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ACTIVE PHARMA INGREDIENTS

29 API Suppliers, 19 USDMF, 6 CEP/COS, 4 EU WC, 18 NDC API, 13 Listed Suppliers, $ API Reference Price

29 API Suppliers
19 USDMF
6 CEP/COS
4 EU WC
18 NDC API
13 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

11 Drugs in Development

11 Drugs in Development

FINISHED DOSAGE FORMULATIONS

174 FDF Dossiers, 120 FDA Orange Book, 13 Europe, 14 Canada, 8 Australia, 4 South Africa, 15 Listed Dossiers

174 FDF Dossiers
120 FDA Orange Book
13 Europe
14 Canada
8 Australia
4 South Africa
15 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - 0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, EXTENDED RELEASE;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, EXTENDED RELEASE;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

drugProductComposition
TABLET;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - 0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, EXTENDED RELEASE;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, EXTENDED RELEASE;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 5 SPI Pharma, 5 DKSH, 1 Pharm-RX Chemical, 7 Faran Shimi Pharmaceutical, 8 Boai NKY Pharmaceuticals Ltd, 13 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 9 Actylis, 1 Aeon Procare, 1 Alcedo Pharmachem, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 21 BASF, 1 Clariant, 11 Corel Pharma Chem, 6 DFE Pharma, 12 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 30 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 12 Microlex e.U, 1 Nanjing Bold Chemical, 3 Novo Excipients, 4 Pharmatrans-Sanaq, 8 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 25 Roquette, 13 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 12 Sigachi Industries, 2 The Dow Chemical Company, 2 Ulanqab Kema New Material, 4 Vasa Pharmachem, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
2 Rochem International Inc
5 SPI Pharma
5 DKSH
1 Pharm-RX Chemical
7 Faran Shimi Pharmaceutical
8 Boai NKY Pharmaceuticals Ltd
13 Gangwal Healthcare
3 Nanjing Well Pharmaceutical
1 Pfanstiehl
1 ACG Worldwide
9 Actylis
1 Aeon Procare
1 Alcedo Pharmachem
9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
21 BASF
1 Clariant
11 Corel Pharma Chem
6 DFE Pharma
12 Gangwal Chemicals
5 Ideal Cures Pvt Ltd
4 Ingredion Pharma Solutions
30 Kerry
3 Kima Chemical
6 Lonza Capsugel
12 Microlex e.U
1 Nanjing Bold Chemical
3 Novo Excipients
4 Pharmatrans-Sanaq
8 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
25 Roquette
13 Seppic
6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
12 Sigachi Industries
2 The Dow Chemical Company
2 Ulanqab Kema New Material
4 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

73 Fillers, Diluents & Binders, 47 Coating Systems & Additives, 41 Direct Compression, 41 Disintegrants & Superdisintegrants, 28 Granulation, 26 Thickeners and Stabilizers, 25 Controlled & Modified Release, 22 Solubilizers, 18 Lubricants & Glidants, 18 Co-Processed Excipients, 16 Taste Masking, 15 Parenteral, 13 Film Formers & Plasticizers, 10 Chewable & Orodispersible Aids, 9 Topical, 7 Emulsifying Agents, 7 API Stability Enhancers, 6 Rheology Modifiers, 5 Empty Capsules, 4 Vegetarian Capsules, 4 Coloring Agents, 3 Surfactant & Foaming Agents

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 1 STOCK RECAP #PipelineProspector, 33 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
1 STOCK RECAP #PipelineProspector
33 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 US Medicaid Prescriptions, 17 Finished Drug Prices

globalSalesInformation
3 US Medicaid Prescriptions
17 Finished Drug Prices

MARKET PLACE

10 APIs, 3 FDF Dossiers

marketPlace
10 APIs
3 FDF Dossiers

PATENTS & EXCLUSIVITIES

6 US Patents

patents
6 US Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 4 Others

otherSolutions
2 EDQM
2 USP
4 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 9,515

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

174

FDF Dossiers

120

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

11DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

111,223,658

Annual Reports (USD Million)

Finished Drug Prices

265 RELATED EXCIPIENT COMPANIES

438EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 4205-91-8, Clonidine hcl, 2-(2,6-dichloroanilino)-2-imidazoline hydrochloride, Kapvay, N-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-amine hydrochloride, St-155

Molecular Formula

C₉H₁₀Cl₃N₃

Molecular Weight

266.6 g/mol

InChI Key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

FDA UNII

W76I6XXF06

An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.

