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Chemistry

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Also known as: Colforsin, 66575-29-9, Coleonol, Colforsina, Colforsine, Colforsinum
Molecular Formula
C22H34O7
Molecular Weight
410.5  g/mol
InChI Key
OHCQJHSOBUTRHG-KGGHGJDLSA-N
FDA UNII
1F7A44V6OU

Coleus Forskohlii Extract
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
1 2D Structure

Coleus Forskohlii Extract

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
2.1.2 InChI
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
2.1.3 InChI Key
OHCQJHSOBUTRHG-KGGHGJDLSA-N
2.1.4 Canonical SMILES
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
2.1.5 Isomeric SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
2.2 Other Identifiers
2.2.1 UNII
1F7A44V6OU
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Coleonol

2. Colforsin

3. N,n-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1h-naphtho(2,1-b)pyran-6-yl Ester Hcl

4. Nkh 477

5. Nkh-477

6. Nkh477

2.3.2 Depositor-Supplied Synonyms

1. Colforsin

2. 66575-29-9

3. Coleonol

4. Colforsina

5. Colforsine

6. Colforsinum

7. Boforsin

8. Hl 362

9. Coleonolk

10. L 75 1362b

11. Forskolin (gmp)

12. 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one

13. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1h-benzo[f]chromen-5-yl Acetate

14. Hl-362

15. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1h-benzo[f]chromen-5-yl Acetate

16. Chembl52606

17. L-751362b

18. 1f7a44v6ou

19. [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-5-yl] Acetate

20. Chebi:42471

21. Nsc375489

22. Nsc-357088

23. Nsc-375489

24. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1h-naphtho(2,1-b)pyran-1-one 5-acetate

25. Ncgc00024996-02

26. L-75-1362b

27. 66428-89-5

28. Dsstox_cid_20484

29. Dsstox_rid_79500

30. Dsstox_gsid_40484

31. 1h-naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3r,4ar,5s,6s,6as,10s,10ar,10bs)-

32. Colforsine [french]

33. Colforsinum [latin]

34. Colforsina [spanish]

35. Forslean

36. Colforsin [usan:inn]

37. Fok

38. Smr000471881

39. Cas-66575-29-9

40. C22h34o7

41. Einecs 266-410-9

42. Nsc 357088

43. Nsc 375489

44. Unii-1f7a44v6ou

45. Ocufors

46. Timsaponin-c

47. Forskolin- Bio-x

48. (-)-forskolin

49. Mfcd00082317

50. Forskolin - 10%

51. Forskolin - 20%

52. Forskolin - 40%

53. Colforsin [inn]

54. Colforsin [mi]

55. Colforsin (usan/inn)

56. Colforsin [usan]

57. Forskolin [vandf]

58. Colforsin [mart.]

59. Forskolin/ Rolipram Mixture

60. Molmap_000021

61. 7-beta-acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one

62. Colforsin [who-dd]

63. Forskolin [usp-rs]

64. Schembl4928

65. 1h-naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-

66. Cid_47936

67. Mls001066384

68. Mls001333255

69. Mls001333256

70. Mls002172462

71. Mls002695942

72. Forskolin, Analytical Standard

73. Forskohlii Root Extract (forslean)(20% Forskohlin)

74. Regid_for_cid_47936

75. Gtpl5190

76. Dtxsid8040484

77. Bcbcmap01_000132

78. Ohcqjhsobutrhg-kgghgjdlsa-

79. Bio1_000443

80. Bio1_000932

81. Bio1_001421

82. Hms2235c17

83. Hms3267i16

84. Hms3412g19

85. Hms3676g19

86. Ex-a5963

87. Zinc3977779

88. Tox21_110940

89. Tox21_302399

90. Bdbm50010261

91. Hy-15371g

92. S2449

93. Akos024456384

94. Tox21_110940_1

95. Am81249

96. Ccg-268774

97. Cs-1454

98. Db02587

99. Lmpr0104030004

100. Smp1_000128

101. Ncgc00024996-03

102. Ncgc00024996-04

103. Ncgc00024996-05

104. Ncgc00024996-06

105. Ncgc00024996-07

106. Ncgc00024996-34

107. Ncgc00177971-03

108. Ncgc00255526-01

109. 1h-naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3r-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-

