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    Chemistry

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    Also known as: Cloxacillin sodium, 7081-44-9, Cloxacillin sodium monohydrate, Bactopen, Sodium cloxacillin monohydrate, Tegopen
    Molecular Formula
    C19H19ClN3NaO6S
    Molecular Weight
    475.9  g/mol
    InChI Key
    KCUWTKOTPIUBRI-VICXVTCVSA-M
    FDA UNII
    65LCB00B4Y
    Cloxacillin Sodium
    A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
    1 2D Structure

    Cloxacillin Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
    2.1.2 InChI
    InChI=1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
    2.1.3 InChI Key
    KCUWTKOTPIUBRI-VICXVTCVSA-M
    2.1.4 Canonical SMILES
    CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]
    2.1.5 Isomeric SMILES
    CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    65LCB00B4Y
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Chloroxacillin

    2. Cloxacillin

    3. Cloxacillin Sodium

    4. Cloxacillin, Sodium

    5. Sodium Cloxacillin

    6. Sodium, Cloxacillin

    7. Syntarpen

    8. Tegopen

    2.3.2 Depositor-Supplied Synonyms

    1. Cloxacillin Sodium

    2. 7081-44-9

    3. Cloxacillin Sodium Monohydrate

    4. Bactopen

    5. Sodium Cloxacillin Monohydrate

    6. Tegopen

    7. Orbenin

    8. Cloxacillin Sodium Hydrate

    9. Ekvacillin

    10. Latocillin

    11. Cloxypen

    12. Methocillin-s

    13. Cloxacillin Sodium Salt Monohydrate

    14. Cloxacillin (sodium Monohydrate)

    15. Cloxacillin (as Sodium)

    16. Brl-1621

    17. P-25

    18. 65lcb00b4y

    19. Chebi:34978

    20. Monosodium (2s,5r,6r)-6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate Monohydrate

    21. Sodium (2s,5r,6r)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Hydrate

    22. Sodium;(2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate

    23. Staphobristol-250

    24. Orbenin Sodium Hydrate

    25. Cloxacap

    26. Prostaphlin-a Monohydrate

    27. Brl-1621 Sodium Salt Monohydrate

    28. Unii-65lcb00b4y

    29. Cloxacillin Nataarium-1-wasser

    30. Cloxapen (tn)

    31. Tegopen (tn)

    32. Cloxacillin Sodium [usan:usp:jan]

    33. 642-78-4

    34. Cloxacillin Sodium (usp)

    35. Schembl41012

    36. Chembl1200388

    37. Cloxacillin Sodium [usan]

    38. Dtxsid60110018

    39. Cloxacillin Sodium [vandf]

    40. Bcp13532

    41. Cloxacillin Sodium [usp-rs]

    42. Cloxacillin Sodium [who-dd]

    43. Cloxacillin Sodium [who-ip]

    44. Cloxacillin Sodium Hydrate (jp17)

    45. Hy-b0466

    46. Mfcd00150735

    47. S2564

    48. Akos015896310

    49. Akos015962898

    50. Ac-7623

    51. Ccg-269503

    52. Cloxacillin Sodium [green Book]

    53. Cloxacillin Sodium [orange Book]

    54. Cloxacillin Sodium Hydrate [jan]

    55. Cloxacillin Sodium [ep Monograph]

    56. Cloxacillin Sodium [usp Impurity]

    57. 1,3-dichloro-7-bromoisoquinoline

    58. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, Monohydrate, (2s-(2alpha,5alpha,6beta))-

    59. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, Sodium Salt, Monohydrate

