List of Europe Written Confirmation (EU WC) issued for Citalopram Hydrobromide Active Pharmaceutical Ingredient listed on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

42 API Suppliers, 28 USDMF, 14 CEP/COS, 13 EU WC, 15 NDC API, 20 Listed Suppliers, $ API Reference Price

42 API Suppliers
28 USDMF
14 CEP/COS
13 EU WC
15 NDC API
20 Listed Suppliers
$ API Reference Price

INTERMEDIATES

4 Intermediates Suppliers

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

213 FDF Dossiers, 95 FDA Orange Book, 40 Europe, 55 Canada, 8 South Africa, 15 Listed Dossiers

213 FDF Dossiers
95 FDA Orange Book
40 Europe
55 Canada
8 South Africa
15 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 10MG BASE, TABLET;ORAL - EQ 20MG BASE, TABLET;ORAL - EQ 40MG BASE

drugProductComposition
TABLET;ORAL - EQ 10MG BASE
TABLET;ORAL - EQ 20MG BASE
TABLET;ORAL - EQ 40MG BASE

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 17 SPI Pharma, 2 Seqens, 8 DKSH, 2 Jai Radhe Sales, 11 Boai NKY Pharmaceuticals Ltd, 14 Gangwal Healthcare, 6 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 ACG Worldwide, 7 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Avesta Pharma, 33 BASF, 2 Clariant, 10 Corel Pharma Chem, 6 DFE Pharma, 2 Finar, 12 Gangwal Chemicals, 1 Huzhou Sunflower Pharmaceutical, 7 Ideal Cures Pvt Ltd, 5 Ingredion Pharma Solutions, 33 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 15 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 5 Novo Excipients, 4 Pharmatrans-Sanaq, 8 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 29 Roquette, 13 Seppic, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 2 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 2 The Dow Chemical Company, 3 Ulanqab Kema New Material, 1 Valens Pharmachem, 4 Vasa Pharmachem, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
2 Rochem International Inc
17 SPI Pharma
2 Seqens
8 DKSH
2 Jai Radhe Sales
11 Boai NKY Pharmaceuticals Ltd
14 Gangwal Healthcare
6 Nanjing Well Pharmaceutical
1 Pfanstiehl
4 ACG Worldwide
7 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Avesta Pharma
33 BASF
2 Clariant
10 Corel Pharma Chem
6 DFE Pharma
2 Finar
12 Gangwal Chemicals
1 Huzhou Sunflower Pharmaceutical
7 Ideal Cures Pvt Ltd
5 Ingredion Pharma Solutions
33 Kerry
3 Kima Chemical
6 Lonza Capsugel
15 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
5 Novo Excipients
4 Pharmatrans-Sanaq
8 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
29 Roquette
13 Seppic
7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
2 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
2 The Dow Chemical Company
3 Ulanqab Kema New Material
1 Valens Pharmachem
4 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

101 Fillers, Diluents & Binders, 56 Coating Systems & Additives, 50 Direct Compression, 42 Disintegrants & Superdisintegrants, 33 Controlled & Modified Release, 32 Solubilizers, 31 Granulation, 31 Thickeners and Stabilizers, 27 Film Formers & Plasticizers, 24 Parenteral, 21 Taste Masking, 20 Co-Processed Excipients, 19 Topical, 18 Chewable & Orodispersible Aids, 18 Lubricants & Glidants, 9 Emulsifying Agents, 9 Empty Capsules, 8 API Stability Enhancers, 5 Surfactant & Foaming Agents, 5 Coloring Agents, 5 Rheology Modifiers, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 2 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 15 Finished Drug Prices

globalSalesInformation
2 US Medicaid Prescriptions
15 Finished Drug Prices

MARKET PLACE

2 APIs

marketPlace
2 APIs

PATENTS & EXCLUSIVITIES

6 Health Canada Patents

patents
6 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 1 USP , 1 Others

otherSolutions
3 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 168

MARKET PLACE

API

FDF

4INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

213

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

62,057,930

Annual Reports (USD Million)

Finished Drug Prices

325 RELATED EXCIPIENT COMPANIES

569EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 59729-32-7, Citalopram hbr, Celexa, Cipramil, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide, Elopram

Molecular Formula

C₂₀H₂₂BrFN₂O

Molecular Weight

405.3 g/mol

InChI Key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

FDA UNII

I1E9D14F36

A furancarbonitrile that is one of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.

