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Chemistry

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Also known as: 59729-32-7, Citalopram hbr, Celexa, Cipramil, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide, Elopram
Molecular Formula
C20H22BrFN2O
Molecular Weight
405.3  g/mol
InChI Key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
FDA UNII
I1E9D14F36

Citalopram Hydrobromide
A furancarbonitrile that is one of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
1 2D Structure

Citalopram Hydrobromide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;hydrobromide
2.1.2 InChI
InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
2.1.3 InChI Key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br
2.2 Other Identifiers
2.2.1 UNII
I1E9D14F36
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Celexa

2. Citalopram

3. Cytalopram

4. Lu-10-171

5. Lu10171

6. Seropram

2.3.2 Depositor-Supplied Synonyms

1. 59729-32-7

2. Citalopram Hbr

3. Celexa

4. Cipramil

5. 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

6. Elopram

7. Seropram

8. Bonitrile Hbr

9. Nitalapram Hbr

10. Lu 10-171-b

11. Citalopram (hydrobromide)

12. Citalopram, Hydrobromide Salt

13. Lu 10-171 Hbr

14. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3h-2-benzofuran-5-carbonitrile;hydrobromide

15. Nsc-758684

16. Citalopram (as Hydrobromide)

17. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile Hydrobromide

18. I1e9d14f36

19. Cipram

20. (s)-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

21. Lu 10-171

22. Lu-10-171-b

23. Citalopram D4 Hbr

24. 59729-32-7 (hbr)

