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Chemistry

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Also known as: 21462-39-5, Clindamycin hcl, Cleocin, Clinsol, Clintabs, Antirobe
Molecular Formula
C18H34Cl2N2O5S
Molecular Weight
461.4  g/mol
InChI Key
AUODDLQVRAJAJM-XJQDNNTCSA-N
FDA UNII
T20OQ1YN1W

Clindamycin Hydrochloride
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
1 2D Structure

Clindamycin Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
2.1.2 InChI
InChI=1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
2.1.3 InChI Key
AUODDLQVRAJAJM-XJQDNNTCSA-N
2.1.4 Canonical SMILES
CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl
2.1.5 Isomeric SMILES
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
T20OQ1YN1W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7 Chloro 7 Deoxylincomycin

2. 7-chloro-7-deoxylincomycin

3. Chlolincocin

4. Chlorlincocin

5. Cleocin

6. Clindamycin

7. Clindamycin Monohydrochloride

8. Clindamycin Monohydrochloride, Monohydrate

9. Dalacin C

10. Hydrochloride, Clindamycin

11. Monohydrate Clindamycin Monohydrochloride

12. Monohydrochloride, Clindamycin

13. Monohydrochloride, Monohydrate Clindamycin

2.3.2 Depositor-Supplied Synonyms

1. 21462-39-5

2. Clindamycin Hcl

3. Cleocin

4. Clinsol

5. Clintabs

6. Antirobe

7. Sobelin

8. Clindamycin (hydrochloride)

9. Dalacin C

10. T20oq1yn1w

11. Clindamycin (as Hydrochloride)

12. Nsc-756696

13. (2s,4r)-n-((1s,2s)-2-chloro-1-((2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide Hydrochloride

14. U-21251f

15. 21462-39-5 (hcl)

16. Benzaclin

17. Dalacin (tn)

18. Mfcd07793327

19. (2s,4r)-n-[(1s,2s)-2-chloro-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride

20. Methyl-7-chloro-6,7,8-trideoxy-6-[[[(2s,4r)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-l-threo-?-d-galacto-octopyranoside Hydrochloride

21. Cleocin Hydrochloride

22. C18h33cln2o5s.hcl

23. Clinimycin Hcl

24. Antirobe Vet.

25. Cleocin Hcl

26. Sobelin Hcl

27. Ncgc00016752-01

28. Clindamycin Hcl (dalacin)

29. Unii-t20oq1yn1w

30. Cleocin Hydrochloride (tn)

31. Schembl3153

32. Cas-21462-39-5

33. Dsstox_cid_25428

34. Dsstox_rid_80872

35. Dsstox_gsid_45428

36. Chembl1200588

37. Dtxsid4045428

38. Hy-b0408a

39. Chebi:176915

40. Act02688

41. Amy33461

42. Einecs 244-398-6

43. Tox21_110591

44. Clindamycin Hydrochloride [mi]

45. Akos015843964

46. Akos015960823

47. Clindamycin Hydrochloride (jp17/usp)

48. Ccg-269349

49. Clindamycin Hydrochloride [jan]

50. Nsc 756696

51. 7-chloro-7-deoxylincomycin Hydrochloride

52. Clindamycin Hydrochloride [mart.]

53. Clindamycin Hydrochloride [vandf]

54. Ac-12179

55. As-13649

56. Clindamycin Hydrochloride [usp-rs]

57. Clindamycin Hydrochloride [usp:ban:jan]

58. Clindamycin Hydrochloride [who-dd]

59. Clindamycin Hydrochloride Anhydrous

60. U 21251f

61. 7(s)-chloro-7-deoxylincomycin Hyddrochloride

62. Clindamycin Hydrochloride [green Book]

63. Clindamycin Hydrochloride [ep Monograph]

64. Clindamycin Hydrochloride [orange Book]

65. D02132

66. Ec 244-398-6

67. Clindamycin Hydrochloride [usp Monograph]

68. Clindamycin Hydrochloride, Lincosamide Antibiotic

69. 462c395

70. A815398

71. A915128

72. Clindamycin Hydrochloride 100 Microg/ml In Methanol

73. Clindamycin Hydrochloride 1000 Microg/ml In Methanol

74. Q27289558

75. Clindamycin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

76. (2s,4r)-n-((1s,2s)-2-chloro-1-((2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamidehydrochloride

