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Chemistry

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Also known as: 50-22-6, 17-deoxycortisol, Kendall's compound b, Reichstein's substance h, Corticosteron, 11beta,21-dihydroxyprogesterone
Molecular Formula
C21H30O4
Molecular Weight
346.5  g/mol
InChI Key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
FDA UNII
W980KJ009P

Corticosterone
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
1 2D Structure

Corticosterone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
2.1.2 InChI
InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
2.1.3 InChI Key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
2.1.4 Canonical SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
2.1.5 Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
2.2 Other Identifiers
2.2.1 UNII
W980KJ009P
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 50-22-6

2. 17-deoxycortisol

3. Kendall's Compound B

4. Reichstein's Substance H

5. Corticosteron

6. 11beta,21-dihydroxyprogesterone

7. Compound B

8. Reichstein's B

9. (11beta)-11,21-dihydroxypregn-4-ene-3,20-dione

10. 11-hydroxycorticoaldosterone

11. 11beta,21-dihydroxy-4-pregnene-3,20-dione

12. 4-pregnene-11beta,21-diol-3,20-dione

13. 11,21-dihydroxyprogesterone

14. 11beta,21-dihydroxypregn-4-ene-3,20-dione

15. Nsc-9705

16. 11-beta,21-dihydroxypregn-3,20-dione

17. Chebi:16827

18. Nsc9705

19. 4-pregnene-11-beta,21-diol-3,20-dione

20. Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-

21. Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy-

22. Pregn-4-ene-3,20-dione, 11-beta,21-dihydroxy-

23. (11-beta)-11,21-dihydroxypregn-4-ene-3,20-dione

24. Mls000028536

25. Chembl110739

26. (8s,9s,10r,11s,13s,14s,17s)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

27. W980kj009p

28. 11.beta.,21-dihydroxyprogesterone

29. Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11b)-

30. Ncgc00022472-05

31. Smr000058318

32. 4-pregnene-11.beta.,21-diol-3,20-dione

33. Dsstox_cid_2474

34. Corticosterone 100 Microg/ml In Acetonitrile

35. Dsstox_rid_76598

36. Dsstox_gsid_22474

37. (11.beta.)-11,21-dihydroxypregn-4-ene-3,20-dione

38. (8s,9s,10r,11s,13s,14s,17s)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3h-cyclopenta[a]phenanthren-3-one

