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Chemistry

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Also known as: 17321-77-6, Clomipramine hcl, Anafranil, 3-(3-chloro-10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine hydrochloride, Chlorimipramine hydrochloride, 3-chloroimipramine hydrochloride
Molecular Formula
C19H24Cl2N2
Molecular Weight
351.3  g/mol
InChI Key
WIMWMKZEIBHDTH-UHFFFAOYSA-N
FDA UNII
2LXW0L6GWJ

Clomipramine Hydrochloride
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
1 2D Structure

Clomipramine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
2.1.3 InChI Key
WIMWMKZEIBHDTH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
2LXW0L6GWJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Anafranil

2. Chlomipramine

3. Chlorimipramine

4. Clomipramine

5. Clomipramine Maleate (1:1)

6. Clomipramine Monohydrochloride

7. Hydiphen

8. Hydrochloride, Clomipramine

9. Monohydrochloride, Clomipramine

2.3.2 Depositor-Supplied Synonyms

1. 17321-77-6

2. Clomipramine Hcl

3. Anafranil

4. 3-(3-chloro-10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine Hydrochloride

5. Chlorimipramine Hydrochloride

6. 3-chloroimipramine Hydrochloride

7. Chloroimipramine Monohydrochloride

8. Clomipramine (hydrochloride)

9. Clomipramine Monohydrochloride

10. 2lxw0l6gwj

11. Nsc-759323

12. G 34586

13. Mls000028511

14. Chebi:3755

15. G-34586

16. 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(b,f)azepine Monohydrochloride

17. 5h-dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-n,n-dimethyl-, Monohydrochloride

18. Anaphranil

19. Smr000058295

20. Anafranil (tn)

21. 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-n,n-dimethylpropan-1-amine;hydrochloride

22. (3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine Hydrochloride

23. 3-(3-chloro-10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-aminium Chloride

24. 5h-dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-n,n-dimethyl-, Hydrochloride (1:1)

25. Anafranil Hydrochloride

26. Sr-01000003088

27. Einecs 241-344-3

28. Unii-2lxw0l6gwj

29. Cas-17321-77-6

30. Clomipramine, Hcl

31. Prestwick_72

32. Mfcd00069234

33. Vr-776

34. Cpd000058295

35. I615

36. Opera_id_368

37. Clomipramine Hydrochloride [usan:usp:jan]

38. Dsstox_cid_22633

39. Dsstox_rid_80064

40. Dsstox_gsid_42633

41. Schembl41747

42. Mls001074205

43. Mls002222159

44. Mls002548879

45. Spectrum2300061

46. Regid_for_cid_68539

47. Chembl1200710

48. Clomipramine-[d6] Hydrochloride

49. Dtxsid3042633

50. Clomipramine Hydrochloride- Bio-x

51. Hms1568f20

52. Pharmakon1600-02300061

53. Amy40405

54. Bcp28468

55. Hy-b0457

56. Tox21_301819

57. Tox21_500307

58. Ccg-39492

59. Nsc759323

60. S2541

61. Anafranil Hydrochloride; Chloripramine

62. Akos015895084

63. Clomipramine Hydrochloride (anafranil)

64. Ac-8082

65. Clomipramine Hydrochloride (jp17/usp)

66. Clomipramine Hydrochloride [mi]

67. Ks-1044

68. Lp00307

69. Nc00678

70. Nsc 759323

71. (non-labelled)clomipramine-13c-d3 Hcl

72. Clomipramine Hydrochloride [jan]

73. Clomipramine Hydrochloride [usan]

74. Ncgc00093756-01

75. Ncgc00093756-02

76. Ncgc00093756-03

77. Ncgc00093756-04

78. Ncgc00178275-01

79. Ncgc00178275-02

80. Ncgc00255897-01

81. Ncgc00260992-01

82. 5h-dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-, Monohydrochloride

