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Clindamycin Palmitate

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2 SPI Pharma
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1 Gangwal Healthcare
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Synopsis

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Chemistry

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Also known as: Clindamycin palmitate hcl, 25507-04-4, Cleocin pediatric, Clindamycin 2-palmitate hydrochloride, Vn9a8jm7m7, U-25,179 e

Molecular Formula

C₃₄H₆₄Cl₂N₂O₆S

Molecular Weight

699.9 g/mol

InChI Key

GTNDZRUWKHDICY-DJHAJVGHSA-N

FDA UNII

VN9A8JM7M7

Clindamycin Palmitate Hydrochloride is the palmitate hydrochloride form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin palmitate hydrochloride is used for oral suspension.

1 2D Structure

Clindamycin Palmitate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] hexadecanoate;hydrochloride

2.1.2 InChI

InChI=1S/C34H63ClN2O6S.ClH/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-21-27(38)42-32-30(40)29(39)31(43-34(32)44-5)28(24(3)35)36-33(41)26-22-25(20-7-2)23-37(26)4;/h24-26,28-32,34,39-40H,6-23H2,1-5H3,(H,36,41);1H/t24-,25+,26-,28+,29+,30-,31+,32+,34+;/m0./s1

2.1.3 InChI Key

GTNDZRUWKHDICY-DJHAJVGHSA-N

2.1.4 Canonical SMILES

CCCCCCCCCCCCCCCC(=O)OC1C(C(C(OC1SC)C(C(C)Cl)NC(=O)C2CC(CN2C)CCC)O)O.Cl

2.1.5 Isomeric SMILES

CCCCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1SC)[C@@H]([C@H](C)Cl)NC(=O)[C@@H]2C[C@H](CN2C)CCC)O)O.Cl

2.2 Other Identifiers

2.2.1 UNII

VN9A8JM7M7

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 7-chloro-7-deoxylincomycin Palmitate

2. 7-chlorolincomycin Palmitate

3. Cleocin Palmitate

4. Clindamycin Palmitate

2.3.2 Depositor-Supplied Synonyms

1. Clindamycin Palmitate Hcl

2. 25507-04-4

3. Cleocin Pediatric

4. Clindamycin 2-palmitate Hydrochloride

5. Vn9a8jm7m7

6. U-25,179 E

7. 25507-04-4 (palmitate Hcl)

8. Nsc-759141

9. U-25179e

10. U-25179-e

11. Clindamycin Palmitate (hydrochloride)

12. (2r,3r,4s,5r,6r)-6-((1s,2s)-2-chloro-1-((2s,4r)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2h-pyran-3-yl Palmitate

13. (2r,3r,4s,5r,6r)-6-((1s,2s)-2-chloro-1-((2s,4r)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2h-pyran-3-yl Palmitate Hydrochloride

14. [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] Hexadecanoate;hydrochloride

15. Unii-vn9a8jm7m7

16. Ncgc00185773-02

17. U 25179e

18. Cleocin Pediatric (tn)

19. Dsstox_cid_28660

20. Dsstox_rid_82930

21. Dsstox_gsid_48734

22. Schembl41416

23. Clindamycin Palmitate Hydrochloride [usan:usp:jan]

24. Chembl1200632

25. Dtxsid3048734

26. Niosh/gf2450000

27. Chebi:34647

28. Hy-b1454

29. Tox21_113175

30. Mfcd09752824

31. Akos030242182

32. Ccg-270385

33. Nsc 759141

34. As-58470

35. Clindamycin-2-palmitate, Monohydrochloride

36. Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside 2-palmitate Monohydrochloride

37. Cas-25507-04-4

38. Cs-0013162

39. Gf24500000

40. Clindamycin Palmitate Hydrochloride (jan/usp)

41. D01990

42. F20748

43. Clindamycin Palmitate Hydrochloride [jan]

44. Clindamycin Palmitate Hydrochloride [mart.]

45. Clindamycin Palmitate Hydrochloride [usan]

46. Clindamycin Palmitate Hydrochloride [vandf]

47. Clindamycin Palmitate Hydrochloride [usp-rs]

48. Clindamycin Palmitate Hydrochloride [who-dd]

49. J-016026

50. Q27291919

51. Clindamycin Palmitate Hydrochloride [orange Book]

52. Clindamycin Palmitate Hydrochloride [usp Monograph]

53. L-threo-.alpha.-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-2-hexadecanoate, Monohydrochloride, (2s-trans)-

54. L-threo-alpha-d-galacto-octopyranoside, Methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-2-hexadecanoate, Monohydrochloride, (2s-trans)-

55. Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-.alpha.-d-galacto-octopyranoside 2-palmitate Monohydrochloride

2.4 Create Date

2007-05-07

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₆₄Cl₂N₂O₆S
Molecular Weight	699.9 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	23
Exact Mass	698.3862143 g/mol
Monoisotopic Mass	698.3862143 g/mol
Topological Polar Surface Area	134 Å²
Heavy Atom Count	45
Formal Charge	0
Complexity	810
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Clindamycin palmitate hydrochloride
Drug Label	Clindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compoun...
Active Ingredient	Clindamycin palmitate hydrochloride
Dosage Form	For solution
Route	Oral
Strength	eq 75mg base/5ml
Market Status	Prescription
Company	Lyne; Amneal Pharms; Paddock Labs; Aurobindo Pharma

