menu
    • menu

    Find Chloroform manufacturers, exporters & distributors on PharmaCompass

    Evonik

    Virtual Booth

    Contact Supplier

    Sharp is a global leader in pharmaceutical packaging and clinical trial supply services.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-04-21

    Virtual Booth

    Contact Supplier

    Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

    Virtual Booth

    Contact Supplier

    USP reference standards; highly characterized specimens of drug substances, impurities, excipients, degradation products & more.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-04-14

    Virtual Booth

    Contact Supplier

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    MARKET PLACE

    PharmaCompass

    Synopsis

    Related ProductsRelated Products

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    2

    API Suppliers

    API Suppliers

    1

    USDMF

    US DMFs Filed

    0

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    1

    Listed Suppliers

    Other Suppliers

    0INTERMEDIATES

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    0

    USP

    0

    JP

    0

    Others

    FINISHED DOSAGE FORMULATIONS

    2

    FDF Dossiers

    FDF Dossiers

    0

    FDA Orange Book

    FDA (Orange Book)

    0

    Europe

    Europe

    0

    Canada

    Canada

    0

    Australia

    Australia

    2

    South Africa

    South Africa

    0

    Listed Dossiers

    Listed Dossiers

    0 DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    15RELATED EXCIPIENT COMPANIES

    27EXCIPIENTS BY APPLICATIONS

    PATENTS & EXCLUSIVITIES

    0

    US Patents

    0

    US Exclusivities

    0

    Health Canada Patents

    API REF. PRICE (USD/KG)

    $
    $ 4

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Regulatory FDF Prices

    NA

    API/FDF Prices: Book a Demo to
    explore the features and consider
    upgrading later

    MARKET PLACE

    2

    API

    0

    FDF

    DIGITAL CONTENT

    0

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    0

    News #PharmaBuzz

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: Trichloromethane, 67-66-3, Methane, trichloro-, Trichlormethan, Formyl trichloride, Trichloroform
    Molecular Formula
    CHCl3
    Molecular Weight
    119.37  g/mol
    InChI Key
    HEDRZPFGACZZDS-UHFFFAOYSA-N
    FDA UNII
    7V31YC746X
    Chloroform
    A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.
    1 2D Structure

    Chloroform

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    chloroform
    2.1.2 InChI
    InChI=1S/CHCl3/c2-1(3)4/h1H
    2.1.3 InChI Key
    HEDRZPFGACZZDS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(Cl)(Cl)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7V31YC746X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Trichloromethane

