Find Collagenase Clostridium Histolyticum manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Unii-15z7208b52, Unii-231982l46k, Collagenase (clostridium histolyticum gene colh isoenzyme aux-ii), 955089-04-0, 955089-06-2, 15z7208b52
Molecular Formula
Ca2+4
Molecular Weight
80.16  g/mol
InChI Key
XRZGBICBMVJLMH-UHFFFAOYSA-N

Collagenase Clostridium Histolyticum
1 2D Structure

Collagenase Clostridium Histolyticum

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium(2+)
2.1.2 InChI
InChI=1S/2Ca/q2*+2
2.1.3 InChI Key
XRZGBICBMVJLMH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[Ca+2].[Ca+2]
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Unii-15z7208b52

2. Unii-231982l46k

3. Collagenase (clostridium Histolyticum Gene Colh Isoenzyme Aux-ii)

4. 955089-04-0

5. 955089-06-2

6. 15z7208b52

7. 231982l46k

2.3 Create Date
2007-12-04
3 Chemical and Physical Properties
Molecular Weight 80.16 g/mol
Molecular Formula Ca2+4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass79.9251817 g/mol
Monoisotopic Mass79.9251817 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count2
Formal Charge4
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

Drugs in Development

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Details:

The companies will merge and integrate their entire pipelines, including Xiaflex (collagenase clostridium histolyticum) for treating adult patients with Dupuytren’s contracture.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Musculoskeletal Brand Name: Xiaflex

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Mallinckrodt Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Merger March 13, 2025

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01

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : The companies will merge and integrate their entire pipelines, including Xiaflex (collagenase clostridium histolyticum) for treating adult patients with Dupuytren’s contracture.

Product Name : Xiaflex

Product Type : Enzyme

Upfront Cash : Undisclosed

March 13, 2025

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Details:

Xiaflex (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is indicated for Dupuytren's Contracture treatment.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Dermatology Brand Name: Xiaflex

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 12, 2025

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02

Endo Pharm

Ireland
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German Wound Congress
Not Confirmed

Endo Pharm

Ireland
arrow
German Wound Congress
Not Confirmed

Details : Xiaflex (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is indicated for Dupuytren's Contracture treatment.

Product Name : Xiaflex

Product Type : Enzyme

Upfront Cash : Inapplicable

March 12, 2025

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Details:

Xiaflex (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is indicated for Dupuytren's Contracture treatment.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Musculoskeletal Brand Name: Xiaflex

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 20, 2024

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Endo Pharm

Ireland
arrow
German Wound Congress
Not Confirmed

Endo Pharm

Ireland
arrow
German Wound Congress
Not Confirmed

Details : Xiaflex (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is indicated for Dupuytren's Contracture treatment.

Product Name : Xiaflex

Product Type : Enzyme

Upfront Cash : Inapplicable

November 20, 2024

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Details:

EN3835 (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is being investigated for plantar fibromatosis.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Rare Diseases and Disorders Brand Name: Qwo

Study Phase: Phase IIIProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 13, 2023

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04

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : EN3835 (collagenase clostridium histolyticum) is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers. It is being investigated for plantar fibromatosis.

Product Name : Qwo

Product Type : Enzyme

Upfront Cash : Inapplicable

March 13, 2023

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Details:

Qwo® (collagenase clostridium histolyticum-aaes), an FDA-approved injectable is used for the treatment of moderate to severe cellulite in the buttocks of adult women. QWO is contraindicated in patients with a history of hypersensitivity to collagenase.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Dermatology Brand Name: Qwo

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 10, 2022

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05

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : Qwo® (collagenase clostridium histolyticum-aaes), an FDA-approved injectable is used for the treatment of moderate to severe cellulite in the buttocks of adult women. QWO is contraindicated in patients with a history of hypersensitivity to collagenase.

Product Name : Qwo

Product Type : Enzyme

Upfront Cash : Inapplicable

July 10, 2022

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Details:

Qwo (collagenase clostridium histolyticum-aaes), is a prescription medicine used to treat moderate to severe cellulite in the buttocks of adult women, may cause serious side effects including allergic.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Dermatology Brand Name: Qwo

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 05, 2022

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06

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : Qwo (collagenase clostridium histolyticum-aaes), is a prescription medicine used to treat moderate to severe cellulite in the buttocks of adult women, may cause serious side effects including allergic.

