Find Clothiapine manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Clotiapine, 2058-52-8, Entumin, Etumine, Hf 2159, Clothiapine [usan]
Molecular Formula
C18H18ClN3S
Molecular Weight
343.9  g/mol
InChI Key
KAAZGXDPUNNEFN-UHFFFAOYSA-N
FDA UNII
Z05HCY0X1T

Clothiapine
Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients.
1 2D Structure

Clothiapine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
2.1.2 InChI
InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
2.1.3 InChI Key
KAAZGXDPUNNEFN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
2.2 Other Identifiers
2.2.1 UNII
Z05HCY0X1T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Clotiapine

2. Entumine

2.3.2 Depositor-Supplied Synonyms

1. Clotiapine

2. 2058-52-8

3. Entumin

4. Etumine

5. Hf 2159

6. Clothiapine [usan]

7. S-805c

8. Clotiapine [inn]

9. Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

10. Hf-2159

11. Lw 2159

12. 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine

13. 2-chloro-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine

14. Dibenzo[b,f][1,4]thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

15. Z05hcy0x1t

16. Chembl304902

17. Entumine

18. 2-chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine

19. 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine

20. Clothiapine (usan)

21. Ncgc00160387-01

22. 2-chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine

23. Dsstox_cid_2851

24. Dsstox_rid_76758

25. Dsstox_gsid_22851

26. Clotiapina

27. Clotiapinum

28. Clotiapinum [inn-latin]

29. Clotiapina [inn-spanish]

30. Cas-2058-52-8

31. Einecs 218-162-8

32. Unii-z05hcy0x1t

33. Brn 0568276

34. Entumin (tn)

35. Kinetinriboside

36. Clotiapine (jan/inn)

37. Clothiapine [mi]

38. Clotiapine [jan]

39. W 130

40. Biomol-nt_000008

41. Clotiapine [mart.]

42. Clotiapine [who-dd]

43. Schembl122941

44. Bpbio1_001137

45. Dtxsid5022851

46. Chebi:31424

47. Chebi:108591

48. Hms2089l15

49. Bcp06511

50. Tox21_111779

51. Bdbm50040237

52. Hf2159

53. Pdsp1_000469

54. Pdsp2_000467

55. Zinc26185346

56. Akos005065858

57. Tox21_111779_1

58. Db13256

59. Mrf-0000024

60. Ncgc00160387-02

61. Ncgc00160387-03

62. Ncgc00160387-04

63. Db-045296

64. Hy-117083

65. Cs-0063673

66. Ft-0603194

67. D01597

68. Ab01275460-01

69. Sr-05000001467

70. J-013441

71. Q3661095

72. Sr-05000001467-1

73. Brd-k10990317-001-01-1

74. Brd-k10990317-001-02-9

75. 8-chloro-6-(4-methyl-1-piperazinyl)benzo[b][1,4]benzothiazepine

76. (e)-2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine

77. 2-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine

78. 2-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine(clothiapine)

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 343.9 g/mol
Molecular Formula C18H18ClN3S
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass343.0909965 g/mol
Monoisotopic Mass343.0909965 g/mol
Topological Polar Surface Area44.1 Ų
Heavy Atom Count23
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


4.2 ATC Code

N - Nervous system

N05 - Psycholeptics

N05A - Antipsychotics

N05AH - Diazepines, oxazepines, thiazepines and oxepines

N05AH06 - Clotiapine


Europe

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LAB.JUVISE' PHARMACEUTICALS

Country
Vitafoods India
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LAB.JUVISE' PHARMACEUTICALS

Country
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Vitafoods India
Not Confirmed

clothiapine

Brand Name : Entumin

Dosage Form : Clotiapina 100Mg/Ml 10Ml Oral Use

Dosage Strength : os gtt 10 ml 100 mg/ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

Medius AG

Country
Vitafoods India
Not Confirmed
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Medius AG

Country
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Vitafoods India
Not Confirmed

Clotiapine

Brand Name : Entumin

Dosage Form : Tabl

Dosage Strength : 40mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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03

Medius AG

Country
Vitafoods India
Not Confirmed
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Medius AG

Country
arrow
Vitafoods India
Not Confirmed

Clotiapine

Brand Name : Entumin

Dosage Form : Tabl

Dosage Strength : 40mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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ABOUT THIS PAGE

Clothiapine Manufacturers

A Clothiapine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Clothiapine, including repackagers and relabelers. The FDA regulates Clothiapine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Clothiapine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Clothiapine Suppliers

A Clothiapine supplier is an individual or a company that provides Clothiapine active pharmaceutical ingredient (API) or Clothiapine finished formulations upon request. The Clothiapine suppliers may include Clothiapine API manufacturers, exporters, distributors and traders.

Clothiapine GMP

Clothiapine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Clothiapine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Clothiapine GMP manufacturer or Clothiapine GMP API supplier for your needs.

Clothiapine CoA

A Clothiapine CoA (Certificate of Analysis) is a formal document that attests to Clothiapine's compliance with Clothiapine specifications and serves as a tool for batch-level quality control.

Clothiapine CoA mostly includes findings from lab analyses of a specific batch. For each Clothiapine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Clothiapine may be tested according to a variety of international standards, such as European Pharmacopoeia (Clothiapine EP), Clothiapine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Clothiapine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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