    2.3.2 Depositor-Supplied Synonyms

    1. Trichloromethane

    2. 67-66-3

    3. Methane, Trichloro-

    4. Trichlormethan

    5. Formyl Trichloride

    6. Trichloroform

    7. Methenyl Trichloride

    8. Methyl Trichloride

    9. Methane Trichloride

    10. Chloroforme

    11. Chcl3

    12. R 20 (refrigerant)

    13. Cloroformio

    14. Triclorometano

    15. Trichloormethaan

    16. Freon 20

    17. 1,1,1-trichloromethane

    18. Rcra Waste Number U044

    19. Methenyl Chloride

    20. Nci-c02686

    21. Methylidyne Trichloride

    22. Refrigerant R20

    23. Hsdb 56

    24. Chloroformum

    25. Chloroform Bp

    26. Trichloro-methane

    27. Nsc 77361

    28. R 20

    29. Chloroform [un1888] [poison]

    30. Hcc 20

    31. Nsc-77361

    32. Chebi:35255

    33. 7v31yc746x

    34. Ncgc00090794-01

    35. Chloroform Chcl3

    36. Chloroform, Hplc Grade

    37. Dsstox_cid_306

    38. Dsstox_rid_75501

    39. Dsstox_gsid_20306

    40. Chloroform, Analytical Standard

    41. Chloroforme [french]

    42. Caswell No. 192

    43. Cloroformio [italian]

    44. Trichlormethan [czech]

    45. Chloroform [nf Xvii]

    46. Trichloormethaan [dutch]

    47. Triclorometano [italian]

    48. Mfcd00000826

    49. Cas-67-66-3

    50. Chloroform [nf]

    51. Ccris 137

    52. Chloroform, Acs

    53. Chloroformwith Amylene

    54. Chloroformwith Ethanol

    55. Einecs 200-663-8

    56. Un1888

    57. Rcra Waste No. U044

    58. Epa Pesticide Chemical Code 020701

    59. Brn 1731042

    60. Chlorform

    61. Chloroforrn

    62. Cloroform

    63. Trichlormethane

    64. Trichlorocarbon

    65. Chloro Form

    66. Chloro-form

    67. Unii-7v31yc746x

    68. Chloroform-

    69. Ai3-24207

    70. Chloroform, For Hplc, >=99.8%, Contains 0.5-1.0% Ethanol As Stabilizer

    71. Trichloro- Methane

    72. Chloroform Solution

    73. Methane Trichloride

    74. Tris(chloranyl)methane

    75. Ccl3h

    76. Hccl3

    77. Chloroform, For Hplc

    78. Trichloromethane, 9ci

    79. Chloroform [ii]

    80. Chloroform [mi]

    81. Chloroform, Ethanol-free

    82. Chloroformium Pro Narcosi

    83. Wln: Gygg

    84. Chloroform [hsdb]

    85. Chloroform [iarc]

    86. Chloroform [inci]

    87. Aqualine™ Matrix K

    88. Chloroform [vandf]

    89. Chloroformum [hpus]

    90. Ec 200-663-8

    91. Chloroform [mart.]

    92. Chloroform [usp-rs]

    93. Chloroform [who-dd]

    94. 4-01-00-00042 (beilstein Handbook Reference)

