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ACTIVE PHARMA INGREDIENTS

18 API Suppliers, 14 USDMF, 1 CEP/COS, 3 EU WC, 1 KDMF, 7 NDC API, 4 Listed Suppliers, $ API Reference Price

18 API Suppliers
14 USDMF
1 CEP/COS
3 EU WC
1 KDMF
7 NDC API
4 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

108 FDF Dossiers, 38 FDA Orange Book, 44 Europe, 10 Canada, 14 South Africa, 2 Listed Dossiers

108 FDF Dossiers
38 FDA Orange Book
44 Europe
10 Canada
14 South Africa
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 20MG BASE;0.45MG, TABLET;ORAL - 0.3MG, TABLET;ORAL - 0.45MG, TABLET;ORAL - 0.625MG, TABLET;ORAL - 0.9MG, TABLET;ORAL - 1.25MG

drugProductComposition
TABLET;ORAL - EQ 20MG BASE;0.45MG
TABLET;ORAL - 0.3MG
TABLET;ORAL - 0.45MG
TABLET;ORAL - 0.625MG
TABLET;ORAL - 0.9MG
TABLET;ORAL - 1.25MG

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 2 DKSH, 3 Faran Shimi Pharmaceutical, 10 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 11 BASF, 11 Corel Pharma Chem, 4 DFE Pharma, 1 Finar, 8 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 30 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 10 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 15 Roquette, 13 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 3 The Dow Chemical Company, 2 Vasa Pharmachem, 1 Vertellus

EXCIPIENTS BY APPLICATIONS

57 Fillers, Diluents & Binders, 45 Coating Systems & Additives, 27 Direct Compression, 27 Controlled & Modified Release, 18 Thickeners and Stabilizers, 16 Granulation, 15 Solubilizers, 15 Co-Processed Excipients, 13 Film Formers & Plasticizers, 10 Taste Masking, 10 Topical, 10 Lubricants & Glidants, 10 Disintegrants & Superdisintegrants, 8 Parenteral, 6 Chewable & Orodispersible Aids, 5 Emulsifying Agents, 5 Empty Capsules, 4 Coloring Agents, 4 Vegetarian Capsules, 4 API Stability Enhancers, 3 Rheology Modifiers, 3 Surfactant & Foaming Agents

DIGITAL CONTENT

5 DATA COMPILATION #PharmaFlow, 10 NEWS #PharmaBuzz

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5 DATA COMPILATION #PharmaFlow
10 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

50 Finished Drug Prices, 5 Annual Reports

globalSalesInformation
50 Finished Drug Prices
5 Annual Reports

MARKET PLACE

12 APIs, 1 FDF Dossiers

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12 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 US Patents

patents
4 US Patents

REF. STANDARDS & IMPURITIES

3 EDQM

otherSolutions
3 EDQM

Symbiotec Conjugated Estrogens

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,062

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

108

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

2,829

Finished Drug Prices

185 RELATED EXCIPIENT COMPANIES

315EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sodium estrone sulfate, Estrone sodium sulfate, 438-67-5, Estrone sodium sulphate, Estrone 3-sulfate sodium salt, Conestoral

