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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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4 RELATED EXCIPIENT COMPANIES

5EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 168626-94-6, Conivaptan hcl, Vaprisol, Ym 087, Conivaptan (hydrochloride), Ci-1025
Molecular Formula
C32H27ClN4O2
Molecular Weight
535.0  g/mol
InChI Key
BTYHAFSDANBVMJ-UHFFFAOYSA-N
FDA UNII
75L57R6X36

Conivaptan
1 2D Structure

Conivaptan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide;hydrochloride
2.1.2 InChI
InChI=1S/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22;/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);1H
2.1.3 InChI Key
BTYHAFSDANBVMJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NC2=C(N1)CCN(C3=CC=CC=C32)C(=O)C4=CC=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=CC=C6.Cl
2.2 Other Identifiers
2.2.1 UNII
75L57R6X36
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (1,1'-biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1h)-yl)carbonyl)phenyl)-

2. (1,1'-biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1h)-yl)carbonyl)phenyl)-, Monohydrochloride

3. 4''-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1h)-yl)carbonyl)-2-biphenylcarboxanilide

4. Ci-1025

5. Conivaptan

6. Conivaptan Hcl

7. Vaprisol

8. Ym 087

9. Ym-087

10. Ym087

2.3.2 Depositor-Supplied Synonyms

1. 168626-94-6

2. Conivaptan Hcl

3. Vaprisol

4. Ym 087

5. Conivaptan (hydrochloride)

6. Ci-1025

7. Conivaptan Hydrochloride [usan]

8. Ym-087

9. N-[4-(2-methyl-4,5-dihydro-3h-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide Hydrochloride

10. Ym087

11. Conivaptan Hcl (vaprisol)

12. 8626-94-6

13. Chebi:31430

14. 75l57r6x36

15. (1,1'-biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1h)-yl)carbonyl)phenyl)-, Monohydrochloride

16. [1,1'-biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1h)-yl)carbonyl]phenyl]-, Hydrochloride (1:1)

17. 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1h)-yl)carbonyl)-2-biphenylcarboxanilide Monohydrochloride

18. N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide Hydrochloride

19. 4'-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)-carbonyl]-2-phenylbenzanilide Monohydrochloride

20. N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),4,10,12-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide Hydrochloride

21. Smr004701209

22. Unii-75l57r6x36

23. Vaprisol (tn)

24. Mls006010030

25. Mls006010233

26. Schembl387232

27. Conivaptan Hcl [vandf]

28. Chembl1201108

29. Dtxsid70168585

30. Vaprisol, Conivaptan Hydrochloride

31. Bcp28426

32. Ex-a1128

33. Conivaptan Hydrochloride (jan/usan)

34. Conivaptan Hydrochloride [mi]

35. Hy-18347a

36. Mfcd00945712

37. Conivaptan Hydrochloride [jan]

38. Akos015994583

39. Akos025401635

40. Ccg-269940

41. Cs-2015

42. Fe-0225

43. Conivaptan Hydrochloride [mart.]

44. Conivaptan Hydrochloride [who-dd]

45. Ac-23918

46. N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1h)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide Hydrochloride

47. Db-064699

48. Am20090724

49. Ft-0657174

50. Sw219215-1

51. Conivaptan Hydrochloride [orange Book]

52. D01236

53. 626c946

54. A810997

55. J-010472

56. Q27114306

57. 4''-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1h)-yl)carbonyl)-2-biphenylcarboxanilide Monohydrochloride

58. 4'-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]-2-phenylbenzanilide Hydrochloride

59. N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamidehydrochloride

60. N-[4-(2-methyl-4,5-dihydro-1h-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide;hydrochloride

61. N-[4-(2-methyl-4,5-dihydro-3h-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide;hydrochloride

62. N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1h)-yl)carbonyl]phenyl]-[1,1?-biphenyl]-2-carboxamide Hydrochloride

63. N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1h)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 535.0 g/mol
Molecular Formula C32H27ClN4O2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass534.1822538 g/mol
Monoisotopic Mass534.1822538 g/mol
Topological Polar Surface Area78.1 Ų
Heavy Atom Count39
Formal Charge0
Complexity820
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameVaprisol
PubMed HealthConivaptan (Injection)
Drug ClassesEndocrine-Metabolic Agent
Drug LabelConivaptan hydrochloride is chemically [1,1'-biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, monohydrochloride, having a molecular weight of 535.04 and molecular formula C32H26N4O2HCl. Th...
Active IngredientConivaptan hydrochloride
Dosage FormInjectable
Routeinjection
Strength20mg
Market StatusPrescription
CompanyAstellas

2 of 2  
Drug NameVaprisol
PubMed HealthConivaptan (Injection)
Drug ClassesEndocrine-Metabolic Agent
Drug LabelConivaptan hydrochloride is chemically [1,1'-biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, monohydrochloride, having a molecular weight of 535.04 and molecular formula C32H26N4O2HCl. Th...
Active IngredientConivaptan hydrochloride
Dosage FormInjectable
Routeinjection
Strength20mg
Market StatusPrescription
CompanyAstellas

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antidiuretic Hormone Receptor Antagonists

Endogenous compounds and drugs that inhibit or block the activity of ANTIDUIRETIC HORMONE RECEPTORS. (See all compounds classified as Antidiuretic Hormone Receptor Antagonists.)


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ABOUT THIS PAGE

Conivaptan Manufacturers

A Conivaptan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Conivaptan, including repackagers and relabelers. The FDA regulates Conivaptan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Conivaptan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Conivaptan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Conivaptan Suppliers

A Conivaptan supplier is an individual or a company that provides Conivaptan active pharmaceutical ingredient (API) or Conivaptan finished formulations upon request. The Conivaptan suppliers may include Conivaptan API manufacturers, exporters, distributors and traders.

click here to find a list of Conivaptan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Conivaptan GMP

Conivaptan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Conivaptan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Conivaptan GMP manufacturer or Conivaptan GMP API supplier for your needs.

Conivaptan CoA

A Conivaptan CoA (Certificate of Analysis) is a formal document that attests to Conivaptan's compliance with Conivaptan specifications and serves as a tool for batch-level quality control.

Conivaptan CoA mostly includes findings from lab analyses of a specific batch. For each Conivaptan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Conivaptan may be tested according to a variety of international standards, such as European Pharmacopoeia (Conivaptan EP), Conivaptan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Conivaptan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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