1 2D Structure

Clonidine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

2.1.2 InChI

InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

2.1.3 InChI Key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

W76I6XXF06

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Catapres

2. Catapresan

3. Catapressan

4. Chlophazolin

5. Clofelin

6. Clofenil

7. Clonidine

8. Clonidine Dihydrochloride

9. Clonidine Monohydrobromide

10. Clonidine Monohydrochloride

11. Clopheline

12. Dihydrochloride, Clonidine

13. Dixarit

14. Gemiton

15. Hemiton

16. Hydrochloride, Clonidine

17. Isoglaucon

18. Klofelin

19. Klofenil

20. M 5041t

21. M-5041t

22. M5041t

23. Monohydrobromide, Clonidine

24. Monohydrochloride, Clonidine

25. St 155

26. St-155

27. St155

2.3.2 Depositor-Supplied Synonyms

1. 4205-91-8

2. Clonidine Hcl

3. 2-(2,6-dichloroanilino)-2-imidazoline Hydrochloride

4. Kapvay

5. N-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-amine Hydrochloride

6. St-155

7. Catapresan

8. Jenloga

9. Clonidine (hydrochloride)

10. Nsc-756699

11. 2-(2,6-dichlorophenylamino)-2-imidazoline Hydrochloride

12. W76i6xxf06

13. Dichloranilino Imidazolin

14. 2-((2,6-dichlorophenyl)imino)imidazolidine Monohydrochloride

15. Benzenamine, 2,6-dichloro-n-2-imidazolidinylidene-, Monohydrochloride

16. Chlophazolin

17. Dispaclonidin

18. Normopresan

19. Atensina

20. Barclyd

21. Capresin

22. Caprysin

23. Catanidin

24. Clofelin

25. Clonilou

26. Clonisin

27. Clonistada

28. Dixarit

29. Edolglau

30. Glausine

31. Haemiton

32. Ipotensium

33. Isoglaucon

34. Katapresan

35. Klophelin

36. Iporel

37. 1h-imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- [cas]

38. Apo-clonidine

39. Clonidil-riker

40. Novo-clonidine

41. Clonid-ophal

42. Nu-clonidine

43. N-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-amine Hcl

44. 1h-imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, Monohydrochloride (9ci)

45. 2-[(2,6-dichlorophenyl)amino-2-imidazoline Hydrochloride

46. Bapresan

47. Clonicel

48. Trialox

49. Clonidine Monohydrochloride

50. Smr000466276

51. 205c918

52. Sr-01000075246

53. Einecs 224-121-5

54. Cas-4205-91-8

55. Mfcd00036705

56. N-(2,6-dichlorophenyl)imidazolidin-2-imine;hydrochloride

57. Unii-w76i6xxf06

58. Clonidine-hcl

59. Sr-01000759380

60. Prestwick_73

61. Catapres (tn)

62. 4,5-dihydro-

63. 2-((2,6-dichlorophenyl)amino)-2-imidazoline Hydrochloride

64. 2-imidazoline, 2-(2,6-dichloroanilino)-, Monohydrochloride

65. 2-(2,6-dichlorophenylamino)-2-imidazolin Hydrochlorid [german]

66. Benzenamine, 2,6-dichloro-n-2-imidazolidinylidene-, Hydrochloride

67. Clonidine Hydrochloride [usan:usp:ban:jan]

68. 1h-imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, Monohydrochloride