    60. As-60182

    61. Cloxacillin Sodium [usp Monograph]

    62. D02231

    63. Ab01568256_01

    64. Cloxacillin Sodium Salt Monohydrate [mi]

    65. Q-200886

    66. Cloxacillin Sodium Hydrate 100 Microg/ml In Methanol

    67. Q27116347

    68. Z2574937894

    69. Cloxacillin Sodium, Antibiotic For Culture Media Use Only

    70. Cloxacillin Sodium, European Pharmacopoeia (ep) Reference Standard

    71. Cloxacillin Sodium Salt Monohydrate, Beta-lactamase-resistant Antibiotic

    72. Cloxacillin Sodium Salt Monohydrate, Vetranal(tm), Analytical Standard

    73. Cloxacillin Sodium, United States Pharmacopeia (usp) Reference Standard

    74. Cloxacillin Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

    75. (2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

    76. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, Monohydrate, (2s-(2.alpha.,5.alpha.,6.beta.))-

    77. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, Sodium Salt, Hydrate (1:1:1), (2s,5r,6r)-

    78. Sodium (2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Hydrate

    79. Sodium (2s,5r,6r)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Hydrate

    80. Sodium 2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylate Hydrate

    2.3.3 Other Synonyms

    1. 642-78-4

    2. Cloxacillin Sodium Anhydrous

    3. Sodium Orbenin

    4. Syntarpen Sodium Salt

    5. Monosodium Cloxacillin

    6. Sodium Syntarpen

    7. Austrastaph

    8. Staphybiotic

    9. Ankerbin

    10. Ekvacillin

    11. Gelstaph

    12. Cloxacillin Sodium Salt

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 475.9 g/mol
    Molecular Formula C19H19ClN3NaO6S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass475.0580785 g/mol
    Monoisotopic Mass475.0580785 g/mol
    Topological Polar Surface Area142 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity728
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

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KGAA","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"FLAMINGO PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"501.00","actualQuantity":"501","unit":"KGS","unitRateFc":"80","totalValueFC":"40484.5","currency":"USD","unitRateINR":"6748","date":"19-Apr-2024","totalValueINR":"3380748","totalValueInUsd":"40484.5","indian_port":"MIDC SEZ\/Nanded","hs_no":"29411090","bill_no":"1000018","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"PIAZZ MAESTRI DEL LAVORO,7,20063 CERNUSCO SUL NAVIGLIO MILANO, ITALY IT","customerAddress":"7\/1,CORPORATE PARK,SION-TROMBAY"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"DICLOXACILLIN SODIUM (COMPACTED) EP","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"FRESENIUS KABI IPSUM S.R.L,","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"1800.00","actualQuantity":"1800","unit":"KGS","unitRateFc":"105","totalValueFC":"190942","currency":"USD","unitRateINR":"8867.3","date":"17-Jul-2024","totalValueINR":"15961050","totalValueInUsd":"190942","indian_port":"Madras Air","hs_no":"29411040","bill_no":"4547875","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA ROMA, 10820051 CASSINA DE PECCHIMILANO ITALY","customerAddress":"NO 31, RACE COURSE ROAD,BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"FLUCLOXACILLIN SODIUM (COMPACTED) EP","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"FRESENIUS KABI IPSUM S.R.L,","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"80","totalValueFC":"2424.7","currency":"USD","unitRateINR":"6756","date":"17-Jul-2024","totalValueINR":"202680","totalValueInUsd":"2424.7","indian_port":"Madras Air","hs_no":"29411090","bill_no":"4550073","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA ROMA, 10820051 CASSINA DE PECCHIMILANO ITALY","customerAddress":"NO 31, RACE COURSE ROAD,BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"FLUCLOXACILLIN SODIUM (COMPACTED) EP","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"FRESENIUS KABI IPSUM S.R.L,","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"211.01","actualQuantity":"211.009","unit":"KGS","unitRateFc":"80","totalValueFC":"17054.2","currency":"USD","unitRateINR":"6756","date":"17-Jul-2024","totalValueINR":"1425576.8","totalValueInUsd":"17054.2","indian_port":"Madras Air","hs_no":"29411090","bill_no":"4550073","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA ROMA, 10820051 CASSINA DE PECCHIMILANO ITALY","customerAddress":"NO 31, RACE COURSE ROAD,BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"FLUCLOXACILLIN SODIUM (POWDER) EP","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"FRESENIUS KABI IPSUM S.R.L,","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"220.00","actualQuantity":"220","unit":"KGS","unitRateFc":"80","totalValueFC":"17780.8","currency":"USD","unitRateINR":"6756","date":"17-Jul-2024","totalValueINR":"1486320","totalValueInUsd":"17780.8","indian_port":"Madras Air","hs_no":"29411090","bill_no":"4547874","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA ROMA, 10820051 CASSINA DE PECCHIMILANO ITALY","customerAddress":"NO 31, RACE COURSE ROAD,BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722364200,"product":"FLUCLOXACILLIN SODIUM COMPACTED","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"FRESENIUS SE & CO. KGAA","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"MEDREICH","customerCountry":"INDIA","quantity":"137.00","actualQuantity":"137","unit":"KGS","unitRateFc":"75","totalValueFC":"10392.9","currency":"USD","unitRateINR":"6341.3","date":"31-Jul-2024","totalValueINR":"868751.25","totalValueInUsd":"10392.9","indian_port":"Bangalore Air","hs_no":"29411090","bill_no":"4808897","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"VIA ROMA, 10820051 CASSINA DE PECCHI MILANOSDNF ITALY","customerAddress":"MEDREICH HOUSE, NO12\/8,"}]
    05-Jan-2021
    30-Oct-2024
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    Cloxacillin (5 kg) API needed in India [ENA19652]
    A company that focuses on the manufacturing and marketing of various third-party and own branded formulations is looking for suppliers of Cloxacillin (5 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    06 Jun 2024