Molecular Formula

C₁₈H₂₁NaO₅S

Molecular Weight

372.4 g/mol

InChI Key

VUCAHVBMSFIGAI-ZFINNJDLSA-M

FDA UNII

6K6FDA543A

1 2D Structure

Conjugated Estrogens

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfate

2.1.2 InChI

InChI=1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,18+;/m1./s1

2.1.3 InChI Key

VUCAHVBMSFIGAI-ZFINNJDLSA-M

2.1.4 Canonical SMILES

CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

6K6FDA543A

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Estrone Sulfate

2. Estrone Sulfate, 14c-labeled

3. Estrone Sulfate, 16-(14)c-labeled

4. Estrone Sulfate, Ammonium Salt

5. Estrone Sulfate, Potassium Salt

6. Estrone Sulfate, Sodium Salt

7. Estrone-3-sulfate

8. Evex

9. Oestrone Sulphate

10. Potassium Estrone Sulfate

11. Sodium Estrone Sulfate

2.3.2 Depositor-Supplied Synonyms

1. Sodium Estrone Sulfate

2. Estrone Sodium Sulfate

3. 438-67-5

4. Estrone Sodium Sulphate

5. Estrone 3-sulfate Sodium Salt

6. Conestoral

7. Hyhorin

8. Morestin

9. Estrone Sulfate Sodium

10. Par Estro

11. Estrone Sulfate Sodium Salt

12. Estrone-3-sulfate Sodium Salt

13. Sodium Estrone Sulphate

14. Sodium Estrone 3-sulfate

15. Oestrone-3-sulphate Sodium Salt

16. Estrogenic Substances (conjugated)

17. Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, Sodium Salt

18. 6k6fda543a

19. Chebi:8389

20. 17-oxoestra-1,3,5(10)-trien-3-yl Sodium Sulfate

21. Nsc-18313

22. Estrone Sulfate (sodium)

23. Sodium;[(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Sulfate

24. Sodium Estrone-3-sulfate

25. 1,3,5(10)-estratrien-3-ol-17-one Sulphate, Sodium Salt

26. Smr000058772

27. Einecs 207-120-4

28. Nsc 18313

29. Unii-6k6fda543a

30. Conjugated Estrogens: Sodium Estrone Sulfate

31. Estrone3-sulfatesodiumsalt

32. Sodium (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta(a)phenanthren-3-yl Sulfate

33. Sodium (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthren-3-yl Sulfate

34. Sodium 17-oxoestra-1(10),2,4-trien-3-yl Sulfate

35. Estrone, Hydrogen Sulfate, Sodium Salt

36. Schembl4616

37. Mls000069757

38. Mls001424259

39. Chembl2106240

40. Dtxsid00860005

41. Dtxsid70881181

42. Hms2052j05

43. Hms2232j23

44. Discontinued. See E889070

45. Akos015967195

46. Estrone Sodium Sulfate [vandf]

47. Ccg-101163

48. Hy-113293b

49. Nc00413

50. Estrone Sodium Sulfate [who-dd]

51. Cs-0108249

52. D00312

53. Q4118295

54. Sodium 17-oxoestra-1,3,5(10)-trien-3-yl Sulfate

55. Estrone 3-sulfate Sodium Salt, Stabilized With Tris

56. Estra-1,3,5(10)-trien-17-one 3-(sulfooxy) Sodium Salt

57. Sodium [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Sulfate

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₁NaO₅S
Molecular Weight	372.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	372.10073922 g/mol
Monoisotopic Mass	372.10073922 g/mol
Topological Polar Surface Area	91.9 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	630
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Premarin
PubMed Health	Conjugated Estrogens (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Musculoskeletal Agent
Drug Label	Premarin Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average com...
Active Ingredient	Estrogens, conjugated
Dosage Form	Tablet; Cream; Injectable
Route	oral; Injection; Oral; Topical, vaginal
Strength	25mg/vial; 0.45mg; 1.25mg; 0.625mg/gm; 0.625mg; 0.9mg; 0.3mg
Market Status	Prescription
Company	Wyeth Pharms

2 of 2
Drug Name	Premarin
PubMed Health	Conjugated Estrogens (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Musculoskeletal Agent
Drug Label	Premarin Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average com...
Active Ingredient	Estrogens, conjugated
Dosage Form	Tablet; Cream; Injectable
Route	oral; Injection; Oral; Topical, vaginal
Strength	25mg/vial; 0.45mg; 1.25mg; 0.625mg/gm; 0.625mg; 0.9mg; 0.3mg
Market Status	Prescription
Company	Wyeth Pharms

API SUPPLIERS

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USDMF

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CEP/COS

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NDC API

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Listed Suppliers

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API Reference Price

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(DHARMAI UNIT)","customerCountry":"BANGLADESH","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"5200","totalValueFC":"20546.8","currency":"USD","unitRateINR":384800,"date":"19-Oct-2021","totalValueINR":"1539200","totalValueInUsd":"20546.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29372900","bill_no":"4016683","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Indore-EPZ\/SEZ","supplierAddress":"385\/2, GRAM PIGDEMBER,, INDORE, M.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635273000,"product":"CONJUGATED ESTROGENS USP (VIDE SEZ SB NO","address":"H N.8-2-269\/W\/4,1ST FLOOR,PLOT NO. 4,WOMENS,S CO-OP. SOCIETY,ROAD NO.2","city":"BANJARA HILLS HYDERABAD,TELANGANA","supplier":"HRV GLOBAL LIFE SCIENCES","supplierCountry":"INDIA","foreign_port":"IMAM KHOMEINI ARPT","customer":"ABURAIHAN PH. CO","customerCountry":"IRAN","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"1304.6","totalValueFC":"316718.4","currency":"USD","unitRateINR":94904,"date":"27-Oct-2021","totalValueINR":"23726000","totalValueInUsd":"316718.4","indian_port":"HYDERABAD AIR","hs_no":"29372900","bill_no":"5592005","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"IRAN","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"H N.8-2-269\/W\/4,1ST FLOOR,PLOT NO. 4,WOMENS,S CO-OP. 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(HANGZHOU)","customer":"CIPLA","customerCountry":"INDIA","quantity":"34.00","actualQuantity":"34","unit":"KGS","unitRateFc":"2530","totalValueFC":"87032.1","currency":"USD","unitRateINR":"212393.5","date":"06-Feb-2024","totalValueINR":"7221379","totalValueInUsd":"87032.1","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"2006055","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"1305, NO.450 CAOYANG ROAD,SHANGHAISDNF CHINA","customerAddress":"MUMBAI CENTRAL,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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FDA Orange Book

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 20MG BASE;0.45MG

USFDA APPLICATION NUMBER - 22247

DOSAGE - TABLET;ORAL - 0.3MG