25. 1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile Monohydrobromide

26. 5-isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, Monohydrobromide

27. Prepram Hbr

28. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Hydrobromide

29. Smr000326936

30. Citalopram Hydrobromide [usan]

31. Lu-10-171

32. Sr-01000003129

33. 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Monohydrobromide

34. Einecs 261-890-6

35. C20h21fn2o.hbr

36. Apertia

37. Prisdal

38. Lupram

39. Sepram

40. Unii-i1e9d14f36

41. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

42. Citalopram Hydrobromide [usan:usp]

43. Celexa (tn)

44. Mfcd02101306

45. Cpd000326936

46. Schembl1118

47. Mls000758293

48. Mls000860078

49. Mls001401376

50. Mls002222294

51. Citalopram Hydrobromide (usp)

52. Citalopram Hydrobromide Solution

53. Chembl1200781

54. Dtxsid40872344

55. Pharmakon1600-01504172

56. Citalopram Hydrogen Bromide- Bio-x

57. Hy-b1287

58. Lu-10-171b

59. Citalopram Hydrobromide [mi]

60. Tox21_500258

61. Nsc758684

62. S4749

63. Zd 211

64. Zd-211

65. Citalopram Hydrobromide [hsdb]

66. Akos005145738

67. Ab10921

68. Ac-1595

69. Bcp9000537

70. Ccg-101022

71. Ccg-213271

72. Citalopram Hydrobromide [mart.]

73. Citalopram Hydrobromide [vandf]

74. Cs-4735

75. Ks-1043

76. Lp00258

77. Nc00272

78. Nsc 758684

79. Citalopram Hydrobromide [usp-rs]

80. Citalopram Hydrobromide [who-dd]

81. Ncgc00093717-01

82. Ncgc00093717-02

83. Ncgc00093717-03

84. Ncgc00260943-01

85. Bc164316

86. Citalopram Hydrobromide, >=98% (hplc)

87. Citalopram Hydrobromide [orange Book]

88. Eu-0100258

89. Ft-0600173

90. Citalopram Hydrobromide [ep Monograph]

91. Citalopram Hydrobromide [usp Impurity]

92. C 7861

93. C75790

94. Citalopram Hydrobromide [usp Monograph]

95. D00822

96. 729c327

97. A832439

98. Q-200865

99. Sr-01000003129-2

100. Sr-01000003129-4

101. W-105304

102. Citalopram Hydrobromide 100 Microg/ml In Acetonitrile

103. Q27280253

104. Sr-01000003129-10

105. Z1550648760

106. Citalopram Hydrobromide 0.1 Mg/ml In Methanol (as Free Base)

107. Citalopram Hydrobromide 1.0 Mg/ml In Methanol (as Free Base)

108. Citalopram Hydrobromide, European Pharmacopoeia (ep) Reference Standard

109. Citalopram Hydrobromide, United States Pharmacopeia (usp) Reference Standard

110. 1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile Monohbr

111. Citalopram For System Suitability, European Pharmacopoeia (ep) Reference Standard

112. Citalopram Hydrobromide, Pharmaceutical Secondary Standard; Certified Reference Material

113. 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile Hydrobromide

114. 1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile Hbr

115. 1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

116. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitril E Hydrobromide

117. 5-isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, Monohbr

118. 5-isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, Hydrobromide (1:1)

119. Citalopram Hydrobromide Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

120. Citalopram Hydrobromide Solution, 100 Mug/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 405.3 g/mol
Molecular Formula C20H22BrFN2O
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass404.08995 g/mol
Monoisotopic Mass404.08995 g/mol
Topological Polar Surface Area36.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameCelexa
Active IngredientCitalopram hydrobromide
Dosage FormTablet
RouteOral
Strengtheq 40mg base; eq 20mg base; eq 10mg base
Market StatusPrescription
CompanyForest Labs

2 of 4  
Drug NameCitalopram hydrobromide
PubMed HealthCitalopram (By mouth)
Drug ClassesAntidepressant
Active IngredientCitalopram hydrobromide
Dosage FormTablet; Capsule; Solution
Routeorally disintegrating; Oral
Strengtheq 40mg base; eq 10mg base/5ml; eq 20mg base; eq 10mg base; 40mg
Market StatusPrescription
CompanyMylan Pharms; Glenmark Generics; Silarx; Amneal Pharms Ny; Teva Pharms; Epic Pharma; Apotex; Aurobindo; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Dr Reddys Labs; Pliva; Invagen Pharms; Cipla; Mylan; Roxane; Biovail Labs Intl

3 of 4  
Drug NameCelexa
Active IngredientCitalopram hydrobromide
Dosage FormTablet
RouteOral
Strengtheq 40mg base; eq 20mg base; eq 10mg base
Market StatusPrescription
CompanyForest Labs

4 of 4  
Drug NameCitalopram hydrobromide
PubMed HealthCitalopram (By mouth)
Drug ClassesAntidepressant
Active IngredientCitalopram hydrobromide
Dosage FormTablet; Capsule; Solution
Routeorally disintegrating; Oral
Strengtheq 40mg base; eq 10mg base/5ml; eq 20mg base; eq 10mg base; 40mg
Market StatusPrescription
CompanyMylan Pharms; Glenmark Generics; Silarx; Amneal Pharms Ny; Teva Pharms; Epic Pharma; Apotex; Aurobindo; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Dr Reddys Labs; Pliva; Invagen Pharms; Cipla; Mylan; Roxane; Biovail Labs Intl

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)


Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Serotonin Uptake Inhibitors [MoA]; Serotonin Reuptake Inhibitor [EPC]

API Reference Price

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D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0002","unit":"KGS","unitRateFc":"2650000","totalValueFC":"553.1","currency":"USD","unitRateINR":"231948200","date":"14-Aug-2024","totalValueINR":"46389.64","totalValueInUsd":"553.1","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"5055144","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD,US 21704,UNITED STATES OF AMERICASDNF United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"}]
11-Feb-2021
08-Nov-2024
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 10MG BASE

USFDA APPLICATION NUMBER - 20822

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DOSAGE - TABLET;ORAL - EQ 20MG BASE

USFDA APPLICATION NUMBER - 20822

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DOSAGE - TABLET;ORAL - EQ 40MG BASE

