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Chemistry

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Also known as: 4258-85-9, Sh 818, Clocortolone acetate [usan], Clocortolone 21-acetate, 85061htr8t, Sh-818
Molecular Formula
C24H30ClFO5
Molecular Weight
452.9  g/mol
InChI Key
ARPLCFGLEYFDCN-CDACMRRYSA-N
FDA UNII
85061HTR8T

Clocortolone Acetate
1 2D Structure

Clocortolone Acetate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
2.1.2 InChI
InChI=1S/C24H30ClFO5/c1-12-7-15-16-9-18(26)17-8-14(28)5-6-23(17,4)24(16,25)20(30)10-22(15,3)21(12)19(29)11-31-13(2)27/h5-6,8,12,15-16,18,20-21,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,20+,21-,22+,23+,24+/m1/s1
2.1.3 InChI Key
ARPLCFGLEYFDCN-CDACMRRYSA-N
2.1.4 Canonical SMILES
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)COC(=O)C)C)O)Cl)C)F
2.1.5 Isomeric SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)COC(=O)C)C)O)Cl)C)F
2.2 Other Identifiers
2.2.1 UNII
85061HTR8T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Clocortolone

2.3.2 Depositor-Supplied Synonyms

1. 4258-85-9

2. Sh 818

3. Clocortolone Acetate [usan]

4. Clocortolone 21-acetate

5. 85061htr8t

6. Sh-818

7. Clocortolone Acetate (usan)

8. [2-[(6s,8s,9r,10s,11s,13s,14s,16r,17s)-9-chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

9. Unii-85061htr8t

10. Schembl618722

11. Chembl2106011

12. Chebi:177410

13. Clocortolone 21-acetate [mi]

14. Db14652

15. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-

16. D03541

17. Q27269574

18. [2-[(6s,8s,9r,10s,11s,13s,14s,16r,17s)-9-chloro-6-luoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

19. 9-chloro-6.alpha.-fluoro-11.beta.,21-dihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 21-acetate

20. 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate

21. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methyl-, (6 Alpha,11 Beta, 16 Alpha)-

22. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methyl-, (6alpha,11beta,16alpha)-

2.4 Create Date
2006-11-22
3 Chemical and Physical Properties
Molecular Weight 452.9 g/mol
Molecular Formula C24H30ClFO5
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass452.1765799 g/mol
Monoisotopic Mass452.1765799 g/mol
Topological Polar Surface Area80.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity898
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)


ABOUT THIS PAGE

Clocortolone Acetate Manufacturers

A Clocortolone Acetate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Clocortolone Acetate, including repackagers and relabelers. The FDA regulates Clocortolone Acetate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Clocortolone Acetate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Clocortolone Acetate Suppliers

A Clocortolone Acetate supplier is an individual or a company that provides Clocortolone Acetate active pharmaceutical ingredient (API) or Clocortolone Acetate finished formulations upon request. The Clocortolone Acetate suppliers may include Clocortolone Acetate API manufacturers, exporters, distributors and traders.

click here to find a list of Clocortolone Acetate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Clocortolone Acetate USDMF

A Clocortolone Acetate DMF (Drug Master File) is a document detailing the whole manufacturing process of Clocortolone Acetate active pharmaceutical ingredient (API) in detail. Different forms of Clocortolone Acetate DMFs exist exist since differing nations have different regulations, such as Clocortolone Acetate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Clocortolone Acetate DMF submitted to regulatory agencies in the US is known as a USDMF. Clocortolone Acetate USDMF includes data on Clocortolone Acetate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Clocortolone Acetate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Clocortolone Acetate suppliers with USDMF on PharmaCompass.

Clocortolone Acetate GMP

Clocortolone Acetate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Clocortolone Acetate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Clocortolone Acetate GMP manufacturer or Clocortolone Acetate GMP API supplier for your needs.

Clocortolone Acetate CoA

A Clocortolone Acetate CoA (Certificate of Analysis) is a formal document that attests to Clocortolone Acetate's compliance with Clocortolone Acetate specifications and serves as a tool for batch-level quality control.

Clocortolone Acetate CoA mostly includes findings from lab analyses of a specific batch. For each Clocortolone Acetate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Clocortolone Acetate may be tested according to a variety of international standards, such as European Pharmacopoeia (Clocortolone Acetate EP), Clocortolone Acetate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Clocortolone Acetate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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