83. Bc164325

84. Clomipramine Hydrochloride [mart.]

85. Clomipramine Hydrochloride [vandf]

86. Clomipramine Hydrochloride [usp-rs]

87. Clomipramine Hydrochloride [who-dd]

88. Eu-0100307

89. Ft-0623989

90. Sw196384-4

91. C 7291

92. Clomipramine Hydrochloride [green Book]

93. Clomipramine Hydrochloride [orange Book]

94. D00811

95. Mls-0090819.0001

96. Clomipramine Hydrochloride [ep Monograph]

97. 321c776

98. Clomipramine Hydrochloride [usp Monograph]

99. Clomipramine Hydrochloride, >=98% (hplc), Powder

100. Sr-01000003088-2

101. Sr-01000003088-4

102. Sr-01000003088-5

103. Sr-01000003088-9

104. Q27106187

105. Clomipramine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

106. Clomipramine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

107. 3-chloro-10,11-dihydro-n,n-dimethyl-5h-dibenz(z)[b,f]azepine-5-propanamine Hydrochloride

108. Clomipramine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

109. Clomipramine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

110. 3-(3-chloro-10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine Hcl

111. Clomipramine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

112. Clomipramine Hydrochloride, For Microbiological Assay, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 351.3 g/mol
Molecular Formula C19H24Cl2N2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass350.1316542 g/mol
Monoisotopic Mass350.1316542 g/mol
Topological Polar Surface Area6.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity346
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAnafranil
PubMed HealthClomipramine (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelAnafranil (clomipramine hydrochloride) Capsules USP is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants. Anafranil is available as capsules of 25, 50, and 75 mg for oral a...
Active IngredientClomipramine hydrochloride
Dosage FormCapsule
RouteOral
Strength75mg; 25mg; 50mg
Market StatusPrescription
CompanyMallinckrodt

2 of 4  
Drug NameClomipramine hydrochloride
Drug LabelClomipramine hydrochloride capsules USP are an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants. Clomipramine hydrochloride is available as capsules of 25, 50 and 75 mg for oral...
Active IngredientClomipramine hydrochloride
Dosage FormCapsule
RouteOral
Strength75mg; 25mg; 50mg
Market StatusPrescription
CompanyTeva; Taro; Sandoz; Mylan

3 of 4  
Drug NameAnafranil
PubMed HealthClomipramine (By mouth)
Drug ClassesAntidepressant, Central Nervous System Agent
Drug LabelAnafranil (clomipramine hydrochloride) Capsules USP is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants. Anafranil is available as capsules of 25, 50, and 75 mg for oral a...
Active IngredientClomipramine hydrochloride
Dosage FormCapsule
RouteOral
Strength75mg; 25mg; 50mg
Market StatusPrescription
CompanyMallinckrodt

4 of 4  
Drug NameClomipramine hydrochloride
Drug LabelClomipramine hydrochloride capsules USP are an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants. Clomipramine hydrochloride is available as capsules of 25, 50 and 75 mg for oral...
Active IngredientClomipramine hydrochloride
Dosage FormCapsule
RouteOral
Strength75mg; 25mg; 50mg
Market StatusPrescription
CompanyTeva; Taro; Sandoz; Mylan

4.2 Drug Indication

As an aid in the treatment of separation related disorders in dogs manifested by destruction and inappropriate elimination (defecation and urination) and only in combination with behavioural modification techniques.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antidepressive Agents, Tricyclic

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)


Selective Serotonin Reuptake Inhibitors

Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Selective Serotonin Reuptake Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Tricyclic Antidepressant [EPC]
5.3 ATC Code