69. Clonidinehydrochloride

70. N-(2,6-dichlorophenyl)-

71. Chembl1705

72. Clonidine Hydrochloride,(s)

73. Dsstox_cid_24670

74. Dsstox_rid_80388

75. Dsstox_gsid_44670

76. Schembl40751

77. Mls000758256

78. Mls001424222

79. Clonidine Hydrochloride, Solid

80. 2-(2,6-dichlorophenylamino)-2-imidazolin Hydrochlorid

81. Chebi:3758

82. Dtxsid8044670

83. Hy-b0409a

84. Clonidine Hydrochloride (catapres)

85. Hms1568b18

86. Hms3414h03

87. Hms3678h03

88. Pharmakon1600-01500198

89. Bcp14375

90. Clonidine Hydrochloride [mi]

91. Tox21_301552

92. Tox21_500268

93. Bdbm50020341

94. Ccg-40087

95. Clonidine Hydrochloride (jp17/usp)

96. Clonidine Hydrochloride [jan]

97. N-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-amine;hydrochloride

98. Nsc756699

99. S2458

100. Clonidine Hydrochloride [usan]

101. Akos005267207

102. Akos024458609

103. Akos028114993

104. Ccg-101051

105. Ccg-212540

106. Ccg-229466

107. Clonidine Hydrochloride [mart.]

108. Clonidine Hydrochloride [vandf]

109. Ks-1253

110. Lp00268

111. Nc00301

112. Nsc 756699

113. Clonidine Hydrochloride [usp-rs]

114. Clonidine Hydrochloride [who-dd]

115. Ncgc00093726-01

116. Ncgc00093726-02

117. Ncgc00180902-01

118. Ncgc00256172-01

119. Ncgc00260953-01

120. Ac-10306

121. Ac-29742

122. Clonidine Hydrochloride, >=98.0% (tlc)

123. Clonidine Hydrochloride [ep Impurity]

124. Clonidine Hydrochloride [orange Book]

125. D1353

126. Eu-0100268

127. Ft-0601096

128. Ft-0665123

129. Sw197681-3

130. Clonidine Hydrochloride [ep Monograph]

131. C 7897

132. Clonidine Hydrochloride [usp Monograph]

133. D00604

134. D81843

135. Clorpres Component Clonidine Hydrochloride

136. A825736

137. Clonidine Hydrochloride 100 Microg/ml In Methanol

138. Combipres Component Clonidine Hydrochloride

139. Clonidine Hydrochloride Component Of Clorpres

140. Q-200880

141. Sr-01000075246-1

142. Sr-01000075246-3

143. Sr-01000759380-5

144. Clonidine Hydrochloride (catapres) [largely Precursor]

145. Clonidine Hydrochloride Component Of Combipres

146. Q27292429

147. 2-[(2,6-dichlorophenyl)imino]imidazolidine Hydrochloride

148. Clonidine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

149. Clonidine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

150. Clonidine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

151. Clonidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

152. 1h-imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, Hydrochloride (1:1)

153. N-[2,6-bis(chloranyl)phenyl]-4,5-dihydro-1h-imidazol-2-amine Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₉H₁₀Cl₃N₃
Molecular Weight	266.6 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	264.994030 g/mol
Monoisotopic Mass	264.994030 g/mol
Topological Polar Surface Area	36.4 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	222
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Clonidine hydrochloride
PubMed Health	Clonidine
Drug Classes	Analgesic, Anesthetic Adjunct, Antihypertensive, Antimigraine, Cardiovascular Agent, Central Nervous System Agent, Diagnostic Agent, Pheochromocytoma
Drug Label	Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg, and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base.The fo...
Active Ingredient	Clonidine hydrochloride
Dosage Form	Tablet, extended release; Injectable; Tablet
Route	Injection; Oral
Strength	0.2mg; 1mg/10ml (0.1mg/ml); 0.3mg; 5mg/10ml (0.5mg/ml); 0.1mg
Market Status	Prescription
Company	Exela Pharma Scs; Anchen Pharms; Actavis Elizabeth; Fresenius Kabi Usa; Unichem; Mutual Pharm; Vintage; Alembic Pharms; Hikma Farmaceutica; Luitpold; Sun Pharm Inds; Zydus Pharms Usa; Carlsbad; Mylan; Impax Labs; Dava Pharms

2 of 4
Drug Name	Kapvay
Drug Label	KAPVAY (clonidine hydrochloride) extended-release is a centrally acting alpha2-adrenergic agonist available as 0.1 mg or 0.2 mg extended-release tablets for oral administration. Each 0.1 mg and 0.2 mg tablet is equivalent to 0.087 mg and 0.174 mg, re...
Active Ingredient	Clonidine hydrochloride
Dosage Form	Tablet, extended release
Route	Oral
Strength	0.1mg; 0.2mg
Market Status	Prescription
Company	Concordia Pharms