77. (2s,4r)-n-[(1s,2s)-2-chloro-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride

78. (4r)-n-[(1s,2s)-2-chloro-1-[(3r,4r,6r)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide Hydrochloride;clindamycin Hydrochloride

79. (4r)-n-[(1s,2s)-2-chloro-1-[(3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride

80. L-threo-.alpha.-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-,(2s-trans)-, Monohydrochloride

81. L-threo-alpha-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-((((2s,4r)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, Monohydrochloride

82. L-threo-alpha-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2s-trans)-, Monohydrochloride

83. L-threo-alpha-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-l-2-pyrrolidinyl)carbonyl)amino)-1-thio-, Monohydrochloride, Trans-alpha-

84. Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-.alpha.-d-galacto-octopyranoside Monohydrochloride

85. Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside Monohydrochloride

2.4 Create Date
2007-05-07
3 Chemical and Physical Properties
Molecular Weight 461.4 g/mol
Molecular Formula C18H34Cl2N2O5S
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass460.1565488 g/mol
Monoisotopic Mass460.1565488 g/mol
Topological Polar Surface Area128 Ų
Heavy Atom Count28
Formal Charge0
Complexity502
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 12  
Drug NameAcanya
PubMed HealthBenzoyl Peroxide/Clindamycin (On the skin)
Drug ClassesAntiacne, Antibacterial
Active IngredientBenzoyl peroxide; clindamycin phosphate
Dosage FormGel
RouteTopical
Strength1.2%; 2.5%
Market StatusPrescription
CompanyDow Pharm

2 of 12  
Drug NameBenzaclin
Active IngredientBenzoyl peroxide; clindamycin phosphate
Dosage FormGel
RouteTopical
Strength5%; eq 1% base
Market StatusPrescription
CompanyValeant Bermuda

3 of 12  
Drug NameCleocin
Drug LabelClindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.CLEOCIN HCl Capsules contain cl...
Active IngredientClindamycin palmitate hydrochloride; Clindamycin phosphate
Dosage FormSuppository; Swab; For solution; Cream
RouteTopical; Vaginal; Oral
Strengtheq 1% base; 100mg; eq 2% base; eq 75mg base/5ml
Market StatusPrescription
CompanyPharmacia And Upjohn

4 of 12  
Drug NameCleocin hydrochloride
PubMed HealthBenzoyl Peroxide/Clindamycin (On the skin)
Drug ClassesAntiacne, Antibacterial
Drug LabelClindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.CLEOCIN HCl Capsules contain cl...
Active IngredientClindamycin hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 300mg base; eq 150mg base; eq 75mg base
Market StatusPrescription
CompanyPharmacia And Upjohn

5 of 12  
Drug NameClindamycin hydrochloride
PubMed HealthClindamycin (Vaginal)
Drug ClassesAntibiotic
Drug LabelDESCRIPTIONClindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.The chemical name fo...
Active IngredientClindamycin hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 300mg base; eq 150mg base; eq 75mg base
Market StatusPrescription
CompanyCorepharma; Watson Labs; Mylan Pharms; Ranbaxy; Lannett; Teva; Aurobindo Pharma; Zydus Pharms Usa

6 of 12  
Drug NameDuac
Active IngredientBenzoyl peroxide; clindamycin phosphate
Dosage FormGel
RouteTopical
Strength5%; 1.2%
Market StatusPrescription
CompanyStiefel

7 of 12  
Drug NameAcanya
PubMed HealthBenzoyl Peroxide/Clindamycin (On the skin)
Drug ClassesAntiacne, Antibacterial
Active IngredientBenzoyl peroxide; clindamycin phosphate
Dosage FormGel
RouteTopical
Strength1.2%; 2.5%
Market StatusPrescription
CompanyDow Pharm