2 of 2
Drug Name	Clindamycin palmitate hydrochloride
Drug Label	Clindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compoun...
Active Ingredient	Clindamycin palmitate hydrochloride
Dosage Form	For solution
Route	Oral
Strength	eq 75mg base/5ml
Market Status	Prescription
Company	Lyne; Amneal Pharms; Paddock Labs; Aurobindo Pharma

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Lincosamide Antibacterial [EPC]; Lincosamides [CS]; Neuromuscular Blockade [PE]; Decreased Sebaceous Gland Activity [PE]

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[{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705429800,"product":"CLINDAMYCIN PALMITATE HCL","address":"Floor No.22, Plot No.1, Survey No.83\/1, Galaxy Tower","city":"Hyderabad","supplier":"APITORIA PHARMA PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. K","customer":"APPCO PHARMACEUTICAL CORP","customerCountry":"UNITED STATES","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"1200","totalValueFC":"295572.2","currency":"USD","unitRateINR":98262.039999999994,"date":"17-Jan-2024","totalValueINR":"24565510","totalValueInUsd":"295572.2","indian_port":"Hyderabad Air","hs_no":"29241900","bill_no":"6803947","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"Floor No.22, Plot No.1, Survey No.83\/1, Galaxy Tower, Hyderabad","customerAddress":""},{"dataSource":"API Import","activeIngredients":"CLINDAMYCIN PALMITATE","year":"2021","qtr":"Q1","strtotime":1610044200,"product":"CLINDAMYCIN PALMITATE HYDROCHLORIDE","address":"TUNG BALAMAJITHA ROAD","city":"AMRITSAR,PUNJAB","supplier":"HIGHPHARM MEDCHEM CO.LTD","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1080","totalValueFC":"1092.7","currency":"USD","unitRateINR":"79920","date":"08-Jan-2021","totalValueINR":"79920","totalValueInUsd":"1092.7","indian_port":"DELHI AIR","hs_no":"29339990","bill_no":"2275765","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"","customerAddress":"TUNG BALAMAJITHA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693593000,"product":"CPA-202112001 CLINDAMYCIN PALMITATE(2.5KG)","address":"FIRST FLOOR","city":"CHENNAI","supplier":"CHONGQING CARELIFE PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"STHREE CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"2.50","actualQuantity":"2.5","unit":"KGS","unitRateFc":"600","totalValueFC":"1516.1","currency":"USD","unitRateINR":"50340","date":"02-Sep-2023","totalValueINR":"125850","totalValueInUsd":"1516.1","indian_port":"Madras Air","hs_no":"29419090","bill_no":"7646255","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"3 HUA NANYI ROAD CHONGQING(CHANGSHOCHEMICAL INDUSTRY PARK CHONGQING CHSDNF CN","customerAddress":"FIRST FLOOR"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695061800,"product":"CPA-202309901 CLINDAMYCIN PALMITATE HYDROCHLORIDE (20 KG)(100% EOU)","address":"FIRST FLOOR","city":"CHENNAI","supplier":"CHONGQING CARELIFE PHARMACEUTICAL","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"STHREE CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"600","totalValueFC":"12136.1","currency":"USD","unitRateINR":"50370","date":"19-Sep-2023","totalValueINR":"1007400","totalValueInUsd":"12136.1","indian_port":"Madras Air","hs_no":"29419090","bill_no":"7900236","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"3 HUA NANYI ROAD CHONGQING(CHANGSHOCHEMICAL INDUSTRY PARK CHONGQING CHSDNF CN","customerAddress":"FIRST FLOOR"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698949800,"product":"CLINDAMYCIN PALMITATE HYDROCHLORIDE(100% EOU)","address":"FIRST FLOOR","city":"CHENNAI","supplier":"GANGXIANG INTERNATIONAL HOLDINGS (HK) LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"STHREE CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"650","totalValueFC":"13137.2","currency":"USD","unitRateINR":"54697.5","date":"03-Nov-2023","totalValueINR":"1093950","totalValueInUsd":"13137.2","indian_port":"Madras Air","hs_no":"29419090","bill_no":"8604136","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"LEVEL 54 HOPEWELL CENTRE 183 QUEENSROAD EAST HKSDNF HK","customerAddress":"FIRST FLOOR"}]

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Clindamycin Palmitate

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

13 API Suppliers

8 USDMF

1 EU WC

8 NDC API

7 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

10 FDF Dossiers

9 FDA Orange Book

1 Canada

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

2 SPI Pharma

2 DKSH

1 Faran Shimi Pharmaceutical

1 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

1 Pfanstiehl

2 Actylis

1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 BASF

2 Gangwal Chemicals

1 Nanjing Bold Chemical

1 Pluviaendo

5 Roquette

1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

6 Thickeners and Stabilizers

6 Fillers, Diluents & Binders

5 Taste Masking

5 Direct Compression

3 Solubilizers

3 Emulsifying Agents

2 Coating Systems & Additives

2 Parenteral

2 Granulation

2 Lubricants & Glidants

1 Co-Processed Excipients

1 API Stability Enhancers

1 Film Formers & Plasticizers

1 Topical

1 Controlled & Modified Release

1 Chewable & Orodispersible Aids

DIGITAL CONTENT

3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 Finished Drug Prices

1 Annual Reports

MARKET PLACE

4 APIs

REF. STANDARDS & IMPURITIES

1 USP

1 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 1,260

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

23 RELATED EXCIPIENT COMPANIES

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