Find Clocortolone Pivalate manufacturers, exporters & distributors on PharmaCompass

Clocortolone Pivalate

EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

7 API Suppliers, 5 USDMF, 2 NDC API, 5 Listed Suppliers

7 API Suppliers
5 USDMF
2 NDC API
5 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 FDA Orange Book

2 FDF Dossiers
2 FDA Orange Book

RELATED EXCIPIENT COMPANIES

1 DKSH, 1 Nanjing Well Pharmaceutical, 1 BASF

relatedExcipients
1 DKSH
1 Nanjing Well Pharmaceutical
1 BASF

EXCIPIENTS BY APPLICATIONS

1 Granulation, 1 Direct Compression, 1 Solubilizers, 1 Topical, 1 Lubricants & Glidants, 1 Parenteral

excipientsByApplications
1 Granulation
1 Direct Compression
1 Solubilizers
1 Topical
1 Lubricants & Glidants
1 Parenteral

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 3 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions

globalSalesInformation
2 US Medicaid Prescriptions

MARKET PLACE

1 APIs

marketPlace
1 APIs

REF. STANDARDS & IMPURITIES

1 USP , 2 Others

otherSolutions
1 USP
2 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

335,113

Annual Reports (USD Million)

Finished Drug Prices

3 RELATED EXCIPIENT COMPANIES

6EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 34097-16-0, Clocortolone 21-pivalate, Cloderm, Sh 863, Qbl8izh14x, Purantix

Molecular Formula

C₂₇H₃₆ClFO₅

Molecular Weight

495.0 g/mol

InChI Key

SXYZQZLHAIHKKY-GSTUPEFVSA-N

FDA UNII

QBL8IZH14X

Clocortolone Pivalate is a glucocorticoid receptor agonist with metabolic, anti-inflammatory, and immunosuppressive activity. Clocortolone pivalate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished.

1 2D Structure

Clocortolone Pivalate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate

2.1.2 InChI

InChI=1S/C27H36ClFO5/c1-14-9-16-17-11-19(29)18-10-15(30)7-8-26(18,6)27(17,28)21(32)12-25(16,5)22(14)20(31)13-34-23(33)24(2,3)4/h7-8,10,14,16-17,19,21-22,32H,9,11-13H2,1-6H3/t14-,16+,17+,19+,21+,22-,25+,26+,27+/m1/s1

2.1.3 InChI Key

SXYZQZLHAIHKKY-GSTUPEFVSA-N

2.1.4 Canonical SMILES

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)COC(=O)C(C)(C)C)C)O)Cl)C)F

2.1.5 Isomeric SMILES

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)COC(=O)C(C)(C)C)C)O)Cl)C)F

2.2 Other Identifiers

2.2.1 UNII

QBL8IZH14X

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cl 68

2. Clocortolone Trimethylacetate

3. Cloderm

4. Purantix

2.3.2 Depositor-Supplied Synonyms

1. 34097-16-0

2. Clocortolone 21-pivalate

3. Cloderm

4. Sh 863

5. Qbl8izh14x

6. Purantix

7. Clocortolone Pivalate (200 Mg)

8. Mls002154165

9. [2-[(6s,8s,9r,10s,11s,13s,14s,16r,17s)-9-chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate

10. Chebi:59583

11. Sh-863

12. 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate

13. Cilder

14. Cl 68

15. 9-chloro-6alpha-fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate

16. Unii-qbl8izh14x

17. Clocortolone Pivalate [usan]

18. Clocortolone Pivalate [usan:usp]

19. Ncgc00016824-01

20. Pregna-1,4-diene-3,20-dione, 9-chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-

21. Clocortolone-pivalate

22. Cloderm (tn)

23. Einecs 251-826-5

24. Cas-34097-16-0

25. Prestwick0_001119

26. Prestwick1_001119

27. Prestwick2_001119

28. Prestwick3_001119

29. Schembl5120

30. Dsstox_cid_25460

31. Dsstox_rid_80891

32. Clocortolone Pivalate (usp)

33. Dsstox_gsid_45460

34. Bspbio_001258

35. Spbio_003119

36. Bpbio1_001383

37. Chembl1200975

38. Dtxsid0045460

39. Hms1571o20

40. Hms2098o20

41. Hms2236m06

42. Hms3715o20

43. 9-chloro-6.alpha.-fluoro-11.beta.,21-dihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 21-pivalate

44. Zinc4212603

45. Tox21_110632

46. Clocortolone Pivalate [vandf]

47. Clocortolone Pivalate [mart.]

48. Clocortolone Pivalate [usp-rs]

49. Clocortolone Pivalate [who-dd]

50. Ccg-221119

51. Clocortolone 21-pivalate [mi]

52. Ncgc00179239-01

53. Ncgc00179239-05

54. Smr001233464

55. Clocortolone Pivalate [orange Book]

56. Ab00514058

57. Clocortolone Pivalate [usp Monograph]

58. D02287

59. Sr-01000838872

60. Sr-01000838872-2

61. Brd-k38003476-001-03-4

62. Q39045318

63. (6alpha,11beta,16alpha)-9-chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methypregna-1,4-diene-3,20-dione

64. 9-chloro-6

65. A-fluoro-11

66. A,21-dihydroxy-16

67. A-methylpregna-1,4-diene-3,20-dione 21-pivalate Pound Clocortolone Pivalate)

68. 9alpha-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate

69. Pregna-1,4-diene-3,20-dione, 9-chloro-21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-, (6alpha,11beta,16alpha)-

2.4 Create Date

2005-10-11

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₃₆ClFO₅
Molecular Weight	495.0 g/mol
XLogP3	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	494.2235301 g/mol
Monoisotopic Mass	494.2235301 g/mol
Topological Polar Surface Area	80.7 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	982
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Cloderm
PubMed Health	Clocortolone Pivalate (On the skin)
Drug Classes	Corticosteroid, Weak
Drug Label	Cloderm Cream 0.1% contains the medium potency topical corticosteroid, clocortolone pivalate, in a specially formulated water-washable emollient cream base consisting of purified water, white petrolatum, mineral oil, stearyl alcohol, polyoxyl 40 stea...
Active Ingredient	Clocortolone pivalate
Dosage Form	Cream
Route	Topical
Strength	0.1%
Market Status	Prescription
Company	Promius Pharma

2 of 2
Drug Name	Cloderm
PubMed Health	Clocortolone Pivalate (On the skin)
Drug Classes	Corticosteroid, Weak
Drug Label	Cloderm Cream 0.1% contains the medium potency topical corticosteroid, clocortolone pivalate, in a specially formulated water-washable emollient cream base consisting of purified water, white petrolatum, mineral oil, stearyl alcohol, polyoxyl 40 stea...
Active Ingredient	Clocortolone pivalate
Dosage Form	Cream
Route	Topical
Strength	0.1%
Market Status	Prescription
Company	Promius Pharma

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

API SUPPLIERS