3 of 4
Drug Name	Clonidine hydrochloride
PubMed Health	Clonidine
Drug Classes	Analgesic, Anesthetic Adjunct, Antihypertensive, Antimigraine, Cardiovascular Agent, Central Nervous System Agent, Diagnostic Agent, Pheochromocytoma
Drug Label	Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg, and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base.The fo...
Active Ingredient	Clonidine hydrochloride
Dosage Form	Tablet, extended release; Injectable; Tablet
Route	Injection; Oral
Strength	0.2mg; 1mg/10ml (0.1mg/ml); 0.3mg; 5mg/10ml (0.5mg/ml); 0.1mg
Market Status	Prescription
Company	Exela Pharma Scs; Anchen Pharms; Actavis Elizabeth; Fresenius Kabi Usa; Unichem; Mutual Pharm; Vintage; Alembic Pharms; Hikma Farmaceutica; Luitpold; Sun Pharm Inds; Zydus Pharms Usa; Carlsbad; Mylan; Impax Labs; Dava Pharms

4 of 4
Drug Name	Kapvay
Drug Label	KAPVAY (clonidine hydrochloride) extended-release is a centrally acting alpha2-adrenergic agonist available as 0.1 mg or 0.2 mg extended-release tablets for oral administration. Each 0.1 mg and 0.2 mg tablet is equivalent to 0.087 mg and 0.174 mg, re...
Active Ingredient	Clonidine hydrochloride
Dosage Form	Tablet, extended release
Route	Oral
Strength	0.1mg; 0.2mg
Market Status	Prescription
Company	Concordia Pharms

4.2 Drug Indication

Sedation

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Central alpha-2 Adrenergic Agonist [EPC]; Adrenergic alpha2-Agonists [MoA]

API SUPPLIERS

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USDMF

01

Pcas

France

Antibody Engineering

Not Confirmed

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France

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Digital Content

Clonidine Base

GDUFA

DMF Review : Complete

Rev. Date : 2015-01-29

Pay. Date : 2015-01-16

DMF Number : 12964

Submission : 1998-04-27

Status : Active

Type : II

02

Pcas

France

Antibody Engineering

Not Confirmed

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

Contact Supplier

France

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Digital Content

Clonidine Hydrochloride

GDUFA

DMF Review : Complete

Rev. Date : 2015-01-29

Pay. Date : 2015-01-16

DMF Number : 4778

Submission : 1983-01-21

Status : Active

Type : II

03

Cipla Ltd

India

Antibody Engineering

Not Confirmed

04

Daiwa Pharmaceutical Co Ltd

India

Country

Antibody Engineering

Not Confirmed

10

Temmler Werke Vereinigte Chemische F...

Country

Antibody Engineering

Not Confirmed

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CEP/COS

01

PCAS Ecully FR

France

Antibody Engineering

Not Confirmed

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France

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Digital Content

Clonidine hydrochloride

Certificate Number : CEP 1998-112 - Rev 04

Status : Valid

Issue Date : 2024-02-01

Type : Chemical

Substance Number : 477

02

ALEMBIC PHARMACEUTICALS LIMITED Vad...

India

Antibody Engineering

Not Confirmed

03

Boehringer Ingelheim Pharma GmbH & ...

Germany

Antibody Engineering

Not Confirmed

04

ENALTEC LABS PRIVATE LIMITED Navi M...

India

Antibody Engineering

Not Confirmed

05

SHIVALIK RASAYAN LIMITED New Delhi ...

India

Antibody Engineering

Not Confirmed

06

Unichem Laboratories Limited Mumbai...

