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1. Chlormethiazole
2. Distraneurin
1. 533-45-9
2. Chlormethiazole
3. 5-(2-chloroethyl)-4-methylthiazole
4. Distraneurin
5. 5-(2-chloroethyl)-4-methyl-1,3-thiazole
6. Chlorethiazol
7. Chlormethiazol
8. Clomethiazolum
9. Emineurina
10. Somnevrin
11. Thiazole, 5-(2-chloroethyl)-4-methyl-
12. Clomethiazole [inn]
13. Chloro-s.c.t.z.
14. Distraneurine
15. Wy 1485
16. Sctz [as Edisylate]
17. 0c5dbz19hv
18. Chlorethiazole
19. Clomethiazole (inn)
20. Ncgc00024842-02
21. Clometiazole
22. Dsstox_cid_2842
23. C6h8clns
24. Dsstox_rid_76753
25. Dsstox_gsid_22842
26. Clometiazolo [dcit]
27. Chloraethiazol
28. Clometiazol
29. Clometiazolo
30. Clometiazol [inn-spanish]
31. Clomethiazolum [inn-latin]
32. Cas-533-45-9
33. Einecs 208-565-7
34. Clomethiazole [inn:ban]
35. Unii-0c5dbz19hv
36. 4-methyl-5-(beta-chloroethyl)thiazole
37. Brn 0114244
38. Distraneurine (tn)
39. Sctz (salt/mix)
40. Tocris-0881
41. Heminevrin (salt/mix)
42. Clomethiazole [mi]
43. Biomol-nt_000260
44. Schembl35223
45. 4-27-00-00990 (beilstein Handbook Reference)
46. Mls004754487
47. Clomethiazole [mart.]
48. Clomethiazole [who-dd]
49. Bpbio1_000815
50. Chembl315795
51. Zinc1192
52. Dtxsid6022842
53. Chebi:92875
54. Bdbm234400
55. Clomethiazole [nflis-drug]
56. Tox21_110931
57. Mfcd00868012
58. 4-methyl-5-(2-chloroethyl)-thiazole
59. Akos011348416
60. Tox21_110931_1
61. Ab07565
62. Db06470
63. Sdccgsbi-0633688.p001
64. 5-(2-chloro-ethyl)-4-methyl-thiazole
65. Ncgc00024842-01
66. Ncgc00024842-03
67. Ncgc00024842-04
68. Ncgc00024842-05
69. 4-methyl-5-(.beta.-chloroethyl)thiazole
70. Ac-33175
71. As-13864
72. Smr002529479
73. Db-071667
74. Hy-129105
75. Cs-0103601
76. Ft-0659713
77. En300-60459
78. 33c459
79. 5-(2-chloroethyl)-4-methyl-1,3-thiazole #
80. D07330
81. Q417178
82. W-203012
83. Brd-k50422030-001-01-2
84. Brd-k50422030-003-01-8
85. Z1259086813
| Molecular Weight | 161.65 g/mol |
|---|---|
| Molecular Formula | C6H8ClNS |
| XLogP3 | 2.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 161.0065981 g/mol |
| Monoisotopic Mass | 161.0065981 g/mol |
| Topological Polar Surface Area | 41.1 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 89.1 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in strokes.
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)
Hypnotics and Sedatives
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)
N - Nervous system
N05 - Psycholeptics
N05C - Hypnotics and sedatives
N05CM - Other hypnotics and sedatives
N05CM02 - Clomethiazole
Clomethiazole has known human metabolites that include NLA-715.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system
FDF Dossiers
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ABOUT THIS PAGE
A Clomethiazole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Clomethiazole, including repackagers and relabelers. The FDA regulates Clomethiazole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Clomethiazole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Clomethiazole manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Clomethiazole supplier is an individual or a company that provides Clomethiazole active pharmaceutical ingredient (API) or Clomethiazole finished formulations upon request. The Clomethiazole suppliers may include Clomethiazole API manufacturers, exporters, distributors and traders.
click here to find a list of Clomethiazole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Clomethiazole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Clomethiazole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Clomethiazole GMP manufacturer or Clomethiazole GMP API supplier for your needs.
A Clomethiazole CoA (Certificate of Analysis) is a formal document that attests to Clomethiazole's compliance with Clomethiazole specifications and serves as a tool for batch-level quality control.
Clomethiazole CoA mostly includes findings from lab analyses of a specific batch. For each Clomethiazole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Clomethiazole may be tested according to a variety of international standards, such as European Pharmacopoeia (Clomethiazole EP), Clomethiazole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Clomethiazole USP).
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