (Orange Book)

2

Europe

1

Canada

0

Australia

11

South Africa

29

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

1

EDQM

2

USP

0

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

2

Health Canada Patents

DIGITAL CONTENT

1

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

25

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

4 RELATED EXCIPIENT COMPANIES

5EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 96946-42-8, Nimbex, Cisatracurium besilate, Cisatracurium (besylate), 51w89, Cisatracurium besylate [usan]

Molecular Formula

C₆₅H₈₂N₂O₁₈S₂

Molecular Weight

1243.5 g/mol

InChI Key

XXZSQOVSEBAPGS-DONVQRBFSA-L

FDA UNII

Y78PS7MEDE

Cisatracurium Besylate

Cisatracurium Besylate is the besylate salt form of cisatracurium, a non-depolarizing skeletal muscle relaxant of the benzylisoquinolinium class, with skeletal muscle relaxing activity. Cisatracurium besylate acts as a competitive acetylcholine antagonist that binds to nicotinic receptors at the neuromuscular junction. This blocks neuromuscular transmission and causes neuromuscular relaxation.

1 2D Structure

Cisatracurium Besylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

benzenesulfonate;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate

2.1.2 InChI

InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2/t42-,43-,54-,55-;;/m1../s1

2.1.3 InChI Key

XXZSQOVSEBAPGS-DONVQRBFSA-L

2.1.4 Canonical SMILES

C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]

2.1.5 Isomeric SMILES

C[N@@+]1(CCC2=CC(=C(C=C2[C@H]1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N@+]4(CCC5=CC(=C(C=C5[C@H]4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]

2.2 Other Identifiers

2.2.1 UNII

Y78PS7MEDE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 51w89

2. Cisatracurium

3. Cisatracurium Besilate

4. Nimbex

2.3.2 Depositor-Supplied Synonyms

1. 96946-42-8

2. Nimbex

3. Cisatracurium Besilate

4. Cisatracurium (besylate)

5. 51w89

6. Cisatracurium Besylate [usan]

7. Cisatracurium (as Besilate)

8. 80ys8o1mbs

9. Cisatracurium Besilate [inn]

10. Chebi:3721

11. (1r,1'r,2r,2'r)-2,2'-((pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) Benzenesulfonate

12. 96946-42-8 (besylate)

13. (1r,2r)-2-(2-carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium Benzenesulfonate, Pentamethylene Ester

14. (1r-cis,1'r-cis)-atracurium Besylate

15. 51-w89

16. 51w-89

17. 51-w-89

18. Cisatracurium Besilate (inn)

19. Nimbex Preservative Free

20. Cis-atracurium Besylate

21. Unii-80ys8o1mbs

22. Nimbium

23. Atracurium Besylate 1r-cis,1r'-cis Form

24. Nimbex Forte

25. Ncgc00017127-01

26. Cas-64228-81-5

27. Nimbex (tn)

28. Cisatracurium Besylate Preservative Free

29. Cis-atracurium Besilate

30. Isoquinolinium,2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-,(1r,1'r,2r,2'r)-, Dibenzenesulfonate

31. Y78ps7mede

32. Schembl40669

33. Cisatracurium Besylate (usp)

34. Cisatracurium Dibenzenesulfonate

35. Cisatracurium Besylate (nimbex)

36. Chembl1200641

37. Cisatracurium Besylate (~90%)

38. Dtxsid10895045

39. Hms3715p04

40. Hms3884l07

41. Cisatracurium Besylate [mi]

42. Benzenesulfonate;5-[3-[(1r,2r)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1r,2r)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propanoate

43. Ex-a2646

44. Mfcd00871018

45. S2113

46. Cisatracurium Besylate [vandf]

47. Akos026750111

48. Cisatracurium Besilate [mart.]

49. Ccg-221271

50. Cisatracurium Besilate [who-dd]

51. Cisatracurium Besylate [usp-rs]

52. (1r,2r,1'r,2'r)-atracurium Besylate

53. Bs-17985

54. Hy-13596

55. Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, Dibenzenesulfonate, (1r-(1alpha,2alpha(1'r(sup *),2'r(sup *))))-

56. Cisatracurium Besylate [orange Book]

57. Cisatracurium Besilate [ep Monograph]

58. Sw222230-1

59. Cisatracurium Besylate [usp Monograph]

60. 51 W89

61. D00759

62. Q267669

63. W-60404

64. Z2216208615

65. Atracurium Besylate, (1r,1'r,2r,2'r)-(+/-)-

66. Cisatracurium Besilate, Europepharmacopoeia (ep) Reference Standard

67. Cisatracurium Besylate, United States Pharmacopeia (usp) Reference Standard

68. Cisatracurium For Peak Identification, Europepharmacopoeia (ep) Reference Standard

69. Cisatracurium For System Suitability, Europepharmacopoeia (ep) Reference Standard

70. (1r,1'r,2r,2'r)-2,2'-((pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium)benzenesulfonate

