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Synopsis

Synopsis

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Chemistry

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Also known as: 3'-deoxyadenosine, 73-03-0, Cordycepine, 9-cordyceposidoadenine, Adenosine, 3'-deoxy-, 9-(beta-d-3'-deoxyribofuranosyl)adenine
Molecular Formula
C10H13N5O3
Molecular Weight
251.24  g/mol
InChI Key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
FDA UNII
GZ8VF4M2J8

Cordycepin
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic, antioxidant, and anti-inflammatory activities. Cordycepin is an inhibitor of polyadenylation, activates AMP-activated protein kinase (AMPK) and reduces mammalian target of rapamycin (mTOR) signaling, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, plays an important role in the PI3K/AKT/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers.
1 2D Structure

Cordycepin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
2.1.2 InChI
InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
2.1.3 InChI Key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
2.1.4 Canonical SMILES
C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO
2.1.5 Isomeric SMILES
C1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)N)CO
2.2 Other Identifiers
2.2.1 UNII
GZ8VF4M2J8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3'-deoxyadenosine

2. 9-cordyceposidoadenine

3. Cordycepene

4. Cordycepine

2.3.2 Depositor-Supplied Synonyms

1. 3'-deoxyadenosine

2. 73-03-0

3. Cordycepine

4. 9-cordyceposidoadenine

5. Adenosine, 3'-deoxy-

6. 9-(beta-d-3'-deoxyribofuranosyl)adenine

7. 9h-purine, 6-amino-9-(3-deoxy-beta-d-ribofuranosyl)-

8. Nsc 401022

9. Brn 0035194

10. (2r,3r,5s)-2-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol

11. Gz8vf4m2j8

12. Chembl305686

13. Chebi:29014

14. Nsc-63984

15. Nsc-401022

16. Nsc 627047

17. 9-(3-deoxy-b-d-erythro-pentofuranosyl)-9h-purin-6-amine

18. Mfcd00037998

19. (2r,3r,5s)-2-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)oxolan-3-ol

20. 3ad

21. Smr000058644

22. Ccris 3233

23. Einecs 200-791-4

24. Unii-gz8vf4m2j8

25. Nsc627047

26. Cordycepin,(s)

27. Cordyceps 7%

28. 3''-deoxyadenosine

29. 3'-deoxy-adenosine

30. Beta-d-erythro-pentofuranoside, Adenine-9 3-deoxy-

31. Adenine Cordyceposide

32. Starbld0009677

33. 9-cordyceposidoadenosine

34. Cordycepin [mi]

35. 9h-purin-6-amine, 9-(3-deoxy-beta-d-erythro-pentofuranosyl)-

36. Cordycepin [inci]

37. 2'-oh-3'-da Erythro

38. Schembl98323

39. 2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol

40. 4-26-00-03594 (beilstein Handbook Reference)

41. Mls001066343

42. Mls006012047

43. Amot0014

44. Gtpl4630

45. Dtxsid1041007

46. Tcmdc-143080

47. Hms2234e22

48. Hms3413c16

49. Hms3677c16

50. Cordycepin, >=98.0% (hplc)

51. Hy-n0262

52. Zinc1319796

53. Cordycepin, From Cordyceps Militaris

54. (2r,3r,5s)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol

55. Bdbm50144950

56. Nsc 63984

57. Pdsp1_001033

58. Pdsp2_001017

59. S3610

60. (2r,3r,5s)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol

61. 2'-hydroxy-3'-deoxyadenosine Erythro

62. Akos015854875

63. Akos015902254

64. Am85418

65. Ccg-266973

66. Cs-w009017

67. Db12156

68. Ncgc00092360-03

69. Ac-22613

70. As-11189

71. 9-(beta-d-3''-deoxyribofuranosyl)adenine

72. N2808

73. C08431

74. 037c998

75. A837698

76. 9-(3-deoxy-.beta.-d-ribofuranosyl)adenine

77. Q2256677

78. Ncgc00092360-03_c10h13n5o3_3'-deoxyadenosine

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 251.24 g/mol
Molecular Formula C10H13N5O3
XLogP3-1.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass251.10183929 g/mol
Monoisotopic Mass251.10183929 g/mol
Topological Polar Surface Area119 Ų
Heavy Atom Count18
Formal Charge0
Complexity307
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Mutagens

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


ABOUT THIS PAGE

Cordycepin Manufacturers

A Cordycepin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cordycepin, including repackagers and relabelers. The FDA regulates Cordycepin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cordycepin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cordycepin Suppliers

A Cordycepin supplier is an individual or a company that provides Cordycepin active pharmaceutical ingredient (API) or Cordycepin finished formulations upon request. The Cordycepin suppliers may include Cordycepin API manufacturers, exporters, distributors and traders.

Cordycepin GMP

Cordycepin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cordycepin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cordycepin GMP manufacturer or Cordycepin GMP API supplier for your needs.

Cordycepin CoA

A Cordycepin CoA (Certificate of Analysis) is a formal document that attests to Cordycepin's compliance with Cordycepin specifications and serves as a tool for batch-level quality control.

Cordycepin CoA mostly includes findings from lab analyses of a specific batch. For each Cordycepin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cordycepin may be tested according to a variety of international standards, such as European Pharmacopoeia (Cordycepin EP), Cordycepin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cordycepin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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