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    06 Jun 2024

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    06 Jun 2024

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    Cloxacillin Sodium (100 kg) API needed in India [ENA19594]
    A company that focuses on manufacturing of various finished formulations including tables, syrups & creams is looking for suppliers of Cloxacillin Sodium (100 kg) API for commercial purposes. The suppliers must support this enquiry with DMF (open part) & CoA.
    28 May 2024

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    28 May 2024

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    28 May 2024

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    Cloxacillin (950 kg) API needed in India [ENA18284]
    A company that deals in various pharmaceutical products is looking for suppliers of Cloxacillin (950 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    11 Oct 2023

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    11 Oct 2023

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    11 Oct 2023

    Cameroon.png
    Various APIs needed in Cameroon [ENA16071]
    A company that focuses on the manufacturing of tablets, capsules and dry syrups is looking for suppliers of Various APIs for commercial purposes. The suppliers must support this enquiry with DMF, GMP & CoA. 1. Amoxicillin Trihydrate (500 kg) API 2. Amoxicillin (250 kg) API 3. Cloxacillin Sodium (250 kg) API
    12 Jan 2023

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    12 Jan 2023

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    Reply Comment (18)

    12 Jan 2023

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    Various APIs needed in Sri Lanka [ENA12073]
    A company that deals in the distribution of pharmaceutical drugs, devices and cosmetics is looking for suppliers of Various APIs for commercial purpose. The required quantity is MOQ for each. The suppliers must support this enquiry with GMP. 1. BP Grade & Non-sterile Cloxacillin Sodium API 2. BP Grade, Non-sterile & DC Paracetamol API
    10 Dec 2021

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    10 Dec 2021

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    10 Dec 2021

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    Various APIs needed in Sri Lanka [ENA10417]
    Medicom, a company that aims to supply top-of-the-range pharmaceutical products and brand-name medical equipment to local hospitals is looking for suppliers of Various APIs. Interested suppliers can contact them via their email: accounts@mediccom.lk. 1. BP Grade Ascorbic Acid (5 MT) API 2. IP Grade Atorvastatin Calcium (1 MT) API 3. BP Grade Carbamazepine (2 MT) API 4. BP Grade Cetirizine Dihydrochloride (200 kg) API 5. USP/ NF Grade Ciprofloxacin Hydrochloride (1.5 MT) API 6. USP Grade Clopidogrel Bisulphate (2 MT) API 7. BP Grade Cloxacillin Sodium (9 MT) API 8. USP Grade Clarithromycin (500 kg) API 9. USP Grade Diclofenac Sodium (3 MT) API 10. BP Grade Domperidone Maleate (1 MT) API
    14 May 2021