Product Name : Qwo

Product Type : Enzyme

Upfront Cash : Inapplicable

May 05, 2022

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Details:

Phase 2 study participants receiving up to 3 doses of Xiaflex (collagenase clostridium histolyticum) showed improvement in change from baseline ifor affected shoulder at Day 95, compared to those study participants receiving placebo was not significant.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Musculoskeletal Brand Name: Qwo

Study Phase: Phase IIProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 07, 2022

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07

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : Phase 2 study participants receiving up to 3 doses of Xiaflex (collagenase clostridium histolyticum) showed improvement in change from baseline ifor affected shoulder at Day 95, compared to those study participants receiving placebo was not significant.

Product Name : Qwo

Product Type : Enzyme

Upfront Cash : Inapplicable

January 07, 2022

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Details:

Endo International plc presentation will include a general overview of collagenase clostridium histolyticum-aaes and will review data from the product's phase 3 pooled trial analyses.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Dermatology Brand Name: Xiaflex

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 24, 2020

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08

Endo Pharm

Ireland
arrow
German Wound Congress
Not Confirmed

Endo Pharm

Ireland
arrow
German Wound Congress
Not Confirmed

Details : Endo International plc presentation will include a general overview of collagenase clostridium histolyticum-aaes and will review data from the product's phase 3 pooled trial analyses.

Product Name : Xiaflex

Product Type : Enzyme

Upfront Cash : Inapplicable

September 24, 2020

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Details:

Endo International will present data relevant to the use of Endo Aesthetics' Qwo™ (collagenase clostridium histolyticum-aaes) for the treatment of moderate to severe cellulite in the buttocks of adult women during the American Society for Dermatologic Surgery's Annual Meeting.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Dermatology Brand Name: Qwo

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 10, 2020

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09

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : Endo International will present data relevant to the use of Endo Aesthetics' Qwo™ (collagenase clostridium histolyticum-aaes) for the treatment of moderate to severe cellulite in the buttocks of adult women during the American Society for Dermatologic ...

Product Name : Qwo

Product Type : Enzyme

Upfront Cash : Inapplicable

September 10, 2020

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  • Deals

Details:

BioSpecifics received a royalty stream from Endo related to Endo's collagenase-based therapies, which currently include XIAFLEX, marketed by Endo Pharmaceuticals.


Lead Product(s): Collagenase Clostridium Histolyticum

Therapeutic Area: Dermatology Brand Name: Xiaflex

Study Phase: Approved FDFProduct Type: Enzyme

Sponsor: Endo Pharm

Deal Size: $540.0 million Upfront Cash: $540.0 million

Deal Type: Acquisition February 12, 2020

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BioSpecifics

Country
arrow
German Wound Congress
Not Confirmed

BioSpecifics

Country
arrow
German Wound Congress
Not Confirmed

Details : BioSpecifics received a royalty stream from Endo related to Endo's collagenase-based therapies, which currently include XIAFLEX, marketed by Endo Pharmaceuticals.

Product Name : Xiaflex

Product Type : Enzyme

Upfront Cash : $540.0 million

February 12, 2020

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FDA Orange Book

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01

AUXILIUM PHARMS

Ireland
German Wound Congress
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AUXILIUM PHARMS

Ireland
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German Wound Congress
Not Confirmed

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM

Brand Name : XIAFLEX

Dosage Form : SOLUTION; INJECTION

Dosage Strength : 0.9MG

Approval Date :

Application Number : 125338

RX/OTC/DISCN :

RLD :

TE Code :

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German Wound Congress
Not Confirmed
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German Wound Congress
Not Confirmed

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM-AAES

Brand Name : QWO

Dosage Form : SOLUTION;SUBCUTANEOUS

Dosage Strength : 0.92MG/VIAL

Approval Date :

Application Number : 761146

RX/OTC/DISCN :

RLD :

TE Code :

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German Wound Congress
Not Confirmed
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German Wound Congress
Not Confirmed

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM-AAES

Brand Name : QWO

Dosage Form : SOLUTION;SUBCUTANEOUS

Dosage Strength : 1.84MG/VIAL

Approval Date :

Application Number : 761146

RX/OTC/DISCN :

RLD :

TE Code :

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Europe

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Orifarm AS

Denmark
German Wound Congress
Not Confirmed
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Orifarm AS

Denmark
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German Wound Congress
Not Confirmed

Collagenase Clostridium Histolyticum

Brand Name : Xiapex

Dosage Form : Powder and liquid to the injection fluid, resolution

Dosage Strength : 0.9 mg

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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German Wound Congress
Not Confirmed
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German Wound Congress
Not Confirmed

Collagenase Clostridium Histolyticum; Chloramphenicol

Brand Name : Iruxol

Dosage Form :