71. (1r,2r)-1-[(3,4-dimethoxyphenyl)methyl]-2-(3-{[5-({3-[(1r,2r)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium Dibenzenesulfonate

72. (1r,2r,1'r,2'r)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] Bisbenzenesulfonate

73. (1r-cis,1'r-cis)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] Bisbenzenesulfonate

74. Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1r,1'r,2r,2'r)-, Benzenesulfonate (1:2)

75. Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1r,1'r,2r,2'r)-, Dibenzenesulfonate

76. Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1r,1'r,2r,2'r)-rel, Dibenzenesulfonate

77. Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, Dibenzenesulfonate, (1r-(1.alpha.,2.alpha.(1'r*,2'r*)))-

78. Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, Dibenzenesulphonate, (1r-(1.alpha.,2.alpha.(1'r*,2'r*)))-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₆₅H₈₂N₂O₁₈S₂
Molecular Weight	1243.5 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	26
Exact Mass	1242.50040612 g/mol
Monoisotopic Mass	1242.50040612 g/mol
Topological Polar Surface Area	258 Å²
Heavy Atom Count	87
Formal Charge	0
Complexity	1560
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Cisatracurium besylate
Active Ingredient	Cisatracurium besylate
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Sandoz

2 of 6
Drug Name	Nimbex
Drug Label	NIMBEX (cisatracurium besylate) is a nondepolarizing skeletal muscle relaxant for intravenous administration. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is one of 10...
Active Ingredient	Cisatracurium besylate
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Abbvie

3 of 6
Drug Name	Nimbex preservative free
Drug Label	Cisatracurium besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is one of 10isomers...
Active Ingredient	Cisatracurium besylate
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml; eq 10mg base/ml
Market Status	Prescription
Company	Abbvie

4 of 6
Drug Name	Cisatracurium besylate
Active Ingredient	Cisatracurium besylate
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Sandoz

5 of 6
Drug Name	Nimbex
Drug Label	NIMBEX (cisatracurium besylate) is a nondepolarizing skeletal muscle relaxant for intravenous administration. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is one of 10...
Active Ingredient	Cisatracurium besylate
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml
Market Status	Prescription
Company	Abbvie

6 of 6
Drug Name	Nimbex preservative free
Drug Label	Cisatracurium besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is one of 10isomers...
Active Ingredient	Cisatracurium besylate
Dosage Form	Injectable
Route	Injection
Strength	eq 2mg base/ml; eq 10mg base/ml
Market Status	Prescription
Company	Abbvie

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Neuromuscular Blocking Agents

Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc. (See all compounds classified as Neuromuscular Blocking Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Nondepolarizing Neuromuscular Blocker [EPC]; Neuromuscular Nondepolarizing Blockade [PE]

API SUPPLIERS

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USDMF

01

Cf Pharma Ltd

Hungary

CPhI Worldwide, Milan

CF Pharma- skilled & highly experienced European API producer based in Hungary.

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Hungary

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Cisatracurium Besylate Version Fa1

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 24902

Submission : 2012-08-27

Status : Active

Type : II

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Cf Pharma Ltd

Hungary

CPhI Worldwide, Milan

CF Pharma- skilled & highly experienced European API producer based in Hungary.

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Hungary

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Cisatracurium Besylate

GDUFA

DMF Review : Complete

Rev. Date : 2014-09-09

Pay. Date : 2014-01-22

DMF Number : 24969

Submission : 2012-08-27

Status : Active

Type : II

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Wavelength Enterprises Ltd

France

CPhI Worldwide, Milan

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

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France

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Cisatracurium Besylate

GDUFA

DMF Review : Complete

Rev. Date : 2017-06-23

Pay. Date : 2017-05-09

DMF Number : 23554

Submission : 2010-02-21

Status : Active

Type : II

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Wavelength Enterprises Ltd

Israel

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Cisatracurium Besylate Process B

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DMF Number : 39123

Submission : 2024-01-29

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Farmhispania Sa

Spain

CPhI Worldwide, Milan

Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

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Cisatracurium Besylate Usp

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Pay. Date : 2020-04-09

DMF Number : 24999

Submission : 2011-05-30

Status : Active

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Alp Pharm Beijing Co Ltd

China

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India

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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