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Chemistry

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Also known as: 105956-97-6, 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Clinafloxacin [inn], Ci-960, 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid, Am-1091
Molecular Formula
C17H17ClFN3O3
Molecular Weight
365.8  g/mol
InChI Key
QGPKADBNRMWEQR-UHFFFAOYSA-N
FDA UNII
8N86XTF9QD

Clinafloxacin
Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of serious side effects.
1 2D Structure

Clinafloxacin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
2.1.2 InChI
InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25)
2.1.3 InChI Key
QGPKADBNRMWEQR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
8N86XTF9QD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

2. Am 1091

3. Am-1091

4. Ci 960

5. Ci-960

6. Pd 127,391

7. Pd 127391

8. Pd-127,391

9. Pd-127391

10. Pd127,391

2.3.2 Depositor-Supplied Synonyms

1. 105956-97-6

2. 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

3. Clinafloxacin [inn]

4. Ci-960

5. 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic Acid

6. Am-1091

7. 8n86xtf9qd

8. Clinafloxacin (hydrochloride)

9. 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

10. Am-1091;ci-960;pd 127391

11. Am 1091 (hydrochloride); Ci 960 (hydrochloride);pd127391 (hydrochloride)

12. 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic Acid

13. Clinafloxacin Ci96 Am1091

14. Unii-8n86xtf9qd

15. Pd 127321

16. Am 1091

17. Pd 127391

18. Pd-127391

19. Clinafloxacin [mi]

20. Bay-v-3545

21. Schembl33959

22. 3-quinolinecarboxylic Acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-

23. Mls000778572

24. Clinafloxacin (pd127391)

25. Clinafloxacin [who-dd]

26. Chembl278255

27. Chebi:94459

28. Gtpl10793

29. Dtxsid80869455

30. Hms2090o15

31. Hms2770f24

32. Hms3714j19

33. Amy28813

34. Bcp21182

35. Hy-b0536

36. Rkl10079

37. Am1091

38. Bbl010979

39. Bdbm50474311

40. Mfcd00865120

41. S4006

42. Stk802100

43. Akos005622667

44. Ccg-220849

45. Db14025

46. Ncgc00246499-01

47. Ac-32467

48. Pd127391

49. Smr000415366

50. Vs-02785

51. Db-040667

52. Pd-127321

53. Ft-0602938

54. 56c976

55. Ab00647129-10

56. Ab00647129_11

57. Ab00647129_13

58. Ab00647129_14

59. A801341

60. A801342

61. Clinafloxacin, Vetranal(tm), Analytical Standard

62. Sr-01000765993

63. J-001508

64. Q3680752

65. Sr-01000765993-2

66. Brd-a93964801-003-01-7

67. 7-(3-azaniumylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate

68. (+/-)-7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

69. 3-quinolinecarboxylic Acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, (+/-)-

70. 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid, Monohydrochloride

71. 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid

72. 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid

73. 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-3-quinolinecarboxylic Acid

74. 7-(3-amino-pyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic Acid

75. 7-(3-amino-pyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic Acid

76. 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic Acid;clinafloxacin

77. 7-(3-azanylpyrrolidin-1-yl)-8-chloranyl-1-cyclopropyl-6-fluoranyl-4-oxidanylidene-quinoline-3-carboxylic Acid

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 365.8 g/mol
Molecular Formula C17H17ClFN3O3
XLogP30.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass365.0942473 g/mol
Monoisotopic Mass365.0942473 g/mol
Topological Polar Surface Area86.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)


ABOUT THIS PAGE

Clinafloxacin Manufacturers

A Clinafloxacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Clinafloxacin, including repackagers and relabelers. The FDA regulates Clinafloxacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Clinafloxacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Clinafloxacin Suppliers

A Clinafloxacin supplier is an individual or a company that provides Clinafloxacin active pharmaceutical ingredient (API) or Clinafloxacin finished formulations upon request. The Clinafloxacin suppliers may include Clinafloxacin API manufacturers, exporters, distributors and traders.

Clinafloxacin GMP

Clinafloxacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Clinafloxacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Clinafloxacin GMP manufacturer or Clinafloxacin GMP API supplier for your needs.

Clinafloxacin CoA

A Clinafloxacin CoA (Certificate of Analysis) is a formal document that attests to Clinafloxacin's compliance with Clinafloxacin specifications and serves as a tool for batch-level quality control.

Clinafloxacin CoA mostly includes findings from lab analyses of a specific batch. For each Clinafloxacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Clinafloxacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Clinafloxacin EP), Clinafloxacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Clinafloxacin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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