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    Chemistry

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    Also known as: Cloxacillin sodium, 7081-44-9, Cloxacillin sodium monohydrate, Bactopen, Sodium cloxacillin monohydrate, Tegopen
    Molecular Formula
    C19H19ClN3NaO6S
    Molecular Weight
    475.9  g/mol
    InChI Key
    KCUWTKOTPIUBRI-VICXVTCVSA-M
    FDA UNII
    65LCB00B4Y
    Cloxacillin Sodium
    A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
    1 2D Structure

    Cloxacillin Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
    2.1.2 InChI
    InChI=1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
    2.1.3 InChI Key
    KCUWTKOTPIUBRI-VICXVTCVSA-M
    2.1.4 Canonical SMILES
    CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]
    2.1.5 Isomeric SMILES
    CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    65LCB00B4Y
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Chloroxacillin

    2. Cloxacillin

    3. Cloxacillin Sodium

    4. Cloxacillin, Sodium

    5. Sodium Cloxacillin

    6. Sodium, Cloxacillin

    7. Syntarpen

    8. Tegopen

    2.3.2 Depositor-Supplied Synonyms

    1. Cloxacillin Sodium

    2. 7081-44-9

    3. Cloxacillin Sodium Monohydrate

    4. Bactopen

    5. Sodium Cloxacillin Monohydrate

    6. Tegopen

    7. Orbenin

    8. Cloxacillin Sodium Hydrate

    9. Ekvacillin

    10. Latocillin

    11. Cloxypen

    12. Methocillin-s

    13. Cloxacillin Sodium Salt Monohydrate

    14. Cloxacillin (sodium Monohydrate)

    15. Cloxacillin (as Sodium)

    16. Brl-1621

    17. P-25

    18. 65lcb00b4y

    19. Chebi:34978

    20. Monosodium (2s,5r,6r)-6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate Monohydrate

    21. Sodium (2s,5r,6r)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Hydrate

    22. Sodium;(2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate

    23. Staphobristol-250

    24. Orbenin Sodium Hydrate

    25. Cloxacap

    26. Prostaphlin-a Monohydrate

    27. Brl-1621 Sodium Salt Monohydrate

    28. Unii-65lcb00b4y

    29. Cloxacillin Nataarium-1-wasser

    30. Cloxapen (tn)

    31. Tegopen (tn)

    32. Cloxacillin Sodium [usan:usp:jan]

    33. 642-78-4

    34. Cloxacillin Sodium (usp)

    35. Schembl41012

    36. Chembl1200388

    37. Cloxacillin Sodium [usan]

    38. Dtxsid60110018

    39. Cloxacillin Sodium [vandf]

    40. Bcp13532

    41. Cloxacillin Sodium [usp-rs]

    42. Cloxacillin Sodium [who-dd]

    43. Cloxacillin Sodium [who-ip]

    44. Cloxacillin Sodium Hydrate (jp17)

    45. Hy-b0466

    46. Mfcd00150735

    47. S2564

    48. Akos015896310

    49. Akos015962898

    50. Ac-7623

    51. Ccg-269503

    52. Cloxacillin Sodium [green Book]

    53. Cloxacillin Sodium [orange Book]

    54. Cloxacillin Sodium Hydrate [jan]

    55. Cloxacillin Sodium [ep Monograph]

    56. Cloxacillin Sodium [usp Impurity]

    57. 1,3-dichloro-7-bromoisoquinoline

    58. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, Monohydrate, (2s-(2alpha,5alpha,6beta))-

    59. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, Sodium Salt, Monohydrate

    60. As-60182

    61. Cloxacillin Sodium [usp Monograph]

    62. D02231

    63. Ab01568256_01

    64. Cloxacillin Sodium Salt Monohydrate [mi]

    65. Q-200886

    66. Cloxacillin Sodium Hydrate 100 Microg/ml In Methanol

    67. Q27116347

    68. Z2574937894

    69. Cloxacillin Sodium, Antibiotic For Culture Media Use Only

    70. Cloxacillin Sodium, European Pharmacopoeia (ep) Reference Standard

    71. Cloxacillin Sodium Salt Monohydrate, Beta-lactamase-resistant Antibiotic

    72. Cloxacillin Sodium Salt Monohydrate, Vetranal(tm), Analytical Standard

    73. Cloxacillin Sodium, United States Pharmacopeia (usp) Reference Standard

    74. Cloxacillin Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

    75. (2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

    76. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, Monohydrate, (2s-(2.alpha.,5.alpha.,6.beta.))-

    77. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, Sodium Salt, Hydrate (1:1:1), (2s,5r,6r)-

    78. Sodium (2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Hydrate

    79. Sodium (2s,5r,6r)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Hydrate

    80. Sodium 2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylate Hydrate

    2.3.3 Other Synonyms

    1. 642-78-4

    2. Cloxacillin Sodium Anhydrous

    3. Sodium Orbenin

    4. Syntarpen Sodium Salt

    5. Monosodium Cloxacillin

    6. Sodium Syntarpen

    7. Austrastaph

    8. Staphybiotic

    9. Ankerbin

    10. Ekvacillin

    11. Gelstaph

    12. Cloxacillin Sodium Salt

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 475.9 g/mol
    Molecular Formula C19H19ClN3NaO6S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass475.0580785 g/mol
    Monoisotopic Mass475.0580785 g/mol
    Topological Polar Surface Area142 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity728
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

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    04-Jan-2021
    30-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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