1 2D Structure

Citalopram Hydrobromide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;hydrobromide

2.1.2 InChI

InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H

2.1.3 InChI Key

WIHMBLDNRMIGDW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br

2.2 Other Identifiers

2.2.1 UNII

I1E9D14F36

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Celexa

2. Citalopram

3. Cytalopram

4. Lu-10-171

5. Lu10171

6. Seropram

2.3.2 Depositor-Supplied Synonyms

1. 59729-32-7

2. Citalopram Hbr

3. Celexa

4. Cipramil

5. 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

6. Elopram

7. Seropram

8. Bonitrile Hbr

9. Nitalapram Hbr

10. Lu 10-171-b

11. Citalopram (hydrobromide)

12. Citalopram, Hydrobromide Salt

13. Lu 10-171 Hbr

14. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3h-2-benzofuran-5-carbonitrile;hydrobromide

15. Nsc-758684

16. Citalopram (as Hydrobromide)

17. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile Hydrobromide

18. I1e9d14f36

19. Cipram

20. (s)-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

21. Lu 10-171

22. Lu-10-171-b

23. Citalopram D4 Hbr

24. 59729-32-7 (hbr)

25. 1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile Monohydrobromide

26. 5-isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, Monohydrobromide

27. Prepram Hbr

28. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Hydrobromide

29. Smr000326936

30. Citalopram Hydrobromide [usan]

31. Lu-10-171

32. Sr-01000003129

33. 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Monohydrobromide

34. Einecs 261-890-6

35. C20h21fn2o.hbr

36. Apertia

37. Prisdal

38. Lupram

39. Sepram

40. Unii-i1e9d14f36

41. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

42. Citalopram Hydrobromide [usan:usp]

43. Celexa (tn)

44. Mfcd02101306

45. Cpd000326936

46. Schembl1118

47. Mls000758293

48. Mls000860078

49. Mls001401376

50. Mls002222294

51. Citalopram Hydrobromide (usp)

52. Citalopram Hydrobromide Solution

53. Chembl1200781

54. Dtxsid40872344

55. Pharmakon1600-01504172

56. Citalopram Hydrogen Bromide- Bio-x

57. Hy-b1287

58. Lu-10-171b

59. Citalopram Hydrobromide [mi]

60. Tox21_500258

61. Nsc758684

62. S4749

63. Zd 211

64. Zd-211

65. Citalopram Hydrobromide [hsdb]

66. Akos005145738

67. Ab10921

68. Ac-1595

69. Bcp9000537

70. Ccg-101022

71. Ccg-213271

72. Citalopram Hydrobromide [mart.]

73. Citalopram Hydrobromide [vandf]

74. Cs-4735

75. Ks-1043

76. Lp00258

77. Nc00272

78. Nsc 758684

79. Citalopram Hydrobromide [usp-rs]

80. Citalopram Hydrobromide [who-dd]

81. Ncgc00093717-01

82. Ncgc00093717-02

83. Ncgc00093717-03

84. Ncgc00260943-01

85. Bc164316

86. Citalopram Hydrobromide, >=98% (hplc)

87. Citalopram Hydrobromide [orange Book]

88. Eu-0100258

89. Ft-0600173

90. Citalopram Hydrobromide [ep Monograph]

91. Citalopram Hydrobromide [usp Impurity]

92. C 7861

93. C75790

94. Citalopram Hydrobromide [usp Monograph]

95. D00822

96. 729c327

97. A832439

98. Q-200865

99. Sr-01000003129-2

100. Sr-01000003129-4

101. W-105304

102. Citalopram Hydrobromide 100 Microg/ml In Acetonitrile

103. Q27280253

104. Sr-01000003129-10

105. Z1550648760

106. Citalopram Hydrobromide 0.1 Mg/ml In Methanol (as Free Base)

107. Citalopram Hydrobromide 1.0 Mg/ml In Methanol (as Free Base)

108. Citalopram Hydrobromide, European Pharmacopoeia (ep) Reference Standard

109. Citalopram Hydrobromide, United States Pharmacopeia (usp) Reference Standard

110. 1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile Monohbr

111. Citalopram For System Suitability, European Pharmacopoeia (ep) Reference Standard

112. Citalopram Hydrobromide, Pharmaceutical Secondary Standard; Certified Reference Material

113. 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile Hydrobromide

114. 1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile Hbr

115. 1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile Hydrobromide

116. 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitril E Hydrobromide

117. 5-isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-, Monohbr

118. 5-isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, Hydrobromide (1:1)

119. Citalopram Hydrobromide Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

120. Citalopram Hydrobromide Solution, 100 Mug/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₂BrFN₂O
Molecular Weight	405.3 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	404.08995 g/mol
Monoisotopic Mass	404.08995 g/mol
Topological Polar Surface Area	36.3 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	466
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Celexa
Active Ingredient	Citalopram hydrobromide
Dosage Form	Tablet
Route	Oral
Strength	eq 40mg base; eq 20mg base; eq 10mg base
Market Status	Prescription
Company	Forest Labs

2 of 4
Drug Name	Citalopram hydrobromide
PubMed Health	Citalopram (By mouth)
Drug Classes	Antidepressant
Active Ingredient	Citalopram hydrobromide
Dosage Form	Tablet; Capsule; Solution
Route	orally disintegrating; Oral
Strength	eq 40mg base; eq 10mg base/5ml; eq 20mg base; eq 10mg base; 40mg
Market Status	Prescription
Company	Mylan Pharms; Glenmark Generics; Silarx; Amneal Pharms Ny; Teva Pharms; Epic Pharma; Apotex; Aurobindo; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Dr Reddys Labs; Pliva; Invagen Pharms; Cipla; Mylan; Roxane; Biovail Labs Intl

3 of 4
Drug Name	Celexa
Active Ingredient	Citalopram hydrobromide
Dosage Form	Tablet
Route	Oral
Strength	eq 40mg base; eq 20mg base; eq 10mg base
Market Status	Prescription
Company	Forest Labs

4 of 4
Drug Name	Citalopram hydrobromide
PubMed Health	Citalopram (By mouth)
Drug Classes	Antidepressant
Active Ingredient	Citalopram hydrobromide
Dosage Form	Tablet; Capsule; Solution
Route	orally disintegrating; Oral
Strength	eq 40mg base; eq 10mg base/5ml; eq 20mg base; eq 10mg base; 40mg
Market Status	Prescription
Company	Mylan Pharms; Glenmark Generics; Silarx; Amneal Pharms Ny; Teva Pharms; Epic Pharma; Apotex; Aurobindo; Aurobindo Pharma; Sun Pharm Inds; Torrent Pharms; Dr Reddys Labs; Pliva; Invagen Pharms; Cipla; Mylan; Roxane; Biovail Labs Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)

Antidepressive Agents, Second-Generation

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin Uptake Inhibitors [MoA]; Serotonin Reuptake Inhibitor [EPC]

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET;ORAL - EQ 10MG BASE

USFDA APPLICATION NUMBER - 20822

DOSAGE - TABLET;ORAL - EQ 20MG BASE

USFDA APPLICATION NUMBER - 20822

DOSAGE - TABLET;ORAL - EQ 40MG BASE

USFDA APPLICATION NUMBER - 20822

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List of Europe Written Confirmation (EU WC) issued for Citalopram Hydrobromide Active Pharmaceutical Ingredient listed on PharmaCompass.com

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DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 10MG BASE

TABLET;ORAL - EQ 20MG BASE

TABLET;ORAL - EQ 40MG BASE

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