India

Antibody Engineering

Not Confirmed

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EU WC

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Listed Suppliers

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API Reference Price

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OMEGA, HIRANANDANI GARDENS,POWAI,","city":"MUMBAI, MAHARASHTRA","supplier":"TEVA PHARMACEUTICAL INDUSTRIES","supplierCountry":"CANADA","foreign_port":"#N\/A","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"150","unit":"GMS","unitRateFc":"4","totalValueFC":"480.9","currency":"CAD","unitRateINR":"235.8","date":"13-Sep-2021","totalValueINR":"35370","totalValueInUsd":"480.9","indian_port":"BOMBAY AIR","hs_no":"29332990","bill_no":"5426304","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"402, OMEGA, HIRANANDANI GARDENS,POWAI,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1643913000,"product":"CLONIDINE HCL","address":"ASTER FLAT NO 402 REGENCY GARDENS, PLOT NO 10 SECTOR 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HEALTHCARE","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"9602.4","totalValueFC":"96848.1","currency":"USD","unitRateINR":"770592.5","date":"16-Aug-2022","totalValueINR":"7705925","totalValueInUsd":"96848.1","indian_port":"APIIC MULTI PRODUCT SEZ NAIDUPET AP","hs_no":"29332990","bill_no":"1000938","productDescription":"API","marketType":"REGULATED MARKET","country":"FINLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HELSINKI (HELSINGFORS)","supplierAddress":"N\/A","customerAddress":"3RD FLOOR, PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672684200,"product":"CLONIDINE HYDROCHLORIDE PH.EUR.","address":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET","city":"HYDERABAD","supplier":"PCAS","supplierCountry":"FINLAND","foreign_port":"NA","customer":"AUROBINDO PHARMA 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INDUSTRIES","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"22","unit":"GMS","unitRateFc":"4.7","totalValueFC":"127","currency":"USD","unitRateINR":"472.1","date":"10-Jan-2023","totalValueINR":"10385.5","totalValueInUsd":"127","indian_port":"BOMBAY AIR","hs_no":"29332990","bill_no":"4114578","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"12TH FLOOR, COMMERZ II,,INTERNATIO NAL BUSNESS PARK,OBEROI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1686853800,"product":"CLONIDINE HYDROCHLORIDE","address":"310,3rd Floor,Sy No 1050,Plot No S2 Manjeera Trinity Corporate,Phase 3","city":"KPHB Kukatpally","supplier":"PCAS","supplierCountry":"FINLAND","foreign_port":"NA","customer":"SLAYBACK PHARMA","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"0.02","unit":"KGS","unitRateFc":"75000","totalValueFC":"1515.6","currency":"USD","unitRateINR":"6228750","date":"16-Jun-2023","totalValueINR":"124575.15","totalValueInUsd":"1515.6","indian_port":"HYDERABAD AIR","hs_no":"29332990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"FINLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"310,3rd Floor,Sy No 1050,Plot No S2 Manjeera Trinity Corporate,Phase 3"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688581800,"product":"CLONIDINE HCL. 1030177. CAS NO. 4205-91-8. B\/N: 22008310 (0.670 KG) & 22008311 (0.670 KG) [22008310 - MFG. DT. 20\/06\/22","address":"1003-GIDC, WADHWAN, Contact No: 918419942141","city":"SURENDRANAGAR","supplier":"PCAS","supplierCountry":"FINLAND","foreign_port":"NA","customer":"MEPRO PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"1.34","actualQuantity":"1.34","unit":"KGS","unitRateFc":"20000","totalValueFC":"29509.8","currency":"EUR","unitRateINR":"1809999.9","date":"06-Jul-2023","totalValueINR":"2425400.285","totalValueInUsd":"29509.8","indian_port":"AHMEDABAD AIR","hs_no":"29332990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"FINLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"1003-GIDC, WADHWAN, Contact No: 918419942141"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706293800,"product":"CLONIDINE HCL (CLONIDINE HYDROCHLORIDE ) ( FOR TEST R & D PURPOSE.)","address":"ASTER FLAT NO 402 REGENCY GARDENS,","city":"KHARGHAR,MAHARASHTRA","supplier":"PCAS","supplierCountry":"FINLAND","foreign_port":"HELSINKI","customer":"PROSFORA TECHNOLOGIES PRIVATE ","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"100000","totalValueFC":"10118.9","currency":"USD","unitRateINR":"8410000","date":"27-Jan-2024","totalValueINR":"841000","totalValueInUsd":"10118.9","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"9858754","productDescription":"API","marketType":"REGULATED MARKET","country":"FINLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HELSINKI","supplierAddress":"MESSUKENTANKATU 8 20210 TURKUSDNFSDNF FINLAND","customerAddress":"ASTER FLAT NO 402 REGENCY GARDENS,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"CLONIDINE HCL CHEMICALS (CAS NO:4205-91-8) (1X10 FIBRE DRUM(22X22X25CM)","address":"NO.299, THAMBU CHETTY STREET,","city":"CHENNAI , TAMILNADU","supplier":"PCAS","supplierCountry":"FINLAND","foreign_port":"HELSINKI","customer":"BAFNA PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"90000","totalValueFC":"9077.4","currency":"USD","unitRateINR":"7614000","date":"14-Aug-2024","totalValueINR":"761400","totalValueInUsd":"9077.4","indian_port":"Madras Air","hs_no":"29332990","bill_no":"5060267","productDescription":"API","marketType":"REGULATED MARKET","country":"FINLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HELSINKI","supplierAddress":"P.O.BOX 979, FI-20101 TURKU,FINLAND.SDNF Finland","customerAddress":"NO.299, THAMBU CHETTY STREET,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725561000,"product":"CLONIDINE HCL (CAS NO:4205-91-8) (QTY:0.150 KGS) ASPER INV","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"PCAS","supplierCountry":"FINLAND","foreign_port":"HELSINKI","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"10000","totalValueFC":"1519.7","currency":"USD","unitRateINR":"849000","date":"06-Sep-2024","totalValueINR":"127350","totalValueInUsd":"1519.7","indian_port":"Hyderabad Air","hs_no":"29332990","bill_no":"5451306","productDescription":"API","marketType":"REGULATED MARKET","country":"FINLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HELSINKI","supplierAddress":"MESSUKENTANKATU 8 PO BOX 979 FIN - 20210,TURKU, FINLAND SDNF Finland","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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DOSAGE - TABLET;ORAL - 0.1MG **Federal Regist...DOSAGE - TABLET;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 17407