    95. Chembl44618

    96. Chloroform, Environmental Grade

    97. Chloroform, P.a., 99.8%

    98. Gtpl2503

    99. Chloroform [green Book]

    100. Chloroform - Reagent Grade Acs

    101. Dtxsid1020306

    102. R 20 (van)

    103. Chloroform With Amylene Hplc Grade

    104. Chloroform, Spectrophotometric Grade

    105. Nsc77361

    106. Zinc8214524

    107. Chloroform (stabilized With Ethanol)

    108. Tox21_111024

    109. Tox21_202494

    110. Chloroform, For Hplc, >=99.5%

    111. Chloroform, For Hplc, >=99.8%

    112. Akos000269026

    113. Chloroform 100 Microg/ml In Methanol

    114. Db11387

    115. Un 1888

    116. Chloroform 5000 Microg/ml In Methanol

    117. Chloroform, Purification Grade, >=99%

    118. Ncgc00090794-02

    119. Ncgc00260043-01

    120. F 20

    121. Trichloromethane 10 Microg/ml In Methanol

    122. Chloroform, Jis Special Grade, >=99.0%

    123. Trichloromethane 100 Microg/ml In Methanol

    124. C0819

    125. Ft-0623661

    126. Trichloromethane 5000 Microg/ml In Methanol

    127. Chlorobutanol Impurity A [ep Impurity]

    128. Chloroform, Hplc Grade Stabilized With Ethanol

    129. Chloroform (stabilized With 2-methyl-2-butene)

    130. Chloroform, Saj Super Special Grade, >=99.0%

    131. A835850

    132. L023971

    133. Q172275

    134. Brd-k88785477-001-01-8

    135. Chloroform, For Hplc, >=99.8%, Amylene Stabilized

    136. Chloroform, 99.8%, Acs Reagent Stabilized With Ethanol

    137. Chloroform, Technical, Amylene Stabilized, >=99% (gc)

    138. F0001-1775

    139. Chloroform, Technical Grade, 95%, Contains 50 Ppm Amylene

    140. Chloroform, Anhydrous, Contains Amylenes As Stabilizer, >=99%

    141. Chloroform, For Hplc, >=99.8% (chloroform + Ethanol, Gc)

    142. Chloroform, For Residue Analysis, Suitable For 5000 Per Jis

    143. Chloroform Solution, 200 Mug/ml In Methanol, Analytical Standard

    144. Chloroform Stabilized With 50-200 Ppm Amylene Acs Reagent Grade

    145. Chloroform, >=99%, Pcr Reagent, Contains Amylenes As Stabilizer

    146. Chloroform, Acs Reagent, >=99.8%, Contains Amylenes As Stabilizer

    147. Chloroform, Ar, Contains 1-2% Ethanol As Stabilizer, >=99.5%

    148. Chloroform, Ar, Contains 100 Ppm Amylene As Stabilizer, >=99.5%

    149. Chloroform, Contains 100-200 Ppm Amylenes As Stabilizer, >=99.5%

    150. Chloroform, Contains Amylenes As Stabilizer, Acs Reagent, >=99.8%

    151. Chloroform, Contains Ethanol As Stabilizer, Acs Reagent, >=99.8%

    152. Chloroform, Lr, Contains 100 Ppm Amylene As Stabilizer, >=99%

    153. Chloroform, P.a., Acs Reagent, 99.8%, Contains 0.005% Amylene

    154. Chloroform, Saj First Grade, >=99.0%, Contains 0.4-0.8% Ethanol

    155. Chloroform, Uv Hplc Spectroscopic, 99.9%, Contains 50 Ppm Amylene

    156. Chloroform Solution, Certified Reference Material, 5000 Mug/ml In Methanol

    157. Chloroform, Acs Reagent, Reag. Ph. Eur., Contains Ethanol As Stabilizer

    158. Chloroform, Anhydrous, >=99%, Contains 0.5-1.0% Ethanol As Stabilizer

    159. Chloroform, Pharmaceutical Secondary Standard; Certified Reference Material

    160. Chloroform, Puriss. P.a., Reag. Iso, Reag. Ph. Eur., 99.0-99.4% (gc)

    161. Chloroform, Suitable For 300 Per Jis, >=99.0%, For Residue Analysis

    162. Chloroform, Uv Hplc Spectroscopic, 99.0%, Contains 0.6-1.0% Ethanol

    163. Chloroform Solution, Nist Standard Reference Material, 1% In Acetone-d6 (99.9 Atom % D)

    164. Chloroform Solution, Nmr Reference Standard, 1% In Acetone-d6 (99.9 Atom % D)

    165. Chloroform Solution, Nmr Reference Standard, 3% In Acetone-d6 (99.9 Atom % D)

    166. Chloroform, Acs Reagent, >=99.8%, Contains 0.5-1.0% Ethanol As Stabilizer

    167. Chloroform, Acs Spectrophotometric Grade, >=99.8%, Contains Amylenes As Stabilizer

    168. Chloroform, Biotech. Grade, >=99.8%, Contains 0.5-1.0% Ethanol As Stabilizer

    169. Chloroform, P.a., Acs Reagent, Reag. Iso, 99.8%, Contains 50 Ppm Amylene

    170. Chloroform, Puriss. P.a., Acs Reagent, >=99.8% (chloroform + Ethanol, Gc)

    171. Chloroform, Reagentplus(r), >=99.8%, Contains 0.5-1.0% Ethanol As Stabilizer

    172. Residual Solvent Class 2 - Chloroform, United States Pharmacopeia (usp) Reference Standard

    173. 8013-54-5

    174. Chloroform Solution, Nmr Reference Standard, 0.3% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 3 Mm X 8 In.

    175. Chloroform Solution, Nmr Reference Standard, 0.3% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 5 Mm X 8 In.

    176. Chloroform Solution, Nmr Reference Standard, 1% In Acetone-d6 (99,9 Atom % D), Tms 0.1 %, Nmr Tube Size 5 Mm X 8 In.

    177. Chloroform Solution, Nmr Reference Standard, 1% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 10 Mm X 8 In.

    178. Chloroform Solution, Nmr Reference Standard, 1% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 3 Mm X 8 In.

    179. Chloroform Solution, Nmr Reference Standard, 1% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 4 Mm X 8 In.

    180. Chloroform Solution, Nmr Reference Standard, 1% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 8 Mm X 8 In.

    181. Chloroform Solution, Nmr Reference Standard, 10% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 3 Mm X 8 In.

    182. Chloroform Solution, Nmr Reference Standard, 2% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 5 Mm X 8 In.

    183. Chloroform Solution, Nmr Reference Standard, 2% In Chloroform-d (99.8 Atom % D), Nmr Tube Size 3 Mm X 8 In.

    184. Chloroform Solution, Nmr Reference Standard, 2% In Chloroform-d (99.8 Atom % D), Nmr Tube Size 5 Mm X 8 In.

    185. Chloroform Solution, Nmr Reference Standard, 20% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 5 Mm X 8 In.

    186. Chloroform Solution, Nmr Reference Standard, 3% In Acetone-d6 (99.9 Atom % D), Tms 0.2 %, Nmr Tube Size 3 Mm X 8 In.

    187. Chloroform Solution, Nmr Reference Standard, 3% In Acetone-d6 (99.9 Atom % D), Tms 0.2 %, Nmr Tube Size 5 Mm X 8 In.

    188. Chloroform Solution, Nmr Reference Standard, 5% In Acetone-d6 (99.9 Atom % D), Chromium(iii) Acetylacetonate 0.2 %

    189. Chloroform Solution, Nmr Reference Standard, 5% In Acetone-d6 (99.9 Atom % D), Chromium(iii) Acetylacetonate 2 %, Nmr Tube Size 10 Mm X 8 In.

    190. Chloroform Solution, Nmr Reference Standard, 5% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 3 Mm X 8 In.

    191. Chloroform Solution, Nmr Reference Standard, 5% In Acetone-d6 (99.9 Atom % D), Nmr Tube Size 5 Mm X 8 In.

    192. Chloroform Solution, Nmr Reference Standard, 50% In Acetone-d6 (99.9 Atom % D), Chromium(iii) Acetylacetonate 0.2 %

    193. Chloroform Solution, Nmr Reference Standard, 50% In Acetone-d6 (99.9 Atom % D), Chromium(iii) Acetylacetonate 0.2 %, Nmr Tube Size 10 Mm X 8 In.

    194. Chloroform, Acs Spectrophotometric Grade, >=99.8%, Contains 0.5-1.0% Ethanol As Stabilizer

    195. Chloroform, Contains Ethanol As Stabilizer, Meets Analytical Specification Of Dab9, Bp, 99-99.4% (gc)

    196. Chloroform, Hplc Plus, For Hplc, Gc, And Residue Analysis, >=99.9%, Contains 0.5-1.0% Ethanol As Stabilizer

    197. Chloroform, Hplc Plus, For Hplc, Gc, And Residue Analysis, >=99.9%, Contains Amylenes As Stabilizer

    198. Residual Solvent - Chloroform, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 119.37 g/mol
    Molecular Formula CHCl3
    XLogP32.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count0
    Rotatable Bond Count0
    Exact Mass117.914383 g/mol
    Monoisotopic Mass117.914383 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count4
    Formal Charge0
    Complexity8
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    MEDICATION (VET): As inhalation anesthetic in horses & now rarely in cattle, sheep, cats or dogs because of dangerous complications & superior alternatives; internally, well dilute in intestinal colic & flatulence; in expectorants, & less commonly as anthelmintic (swine, dogs) ... . /Former use/

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 104

    MEDICATION (VET): Used/ externally, as liniment-type counterirritant for relief of deep seated pain, to expel screwworm larvae from wounds, as skin cleanser (fat solvent), & as skin coolant & local anesthetic due to its evaporation. ... Internally, it is given in various mixt well dilute to avoid gastric irritation ... . /Former use/

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 104

    Has been used as an anesthetic and in pharmaceutical preparations.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 379

    Chloroform was used chiefly as an anesthetic and in pharmaceutical preparation immediately prior to World War II. However, these uses have been banned.

    Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 5(79) 694

    4.2 Drug Warning

    An increased incidence of cardiac arrhythmias has been demonstrated during surgery in patients anesthetized with chloroform as compared with other anesthetic agents at vapor concentrations of 22,500 ppm.

    Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2

    Maternal Medication usually Compatible with Breast-Feeding: Chloroform: Reported Sign or Symptom in Infant or Effect on Lactation: None. /from Table 6/

    Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)

    4.3 Minimum/Potential Fatal Human Dose

    Fatal doses of liquid anesthetic agents by ingestion or inhalation are approx as follows: ... chloroform, 10 mL ... .

    Dreisbach, R.H. Handbook of Poisoning. 12th ed. Norwalk, CT: Appleton and Lange, 1987., p. 314

    The mean lethal dose for an adult is estimated to be about 45 g.

    WHO; EHC163: Chloroform (1994) Available from, as of January 2, 2018: https://www.inchem.org/documents/ehc/ehc/ehc163.htm

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Solvents

    Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant and Hackh's Chemical Dictionary, 5th ed) (See all compounds classified as Solvents.)

    5.2 ATC Code

    N - Nervous system

    N01 - Anesthetics

    N01A - Anesthetics, general

    N01AB - Halogenated hydrocarbons

    N01AB02 - Chloroform

    5.3 Absorption, Distribution and Excretion

    Chloroform can be absorbed through lung, from GI tract and to some extent through skin. Inhalation route is ... primary source of ... absorption in man.

    Doull, J., C.D. Klaassen, and M. D. Amdur (eds.). Casarett and Doull's Toxicology. 2nd ed. New York: Macmillan Publishing Co., 1980., p. 47

    Chloroform is rapidly absorbed & distributed to all organs, with relatively high concn in nervous tissue. After intraduodenal injection of (14)C-chloroform to rats, 70% ... was found unchanged in expired air & 4% as (14)CO2(carbon dioxide) during 24 hr. ... Liver and, to much lesser extent, kidney were main organs in which CO2 was formed.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V20 414 (1979)

    In man, pulmonary excretions of chloroform and its CO2 (carbon dioxide) metab account substantially for single oral dose of 0.5 or 1.0 g. Amongst 9 subjects, up to 68% of dose is excreted unchanged & up to 51% of CO2; not more than 4% of dose is excreted unchanged after 8 hr.

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 329

    ... /Chloroform crosses/ placenta rapidly and enters fetal circulation.

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 635

    For more Absorption, Distribution and Excretion (Complete) data for Chloroform (50 total), please visit the HSDB record page.

    5.4 Metabolism/Metabolites

    When (14)C-chloroform was admin orally to mice, rats, & monkeys, radioactivity was found in expired air. Most of dose was excreted unchanged by monkeys, as (14)CO2 (carbon dioxide) by mice, & as both by rats. Three metabolites were detected in urine of rats & mice, one of which was identified as urea.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V20 414 (1979)

    Haloforms are metabolized to carbon monoxide by hepatic microsomal mixed function oxidases & this reaction is markedly stimulated by sulfhydryl cmpd. Max stimulation occurred at 0.5 mmol glutathione. A mechanism for conversion to carbon monoxide is proposed.

    PMID:526325 Stevens JL et al; Biochemical Pharmacology 28: 3189 (1979)

    Trihalomethanes (haloforms) were metab to carbon monoxide by rat liver microsomal fraction requiring nadph & molecular oxygen. Metabolism followed halide order; thus, chloroform yielded smallest amt. Results suggest cytochrome p450 dependent system.

    Ahmed AE et al; Drug Metabolism Disposition 5 (2): 198 (1976)

    Deuterium-labeled chloroform was less toxic and less readily metabolized than /normal/ chloroform, suggesting that the cleavage of the C-H bond is the rate-limiting step in the process resulting in hepatotoxicity.

    Pohl LR; Rev Biochem Toxicol 1: 79 (1979)

    For more Metabolism/Metabolites (Complete) data for Chloroform (22 total), please visit the HSDB record page.

    5.5 Biological Half-Life

    Whole body: 1.5 hours; [TDR, p. 318]

    TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 318

    After inhalation of approximately 5 mg (38)Cl-chloroform, about 80% of the chloroform was found to have been absorbed ... . Eight volunteers expired 18 to 67% of an oral dose of 500 mg (13)C-chloroform (in capsules of olive oil) unchanged; in two subjects, about half of the dose was eliminated in the expired air as (13)CO2. The decline in the concentration of chloroform in blood was described by a two-compartment model, with initial and second-phase half-lives of 14 and 90 min, respectively, averaged over four subjects.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V73 153 (1999)

    In humans given a single oral dose of 0.5 g chloroform, about 50-52% of the dose was absorbed, and virtually all of the absorbed dose was metabolized to carbon dioxide. Blood levels peaked after 1.5 hr and declined in line with a two-compartment model with half-lives of 13 and 90 min, respectively ...

    WHO; Concise International Chemical Assessment Document 58-chloroform. 2004 Available from, as of August 26, 2008: https://www.inchem.org/documents/cicads/cicads/cicad58.htm

    5.6 Mechanism of Action

    The feasibility of an oxygen-independent mechanism of chloroform bioactivation was indicated by the covalent binding to lipid and protein occurring in anaerobic incubations of chloroform and microsomes in the presence of NADPH. Under these conditions, the loss of cytochrome p450 and the inhibition of related mono-oxygenases were also observed. The chloroform anoxic biotransformation was negligible in uninduced microsomes and seemed to be catalyzed mainly by phenobarbital-inducible p450 isozymes. Biotransformation could also be supported by NADH as the source of reducing equivalents. Anaerobic metabolism of chloroform led to decreased levels of the main phenobarbital-induced p450 isozymes even at low chloroform concentration, and did not affect benzo(a)pyrene hydroxylase activity. These effects were not decreased by thiolic compounds. The oxidation products of chloroform caused a general impairment of the monoxygenase system, probably related to the formation of protein aggregates with very high molecular weight. In the presence of physiological concentrations of GSH, the targets of aerobically-produced metabolite were lipids, and, to a smaller extent, p450. At low chloroform concentrations and/or in the presence of GSH, the most changes to microsomal structures seemed to be produced by the reductively-formed intermediates.

    PMID:3769050 Testai E, Vittozi L; Chem-Biol Interact 59 (2): 157-72 (1986)

    Related Excipient Companies

    Upload your portfolio for free, ask us

    Excipients by Applications

    Click here to find the perfect excipient manufacturers by their capabilities

    Parenteral

    read-more
    read-more

    Coating Systems & Additives

    read-more
    read-more

    Co-Processed Excipients

    read-more
    read-more

    Fillers, Diluents & Binders

    read-more
    read-more

    Granulation

    read-more
    read-more

    Taste Masking

    read-more
    read-more

    Direct Compression

    read-more
    read-more

    Topical

    read-more
    read-more

    Thickeners and Stabilizers

    read-more
    read-more

    Controlled & Modified Release

    read-more
    read-more

    Film Formers & Plasticizers

    read-more
    read-more

    Market Place

    Do you need sourcing support? Ask us

    ABOUT THIS PAGE

    Looking for 67-66-3 / Chloroform API manufacturers, exporters & distributors?

    Chloroform manufacturers, exporters & distributors 1

    92

    PharmaCompass offers a list of Chloroform API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chloroform manufacturer or Chloroform supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chloroform manufacturer or Chloroform supplier.

    PharmaCompass also assists you with knowing the Chloroform API Price utilized in the formulation of products. Chloroform API Price is not always fixed or binding as the Chloroform Price is obtained through a variety of data sources. The Chloroform Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Chloroform

    Synonyms

    Trichloromethane, 67-66-3, Methane, trichloro-, Trichlormethan, Formyl trichloride, Trichloroform

    Cas Number

    67-66-3

    Unique Ingredient Identifier (UNII)

    7V31YC746X

    About Chloroform

    A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.

    cloroform Manufacturers

    A cloroform manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of cloroform, including repackagers and relabelers. The FDA regulates cloroform manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. cloroform API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of cloroform manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    cloroform Suppliers

    A cloroform supplier is an individual or a company that provides cloroform active pharmaceutical ingredient (API) or cloroform finished formulations upon request. The cloroform suppliers may include cloroform API manufacturers, exporters, distributors and traders.

    click here to find a list of cloroform suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    cloroform USDMF

    A cloroform DMF (Drug Master File) is a document detailing the whole manufacturing process of cloroform active pharmaceutical ingredient (API) in detail. Different forms of cloroform DMFs exist exist since differing nations have different regulations, such as cloroform USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A cloroform DMF submitted to regulatory agencies in the US is known as a USDMF. cloroform USDMF includes data on cloroform's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The cloroform USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of cloroform suppliers with USDMF on PharmaCompass.

    cloroform GMP

    cloroform Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of cloroform GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right cloroform GMP manufacturer or cloroform GMP API supplier for your needs.

    cloroform CoA

    A cloroform CoA (Certificate of Analysis) is a formal document that attests to cloroform's compliance with cloroform specifications and serves as a tool for batch-level quality control.

    cloroform CoA mostly includes findings from lab analyses of a specific batch. For each cloroform CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    cloroform may be tested according to a variety of international standards, such as European Pharmacopoeia (cloroform EP), cloroform JP (Japanese Pharmacopeia) and the US Pharmacopoeia (cloroform USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search