QN06AA04


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ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"LUNDBACK PHARMACEUTICALS ITALY S.P.A.","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"920.9","totalValueFC":"139857.2","currency":"USD","unitRateINR":"78134.7","date":"03-Sep-2024","totalValueINR":"11720202","totalValueInUsd":"139857.2","indian_port":"M\/s MAHARASHTRA AIRPORT DEVELOPMENTCOMPANYLIMITED","hs_no":"29339990","bill_no":"1002112","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"N\/A","customerAddress":"159, C.S.T. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731868200,"product":"CLOMIPRAMINE HYDROCHLORIDE USP","address":"ALEMBIC ROAD","city":"GUJARAT","supplier":"H. 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05-Jan-2021
23-Nov-2024
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CAPSULE;ORAL - 25MG

USFDA APPLICATION NUMBER - 19906

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DOSAGE - CAPSULE;ORAL - 50MG

USFDA APPLICATION NUMBER - 19906

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DOSAGE - CAPSULE;ORAL - 75MG

USFDA APPLICATION NUMBER - 19906

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ABOUT THIS PAGE

Clomipramine Hydrochloride Manufacturers

A Clomipramine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Clomipramine Hydrochloride, including repackagers and relabelers. The FDA regulates Clomipramine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Clomipramine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Clomipramine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Clomipramine Hydrochloride Suppliers

A Clomipramine Hydrochloride supplier is an individual or a company that provides Clomipramine Hydrochloride active pharmaceutical ingredient (API) or Clomipramine Hydrochloride finished formulations upon request. The Clomipramine Hydrochloride suppliers may include Clomipramine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Clomipramine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Clomipramine Hydrochloride USDMF

A Clomipramine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Clomipramine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Clomipramine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Clomipramine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Clomipramine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Clomipramine Hydrochloride USDMF includes data on Clomipramine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Clomipramine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Clomipramine Hydrochloride suppliers with USDMF on PharmaCompass.

Clomipramine Hydrochloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Clomipramine Hydrochloride Drug Master File in Japan (Clomipramine Hydrochloride JDMF) empowers Clomipramine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Clomipramine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Clomipramine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Clomipramine Hydrochloride suppliers with JDMF on PharmaCompass.

Clomipramine Hydrochloride KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Clomipramine Hydrochloride Drug Master File in Korea (Clomipramine Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Clomipramine Hydrochloride. The MFDS reviews the Clomipramine Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Clomipramine Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

After submitting a Clomipramine Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Clomipramine Hydrochloride API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Clomipramine Hydrochloride suppliers with KDMF on PharmaCompass.

Clomipramine Hydrochloride CEP

A Clomipramine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Clomipramine Hydrochloride Certificate of Suitability (COS). The purpose of a Clomipramine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Clomipramine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Clomipramine Hydrochloride to their clients by showing that a Clomipramine Hydrochloride CEP has been issued for it. The manufacturer submits a Clomipramine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Clomipramine Hydrochloride CEP holder for the record. Additionally, the data presented in the Clomipramine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Clomipramine Hydrochloride DMF.

A Clomipramine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Clomipramine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Clomipramine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

Clomipramine Hydrochloride WC

A Clomipramine Hydrochloride written confirmation (Clomipramine Hydrochloride WC) is an official document issued by a regulatory agency to a Clomipramine Hydrochloride manufacturer, verifying that the manufacturing facility of a Clomipramine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Clomipramine Hydrochloride APIs or Clomipramine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Clomipramine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Clomipramine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Clomipramine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Clomipramine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Clomipramine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Clomipramine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Clomipramine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Clomipramine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Clomipramine Hydrochloride suppliers with NDC on PharmaCompass.

Clomipramine Hydrochloride GMP

Clomipramine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Clomipramine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Clomipramine Hydrochloride GMP manufacturer or Clomipramine Hydrochloride GMP API supplier for your needs.

Clomipramine Hydrochloride CoA

A Clomipramine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Clomipramine Hydrochloride's compliance with Clomipramine Hydrochloride specifications and serves as a tool for batch-level quality control.

Clomipramine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Clomipramine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Clomipramine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Clomipramine Hydrochloride EP), Clomipramine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Clomipramine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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