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6 API Suppliers, 1 USDMF, 2 JDMF, 2 NDC API, 5 Listed Suppliers

6 API Suppliers
1 USDMF
2 JDMF
2 NDC API
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FINISHED DOSAGE FORMULATIONS

5 FDF Dossiers, 2 Europe, 3 Listed Dossiers

5 FDF Dossiers
2 Europe
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RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 1 SPI Pharma, 2 Seqens, 7 DKSH, 6 Gangwal Healthcare, 1 Pfanstiehl, 4 ACG Worldwide, 6 Actylis, 1 Aeon Procare, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 11 BASF, 10 Corel Pharma Chem, 2 DFE Pharma, 1 Finar, 7 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 17 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 10 Microlex e.U, 2 Nomisma Healthcare, 2 Novo Excipients, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 11 Roquette, 6 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 The Dow Chemical Company, 2 Vasa Pharmachem

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52 Coating Systems & Additives, 30 Fillers, Diluents & Binders, 28 Controlled & Modified Release, 24 Thickeners and Stabilizers, 16 Lubricants & Glidants, 15 Direct Compression, 10 Film Formers & Plasticizers, 10 Topical, 9 Empty Capsules, 9 Granulation, 8 Co-Processed Excipients, 7 Disintegrants & Superdisintegrants, 7 Parenteral, 6 Taste Masking, 5 API Stability Enhancers, 5 Solubilizers, 4 Vegetarian Capsules, 4 Coloring Agents, 4 Emulsifying Agents, 3 Chewable & Orodispersible Aids, 2 Rheology Modifiers

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Synopsis

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Chemistry

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Also known as: Cobamamide, 13870-90-1, Calomide, Cobalamine coenzyme, Vitamin b12 coenzyme, 5-deoxyadenosylcobalamin

Molecular Formula

C₇₂H₁₀₀CoN₁₈O₁₇P

Molecular Weight

1579.6 g/mol

InChI Key

OAJLVMGLJZXSGX-SLAFOUTOSA-L

1 2D Structure

Cobamamide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate

2.1.2 InChI

InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6+,7+,10+;/m11./s1

2.1.3 InChI Key

OAJLVMGLJZXSGX-SLAFOUTOSA-L

2.1.4 Canonical SMILES

CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[CH2-]C1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O.[Co+3]

2.1.5 Isomeric SMILES

CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]\4([C@H]([C@@H]5[C@]6([C@@]([C@@H](C(=N6)/C(=C\7/[C@@]([C@@H](C(=N7)/C=C\8/C([C@@H](C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[CH2-][C@@H]1[C@@H]([C@@H]([C@H](O1)N2C=NC3=C(N=CN=C32)N)O)O.[Co+3]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 3',4'-anhydroadenosylcobalamin

2. 5'-deoxyadenosylcobalamin

3. Adenosylcobalamin

4. Adocbl

5. Cobamamide

6. Desoxyadenosylcobalamine

7. Dibencozide

8. Indusil T

9. Vitamin B12 Coenzyme

2.2.2 Depositor-Supplied Synonyms

1. Cobamamide

2. 13870-90-1

3. Calomide

4. Cobalamine Coenzyme

5. Vitamin B12 Coenzyme

6. 5-deoxyadenosylcobalamin

7. 5'-deoxyadenosylcobalamine

8. Mfcd00135609

9. Akos025311252

2.3 Create Date

2006-04-29

3 Chemical and Physical Properties

Molecular Formula	C₇₂H₁₀₀CoN₁₈O₁₇P
Molecular Weight	1579.6 g/mol
Hydrogen Bond Donor Count	12
Hydrogen Bond Acceptor Count	27
Rotatable Bond Count	27
Exact Mass	1578.658339 g/mol
Monoisotopic Mass	1578.658339 g/mol
Topological Polar Surface Area	571 Å²
Heavy Atom Count	109
Formal Charge	0
Complexity	3730
Isotope Atom Count	0
Defined Atom Stereocenter Count	18
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	3
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 ATC Code

B - Blood and blood forming organs

B03 - Antianemic preparations

B03B - Vitamin b12 and folic acid

B03BA - Vitamin b12 (cyanocobalamin and analogues)

B03BA04 - Cobamamide

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USDMF

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JDMF

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Controlled & Modified Release

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Lubricants & Glidants

Direct Compression

Film Formers & Plasticizers

Topical

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ABOUT THIS PAGE

List of Suppliers' Api Stability Enhancers Excipients Application used in Cobamamide on PharmaCompass.com

Cobamamide

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

6 API Suppliers

1 USDMF

2 JDMF

2 NDC API

5 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

5 FDF Dossiers

2 Europe

3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc

1 SPI Pharma

2 Seqens

7 DKSH

6 Gangwal Healthcare

1 Pfanstiehl

4 ACG Worldwide

6 Actylis

1 Aeon Procare

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

11 BASF

10 Corel Pharma Chem

2 DFE Pharma

1 Finar

7 Gangwal Chemicals

7 Ideal Cures Pvt Ltd

17 Kerry

3 Kima Chemical

6 Lonza Capsugel

10 Microlex e.U

2 Nomisma Healthcare

2 Novo Excipients

1 Pharmatrans-Sanaq

2 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

11 Roquette

6 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

9 Sigachi Industries

2 The Dow Chemical Company

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

52 Coating Systems & Additives

30 Fillers, Diluents & Binders

28 Controlled & Modified Release

24 Thickeners and Stabilizers

16 Lubricants & Glidants

15 Direct Compression

10 Film Formers & Plasticizers

10 Topical

9 Empty Capsules

9 Granulation

8 Co-Processed Excipients

7 Disintegrants & Superdisintegrants

7 Parenteral

6 Taste Masking

5 API Stability Enhancers

5 Solubilizers

4 Vegetarian Capsules

4 Coloring Agents

4 Emulsifying Agents

3 Chewable & Orodispersible Aids

2 Rheology Modifiers

GLOBAL SALES INFORMATION

2 Finished Drug Prices

MARKET PLACE

12 APIs

REF. STANDARDS & IMPURITIES

1 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)