110. 1h-naphtho(2,1-b)pyran-1-one, Dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-

111. 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1h-naphtho(2,1-b)pyran-1-one

112. Ac-33150

113. As-17443

114. Bf164487

115. Hy-15371

116. Xf165210

117. Xf165211

118. Xf165212

119. Cs-0622781

120. F0855

121. M-410

122. C09076

123. D03584

124. Mls-0318096.0001

125. A850885

126. Q412747

127. Sr-01000597378

128. Forskolin (constituent Of Forskohlii) [dsc]

129. Forskolin, For Use In Molecular Biology Applications

130. Q-200888

131. Sr-01000597378-1

132. Brd-k09602097-001-04-5

133. Forskolin, From Coleus Forskohlii, >=98% (hplc), Powder

134. Forskolin, United States Pharmacopeia (usp) Reference Standard

135. Coleonol;7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one

136. (3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1h-naphtho[2,1-b]pyran-5-yl Acetate

137. [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-5-yl] Acetate

138. [3r-(3

139. [3r-(3?,4a?,5?,6?,6a?,10?,10a?,10b?)]-5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1h-naphtho[2,1-b]pyran-1-one

140. [3r-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(acetyloxy)-3-e Thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1h-naphtho[2,1-b]pyran-1-one

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 410.5 g/mol
Molecular Formula C22H34O7
XLogP31
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass410.23045342 g/mol
Monoisotopic Mass410.23045342 g/mol
Topological Polar Surface Area113 Ų
Heavy Atom Count29
Formal Charge0
Complexity747
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)


Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


API Reference Price

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02-Jul-2022
02-Jan-2023
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ABOUT THIS PAGE

Coleus Forskohlii Extract Manufacturers

A Coleus Forskohlii Extract manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Coleus Forskohlii Extract, including repackagers and relabelers. The FDA regulates Coleus Forskohlii Extract manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Coleus Forskohlii Extract API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Coleus Forskohlii Extract manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Coleus Forskohlii Extract Suppliers

A Coleus Forskohlii Extract supplier is an individual or a company that provides Coleus Forskohlii Extract active pharmaceutical ingredient (API) or Coleus Forskohlii Extract finished formulations upon request. The Coleus Forskohlii Extract suppliers may include Coleus Forskohlii Extract API manufacturers, exporters, distributors and traders.

click here to find a list of Coleus Forskohlii Extract suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Coleus Forskohlii Extract USDMF

A Coleus Forskohlii Extract DMF (Drug Master File) is a document detailing the whole manufacturing process of Coleus Forskohlii Extract active pharmaceutical ingredient (API) in detail. Different forms of Coleus Forskohlii Extract DMFs exist exist since differing nations have different regulations, such as Coleus Forskohlii Extract USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Coleus Forskohlii Extract DMF submitted to regulatory agencies in the US is known as a USDMF. Coleus Forskohlii Extract USDMF includes data on Coleus Forskohlii Extract's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Coleus Forskohlii Extract USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Coleus Forskohlii Extract suppliers with USDMF on PharmaCompass.

Coleus Forskohlii Extract GMP

Coleus Forskohlii Extract Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Coleus Forskohlii Extract GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Coleus Forskohlii Extract GMP manufacturer or Coleus Forskohlii Extract GMP API supplier for your needs.

Coleus Forskohlii Extract CoA

A Coleus Forskohlii Extract CoA (Certificate of Analysis) is a formal document that attests to Coleus Forskohlii Extract's compliance with Coleus Forskohlii Extract specifications and serves as a tool for batch-level quality control.

Coleus Forskohlii Extract CoA mostly includes findings from lab analyses of a specific batch. For each Coleus Forskohlii Extract CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Coleus Forskohlii Extract may be tested according to a variety of international standards, such as European Pharmacopoeia (Coleus Forskohlii Extract EP), Coleus Forskohlii Extract JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Coleus Forskohlii Extract USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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