DOSAGE - TABLET;ORAL - 0.2MG **Federal Regist...DOSAGE - TABLET;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 17407

DOSAGE - TABLET;ORAL - 0.3MG **Federal Regist...DOSAGE - TABLET;ORAL - 0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 17407

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 0.1M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22331

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 0.2M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22331

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Patents & EXCLUSIVITIES

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US Patents

01

ATHENA

France

AES 2024

Not Confirmed

Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

Patent Expiration Date : 2027-04-17

CLONIDINE

US Patent Number : 8337890

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22500

Patent Use Code :

Patent Use Description :

Patent Expiration Date : 2027-04-17

02

ATHENA

France

AES 2024

Not Confirmed

Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

Patent Expiration Date : 2031-09-08

CLONIDINE

US Patent Number : 8623409

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22500

Patent Use Code :

Patent Use Description :

Patent Expiration Date : 2031-09-08

03

ATHENA

France

AES 2024

Not Confirmed

Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

Patent Expiration Date : 2027-04-17

CLONIDINE

US Patent Number : 8337890

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22500

Patent Use Code :

Patent Use Description :

Patent Expiration Date : 2027-04-17

04

ATHENA

France

AES 2024

Not Confirmed

Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

Patent Expiration Date : 2031-09-08

CLONIDINE

US Patent Number : 8623409

Drug Substance Claim :

Drug Product Claim : Y

Application Number : 22500

Patent Use Code :

Patent Use Description :

Patent Expiration Date : 2031-09-08

05

TRIS PHARMA INC

CLONIDINE HYDROCHLORIDE

AES 2024

Not Confirmed

06

TRIS PHARMA INC

CLONIDINE HYDROCHLORIDE

AES 2024

Not Confirmed

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TABLET;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - 0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, EXTENDED RELEASE;ORAL - 0.1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, EXTENDED RELEASE;ORAL - 0.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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47 Coating Systems & Additives

41 Direct Compression

41 Disintegrants & Superdisintegrants

28 Granulation

26 Thickeners and Stabilizers

25 Controlled & Modified Release

22 Solubilizers

TABLET;ORAL - 0.1MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - 0.2MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - 0.3MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, EXTENDED RELEASE;ORAL - 0.1MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, EXTENDED RELEASE;ORAL - 0.2MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons