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1. 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo(6,7)-1,4-diazepino(5,4-b)oxazol-6-one
2. 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b(5h)-tetrahydro-oxazolo(3,2-d)(1,4)benzodiazepine-6-one
3. Cs 370
4. Former Cas Registry Number Of Cloxazolam
5. Mt 14-411
6. Olcadil
1. Cloxazolazepam
2. Sepazon
3. Olcadil
4. 24166-13-0
5. Enadel
6. Cloxazolamum
7. Betavel
8. Lubalix
9. Tolestan
10. Cs 370
11. Mt 14-411
12. Gyl649z0hy
13. Chebi:31426
14. 10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
15. Oxazolo(3,2-d)(1,4)benzodiazepin-6(5h)-one, 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-
16. 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo(3,2-d) (1,4)benzodiazepin-6(5h)-one
17. Cloxam
18. Cloxazolam [inn:jan]
19. Cloxazolamum [inn-latin]
20. Unii-gyl649z0hy
21. Brn 0569691
22. Sepazone
23. Dea No. 2753
24. 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo[3,2-d] [1,4]benzodiazepin-6(5h)-one
25. Sepazon (tn)
26. Cloxazolam [mi]
27. Cloxazolam [inn]
28. Cloxazolam [jan]
29. Dsstox_cid_2854
30. Cloxazolam (jp17/inn)
31. Cloxazolam [mart.]
32. Cloxazolam [who-dd]
33. Dsstox_rid_97543
34. Dsstox_gsid_22854
35. Us9271961, Cloxazolam
36. Schembl157225
37. Chembl2107254
38. Dtxsid0022854
39. Bdbm220121
40. Tox21_113693
41. Db01553
42. Ncgc00249917-01
43. 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5h)-one
44. 10-chloro-2,3,5,6,7,11b-hexahydro-11b-(o-chlorophenyl)benzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one
45. Cas-24166-13-0
46. D01268
47. Q4385221
48. 10-chloro-11 B-(2-chlorophenyl)- 2,3,5,11b-tetrahydrooxazolo[3,2-d] [1,4]benzodiazepin-6(7h)-one
49. 10-chloro-11b-(2-chlorophenyl)-2,3, 5,11b-tetrahydrooxazolo[3,2-d] [1,4]benzodiazepin-6(7h)-one
50. 10-chloro-11b-(2-chlorophenyl)-2,3,5,11b-tetrahydrooxazolo[3,2-d] [1,4]benzodiazepin-6(7h)-one
51. 10-chloro-11b-(2-chlorophenyl)-2,3,5,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(7h)-one
52. 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5h)-one #
| Molecular Weight | 349.2 g/mol |
|---|---|
| Molecular Formula | C17H14Cl2N2O2 |
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 348.0432331 g/mol |
| Monoisotopic Mass | 348.0432331 g/mol |
| Topological Polar Surface Area | 41.6 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 478 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to surgery.
Studies have shown a superiority of 4mg/day of cloxazepam to 12mg/day of bromazepam in terms of anxiety, depressed mood, and sleep; an insignificant difference in terms of sedative effect; and less muscle relaxant effects. [3] Cloxazolam, administered as a single oral dose of 3mg, when compared to a single 5 mg dose of diazepam in one study, showed similar subjective measures; however, there cloxazolam caused more fatigue, and less mood improvement. Cloxazolam also induced a significant increase in heart rate in the control group of this study. [3]
N05BA22
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N05 - Psycholeptics
N05B - Anxiolytics
N05BA - Benzodiazepine derivatives
N05BA22 - Cloxazolam
Route of Elimination
Renal elimination.
Cloxazolam is metabolised by the liver into the active metabolite chlordesmethyldiazepam (delorazepam). [5]
65 hours
Cloxazolam is a long acting benzodiazepine. It acts as a prodrug, with pharmacologically active metabolites, which bind to to the GABAa receptor, which other benzodiazepines bind to, to illicit a physiological response. [wiki]
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A Cloxazolam manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cloxazolam, including repackagers and relabelers. The FDA regulates Cloxazolam manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cloxazolam API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Cloxazolam manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Cloxazolam supplier is an individual or a company that provides Cloxazolam active pharmaceutical ingredient (API) or Cloxazolam finished formulations upon request. The Cloxazolam suppliers may include Cloxazolam API manufacturers, exporters, distributors and traders.
click here to find a list of Cloxazolam suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Cloxazolam Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Cloxazolam GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cloxazolam GMP manufacturer or Cloxazolam GMP API supplier for your needs.
A Cloxazolam CoA (Certificate of Analysis) is a formal document that attests to Cloxazolam's compliance with Cloxazolam specifications and serves as a tool for batch-level quality control.
Cloxazolam CoA mostly includes findings from lab analyses of a specific batch. For each Cloxazolam CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Cloxazolam may be tested according to a variety of international standards, such as European Pharmacopoeia (Cloxazolam EP), Cloxazolam JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cloxazolam USP).
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