8 of 12  
Drug NameBenzaclin
Active IngredientBenzoyl peroxide; clindamycin phosphate
Dosage FormGel
RouteTopical
Strength5%; eq 1% base
Market StatusPrescription
CompanyValeant Bermuda

9 of 12  
Drug NameCleocin
Drug LabelClindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.CLEOCIN HCl Capsules contain cl...
Active IngredientClindamycin palmitate hydrochloride; Clindamycin phosphate
Dosage FormSuppository; Swab; For solution; Cream
RouteTopical; Vaginal; Oral
Strengtheq 1% base; 100mg; eq 2% base; eq 75mg base/5ml
Market StatusPrescription
CompanyPharmacia And Upjohn

10 of 12  
Drug NameCleocin hydrochloride
PubMed HealthBenzoyl Peroxide/Clindamycin (On the skin)
Drug ClassesAntiacne, Antibacterial
Drug LabelClindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.CLEOCIN HCl Capsules contain cl...
Active IngredientClindamycin hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 300mg base; eq 150mg base; eq 75mg base
Market StatusPrescription
CompanyPharmacia And Upjohn

11 of 12  
Drug NameClindamycin hydrochloride
PubMed HealthClindamycin (Vaginal)
Drug ClassesAntibiotic
Drug LabelDESCRIPTIONClindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.The chemical name fo...
Active IngredientClindamycin hydrochloride
Dosage FormCapsule
RouteOral
Strengtheq 300mg base; eq 150mg base; eq 75mg base
Market StatusPrescription
CompanyCorepharma; Watson Labs; Mylan Pharms; Ranbaxy; Lannett; Teva; Aurobindo Pharma; Zydus Pharms Usa

12 of 12  
Drug NameDuac
Active IngredientBenzoyl peroxide; clindamycin phosphate
Dosage FormGel
RouteTopical
Strength5%; 1.2%
Market StatusPrescription
CompanyStiefel

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Lincosamide Antibacterial [EPC]; Lincosamides [CS]; Neuromuscular Blockade [PE]; Decreased Sebaceous Gland Activity [PE]

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Nuray Chemicals Private Limited

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Rochem International Inc

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Alchymars ICM SM

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Zhejiang Hisoar Pharmaceutical

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Nanyang Pukang Pharmaceutical Co.,...

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UQUIFA

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Virtual BoothNuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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Clindamycin Hydrochloride

About the Company : Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in th...

Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in the Indian state of Tamil Nadu. Nuray’s expertise and experience lie in developing the chemistry requirements of the pharmaceutical industry, including the synthesis of NCEs, impurities, metabolites, method development, advanced intermediates and APIs for commercial launch. With its focus on maintaining the highest levels of quality, reliability and transparency, Nuray has emerged as a trusted partner in the global generic market.
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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Clindamycin Hydrochloride

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
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About the Company : We are a privately held Italian company founded in 1973. We are a fully integrated manufacturer of Cephalosporin, Carbapenem and Penicillin APIs as well as Finished Dosage Formula...

We are a privately held Italian company founded in 1973. We are a fully integrated manufacturer of Cephalosporin, Carbapenem and Penicillin APIs as well as Finished Dosage Formulations (Solid and Injectable). We export our products to MORE than 100 countries all over the world. Our production sites, most of them regularly inspected by EUROPEN AND USA AUTHORITIES (FDA), have strict Quality Standards and our R&D Know-how make us a leading company. Our Commitment: to work in the present while concentrating on the future, because on markets where research and technology are factors of primary importance.
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About the Company : ALCHYMARS ICM SM PRIVATE LIMITED is a financial services company based out of Tamil Nadu, India. Alchymars Icm Sm Private Limited is a Private incorporated on 21 January 2000. It i...