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    14 May 2021

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    14 May 2021

    SriLanka.png
    BP Grade Cloxacillin Sodium & BP Grade Amoxicillin Trihydrate APIs needed in Sri Lanka [ENA07442]
    Addplus Solutions, an organization involved in supply of APIs, excipients & formulations to pharmaceutical & nutraceutical is looking for suppliers of BP Grade Cloxacillin Sodium & BP Grade Amoxicillin Trihydrate APIs. The required quantity is 9 MT each. The suppliers must support this enquiry with CoA. Interested suppliers can contact them via their email: addplussolution@gmail.com.
    01 Jun 2020

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    01 Jun 2020

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    01 Jun 2020

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    Various APIs needed in India [ENA06023]
    One of the fastest-growing pharmaceutical companies in India offering a wide range of formulation products is looking for suppliers of APIs. 1. Dobutamine Hydrochloride 2. Tranexamic Acid 3. Ampicillin Sodium 4. Cloxacillin Sodium 5. Benzathine Benzylpenicillin (Sterile)
    11 Dec 2019

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    11 Dec 2019

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    11 Dec 2019

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    USP/IP/BP Grade Aminophylline Dihydrate & other APIs needed in India [ENA05643]
    A pharmaceutical company with its main focus in manufacturing and supplying a wide range of pharmaceutical products is looking for suppliers of below mentioned APIs. The material should be of at least 3-4 years shelf life. 1. Aminophylline Dihydrate- 2.1 kg 2. Amoxicillin and Clavulanate Potassium (Sterile)- 7.1 kg 3. Azithromycin Dihydrate- 125 kg 4. Beclomethasone Dipropionate- 0.75 kg 5. Benzocaine- 15 kg 6. Calcium D-Saccharate- 20 kg 7. Ceftriaxone Sodium (Sterile)- 108 kg 8. Cefuroxime Sodium (Sterile)- 8.1 kg 9. Cholecalciferol- 1075 g 10. Clotrimazole- 44 kg 11. Cloxacillin Sodium (Sterile)- 19.5 kg 12. Ephedrine HCl- 3 kg 13. Erythromycin Stearate- 315 kg 14. Ethamsylate- 25 kg 15. Ethyl Oleate- 565 kg 16. Fluconazole- 86 kg 17. Gentamicin Sulphate- 75 kg 18. Hydrocortisone Sodium Succinate (Sterile)- 55 kg 19. Itraconazole Pellets (40%) 200mg- 80 kg 20. Lansoprazole Enteric Coated Pellets 30mg- 100 kg 21. Lidocaine HCl- 60 kg 22. Maltodextrin- 2 kg 23. Nandrolone Decanoate- 1.2 kg 24. Nefopam HCl- 2 kg 25. Neomycin Sulfate- 18 kg 26. Oxetacaine- 2.1 kg 27. Piroxicam- 2.5 kg 28. Sodium Metabisulphite- 60 kg 29. Sulbactam Sodium (Sterile)- 45 kg 30. Tranexamic Acid- 100 kg 31. Roxithromycin- 143 kg 32. Mefenamic Acid- 500 kg 33. Metronidazole Benzoate- 350 kg
    01 Nov 2019

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    01 Nov 2019

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    01 Nov 2019

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    IP grade Cloxacillin, Amoxicillin and other APIs needed in India [ENA04980]
    A pharmaceutical manufacturing company delivering products in domestic as well as the international market of beta lactam formulations is looking for suppliers of mentioned APIs. 1. Cloxacillin - 1 MT/quarter 2. Amoxicillin - 1 MT/ quarter 3. Clavulanate Potassium - 500 kg/ quarter 4. Ampicillin.
    26 Aug 2019

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    26 Aug 2019

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    26 Aug 2019

    Only 10 entries up to this point, click to access all click full view read-more
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