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Chemistry

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Also known as: Coltramyl, Thiocolchicine glycoside, Coltrax, Miorel, N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide, Nsc624673
Molecular Formula
C27H33NO10S
Molecular Weight
563.6  g/mol
InChI Key
LEQAKWQJCITZNK-MSQQGMGVSA-N

Thiocolchicoside
1 2D Structure

Thiocolchicoside

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
2.1.2 InChI
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16?,19-,22-,23+,24-,27-/m1/s1
2.1.3 InChI Key
LEQAKWQJCITZNK-MSQQGMGVSA-N
2.1.4 Canonical SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC4C(C(C(C(O4)CO)O)O)O
2.1.5 Isomeric SMILES
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 2,14-di-(demethoxy)-2-glucosidoxy-14- Methylthiocolchicine

2. Coltramyl

3. Miorel

4. Myoplge

5. Thiocolchicoside

2.2.2 Depositor-Supplied Synonyms

1. Coltramyl

2. Thiocolchicine Glycoside

3. Coltrax

4. Miorel

5. N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide

6. Nsc624673

7. 2-demethoxy-2-glucosidoxythiocolchicine

8. Nsc-147755

9. Thiocolchicoside-d3

10. Prestwick_875

11. Prestwick0_000539

12. Prestwick1_000539

13. Prestwick2_000539

14. Prestwick3_000539

15. Bspbio_000557

16. Mls002153865

17. 602-41-5 (unlabeled)

18. Schembl719194

19. Spbio_002478

20. Bpbio1_000613

21. Chembl1705373

22. Chebi:91529

23. Hms1569l19

24. Hms2096l19

25. Hms2234k08

26. Bdbm50248250

27. N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide

28. Smr001233221

29. Sr-01000841233

30. Q1165293

31. Sr-01000841233-2

32. Brd-a11605036-001-03-2

33. N-(3-(hexopyranosyloxy)-1,2-dimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

2.3 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 563.6 g/mol
Molecular Formula C27H33NO10S
XLogP3-0.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass563.18251742 g/mol
Monoisotopic Mass563.18251742 g/mol
Topological Polar Surface Area189 Ų
Heavy Atom Count39
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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07-Jan-2021
28-Mar-2025
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Looking for / Thiocolchicoside API manufacturers, exporters & distributors?

Thiocolchicoside manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Thiocolchicoside API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Thiocolchicoside manufacturer or Thiocolchicoside supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Thiocolchicoside manufacturer or Thiocolchicoside supplier.

PharmaCompass also assists you with knowing the Thiocolchicoside API Price utilized in the formulation of products. Thiocolchicoside API Price is not always fixed or binding as the Thiocolchicoside Price is obtained through a variety of data sources. The Thiocolchicoside Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Thiocolchicoside

Synonyms

Coltramyl, Thiocolchicine glycoside, Coltrax, Miorel, N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide, Nsc624673

Coltramyl Manufacturers

A Coltramyl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Coltramyl, including repackagers and relabelers. The FDA regulates Coltramyl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Coltramyl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Coltramyl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Coltramyl Suppliers

A Coltramyl supplier is an individual or a company that provides Coltramyl active pharmaceutical ingredient (API) or Coltramyl finished formulations upon request. The Coltramyl suppliers may include Coltramyl API manufacturers, exporters, distributors and traders.

click here to find a list of Coltramyl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Coltramyl USDMF

A Coltramyl DMF (Drug Master File) is a document detailing the whole manufacturing process of Coltramyl active pharmaceutical ingredient (API) in detail. Different forms of Coltramyl DMFs exist exist since differing nations have different regulations, such as Coltramyl USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Coltramyl DMF submitted to regulatory agencies in the US is known as a USDMF. Coltramyl USDMF includes data on Coltramyl's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Coltramyl USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Coltramyl suppliers with USDMF on PharmaCompass.

Coltramyl CEP

A Coltramyl CEP of the European Pharmacopoeia monograph is often referred to as a Coltramyl Certificate of Suitability (COS). The purpose of a Coltramyl CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Coltramyl EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Coltramyl to their clients by showing that a Coltramyl CEP has been issued for it. The manufacturer submits a Coltramyl CEP (COS) as part of the market authorization procedure, and it takes on the role of a Coltramyl CEP holder for the record. Additionally, the data presented in the Coltramyl CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Coltramyl DMF.

A Coltramyl CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Coltramyl CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Coltramyl suppliers with CEP (COS) on PharmaCompass.

Coltramyl WC

A Coltramyl written confirmation (Coltramyl WC) is an official document issued by a regulatory agency to a Coltramyl manufacturer, verifying that the manufacturing facility of a Coltramyl active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Coltramyl APIs or Coltramyl finished pharmaceutical products to another nation, regulatory agencies frequently require a Coltramyl WC (written confirmation) as part of the regulatory process.

click here to find a list of Coltramyl suppliers with Written Confirmation (WC) on PharmaCompass.

Coltramyl GMP

Coltramyl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Coltramyl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Coltramyl GMP manufacturer or Coltramyl GMP API supplier for your needs.

Coltramyl CoA

A Coltramyl CoA (Certificate of Analysis) is a formal document that attests to Coltramyl's compliance with Coltramyl specifications and serves as a tool for batch-level quality control.

Coltramyl CoA mostly includes findings from lab analyses of a specific batch. For each Coltramyl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Coltramyl may be tested according to a variety of international standards, such as European Pharmacopoeia (Coltramyl EP), Coltramyl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Coltramyl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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