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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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FDF

FINISHED DOSAGE FORMULATIONS

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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USP

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JP

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PATENTS & EXCLUSIVITIES

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Health Canada Patents

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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GLOBAL SALES INFORMATION

US Medicaid

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as:
Molecular Formula
C23H30Cl2N8O4
Molecular Weight
553.4  g/mol
InChI Key
STGQPVQAAFJJFX-UHFFFAOYSA-N

Copanlisib
1 2D Structure

Copanlisib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide;dihydrochloride
2.1.2 InChI
InChI=1S/C23H28N8O4.2ClH/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15;;/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32);2*1H
2.1.3 InChI Key
STGQPVQAAFJJFX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5.Cl.Cl
2.1.5 Isomeric SMILES
COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5.Cl.Cl
2.2 Create Date
2012-11-12
3 Chemical and Physical Properties
Molecular Weight 553.4 g/mol
Molecular Formula C23H30Cl2N8O4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass552.1767069 g/mol
Monoisotopic Mass552.1767069 g/mol
Topological Polar Surface Area140 A^2
Heavy Atom Count37
Formal Charge0
Complexity796
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 1  
Drug NameALIQOPA
Active IngredientCOPANLISIB DIHYDROCHLORIDE
CompanyBAYER HEALTHCARE (Application Number: N209936. Patents: 7511041, 8466283, 9636344)

API SUPPLIERS

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01

Sun-shine Chem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

American Pharma Summit
Not Confirmed
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Sun-shine Chem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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American Pharma Summit
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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02

Sun-shine Chem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

American Pharma Summit
Not Confirmed
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Sun-shine Chem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

arrow
American Pharma Summit
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Listed Suppliers

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01

euroPLX 86 Munich
Not Confirmed
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euroPLX 86 Munich
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Copanlisib hydrochloride

About the Company : Wuhan Sun-shine chemical Corporation Limited (Shanghai Sun-shine Chemical Technology Corporation Limited) is a high-tech enterprise engaged inR&D and sales of related compounds of ...

Wuhan Sun-shine chemical Corporation Limited (Shanghai Sun-shine Chemical Technology Corporation Limited) is a high-tech enterprise engaged inR&D and sales of related compounds of new drugs, specialty pharmaceutical API, advanced intermediates, organic synthetic masonry, and high-end reagents, etc. The special services we provide include: the technical development of chiral drugs, the development of an active molecular library. Sun-shine chemical has over 1,500m² of operation premises. The R&D laboratory is more than 1,000m² and is equipped with a variety of R&D laboratory equipment.
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02

euroPLX 86 Munich
Not Confirmed
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euroPLX 86 Munich
Not Confirmed

Copanlisib

About the Company : Wuhan Sun-shine chemical Corporation Limited (Shanghai Sun-shine Chemical Technology Corporation Limited) is a high-tech enterprise engaged inR&D and sales of related compounds of ...

Wuhan Sun-shine chemical Corporation Limited (Shanghai Sun-shine Chemical Technology Corporation Limited) is a high-tech enterprise engaged inR&D and sales of related compounds of new drugs, specialty pharmaceutical API, advanced intermediates, organic synthetic masonry, and high-end reagents, etc. The special services we provide include: the technical development of chiral drugs, the development of an active molecular library. Sun-shine chemical has over 1,500m² of operation premises. The R&D laboratory is more than 1,000m² and is equipped with a variety of R&D laboratory equipment.
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Drugs in Development

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Details:

Aliqopa® (copanlisib) is a kinase inhibitor indicated for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two prior systemic therapies and now work with the FDA on a voluntary withdrawal.


Lead Product(s): Copanlisib

Therapeutic Area: Oncology Brand Name: Aliqopa

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 13, 2023

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01

Bayer AG

Germany
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American Pharma Summit
Not Confirmed

Bayer AG

Germany
arrow
American Pharma Summit
Not Confirmed

Details : Aliqopa® (copanlisib) is a kinase inhibitor indicated for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two prior systemic therapies and now work with the FDA on a voluntary withdrawal.

Brand Name : Aliqopa

Molecule Type : Small molecule

Upfront Cash : Not Applicable

November 13, 2023

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Details:

In the Phase III trial CHRONOS-3 of 458 patients with indolent non-Hodgkin’s Lymphoma, the investigational combination of Aliqopa and rituximab was statistically significant in delaying disease progression or death compared to rituximab and placebo.


Lead Product(s): Copanlisib,Rituximab

Therapeutic Area: Oncology Brand Name: Aliqopa

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 10, 2021

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02

Bayer AG

Germany
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American Pharma Summit
Not Confirmed

Bayer AG

Germany
arrow
American Pharma Summit
Not Confirmed

Details : In the Phase III trial CHRONOS-3 of 458 patients with indolent non-Hodgkin’s Lymphoma, the investigational combination of Aliqopa and rituximab was statistically significant in delaying disease progression or death compared to rituximab and placebo.

Brand Name : Aliqopa

Molecule Type : Small molecule

Upfront Cash : Not Applicable

April 10, 2021

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Details:

Phase III study CHRONOS-3 in patients with relapsed indolent Non-Hodgkin's Lymphoma (iNHL) who have received one or more prior lines of rituximab-containing therapy meets primary endpoint of progression-free survival .


Lead Product(s): Copanlisib,Rituximab

Therapeutic Area: Oncology Brand Name: Aliqopa

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 14, 2020

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03

Bayer AG

Germany
arrow
American Pharma Summit
Not Confirmed

Bayer AG

Germany
arrow
American Pharma Summit
Not Confirmed

Details : Phase III study CHRONOS-3 in patients with relapsed indolent Non-Hodgkin's Lymphoma (iNHL) who have received one or more prior lines of rituximab-containing therapy meets primary endpoint of progression-free survival .

Brand Name : Aliqopa

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 14, 2020

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INTERMEDIATES SUPPLIERS

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Fi Europe 2024
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Fi Europe 2024
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CAS Number : 57616-74-7

End Use API : Copanlisib

About The Company : Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speci...

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