ALCHYMARS ICM SM PRIVATE LIMITED is a financial services company based out of Tamil Nadu, India. Alchymars Icm Sm Private Limited is a Private incorporated on 21 January 2000. It is classified as Non-govt company and is registered at Registrar of Companies, Chennai. Its authorized share capital is Rs. 112,000,000 and its paid up capital is Rs. 104,516,008. It is inolved in Other financial intermediation
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Concord Biotech Limited is a leading vertically integrated, R&D driven biotechnological powerhouse that manufactures Active Pharmaceutical Ingredients through fermentation & semi-synthetic process and Finished formulations. Concord founded in the year 2000 has transformed from a single-product company to a broad-spectrum solution provider, offering products across diversified therapeutic segments. Concord is globally known for its products and has a commanding presence in more than 50 countries worldwide with efficient distribution infrastructure in markets like North America, Europe, Japan, Central & Latin America, Africa, Australia, etc.
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CLINDAMYCIN HYDROCHLORIDE

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HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, Thinkchem specializes in exporting pharmaceuticals, veterinary drugs, feed additives, intermediates, fine chemicals, plants extracts, pesticides, food & nutrition additives. Thinkchem is good at offering excellent outsourcing services to overseas customers as well as laboratory support. Thinkchem is equipped with modern lab apparatus including HPLC, GC. TLC AND NMR, motivated by a team of highly qualified personnel using these equipments.
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About the Company : HENGDIAN GROUP was established in 1975, till now it has become a transnational,conglomerate group and been one of the largest private-owned enterprises in China. The Pharmaceutical...

HENGDIAN GROUP was established in 1975, till now it has become a transnational,conglomerate group and been one of the largest private-owned enterprises in China. The Pharmaceutical & Chemical division has 3 sub-companies with over 3,000 employees of which over 30% are technicians; This division is mainly producing APIs, Agrochemical and Dyestuffs with related intermediates as well as other special chemicals. The group also focuses on CONTRACT MANUFACTURE service under GMP and confidential agreement with our clients.
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Trifarma

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Clindamycin Hydrochloride

About the Company : TRIFARMA S.p.A. is an international and independent Group with the Mission to develop, manufacture and supply worldwide high quality APIs (Active Pharmaceutical Ingredients) to the...

TRIFARMA S.p.A. is an international and independent Group with the Mission to develop, manufacture and supply worldwide high quality APIs (Active Pharmaceutical Ingredients) to the global pharmaceutical industry. In order to further improve its presence on the globalized pharmaceutical marketplace, the two Italian API factories (formerly named Alchymars SpA and ICM Industria Chimica Milanese SpA) have merged into TRIFARMA SpA, thus creating a larger and industrially, commercially stronger organization. The Shareholders of Trifarma also control the Indian company Alchymars ICM SM Pvt Ltd (abbreviated as AIS) located in Chennai, India.
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09

Unipex

France
Antibody Engineering
Not Confirmed
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Unipex

France
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Antibody Engineering
Not Confirmed

CLINDAMYCIN HYDROCHLORIDE

About the Company : Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build ar...

Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build are made to last. They are built on professionalism, respect and transparency. This is how we work, and how we have been working for a long time now, with our client partners and constituents. Unipex has been operational for 50 years, and has always remained true to its core business: the distribution of specialities. This is also why we are independent and we intend to stay that way. Our structure is simple, our commitment is absolute: we work directly with you.
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10

UQUIFA

Spain
Antibody Engineering
Not Confirmed
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UQUIFA

Spain
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Antibody Engineering
Not Confirmed

Clindamycin Hydrochloride

About the Company : With over 85 years of experience, Uquifa provides comprehensive services supporting projects from proof of concept to commercial manufacturing. Uquifa’s business model is built o...

With over 85 years of experience, Uquifa provides comprehensive services supporting projects from proof of concept to commercial manufacturing. Uquifa’s business model is built on a quality manufacturing platform and a strong track record of service and reliability. Uquifa Group manufactures Active Pharmaceutical Ingredients (APIs) and intermediates for the global pharmaceutical and animal health industries.
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13-Jan-2021
30-Oct-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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