39. 11,12-dihydroxyprogesterone

40. Ccris 6753

41. 11-beta,21-dihydroxyprogesterone

42. Compound B Nach Kendall

43. Sr-01000075748

44. Nsc 9705

45. Einecs 200-019-6

46. Substanz H Nach Reichstein

47. Brn 2339601

48. Cortico

49. Unii-w980kj009p

50. Compd B

51. Cas-50-22-6

52. Prestwick_672

53. 11beta,21-dihydroxy-4-prenene-3,20-dione

54. Corticosterone Solution

55. 21-dihydroxyprogesterone

56. (11-beta)-11,21-dihydroxy-pregn-4-ene-3,20-dione

57. Opera_id_1519

58. Prestwick0_000432

59. Prestwick1_000432

60. Prestwick2_000432

61. Prestwick3_000432

62. Corticosterone, >=92%

63. 11-.beta.,20-dione

64. Bmse000669

65. Epitope Id:152207

66. Corticosterone [mi]

67. Bidd:pxr0063

68. Lopac0_000220

69. Schembl22612

70. Bspbio_000444

71. 4-pregnene-11 Corticosteron

72. Mls001074095

73. Mls001424305

74. Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11.beta.)-

75. 11b,21-dihydroxyprogesterone

76. Bidd:er0495

77. Spbio_002383

78. Bpbio1_000490

79. Gtpl2869

80. Dtxsid6022474

81. Corticosterone, Brn 2339601

82. 4-pregnene-11.beta.,20-dione

83. Hms1569g06

84. Hms2052g21

85. Hms2090a08

86. Hms2096g06

87. Hms2231f16

88. Hms3260l21

89. Hms3713g06

90. Hms3885h22

91. Amy22288

92. Hy-b1618

93. Tox21_110879

94. Tox21_201366

95. Tox21_303642

96. Tox21_500220

97. Bdbm50170653

98. Cmc_13412

99. Hsci1_000383

100. Lmst02030186

101. S4752

102. Stl564760

103. Zinc13513592

104. Corticosterone, >=98.5% (hplc)

105. Akos016008541

106. Tox21_110879_1

107. 11-b,21-dihydroxypregn-3,20-dione

108. Ccg-101146

109. Cs-5105

110. Db04652

111. Lp00220

112. Nc00396

113. Sdccgsbi-0050208.p002

114. Smp1_000079

115. Ncgc00022472-06

116. Ncgc00022472-07

117. Ncgc00022472-08

118. Ncgc00022472-10

119. Ncgc00022472-17

120. Ncgc00091029-01

121. Ncgc00256539-01

122. Ncgc00258918-01

123. Ncgc00260905-01

124. 11

125. A

126. As-75743

127. 11,21-dihydroxypregn-4-ene-3,20-dione

128. 11-.beta.,21-dihydroxypregn-3,20-dione

129. 11b,21-dihydroxy-4-pregnene-3,20-dione

130. Pregn-4-ene-3, 11.beta.,21-dihydroxy-

131. 4-pregnen-11.beta.,21-diol-3,20-dione

132. B7469

133. Eu-0100220

134. C 2505

135. C02140

136. D94656

137. Preg-4-ene-3,20-dione,11-b,21-dihydroxy-

138. 11.beta.,21-dihydroxypregn-4-ene-3,20-dione

139. Corticosterone, Vetranal(tm), Analytical Standard

140. Q422543

141. Sr-01000000082

142. (11?)-11,21-dihydroxypregn-4-ene-3,20-dione

143. Pregn-4-ene-3,20-dione, 11.beta.,21-dihydroxy-

144. Sr-01000000082-3

145. Sr-01000075748-1

146. Sr-01000075748-4

147. W-105977

148. Wln: L E5 B666 Ov Mutj A1 Cq E1 Fv1q

149. (11beta)-11,21-dihydroxypregn-4-ene-3,2 0-dione

150. Brd-k73589401-001-04-6

151. Pregn-4-ene-3, 11,21-dihydroxy-, (11.beta.)-

152. (9beta,11alpha)-11,21-dihydroxypregn-4-ene-3,20-dione

153. 11,21-dihydroxypregn-4-ene-3,20-dione, (11.beta.)- #

154. 4793eb71-d789-498e-b641-c5c1c377b9ff

155. 17-deoxycortisol;11

156. A,21-dihydroxyprogesterone;kendalls Compound B

157. Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-beta)- (9ci)

158. Kendall's Compound B; 4-pregnene-11beta,21-diol-3,20-dione; Reichstein's Substance H

159. Corticosterone Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 346.5 g/mol
Molecular Formula C21H30O4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass346.21440943 g/mol
Monoisotopic Mass346.21440943 g/mol
Topological Polar Surface Area74.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


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ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S. PHARMACOPEIAL ","supplierCountry":"CANADA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0009","unit":"KGS","unitRateFc":"184000","totalValueFC":"179.3","currency":"USD","unitRateINR":"14654411.1","date":"20-Sep-2021","totalValueINR":"13188.97","totalValueInUsd":"179.3","indian_port":"HYDERABAD AIR","hs_no":"29372900","bill_no":"5506622","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1642530600,"product":"DESOXYCORTICOSTERONE ACETATE (QTY: 1 X 200 MG, PRICE: USD 252)(FOC)","address":"P.NO. 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ABOUT THIS PAGE

Corticosterone Manufacturers

A Corticosterone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Corticosterone, including repackagers and relabelers. The FDA regulates Corticosterone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Corticosterone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Corticosterone Suppliers

A Corticosterone supplier is an individual or a company that provides Corticosterone active pharmaceutical ingredient (API) or Corticosterone finished formulations upon request. The Corticosterone suppliers may include Corticosterone API manufacturers, exporters, distributors and traders.

click here to find a list of Corticosterone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Corticosterone USDMF

A Corticosterone DMF (Drug Master File) is a document detailing the whole manufacturing process of Corticosterone active pharmaceutical ingredient (API) in detail. Different forms of Corticosterone DMFs exist exist since differing nations have different regulations, such as Corticosterone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Corticosterone DMF submitted to regulatory agencies in the US is known as a USDMF. Corticosterone USDMF includes data on Corticosterone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Corticosterone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Corticosterone suppliers with USDMF on PharmaCompass.

Corticosterone GMP

Corticosterone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Corticosterone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Corticosterone GMP manufacturer or Corticosterone GMP API supplier for your needs.

Corticosterone CoA

A Corticosterone CoA (Certificate of Analysis) is a formal document that attests to Corticosterone's compliance with Corticosterone specifications and serves as a tool for batch-level quality control.

Corticosterone CoA mostly includes findings from lab analyses of a specific batch. For each Corticosterone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Corticosterone may be tested according to a variety of international standards, such as European Pharmacopoeia (Corticosterone EP), Corticosterone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Corticosterone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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