USFDA APPLICATION NUMBER - 20822

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ABOUT THIS PAGE

Citalopram Hydrobromide Manufacturers

A Citalopram Hydrobromide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Citalopram Hydrobromide, including repackagers and relabelers. The FDA regulates Citalopram Hydrobromide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Citalopram Hydrobromide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Citalopram Hydrobromide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Citalopram Hydrobromide Suppliers

A Citalopram Hydrobromide supplier is an individual or a company that provides Citalopram Hydrobromide active pharmaceutical ingredient (API) or Citalopram Hydrobromide finished formulations upon request. The Citalopram Hydrobromide suppliers may include Citalopram Hydrobromide API manufacturers, exporters, distributors and traders.

click here to find a list of Citalopram Hydrobromide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Citalopram Hydrobromide USDMF

A Citalopram Hydrobromide DMF (Drug Master File) is a document detailing the whole manufacturing process of Citalopram Hydrobromide active pharmaceutical ingredient (API) in detail. Different forms of Citalopram Hydrobromide DMFs exist exist since differing nations have different regulations, such as Citalopram Hydrobromide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Citalopram Hydrobromide DMF submitted to regulatory agencies in the US is known as a USDMF. Citalopram Hydrobromide USDMF includes data on Citalopram Hydrobromide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Citalopram Hydrobromide USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Citalopram Hydrobromide suppliers with USDMF on PharmaCompass.

Citalopram Hydrobromide CEP

A Citalopram Hydrobromide CEP of the European Pharmacopoeia monograph is often referred to as a Citalopram Hydrobromide Certificate of Suitability (COS). The purpose of a Citalopram Hydrobromide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Citalopram Hydrobromide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Citalopram Hydrobromide to their clients by showing that a Citalopram Hydrobromide CEP has been issued for it. The manufacturer submits a Citalopram Hydrobromide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Citalopram Hydrobromide CEP holder for the record. Additionally, the data presented in the Citalopram Hydrobromide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Citalopram Hydrobromide DMF.

A Citalopram Hydrobromide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Citalopram Hydrobromide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Citalopram Hydrobromide suppliers with CEP (COS) on PharmaCompass.

Citalopram Hydrobromide WC

A Citalopram Hydrobromide written confirmation (Citalopram Hydrobromide WC) is an official document issued by a regulatory agency to a Citalopram Hydrobromide manufacturer, verifying that the manufacturing facility of a Citalopram Hydrobromide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Citalopram Hydrobromide APIs or Citalopram Hydrobromide finished pharmaceutical products to another nation, regulatory agencies frequently require a Citalopram Hydrobromide WC (written confirmation) as part of the regulatory process.

click here to find a list of Citalopram Hydrobromide suppliers with Written Confirmation (WC) on PharmaCompass.

Citalopram Hydrobromide NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Citalopram Hydrobromide as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Citalopram Hydrobromide API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Citalopram Hydrobromide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Citalopram Hydrobromide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Citalopram Hydrobromide NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Citalopram Hydrobromide suppliers with NDC on PharmaCompass.

Citalopram Hydrobromide GMP

Citalopram Hydrobromide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Citalopram Hydrobromide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Citalopram Hydrobromide GMP manufacturer or Citalopram Hydrobromide GMP API supplier for your needs.

Citalopram Hydrobromide CoA

A Citalopram Hydrobromide CoA (Certificate of Analysis) is a formal document that attests to Citalopram Hydrobromide's compliance with Citalopram Hydrobromide specifications and serves as a tool for batch-level quality control.

Citalopram Hydrobromide CoA mostly includes findings from lab analyses of a specific batch. For each Citalopram Hydrobromide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Citalopram Hydrobromide may be tested according to a variety of international standards, such as European Pharmacopoeia (Citalopram Hydrobromide EP), Citalopram Hydrobromide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Citalopram Hydrobromide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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