Dosage Strength : Pom Derm 30 G  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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German Wound Congress
Not Confirmed
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German Wound Congress
Not Confirmed

collagenase clostridium histolyticum

Brand Name : Xiapex

Dosage Form : POWDER AND SOLVENT FOR SOLUTION FOR INJECTION

Dosage Strength : 0.9 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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04

German Wound Congress
Not Confirmed
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German Wound Congress
Not Confirmed

Collagenase Clostridium Histolyticum

Brand Name : Xiapex

Dosage Form : Collagenase Clostridium Histolyticum 0,9Mg 1 Units Use Intralesional

Dosage Strength : 1 vial groun 0.9 mg + 1 vial solv

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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German Wound Congress
Not Confirmed
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German Wound Congress
Not Confirmed

Collagenase Clostridium Histolyticum

Brand Name : Xiapex

Dosage Form : Powder and liquid to the injection fluid, resolution

Dosage Strength : 0.9 mg

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Vefa Ilac

Turkey
German Wound Congress
Not Confirmed
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Vefa Ilac

Turkey
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German Wound Congress
Not Confirmed

Glucosamine Sulphate Potassium Chloride; Chondroitin Sulfate A; Collagenase Clostridium Histolyticum; Cucurmin; Fennel; eucalyptol; Clove Oil; Menthol

Brand Name : Arteasy

Dosage Form : CREAM

Dosage Strength :

Packaging : 50 ML

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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ABOUT THIS PAGE

Looking for 955089-06-2 / Collagenase Clostridium Histolyticum API manufacturers, exporters & distributors?

Collagenase Clostridium Histolyticum manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Collagenase Clostridium Histolyticum API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Collagenase Clostridium Histolyticum manufacturer or Collagenase Clostridium Histolyticum supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Collagenase Clostridium Histolyticum manufacturer or Collagenase Clostridium Histolyticum supplier.

PharmaCompass also assists you with knowing the Collagenase Clostridium Histolyticum API Price utilized in the formulation of products. Collagenase Clostridium Histolyticum API Price is not always fixed or binding as the Collagenase Clostridium Histolyticum Price is obtained through a variety of data sources. The Collagenase Clostridium Histolyticum Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Collagenase Clostridium Histolyticum

Synonyms

Unii-15z7208b52, Unii-231982l46k, Collagenase (clostridium histolyticum gene colh isoenzyme aux-ii), 955089-04-0, 955089-06-2, 15z7208b52

Cas Number

955089-06-2

Collagenase Clostridium Histolyticum Manufacturers

A Collagenase Clostridium Histolyticum manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Collagenase Clostridium Histolyticum, including repackagers and relabelers. The FDA regulates Collagenase Clostridium Histolyticum manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Collagenase Clostridium Histolyticum API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Collagenase Clostridium Histolyticum Suppliers

A Collagenase Clostridium Histolyticum supplier is an individual or a company that provides Collagenase Clostridium Histolyticum active pharmaceutical ingredient (API) or Collagenase Clostridium Histolyticum finished formulations upon request. The Collagenase Clostridium Histolyticum suppliers may include Collagenase Clostridium Histolyticum API manufacturers, exporters, distributors and traders.

click here to find a list of Collagenase Clostridium Histolyticum suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Collagenase Clostridium Histolyticum NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Collagenase Clostridium Histolyticum as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Collagenase Clostridium Histolyticum API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Collagenase Clostridium Histolyticum as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Collagenase Clostridium Histolyticum and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Collagenase Clostridium Histolyticum NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Collagenase Clostridium Histolyticum suppliers with NDC on PharmaCompass.

Collagenase Clostridium Histolyticum GMP

Collagenase Clostridium Histolyticum Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Collagenase Clostridium Histolyticum GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Collagenase Clostridium Histolyticum GMP manufacturer or Collagenase Clostridium Histolyticum GMP API supplier for your needs.

Collagenase Clostridium Histolyticum CoA

A Collagenase Clostridium Histolyticum CoA (Certificate of Analysis) is a formal document that attests to Collagenase Clostridium Histolyticum's compliance with Collagenase Clostridium Histolyticum specifications and serves as a tool for batch-level quality control.

Collagenase Clostridium Histolyticum CoA mostly includes findings from lab analyses of a specific batch. For each Collagenase Clostridium Histolyticum CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Collagenase Clostridium Histolyticum may be tested according to a variety of international standards, such as European Pharmacopoeia (Collagenase Clostridium Histolyticum EP), Collagenase Clostridium Histolyticum JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Collagenase Clostridium Histolyticum USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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